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(R)-1,2,3,4-tetrahydro-1-naphthol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
i.e. R-tetralol
-
?
(S)-1,2,3,4-tetrahydro-1-naphthol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
i.e. S-tetralol
-
?
(S)-1,2,3,4-tetrahydro-1-naphthol + NADP+
3,4-dihydronaphthalen-1(2H)-one + NADPH + H+
i.e. S-tetralol
-
?
(S)-1-indanol + NAD+
2,3-dihydro-1H-inden-1-one + NADH + H+
-
-
?
(S)-camphorquinone + NADH + H+
? + NAD+
-
-
?
(S)-camphorquinone + NADPH + H+
? + NADP+
-
-
?
1-acenaphthenol + NAD+
acenaphthylen-1(2H)-one + NADH + H+
-
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
17-oxo steroids + NADPH
?
-
maintenance of balance between oxidized and reduced steroids in blood
-
?
17alpha-hydroxypregnenolone + NAD(P)+
17alpha-hydroxy-pregn-5-en-3,20-dione + NAD(P)H + H+
-
-
-
?
17beta-estradiol + NAD+
estrone + NADH + H+
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NAD(P)H + H+
testosterone + NAD(P)+
-
-
?
2-cyclohexen-1-ol + NAD+
2-cyclohexen-1-one + NADH + H+
-
-
?
20alpha-dihydroprogesterone + NAD+
4-pregnen-3alpha,20beta-diol + NADH
-
-
-
r
20alpha-dihydroprogesterone + NADP+
4-pregnen-3alpha,20beta-diol + NADPH
-
-
-
r
20alpha-hydroxypregn-4-en-3-one + NADP+
progesterone + NADPH
-
-
-
r
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+
?
3beta-hydroxy-5alpha-androstan-17-one + NADP+
5alpha-androstane-3,17-dione + NADPH
-
-
-
?
3beta-hydroxyprogesterone + NADH + H+
? + NAD+
-
-
?
4-androsten-17beta-ol-3-one + NAD(P)+
4-androstene-3,17-dione + NAD(P)H + H+
17keto function is reduced. NADP+ is 3-5times less effective than NAD+
-
?
4-androsten-3,17-dione + NADPH + H+
testosterone + NADP+
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
4-androstene-3alpha,17beta-diol + NAD+
? + NADH + H+
-
-
?
4-estrene-17beta-ol-3-one + NADP+
4-estrene-3,17-dione + NADPH
-
-
-
r
4-estrene-3,17-dione + NADPH
4-estrene-17beta-ol-3-one + NADP+
-
-
-
r
5-androsten-3beta-ol-17-one + NAD(P)+
5-androstene-3,17-dione + NAD(P)H + H+
NADP+ is 3-5times less effective than NAD+
-
?
5-androstene-3beta,17beta-diol + NAD+
? + NADH + H+
-
-
?
5-androstenedione + NADPH
5alpha-dihydrotestosterone + NADP+
-
isozyme 17beta-HSD3
-
r
5-pregnen-3beta-ol-20-one + NAD(P)+
5-pregnene-3,20-dione + NAD(P)H + H+
NADP+ is 3-5times less effective than NAD+
-
?
5alpha-androst-16-en-3-one + NADH
3beta-hydroxy-5alpha-androst-16-ene + NAD+
-
-
-
?
5alpha-androstan-3alpha-ol-17-one + NAD+
5alpha-androstan-3,20-dione + NADH + H+
-
-
?
5alpha-androstan-3beta-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
-
?
5alpha-androstane-3alpha,17beta-diol + NAD+
?
-
-
?
5alpha-androstane-3beta,17beta-diol + NADP+
3beta-hydroxy-5alpha-androstan-17-one + NADPH
-
-
-
?
5alpha-dihydrotestosterone + NAD(P)H
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
5alpha-dihydrotestosterone + NADH + H+
? + NAD+
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3alpha,17beta-diol + NADPH + H+
-
-
-
r
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH
5alpha-pregnan-3alpha-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH + H+
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD(P)+
5alpha-pregnan-3,20-dione + NAD(P)H + H+
NADP+ and NADPH are 3-5times less effective than NAD+ and NADH
-
r
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH + H+
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnane-3,20-dione + NADH + H+
-
-
r
5alpha-pregnane-3,20-dione + NADH + H+
5alpha-pregnan-3beta-ol-20-one + NAD+
-
-
r
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH + H+
-
-
?
5beta-androstan-3alpha-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH + H+
-
-
?
5beta-androstan-3beta-ol-17-one + NADH + H+
? + NAD+
-
-
?
5beta-androstane-3alpha,17beta-diol + NAD+
? + NAD+
-
-
?
5beta-androstane-3beta,17beta-diol + NAD+
? + NAD+
-
-
?
5beta-dihydrotestosterone + NADH + H+
? + NAD+
-
-
?
5beta-pregnan-20alpha-ol-3-one + NAD+
5beta-pregnan-3,20-dione + NADH + H+
-
-
?
5beta-pregnan-3,20-dione + NAD(P)H + H+
3beta-hydroxy-5beta-pregnan-20-one + NAD(P)+
