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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
dihydroxyacetone phosphate + NADH
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
?
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 1-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
glycerol-3-phosphate + NAD+
glycerone phosphate + NADH
glycerone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
r
glycerone phosphate + NADH
L-glycerol-3-phosphate + NAD+
-
-
-
-
r
glycerone phosphate + NADH
sn-glycerol 3-phosphate + NAD+
-
-
-
-
r
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
glycolaldehyde + NADH + H+
?
-
-
-
-
?
glycolaldehyde + NADH + H+
? + NAD+
-
truncated substrate
-
-
r
glycolaldehyde + NADH + H+
ethane-1,2-diol + NAD+
-
-
-
-
r
L-glycerol-3-phosphate + NAD+
glycerone phosphate + NADH
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NADP+
dihydroxyacetone phosphate + NADPH + H+
additional information
?
-
dihydroxyacetone phosphate + NADH

glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH

sn-glycerol 3-phosphate + NAD+
an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analysis
-
-
?
dihydroxyacetone phosphate + NADH
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+

sn-glycerol 3-phosphate + NAD+
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
glycerol-3-phosphate + NAD+

glycerone phosphate + NADH
-
-
-
-
r
glycerol-3-phosphate + NAD+
glycerone phosphate + NADH
-
-
-
-
?
glycerone phosphate + NADH + H+

sn-glycerol 3-phosphate + NAD+
-
-
-
r
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?, r
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
r
glycolaldehyde + NADH

?
-
-
-
-
?
glycolaldehyde + NADH
?
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+

dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 25% the rate of dihydroxyacetone phosphate reduction at optimal pH
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
isozymes GPDH1 can utilize both NADH and NADPH as coenzymes but exhibits significantly higher activities when NADH is used as the coenzyme
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
isozymes GPDH1 can utilize both NADH and NADPH as coenzymes but exhibits significantly higher activities when NADH is used as the coenzyme
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to production of reactive oxygen species in prostate cancer cells
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
favoured reaction of heart isozyme II6.1
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 3% the reaction rate of dihydroxyacetone phosphate reduction at pH 7.0
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
reverse reaction favoured direction
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 3% the reaction rate of dihydroxyacetone phosphate reduction at pH 7.0
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 25% the rate of dihydroxyacetone phosphate reduction at optimal pH
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+

glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
NAD+-linked cGPDH can interconvert DHAP and glycerol 3-phosphate
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NADP+

dihydroxyacetone phosphate + NADPH + H+
-
the measured GPDH activity of isozyme GPDH1 with NADH is approximately twice of that observed with NADPH
-
?
sn-glycerol 3-phosphate + NADP+
dihydroxyacetone phosphate + NADPH + H+
-
the measured GPDH activity of isozyme GPDH2 with NADH is approximately twice of that observed with NADPH
-
?
sn-glycerol 3-phosphate + NADP+
dihydroxyacetone phosphate + NADPH + H+
isozymes GPDH1 can utilize both NADH and NADPH as coenzymes but exhibits significantly higher activities when NADH is used as the coenzyme
-
-
?
sn-glycerol 3-phosphate + NADP+
dihydroxyacetone phosphate + NADPH + H+
-
the measured GPDH activity of isozyme GPDH1 with NADH is approximately twice of that observed with NADPH
-
?
sn-glycerol 3-phosphate + NADP+
dihydroxyacetone phosphate + NADPH + H+
isozymes GPDH1 can utilize both NADH and NADPH as coenzymes but exhibits significantly higher activities when NADH is used as the coenzyme
-
-
?
sn-glycerol 3-phosphate + NADP+
dihydroxyacetone phosphate + NADPH + H+
-
the measured GPDH activity of isozyme GPDH2 with NADH is approximately twice of that observed with NADPH
-
?
additional information

