Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pralnacasan | potent caspase 1 inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | - |
Mus musculus | mature interleukin-1beta + ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Mus musculus | caspase 1 activity is inhibited in mice lacking active cysteine proteases | down |
General Information | Comment | Organism |
---|---|---|
malfunction | caspase 1 deficiency does not affect neutrophil-dominated joint inflammation, whereas in chronic arthritis, the lack of caspase 1 results in reduced joint inflammation and cartilage destruction | Mus musculus |