EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.102 | 3-dehydrosphinganine reductase |
placenta |
highest expression |
656256 |
1.1.1.112 | indanol dehydrogenase |
placenta |
- |
285761 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
placenta |
- |
285914, 285915, 285916, 285919, 285920, 285922, 285923, 285927, 285932, 285933, 285934, 285935, 285937, 654361, 657210, 670524, 711448, 740130 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
placenta |
PGDH protein is concentrated in the parietal yolk sac membrane (PYS) lining the placental surface and in placental blood vessels |
726470 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
- |
389371, 389372, 389389, 655345, 656577, 656788, 763397 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
3beta-HSD I |
389386, 389387, 389395, 389401 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
3beta-hydroxysteroid dehydrogenase type 1 |
693887 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
3betaHSD VI |
389384 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
Hsd3b6 is specifically found in the giant trophoblast cells surrounding the embryonic cavity |
740997 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
in syncytiotrophoblast, cytotrophoblast and intermediate trophoblast immunoreactive 3betaHSD is found from first to third trimester and term |
389388 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
intermediate trophoblast and syncytiotrophoblasts |
763756 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
isozyme 3beta-HSD1 |
662371 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
placenta |
isozyme type 1 |
656091 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
placenta |
- |
285966, 740917, 760443, 761000, 762011 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
placenta |
constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms |
285951 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
placenta |
isozyme 11beta-HSD2 |
700179 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
placenta |
the 11beta-HSD2 expression and activity is 7-8fold higher compared to 11beta-HSD1 in the chorionic plate of small gestational age placentas |
697720 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
placenta |
two forms present, one NAD-specific the other NADP+-dependent |
285955 |
1.1.1.147 | 16alpha-hydroxysteroid dehydrogenase |
placenta |
- |
285969 |
1.1.1.148 | estradiol 17alpha-dehydrogenase |
placenta |
- |
285970 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
placenta |
- |
285977, 285981, 699835, 725822, 726471, 737453, 738806, 739860 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
placenta |
expression profile during pregnancy, overview |
670023 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
placenta |
the protein is strongly detected in the placenta on days 14, 16, and 18 of pregnancy |
760948 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
placenta |
- |
286025 |
1.1.1.172 | 2-oxoadipate reductase |
placenta |
- |
286112 |
1.1.1.184 | carbonyl reductase (NADPH) |
placenta |
- |
347770 |
1.1.1.188 | prostaglandin-F synthase |
placenta |
- |
704349, 740487 |
1.1.1.188 | prostaglandin-F synthase |
placenta |
expression levels in uninucleated trophoblasts of the placentome of pregnant cows, especially chorionic plate and apical tertiary villi, overview |
670525 |
1.1.1.188 | prostaglandin-F synthase |
placenta |
the prostaglandin synthase expression profile favours production of PGD2, PGE2 and PGF2, with high levels of prostaglandin transporters and catabolic prostaglandin dehydrogenase suggesting rapid prostaglandin turnover |
713047 |
1.1.1.188 | prostaglandin-F synthase |
placenta |
utero/placental expression of isoform AKR1C3 is found in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation |
724504 |
1.1.1.189 | prostaglandin-E2 9-reductase |
placenta |
- |
389466, 657211 |
1.1.1.189 | prostaglandin-E2 9-reductase |
placenta |
with and without retained fetal membranes, retained and not retained tissue, activity increases with parturition, activity is higher in the maternal than in the fetal part, overview |
657212 |
1.1.1.197 | 15-hydroxyprostaglandin dehydrogenase (NADP+) |
placenta |
- |
347827, 347829, 347831, 347833, 347834, 347835, 347836, 348018 |
1.1.1.2 | alcohol dehydrogenase (NADP+) |
placenta |
- |
-, 286181, 286182, 286186, 286187 |
1.1.1.205 | IMP dehydrogenase |
placenta |
- |
347931 |
1.1.1.209 | 3(or 17)alpha-hydroxysteroid dehydrogenase |
placenta |
- |
389547 |
1.1.1.21 | aldose reductase |
placenta |
- |
286240, 286244, 286261, 656089, 667553 |
1.1.1.21 | aldose reductase |
placenta |
not |
286239 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
placenta |
- |
656959, 741474 |
1.1.1.231 | 15-hydroxyprostaglandin-I dehydrogenase (NADP+) |
placenta |
- |
348017, 348018 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
placenta |
- |
287212 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
placenta |
3beta-HSD1 is selectively expressed in human placenta, mammary glands and breast tumors in women |
763397 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
placenta |
selective expression of 3beta-HSD1 |
725813 |
1.1.1.300 | NADP-retinol dehydrogenase |
placenta |
- |
656098 |
1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase |
placenta |
- |
722472 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
placenta |
9% mRNA expression of Rdh5 compared to liver |
690797 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
placenta |
strong expression, the 3 kb isoform is the most abundant one |
692332 |
1.1.1.345 | D-2-hydroxyacid dehydrogenase (NAD+) |
placenta |
- |
287843 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
placenta |
- |
725333 |
1.1.1.36 | acetoacetyl-CoA reductase |
placenta |
isozymes AKR1B15.1 and AKR1B15.2 |
740743 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