?
-
-
increased glycerol-3-phosphate levels are associated with enhanced resistance to Colletotrichum higginsianum. Overexpression of the host GLY1 gene, which encodes a G3P dehydrogenase, confers enhanced resistance to the hemibiotrophic fungus Colletotrichum higginsianum
-
-
-
additional information
?
-
-
glyceraldehyde-3-phosphate
-
-
-
additional information
?
-
-
fructose-6-phosphate, fructose-1,6-bisphosphate
-
-
-
additional information
?
-
-
glucose-6-phosphate, acetaldehyde, oxaloacetate
-
-
-
additional information
?
-
-
no substrates: dihydroxyacetone
-
-
-
additional information
?
-
-
glyceraldehyde-3-phosphate
-
-
-
additional information
?
-
-
fructose-6-phosphate, fructose-1,6-bisphosphate
-
-
-
additional information
?
-
-
glucose-6-phosphate, acetaldehyde, oxaloacetate
-
-
-
additional information
?
-
-
no substrates: dihydroxyacetone
-
-
-
additional information
?
-
-
glyceraldehyde-3-phosphate
-
-
-
additional information
?
-
-
no substrates: dihydroxyacetone
-
-
-
additional information
?
-
-
high NaCl tolerance seems to be determined by a combination of enhanced glycerol production, due to an increased expression of DhGPD1 (glycerol 3-phosphate dehydrogenase) and DhGPP2 (glycerol 3-phosphatase)
-
-
-
additional information
?
-
-
involved in cellular acidosis, oxidoresistance, apoptosis by both acidosis and cell-cell contact inhibition, cell growth, and the generation of recombinant proteins
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
glyceraldehyde-3-phosphate
-
-
-
additional information
?
-
-
a decrease in temperature alone is sufficient to activate glycerol production and an increase in GPDH activity plays a critical role in the early stages of this process
-
-
-
additional information
?
-
-
glycerol
-
-
-
additional information
?
-
-
no substrates: dihydroxyacetone
-
-
-
additional information
?
-
high NaCl tolerance seems to be determined by a combination of enhanced glycerol production, due to an increased expression of GPD1 (glycerol 3-phosphate dehydrogenase) and GPP2 (glycerol 3-phosphatase)
-
-
-
additional information
?
-
-
glycerol
-
-
-
additional information
?
-
-
no substrates: dihydroxyacetone
-
-
-
additional information
?
-
-
glycerol
-
-
-
additional information
?
-
-
glyceraldehyde-3-phosphate
-
-
-
additional information
?
-
-
DL-glyceraldehyde, phosphohydroxypyruvate
-
-
-
additional information
?
-
-
fructose-6-phosphate, fructose-1,6-bisphosphate
-
-
-
additional information
?
-
-
no substrates: dihydroxyacetone
-
-
-
additional information
?
-
-
relative to euthermic liver G3PDH, hibernator liver G3PDH has a decreased affinity for its substrate, glycerol-3-phosphate (G3P) at 37°C and 22°C, while at 5°C, there is a significant increase in affinity for G3P in the hibernating form of the enzyme, relative to the euthermic form
-
-
-
additional information
?
-
no activity with NADP+
-
-
-
additional information
?
-
no activity with NADP+
-
-
-
additional information
?
-
no activity with NADP+
-
-
-
additional information
?
-
no activity with NADP+
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 1-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
additional information
?
-
dihydroxyacetone phosphate + NADH

glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+

sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
glycerone phosphate + NADH + H+

sn-glycerol 3-phosphate + NAD+
-
-
-
r
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+

dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 25% the rate of dihydroxyacetone phosphate reduction at optimal pH
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to production of reactive oxygen species in prostate cancer cells
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
favoured reaction of heart isozyme II6.1
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 3% the reaction rate of dihydroxyacetone phosphate reduction at pH 7.0
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
reverse reaction favoured direction
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 3% the reaction rate of dihydroxyacetone phosphate reduction at pH 7.0
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 25% the rate of dihydroxyacetone phosphate reduction at optimal pH
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
sn-glycerol 3-phosphate + NAD+

glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
glycerone phosphate + NADH + H+
-
-
-
r
additional information

