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Literature summary for 3.4.22.36 extracted from
- Superoxide dismutase 1 regulates caspase-1 and endotoxic shock (2008), Nat. Immunol., 9, 866-872.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | caspase-1 activation is induced by ATP and lipopolysaccharides | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type and mutant enzymes in HEK-293T cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C136S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C169S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C244S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C270S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C285S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C331S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C362S | the mutant is hyperactive in normoxic conditions, while the activity of the mutant is similar to that of wild-type caspase-1 in hypoxic conditions | Homo sapiens |
| C362S/C397S | the mutant is hyperactive in normoxic conditions, while the activity of the mutant is similar to that of wild-type caspase-1 in hypoxic conditions | Homo sapiens |
| C364S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C397S | the mutant is hyperactive in normoxic conditions, while the activity of the mutant is similar to that of wild-type caspase-1 in hypoxic conditions | Homo sapiens |
| C69S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C72S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
| C77S | the mutant enzyme shows decreased activity compared to the wild-type enzyme | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | hypoxia abrogates caspase-1 inhibition, overview | Homo sapiens | |
| superoxide | superoxide production decreases the cellular redox potential and specifically inhibites caspase-1 by reversible oxidation and glutathionylation of the redox-sensitive cysteine residues Cys397 and Cys362 | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | Nod-like receptors induce assembling of the inflammasome multiprotein complexes to activate caspase-1 in response to microbial and danger signals, overview. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock, a physiological posttranslational mechanism, overview. Redox-sensitive cysteine residues regulate caspase-1 to identify the redox-sensitive cysteine residues in caspase | ? | - |
? | |
| pro-interleukin-18 + H2O | Homo sapiens | caspase-1 serves an essential function in the initiation of inflammation by proteolytically maturing the cytokines interleukin 1beta and interleukin 18 | interleukin-18 + ? | - |
? | |
| pro-interleukin-1beta + H2O | Homo sapiens | caspase-1 serves an essential function in the initiation of inflammation by proteolytically maturing the cytokines interleukin 1beta and interleukin 18 | interleukin-1beta + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | caspase-1 is gluthathionylated | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | bone marrow-derived macrophages, wild-type and superoxide dismutase-deficient | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ac-YVAD-4-nitroanilide + H2O | - |
Homo sapiens | Ac-YVAD + 4-nitroaniline | - |
? | |
| additional information | Nod-like receptors induce assembling of the inflammasome multiprotein complexes to activate caspase-1 in response to microbial and danger signals, overview. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock, a physiological posttranslational mechanism, overview. Redox-sensitive cysteine residues regulate caspase-1 to identify the redox-sensitive cysteine residues in caspase | Homo sapiens | ? | - |
? | |
| pro-interleukin-18 + H2O | - |
Homo sapiens | interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | caspase-1 serves an essential function in the initiation of inflammation by proteolytically maturing the cytokines interleukin 1beta and interleukin 18 | Homo sapiens | interleukin-18 + ? | - |
? | |
| pro-interleukin-1beta + H2O | - |
Homo sapiens | interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | caspase-1 serves an essential function in the initiation of inflammation by proteolytically maturing the cytokines interleukin 1beta and interleukin 18 | Homo sapiens | interleukin-1beta + ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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