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Information on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.145

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IUBMB Comments

Acts on 3β-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17-dione and on 3β-hydroxypregn-5-en-20-one to form progesterone.

The enzyme appears in viruses and cellular organisms

Synonyms
hsd3b2, hsd3b, dhrs4, 3-beta-hydroxysteroid dehydrogenase, hsd3b6, 3betahsd2, 3beta hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type ii, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hsd type ii, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3beta-hydroxy-DELTA5-steroid + NAD+ = a 3-oxo-DELTA5-steroid + NADH + H+
show the reaction diagram