?
-
-
increased glycerol-3-phosphate levels are associated with enhanced resistance to Colletotrichum higginsianum. Overexpression of the host GLY1 gene, which encodes a G3P dehydrogenase, confers enhanced resistance to the hemibiotrophic fungus Colletotrichum higginsianum
-
-
-
additional information
?
-
-
high NaCl tolerance seems to be determined by a combination of enhanced glycerol production, due to an increased expression of DhGPD1 (glycerol 3-phosphate dehydrogenase) and DhGPP2 (glycerol 3-phosphatase)
-
-
-
additional information
?
-
-
involved in cellular acidosis, oxidoresistance, apoptosis by both acidosis and cell-cell contact inhibition, cell growth, and the generation of recombinant proteins
-
-
-
additional information
?
-
-
a decrease in temperature alone is sufficient to activate glycerol production and an increase in GPDH activity plays a critical role in the early stages of this process
-
-
-
additional information
?
-
high NaCl tolerance seems to be determined by a combination of enhanced glycerol production, due to an increased expression of GPD1 (glycerol 3-phosphate dehydrogenase) and GPP2 (glycerol 3-phosphatase)
-
-
-
additional information
?
-
-
relative to euthermic liver G3PDH, hibernator liver G3PDH has a decreased affinity for its substrate, glycerol-3-phosphate (G3P) at 37°C and 22°C, while at 5°C, there is a significant increase in affinity for G3P in the hibernating form of the enzyme, relative to the euthermic form
-
-
-
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(-)-epigallocatechin-3-gallate
-
noncompetitive
2,3-Dimercaptopropanol
-
competitive inhibitor to glycerophosphate
2,4-Dichlorophenoxyacetic acid
-
-
2-amino-2-hydroxymethylpropane-1,3-diol
-
i.e. Tris
2-hydroxy-1,2,3-nonadecanetricarboxylic acid
3-morpholinosydnonimine
-
-
adenosine diphosphate ribose
ADP
-
at physiological concentration, 10 mM 90% inhibition
ADP-ribose
-
allosteric inhibitor
Cd2+
-
50% inhibition at 8.33 mM; 50% inhibition at 8.3 mM
Cu2+
-
50% inhibition at 12.96 mM; 50% inhibition at 13.0 mM
dihydroxyacetone phosphate
FeCl2
-
0.5 mM, about 10% residual activity
fructose-1,6-bisphosphate
-
at physiological concentration, non-competitive
glycerol
-
slight inhibition
glycerol phosphate
-
0.025 mM, strong inhibition of chloroplastic and cytosolic form, endproduct inhibition
guanidine hydrochloride
-
-
guanidinium hydrochloride
-
-
gymnemic acid
-
may have some pharmacological activities including antidiabetic activity and lipid lowering effects via interaction with G3PDH
iodoacetamide
-
effective inhibitor
K+
-
50% inhibition at 40.66 mM; 50% inhibition at 40.7 mM
Large peptide factor
-
chloroplast enzyme
-
linoleic acid
-
0.003 mM, 40% inhibition of chloroplastic form and 43% inhibition of cytosolic form
malate
-
at high concentration
Mn2+
-
50% inhibition at 36.6 mM
NADH-X
-
allosteric inhibitor
Ni2+
-
50% inhibition at 31.66 mM; 50% inhibition at 31.7 mM
Nucleic acids
-
strongly inhibit
-
o-Iodosobenzoic acid
-
0.5 mM, about 10% residual activity
octyl glucose
-
0.003 mM, 41% inhibition of chloroplastic form and 61% inhibition of cytosolic form
p-mercuribenzoate
-
0.1 mM complete inhibition
palmitic acid
-
0.003 mM, 40% inhibition of chloroplastic form and 43% inhibition of cytosolic form
phenylmethyl sulfonyl fluoride
-
0.5 mM 50% inhibition of cytosolic form, little effect on chloroplastic form
phosphatidyl choline
-
0.003 mM, 42% inhibition of chloroplastic form and 43% inhibition of cytosolic form
phosphite dianion
-
strongly inhibits the mutant N270A enzyme. The N270A mutation results in a change in the effect of phosphite dianion on (kcat/Km)obs for GPDH-catalyzed reduction of glycerone phosphate, from strongly activating to inhibiting
phosphogluconate
-
cytosolic isozyme
reduced thioredoxin
-
stimulation of chloroplastic form
S-nitroso-N-acetylpenicillamine
-
-
sedoheptulose 1,7-bisphosphate
-
0.5 mM, chloroplastic and cytosolic form inhibited by 50%
selenocysteine
-
0.015 mM, 10% residual activity
selenomethionine
-
0.015 mM, 40% residual activity
Small peptide factor
-
cytosolic enzyme
-
SO42-
-
at high concentration, MgSO4 most inhibitory
Sodium selenite
-
0.015 mM, 10% residual activity
Thylakoid fraction
-
0.02 mM 97% inhibition
-
Triton X-100
-
0.006 mM, 50% inhibition of chloroplastic form and 52% inhibition of cytosolic form
Zn2+
-
50% inhibition at 5.66 mM; 50% inhibition at 5.7 mM
ZnCl2
-
0.5 mM, about 10% residual activity
(NH4)2SO4

-
-
(NH4)2SO4
-
inhibition of chloroplastic and cytosolic form
2-hydroxy-1,2,3-nonadecanetricarboxylic acid

-
trypanocidal drug, IC50 0.00055 mM
2-hydroxy-1,2,3-nonadecanetricarboxylic acid
-
IC50 0.0011 mM
adenosine diphosphate ribose

-
0.094 mM slightly inhibits NADH binding by honeybee GPDH, but not by rabbit GPDH
adenosine diphosphate ribose
-
-
ATP

-
weak inhibitor of both isozymes, i.e. GPDH-1 and -3
ATP
-
at physiological concentration, 10 mM 95% inhibition
Cl-

-
competitive inhibitor with respect to dihydroxyacetone phosphate
Cl-
-
cations, i.e. H+, K+, Na+ associated with Cl- do not affect the reduction of dihydroxyacetone phosphate
dihydroxyacetone phosphate