placenta |
- |
286749 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
placenta |
moderate expression level |
-, 722338 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
placenta |
- |
287016 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
placenta |
- |
658489 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
placenta |
the enzyme is primarily expressed in the placenta and ovarian granulose cells |
761067 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
- |
285970, 285977, 285981, 287172, 287173, 287174, 287176, 287181, 287182, 287183, 287184, 287186, 287187, 287188, 287190, 287191, 654934, 655219, 655524, 656371, 658489, 669797, 670033, 670265, 686263, 688272, 688454, 688956, 699435, 700183, 726289, 740408, 740849, 762074 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
17beta-HSD1 |
685552 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
17beta-HSD2 |
685552 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
high expression |
688956 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
isoform 8 is highly expressed, low level of isoform 5 |
656654 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
isozyme 17beta-HSD1 |
675982 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
isozymes AKR1B15.1 and AKR1B15.2 |
740743 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta |
659810 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
organotin compounds are potent stimulators of 17beta-estradiol biosynthesis to enhance 17beta-HSD I activity in placenta |
667555 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
placenta |
the enzyme is primarily expressed in the placenta and ovarian granulose cells |
761067 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
placenta |
isozyme 17beta-HSD1 |
675982 |
1.1.1.71 | alcohol dehydrogenase [NAD(P)+] |
placenta |
- |
655563 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
placenta |
- |
287350 |
1.1.1.96 | diiodophenylpyruvate reductase |
placenta |
- |
287552 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
placenta |
- |
-, 742040, 742042, 743434, 760443 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
placenta |
almost exclusively isozyme 11beta-HSD2 |
667151 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
placenta |
constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms |
285951 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
placenta |
highly expressed |
285953 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
placenta |
the 11beta-HSD2 expression and activity is 7-8fold higher compared to 11beta-HSD1 in the chorionic plate of small gestational age placentas |
697720 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
placenta |
two forms present, one NAD-specific the other NADP+-dependent |
285955 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
placenta |
- |
671327 |
1.11.1.24 | thioredoxin-dependent peroxiredoxin |
placenta |
0.0002 mg Prx I per mg of soluble protein Prx I, 0.0007 mg Prx II per mg of soluble protein, less than 0.0003 mg Prx III per mg of soluble protein, 0.0007 mg Prx V per mg of soluble protein and 0.0002 mg Prx VI per mg of soluble protein |
655756 |
1.11.1.7 | peroxidase |
placenta |
- |
698048 |
1.11.1.8 | iodide peroxidase |
placenta |
TPO is expressed at gene and protein levels in endometrium and placenta, expression is mainly localized to he syncytiotrophoblasts and invasive trophoblast cells |
764516 |
1.11.1.9 | glutathione peroxidase |
placenta |
- |
396616 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
placenta |
- |
743358 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
placenta |
endothelial cell expression in placenta |
765516 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
placenta |
expression of HGO gene |
439388 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
placenta |
- |
395471, 395472, 659803, 666378, 710824, 743358 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
placenta |
brush border microvillous plasma membranes of placental syncytiotrophoblast |
395472 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
placenta |
endothelial cell expression in placenta |
765516 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
placenta |
in the first and second trimester placenta the enzyme is localized to the syncytiotrophoblast, stroma and macrophages. In term placenta confined mainly to vascular endothelial cells of villous blood vessels, and to macrophages within the fetal villus |
660112 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
placenta |
term placenta |
671714 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
placenta |
maternal |
-, 745967 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
placenta |
- |
673951, 742226 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
placenta |
- |
439179, 439183, 439184, 439186, 659235, 659280 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
placenta |
expression of enzyme alpha-I and alpha-II subunits mRNAs |
439242 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
placenta |
expression level of of HIF-P4H-3 mRNA is highest in the adult heart, brain, placenta, lung, and skeletal muscle and in the fetal heart, spleen, and skeletal muscle |
659235 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
placenta |
the level of HIF-P4H-1 mRNA expression is highest in the adult brain, placenta, lung, and kidney |
659235 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
placenta |
- |
439149 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
placenta |
expression of LH2long and LH2short |
659845 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
placenta |
- |
687733 |
1.14.11.8 | trimethyllysine dioxygenase |
placenta |
- |
675029 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
placenta |
- |
765745 |
1.14.13.9 | kynurenine 3-monooxygenase |
placenta |
- |
764034 |