-
high levels of substrate, i.e. dihydroxyacetone phosphate result in inhibition
dihydroxyacetone phosphate
-
substrate inhibition above 1 mM, NADH above 0.2 mM; substrate inhibition only at high concentration, over 1 mM
dihydroxyacetone phosphate
-
0.5 mM, GPDHs more susceptible to inhibition
dihydroxyacetone phosphate
-
substrate inhibition at 0.2 mM
dihydroxyacetone phosphate
-
substrate inhibition at 0.2 mM
iodoacetate

-
-
iodoacetate
-
50 mM, incubated for 60 min
iodoacetate
-
0.1 mM 23% inhibition
iodoacetate
-
reversible by dithiothreitol, 10 mM inhibits to 50%
L-glycerol 3-phosphate

-
inhibits dihydroxyacetone phosphate reduction
L-glycerol 3-phosphate
-
-
L-glycerol 3-phosphate
-
inhibitor of bumble bee enzyme, non-competitive
L-glycerol 3-phosphate
-
competitive inhibitor to dihydroxyacetone phosphate, non-competitive to NADH
L-glycerol 3-phosphate
-
inhibits dihydroxyacetone phosphate reduction
L-glycerol 3-phosphate
-
over 0.025 mM, strong inhibitor of cytosolic and chloroplastic enzyme
Melarsen oxide

-
active principle of the trypanocidal drug melarsoprol and cymelarsen
Melarsen oxide
-
active principle of the trypanocidal drug melarsoprol and cymelarsen; cymelarsen, IC50 0.0015-0.005 mM
N-ethylmaleimide

-
0.1 mM inhibits enzyme over 60%
N-ethylmaleimide
-
1 mM results in 50% inhibition, reversible by NADH, inhibition increases in the presence of dihydroxyacetone phosphate and/or glycerol 3-phosphate
N-ethylmaleimide
-
0.5 mM, about 20% residual activity
N-ethylmaleimide
-
20 mM, complete inhibition; 20 mM, complete loss of activity
N-ethylmaleimide
-
0.1 mM complete inhibition
N-ethylmaleimide
-
reversible by dithiothreitol, 5 mM inhibits more than 90% of the enzyme activity
NaCl

-
inactivation
NaCl
isozyme GPDH1 is severely inhibited by the addition of 100-200 mM NaCl; isozyme GPDH2 is severely inhibited by the addition of 100-200 mM NaCl
NaCl
-
strongly inhibits, 50% activity at 250 mM NaCl
NaCl
-
inactivates irreversibly
NaCl
-
strongly inhibits, 50% activity at 250 mM NaCl
NAD+

-
competitive inhibitor to NADH at physiological concentration; non-competitive to dihydroxyacetone phosphate
NAD+
-
competitive inhibitor to NADH at physiological concentration
NAD+
-
competitive inhibitor to NADH at physiological concentration
NADH

-
at high concentration
NADH
-
at high concentration
NADPH

-
-
NADPH
-
inhibits in presence of saturing concentration of NADH and dihydroxyacetone phosphate
NADPH
-
inhibits in presence of saturing concentration of NADH and dihydroxyacetone phosphate
p-chloromercuribenzoate

-
0.0001 mM inhibits enzyme over 60%
p-chloromercuribenzoate
-
0.05 mM, 100% inhibition
p-chloromercuribenzoate
-
effective inhibitor
p-chloromercuribenzoate
-
10 nM, strong inhibition
p-chloromercuribenzoate
-
10 nM, strong inhibition; reversible by dithiothreitol, 0.001 mM inhibits more than 90% of the enzyme activity
p-chloromercuribenzoate
-
0.1 mM, reversed by thiols, e.g. dithiothreitol
phosphate

-
competitive inhibition
phosphate
phosphate at 5-10 mM severely inhibits the enzymatic activity of isozyme GPDH1; phosphate at 5-10 mM severely inhibits the enzymatic activity of isozyme GPDH2
phosphate
-
competitive inhibitor against dihydroxyacetone phosphate, non-competitive inhibitor against NADH
phosphate
-
slight inhibition of cytosolic form, at higher concentrations above 20-30 mM both forms are inhibited
suramin

-
trypanocidal drug, potent inhibitor, IC50 0.0002 mM
suramin
-
IC50 0.00044 mM
additional information

-
high ionic strength above 0.03 M
-
additional information
GPDH1 transcript level decreases progressively with NaCl concentrations above 3-5 M, the expression level of GPDH1 in 5 M NaCl is only approximately a quarter of that in 2 M NaCl; the GPDH2 transcript level decreases to less than half the level in 1 M NaCl
-
additional information
GPDH1 transcript level decreases progressively with NaCl concentrations above 3-5 M, the expression level of GPDH1 in 5 M NaCl is only approximately a quarter of that in 2 M NaCl; the GPDH2 transcript level decreases to less than half the level in 1 M NaCl
-
additional information
-
not inhibitory: CaCl2, MgCl2, NaCl
-
additional information
-
treatment with 0.075 mg/ml Ascophyllum nodosum extract depressed cellular GPDH activity by approximately 20%
-
additional information
-
coenzyme analogs: acetylpyridine-NAD+, deaminoacetylpyridine-NAD+, pyridinealdehyde-NAD+, deaminopyridinealdehyde-NAD+, potent inhibitors
-
additional information
no inhibition of the cytosolic NAD+-linked cGPDH enzyme by cell-permeant small-molecule inhibitors of mitochondrial mGPDH, EC 1.1.5.3, with a core benzimidazole-phenyl-succinamide structure
-
additional information
-
the hyperthyroid status leads to a significant decrease of both enzyme amount and activity in both female and male animals
-
additional information
-
no inhibition by NADPH, acetaldehyde, glycerol, ethanol
-
additional information
-
-
-
additional information
-
cyclic-AMP
-
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Adenoma, Bile Duct
Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet.
Adenoma, Liver Cell
Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet.
Anemia, Sickle Cell
Decreased G3PDH binding to erythrocyte membranes in sickle cell disease.
Arthritis
Oxidation of articular cartilage glyceraldehyde-3-phosphate dehydrogenase (G3PDH) occurs in vivo during carrageenin-induced arthritis.
Atherosclerosis
[Structure of cytoplasmic glycerol-3-phosphate dehydrogenase in experimental atherosclerosis in rabbits]
beta-Thalassemia
Glycerol-3-phosphate dehydrogenase activity in the red cells of patients with thalassemia.
Breast Neoplasms
Comparative Proteome Analysis of Breast Cancer Tissues Highlights the Importance of Glycerol-3-phosphate Dehydrogenase 1 and Monoacylglycerol Lipase in Breast Cancer Metabolism.
Breast Neoplasms
Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer.
Carcinoma, Ehrlich Tumor
Changes in enzyme pattern of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content.
Carcinoma, Hepatocellular
Proportional activities of glycerol kinase and glycerol 3-phosphate dehydrogenase in rat hepatomas.
Chagas Disease
Differential tissue and flight developmental expression of glycerol-3-phosphate dehydrogenase isozymes in the Chagas disease vector Triatoma infestans.
Cholestasis, Intrahepatic
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
Citrullinemia
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
Dehydration
Cell wall involvement in the glycerol response to high osmolarity in the halotolerant yeast Debaryomyces hansenii.
Dehydration
Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.
Diabetes Mellitus
Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.
Diabetes Mellitus
Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene.
Diabetes Mellitus, Experimental
Adaptive changes of glycerol 3-phosphate dehydrogenase level in rat skin: effects of starvation, alloxan diabetes and insulin.
Diabetes Mellitus, Type 2
Detection of variants in the mitochondrial glycerophosphate dehydrogenase gene in Japanese NIDDM patients.
Diabetes Mellitus, Type 2
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Diabetes Mellitus, Type 2
Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.
Dyslipidemias
Low abdominal subcutaneous preadipocyte adipogenesis is associated with visceral obesity, visceral adipocyte hypertrophy, and a dysmetabolic state.
Fatty Liver
Some lipogenic enzyme activities in rat livers in which an excessive fat accumulation occurred due to feeding low-level amino acid mixture diets.
Fatty Liver
The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice.
Fatty Liver
Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1.
glycerol-3-phosphate dehydrogenase (nad+) deficiency
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
glycerol-3-phosphate dehydrogenase (nad+) deficiency
Expanding the molecular diversity and phenotypic spectrum of glycerol 3-phosphate dehydrogenase 1 deficiency.
glycerol-3-phosphate dehydrogenase (nad+) deficiency
Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise.
glycerol-3-phosphate dehydrogenase (nad+) deficiency
Glycerol-3-phosphate dehydrogenase 1 deficiency induces compensatory amino acid metabolism during fasting in mice.
Head and Neck Neoplasms
[The cytochemical determination of alpha-glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheral blood lymphocytes of patients with hepatobiliary system pathology]
Hepatitis
[The cytochemical determination of alpha-glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheral blood lymphocytes of patients with hepatobiliary system pathology]
Hyperthyroidism
Thyroxine and tri-iodothyronine differently affect uncoupling protein-1 content and antioxidant enzyme activities in rat interscapular brown adipose tissue.
Hypertriglyceridemia
A novel homozygous mutation in the glycerol-3-phosphate dehydrogenase 1 gene in a Chinese patient with transient infantile hypertriglyceridemia: a case report.
Hypertriglyceridemia
Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1.
Hypoglycemia
Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: Role of metabolic reprogramming in counterregulatory failure.
Infections
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Infections
Establishment of a quiescent herpes simplex virus type 1 infection in neurally-differentiated PC12 cells.
Insulin Resistance
Glycerol-3-phosphate dehydrogenase activity in human lymphocytes: effects of insulin, obesity and weight loss.
Insulinoma
Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.
Intellectual Disability
Haploinsufficiency of the GPD2 gene in a patient with nonsyndromic mental retardation.
Leiomyoma
Expression of exon 5 deleted estrogen receptor variant messenger RNA in human uterine myometrium and leiomyoma.
Leukemia
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia.
Leukemia, Myeloid
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Liver Diseases
Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis.
Liver Neoplasms, Experimental
Proportional activities of glycerol kinase and glycerol 3-phosphate dehydrogenase in rat hepatomas.
Lung Diseases, Interstitial
Chemokine gene expression and clonal analysis of B cells in tissues involved by lymphoid interstitial pneumonitis from HIV-infected pediatric patients.
Melanoma
Metabolic characterization of three hamster melanoma variants.
Melanoma, Amelanotic
Metabolic characterization of three hamster melanoma variants.
Metabolism, Inborn Errors
Expanding the molecular diversity and phenotypic spectrum of glycerol 3-phosphate dehydrogenase 1 deficiency.
Microphthalmos
Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.
Myelodysplastic Syndromes
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Neoplasms
Changes in enzyme pattern of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content.
Neoplasms
Expression of exon 5 deleted estrogen receptor variant messenger RNA in human uterine myometrium and leiomyoma.
Neoplasms
Glyceraldehyde-3-phosphate dehydrogenase mRNA expression in hepatocellular carcinoma.
Neoplasms
GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate.
Neoplasms
Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer.
Neoplasms
Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.
Neoplasms
Metabolic characterization of three hamster melanoma variants.
Neoplasms
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Neoplasms
The reversible expression of an adult isozyme locus, Gdc-1, in tumors of the mouse.
Non-alcoholic Fatty Liver Disease
Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis.
Obesity
Association Between Cytosolic Glycerol 3-Phosphate Dehydrogenase Gene Expression in Human Subcutaneous Adipose Tissue and BMI.
Obesity
Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans.
Obesity
Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Prostatic Neoplasms
High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines.
Prostatic Neoplasms
Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.
Prostatic Neoplasms
Simultaneous detection of circulating prostate specific antigen (PSA)-expressing and prostate specific membrane antigen (PSM)-expressing cells by a multiplex reverse transcriptase polymerase chain reaction (RT-PCR) assay.
Seizures
Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia.
Sleep Apnea, Obstructive
The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene.
Starvation
Adaptive changes of glycerol 3-phosphate dehydrogenase level in rat skin: effects of starvation, alloxan diabetes and insulin.
Starvation
Role of glycerol 3-phosphate dehydrogenase in glyceride metabolism. Effect of diet on enzyme activities in chicken liver.
Starvation
The effect of iron limitation on glycerol production and expression of the isogenes for NAD(+)-dependent glycerol 3-phosphate dehydrogenase in Saccharomyces cerevisiae.
Thymoma
Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract.
Thyroid Neoplasms
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Urinary Bladder Neoplasms
Increased activity of glycerol 3-phosphate dehydrogenase and other lipogenic enzymes in human bladder cancer.
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0.3
alpha-glycerol phosphate
-
-
0.11 - 3.39
alpha-glycerophosphate
0.012 - 25
dihydroxyacetone phosphate
0.19 - 1.2
DL-glycerol-3-phosphate
0.59 - 2
glycerol 3-phosphate
1.6
glycerol phosphate
-
-
0.468 - 34
glycerol-3-phosphate
0.137
Glycerone
-
pH 7.6, 25°C
0.052 - 137
glycerone phosphate
0.74
L-glycerol 3-phosphate
-
-
2.3 - 3.9
L-glycerol-3-phosphate
0.41 - 469
sn-glycerol 3-phosphate
0.143
sn-glycerol-3-phosphate
-
measured at pH 9.0
additional information
alpha-glycerophosphate
0.11
alpha-glycerophosphate

-
-
0.33
alpha-glycerophosphate
-
testes
3.39
alpha-glycerophosphate
-
liver
0.012
dihydroxyacetone phosphate

-
-
0.026
dihydroxyacetone phosphate
-
measured at pH 7.5
0.052
dihydroxyacetone phosphate
-
wild type enzyme, at pH 7.5 and 25°C
0.075
dihydroxyacetone phosphate
-
-
0.1
dihydroxyacetone phosphate
-
-
0.12
dihydroxyacetone phosphate
-
-
0.13
dihydroxyacetone phosphate
-
standard deviation 0.03 mM
0.15
dihydroxyacetone phosphate
-
muscle
0.17
dihydroxyacetone phosphate
-
-
0.2
dihydroxyacetone phosphate
-
I6.5
0.2144
dihydroxyacetone phosphate
-
alpha-GPDHs, standard deviation 0.0215 mM
0.23
dihydroxyacetone phosphate
-
in MOPS buffer, 0.33 mM in Tris-histidine
0.23
dihydroxyacetone phosphate
-
-
0.25
dihydroxyacetone phosphate
-
adipose tissue
0.3
dihydroxyacetone phosphate
-
0.30-0.35 mM
0.33
dihydroxyacetone phosphate
-
-
0.46
dihydroxyacetone phosphate
-
-
0.52
dihydroxyacetone phosphate
-
GPDH-1
0.54
dihydroxyacetone phosphate
-
-
0.54
dihydroxyacetone phosphate
at pH 7.0 and 25°C
0.61
dihydroxyacetone phosphate
at pH 7.0 and 25°C
5.7
dihydroxyacetone phosphate
-
mutant enzyme R269A, at pH 7.5 and 25°C
15
dihydroxyacetone phosphate
-
mutant enzyme R269A/N270A, at pH 7.5 and 25°C
25
dihydroxyacetone phosphate
-
mutant enzyme N270A, at pH 7.5 and 25°C
0.19
DL-glycerol-3-phosphate

-
muscle
0.3
DL-glycerol-3-phosphate
-
I6.5
0.4
DL-glycerol-3-phosphate
-
adipose tissue
1.2
DL-glycerol-3-phosphate
-
standard deviation 0.5 mM
0.59
glycerol 3-phosphate

-
GPDH-1
0.909
glycerol 3-phosphate
-
-
1.89
glycerol 3-phosphate
-
alpha-GPDHs, standard deviation 0.25 mM
2
glycerol 3-phosphate
-
-
0.468
glycerol-3-phosphate

-
pH 9.0, 25°C
1.7
glycerol-3-phosphate
-
-
2.25
glycerol-3-phosphate
-
-
34
glycerol-3-phosphate
-
isoform Gut2, pH 6.8
0.052
glycerone phosphate

-
wild-type enzyme, pH 7.5, 25°C
0.154
glycerone phosphate
-
pH 7.5, 5°C, muscle isozyme
0.259
glycerone phosphate
-
pH 7.5, 5°C, liver isozyme
0.26
glycerone phosphate
-
pH 7.5, 25°C
0.279
glycerone phosphate
-
pH 7.5, 22°C, muscle isozyme
0.352
glycerone phosphate
-
pH 7.5, 22°C, liver isozyme
1.5
glycerone phosphate
-
mutant R269A/N270A, pH 7.5, 25°C
2.5
glycerone phosphate
-
mutant N270A, pH 7.5, 25°C
5.7
glycerone phosphate
-
mutant R269A, pH 7.5, 25°C
137
glycerone phosphate
-
pH 9.0, 25°C
2.3
L-glycerol-3-phosphate

-
pH 10.0, 25°C
3.9
L-glycerol-3-phosphate
-
pH 7.5, 25°C
0.0044
NAD+

-
adipose tissue
0.036
NAD+
-
measured at pH 9.0
0.045
NAD+
-
pH 8.5, 22°C, liver isozyme
0.09
NAD+
-
pH 8.5, 5°C, liver isozyme
0.09
NAD+
-
pH 8.0, 5°C, hibernation G3PDH enzyme
0.1003
NAD+
-
alpha-GPDHs, standard deviation 0.0041 mM
0.12
NAD+
-
pH 8.0, 5°C, euthermic G3PDH enzyme
0.143
NAD+
-
pH 8.5, 22°C, muscle isozyme
0.155
NAD+
-
pH 8.5, 5°C, muscle isozyme
0.2
NAD+
-
pH 10.0, 25°C
0.2
NAD+
-
enzyme from euthermic animal, at pH 7.5 and 22°C; enzyme from hibernating animal, at pH 7.5 and 22°C; pH 7.5, 22°C, euthermic G3PDH enzyme and hibernation G3PDH enzyme
0.3
NAD+
-
standard deviation 0.06 mM
0.316
NAD+
-
pH 9.0, 25°C
0.32
NAD+
-
enzyme from hibernating animal, at pH 8.0 and 37°C; pH 8.0, 37°C, hibernation G3PDH enzyme
0.39
NAD+
-
enzyme from euthermic animal, at pH 8.0 and 37°C; pH 8.0, 37°C, euthermic G3PDH enzyme
0.42
NAD+
-
enzyme from hibernating animal, at pH 8.0 and 22°C; pH 8.0, 22°C, hibernation G3PDH enzyme
0.5
NAD+
-
enzyme from euthermic animal, at pH 7.5 and 37°C; pH 7.5, 37°C, euthermic G3PDH enzyme
0.52
NAD+
-
enzyme from euthermic animal, at pH 8.0 and 22°C; pH 8.0, 22°C, euthermic G3PDH enzyme
0.65
NAD+
-
pH 7.5, 25°C
0.69
NAD+
-
enzyme from hibernating animal, at pH 7.5 and 37°C; pH 7.5, 37°C, hibernation G3PDH enzyme
0.001
NADH

-
pH 7.5, 22°C, liver isozyme; pH 7.5, 5°C, liver isozyme; pH 7.5, 5°C, muscle isozyme
0.003
NADH
-
pH 7.5, 22°C, muscle isozyme
0.0043
NADH
-
adipose tissue
0.005
NADH
-
measured at pH 7.5
0.005
NADH
-
pH 7.5, 25°C
0.00526
NADH
-
alpha-GPDHs
0.0066
NADH
-
standard deviation 0.003 mM
0.01
NADH
-
less than 0.01 mM
0.01
NADH
-
less than 0.01 mM
0.032
NADH
-
pH 7.6, 25°C
0.051
NADH
at pH 7.0 and 25°C
0.0589
NADH
recombinant isozyme GDH2
0.0592
NADH
isozyme GPDH2
0.0905
NADH
isozyme GPDH1; recombinant isozyme GDH1
0.11
NADH
at pH 7.0 and 25°C
32.4
NADH
-
pH 9.0, 25°C
0.0589
NADPH

isozyme GPDH1
0.0592
NADPH
recombinant isozyme GDH1
0.0726
NADPH
isozyme GPDH2; recombinant isozyme GDH2
0.41
sn-glycerol 3-phosphate

-
enzyme from hibernating animal, at pH 7.5 and 22°C; pH 7.5, 22°C, hibernation G3PDH enzyme
0.48
sn-glycerol 3-phosphate
-
enzyme from hibernating animal, at pH 8.0 and 5°C; pH 8.0, 5°C, hibernation G3PDH enzyme
0.57
sn-glycerol 3-phosphate
-
enzyme from euthermic animal, at pH 8.0 and 22°C; pH 8.0, 22°C, euthermic G3PDH enzyme
0.61
sn-glycerol 3-phosphate
-
enzyme from euthermic animal, at pH 7.5 and 22°C; pH 7.5, 22°C, euthermic G3PDH enzyme
0.63
sn-glycerol 3-phosphate
-
enzyme from euthermic animal, at pH 7.5 and 37°C; pH 7.5, 37°C, euthermic G3PDH enzyme
0.83
sn-glycerol 3-phosphate
-
enzyme from euthermic animal, at pH 8.0 and 5°C; pH 8.0, 5°C, euthermic G3PDH enzyme
0.88
sn-glycerol 3-phosphate
-
enzyme from euthermic animal, at pH 8.0 and 37°C; pH 8.0, 37°C, euthermic G3PDH enzyme
1.17
sn-glycerol 3-phosphate
-
enzyme from hibernating animal, at pH 7.5 and 37°C; pH 7.5, 37°C, hibernation G3PDH enzyme
1.51
sn-glycerol 3-phosphate
-
enzyme from euthermic animal, at pH 7.5 and 5°C; pH 7.5, 5°C, euthermic G3PDH enzyme
1.56
sn-glycerol 3-phosphate
-
enzyme from hibernating animal, at pH 8.0 and 37°C; pH 8.0, 37°C, hibernation G3PDH enzyme
1.61
sn-glycerol 3-phosphate
-
enzyme from hibernating animal, at pH 8.0 and 22°C; pH 8.0, 22°C, hibernation G3PDH enzyme
469
sn-glycerol 3-phosphate
-
pH 7.6, 25°C
additional information
alpha-glycerophosphate

-
Km values from five different isoelectric focused components
additional information
additional information
-
various Km-values of 4 isozymes of heart, muscle, liver and mammary gland
-
additional information
additional information
-
Km values of isozyme I5.9
-
additional information
additional information
-
Km values of two further allelic isozymes, alpha-GPDHf and alpha-GPDHm
-
additional information
additional information
-
Km values of isozyme GPDH-3
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
-
kinetic analysis, overview. Relative to euthermic liver G3PDH, hibernator liver G3PDH has a decreased affinity for its substrate, glycerol-3-phosphate, at 37°C and 22°C, while at 5°C, there is a significant increase in the affinity for G3P in the hibernating form of the enzyme, relative to the euthermic form. A change in pH from pH 8.0 to pH 7.5 leads to increased G3PDH affinity for NAD+. With a change in pH from pH 8.0 to pH 7.5 at 22°C in the euthermic and hibernator conditions, the Km for NAD+ decreases by 62% and 53%, respectively
-
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