NADP+ is 3-5times less effective than NAD+
-
?
5beta-pregnan-3,20-dione + NADH
3beta-hydroxy-5beta-pregnan-20-one + NAD+
-
-
-
?
5beta-pregnan-3,20-dione + NADPH + H+
5beta-pregnane-3beta-ol-20-one + NADP+
5beta-pregnan-3beta,21-diol-20-one + NAD+
?
-
-
?
5beta-pregnan-3beta,21-diol-20-one + NADH + H+
? + NAD+
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD(P)+
5-pregnan-3,20-dione + NAD(P)H + H+
NADP+ and NADPH are 3-5times less effective than NAD+ and NADH
-
r
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH + H+
-
-
?
alpha-3-hydroxyhexobarbital + NAD+
?
-
-
?
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
-
-
-
?
androst-5-ene-3,11,17-trione + NADPH
17beta-hydroxyandrost-5-ene-3,11-dione + NADP+
androst-5-ene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH
androstane-3,17-dione + NADPH
dihydrotestosterone + NADP+
-
-
-
?
androstanedione + NADPH
dihydrotestosterone + NADP+
-
reduction at C17
-
?
androstenediol + NAD(P)H + H+
testosterone + NAD(P)+
-
reaction catalysed by 3beta-HSD (type 1)
-
?
androstenedione + NAD(P)H + H+
testosterone + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
?
androstenedione + NADPH + H+
testosterone + NADP+
androsterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
androsterone + NADPH
androstane-3beta,17beta-diol + NADP+
-
reduction at C17
-
?
beta-3-hydroxyhexobarbital + NAD+
?
-
-
?
beta-ionol + NAD+
(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one + NADH + H+
-
-
?
cis-benzene dihydrodiol + NAD+
?
-
-
?
cyclohexanol + NAD+
?
-
-
?
dehydroepiandrosterone + NAD(P)+
androst-5-en-3,17-dione + NAD(P)H + H+
dehydroepiandrosterone + NAD(P)H + H+
androstenediol + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
?
dehydroepiandrosterone + NAD+
4-androstene-3,17-dione + NADH + H+
dehydroepiandrosterone + NAD+
androstene-3,17-dione + NADH + H+
-
-
-
?
dehydroepiandrosterone + NADH + H+
? + NAD+
-
-
?
dehydroepiandrosterone + NADPH
5-androstene-3beta,17beta-diol + NADP+
-
reduction at C17
-
?
dehydroepiandrosterone + NADPH
androstene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH + H+
androst-5-ene-3beta,17beta-diol + NADP+
-
-
-
?
dihydroepiandrostendione + NADPH
dihydrotestosterone + NADP+
-
-
-
?
dihydrotestosterone + NAD+
5alpha-androstan-3,17-dione + NADH
-
-
-
r
dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
-
-
-
r
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
-
androsterone inactivation
-
?
epiandrosterone + NADPH
5-androstane-3beta,17beta-diol + NADP+
-
reduction at C17
-
?
epiandrosterone + NADPH
androstane-3beta,17beta-diol + NADP+
reduction at C17
-
?
estradiol + NAD(P)+
estrone + NAD(P)H
estradiol + NAD+
estrone + NADH
-
-
-
?
estradiol + NADP+
estrone + NADPH
estradiol sulfate + NADP+
estrone sulfate + NADPH
-
-
-
?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
?
estrone + NADPH
estradiol + NADP+
-
estrogen activation
-
?
farnesol + NAD+
farnesal + NADH + H+
-
-
?
geraniol + NAD+
geranial + NADH + H+
-
-
?
geranylgeraniol + NAD+
geranylgeranial + NADH + H+
-
-
?
nerol + NAD+
neral + NADH + H+
-
-
?
pregnenolone + NAD(P)+
progesterone + NAD(P)H + H+
pregnenolone + NAD+
progesterone + NADH + H+
pregnenolone + NADP+
progesterone + NADPH + H+
-
-
-
?
pregnenolone + NADPH
progesterone + NADP+
-
-
-
?
pregnenolone + NADPH + H+
isoprogesterone + NADP+
testosterone + 3-acetylpyridine adenine dinucleotide
?
-
-
-
?
testosterone + 3-pyridinealdehyde adenine dinucleotide
?
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
testosterone + NAD(P)+
androstenedione + NAD(P)H + H+
testosterone + NAD+
4-androstenedione + NADPH + H+
-
-
?
testosterone + NAD+
androst-4-en-3,17-dione + NADH
-
-
-
r
testosterone + NAD+
androstenedione + NADH + H+
-
-
-
r
testosterone + NADP+
androst-4-en-3,17-dione + NADPH
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
testosterone + thionicotinamide adenine dinucleotide
?
-
-
-
?
trans-benzene dihydrodiol + NAD+
?
-
-
?
zymosterone + NADPH
zymosterol + NADP+
-
-
-
?
additional information
?
-
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH

11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
i.e. 11beta-hydroxy-androstenedione, reduction at C17
i.e. 11beta-testosterone
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
-
i.e. 11beta-hydroxy-androstenedione, reduction at C17
i.e. 11beta-testosterone
?
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+

?
-
-
-
?
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+
?
-
-
-
?
4-androstene-3,17-dione + NADPH + H+

testosterone + NADP+
-
-
?
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
isozymes 17beta-HSD3 and 17beta-HSD5
-
r
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
selective reduction at C17
-
?
5alpha-dihydrotestosterone + NADP+

5alpha-androstane-3,17-dione + NADPH
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH
-
-
-
?
5beta-pregnan-3,20-dione + NADPH + H+

5beta-pregnane-3beta-ol-20-one + NADP+
-
-
?
5beta-pregnan-3,20-dione + NADPH + H+
5beta-pregnane-3beta-ol-20-one + NADP+
-
-
-
?
androst-5-ene-3,11,17-trione + NADPH

17beta-hydroxyandrost-5-ene-3,11-dione + NADP+
i.e. 11-keto-androstenedione, reduction at C17
i.e. 11-keto-testosterone
?
androst-5-ene-3,11,17-trione + NADPH
17beta-hydroxyandrost-5-ene-3,11-dione + NADP+
-
i.e. 11-ketoandrostenedione, reduction at C17
i.e. 11-keto-testosterone
?
androst-5-ene-3beta,17beta-diol + NADP+

dehydroepiandrosterone + NADPH
-
-
-
r
androst-5-ene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH
-
-
-
r
androst-5-ene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH
-
-
-
r
androstenedione + NADPH + H+

testosterone + NADP+
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
the equilibrium state is 2% testosterone to 95% androstenedione
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
isozymes 17beta-HSD1 and 17beta-HSD8
-
r
androsterone + NADPH

5alpha-androstane-3alpha,17beta-diol + NADP+
-
-
-
?
androsterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NAD(P)+

androst-5-en-3,17-dione + NAD(P)H + H+
-
-
-
?
dehydroepiandrosterone + NAD(P)+
androst-5-en-3,17-dione + NAD(P)H + H+
-
-
-
?
dehydroepiandrosterone + NAD(P)+
androst-5-en-3,17-dione + NAD(P)H + H+
-
-
-
?
dehydroepiandrosterone + NAD+

4-androstene-3,17-dione + NADH + H+
-
-
-
?
dehydroepiandrosterone + NAD+
4-androstene-3,17-dione + NADH + H+
-
-
-
?
dehydroepiandrosterone + NAD+
4-androstene-3,17-dione + NADH + H+
-
-
-
?
dehydroepiandrosterone + NADPH

androstene-3beta,17beta-diol + NADP+
-
reduction at C17
-
?
dehydroepiandrosterone + NADPH
androstene-3beta,17beta-diol + NADP+
reduction at C17
-
?
estradiol + NAD(P)+

estrone + NAD(P)H
-
-
-
?
estradiol + NAD(P)+
estrone + NAD(P)H
-
-
-
?
estradiol + NADP+

estrone + NADPH
-
-
-
?
estradiol + NADP+
estrone + NADPH
-
-
-
r
estradiol + NADP+
estrone + NADPH
-
the equilibrium state is 3% estradiol and 97% estrone
-
r
estradiol + NADP+
estrone + NADPH
-
-
-
r
estradiol + NADP+
estrone + NADPH
-
-
-
r
pregnenolone + NAD(P)+

progesterone + NAD(P)H + H+
-
-
-
?
pregnenolone + NAD(P)+
progesterone + NAD(P)H + H+
-
-
-
?
pregnenolone + NAD(P)+
progesterone + NAD(P)H + H+
-
-
?
pregnenolone + NAD(P)+
progesterone + NAD(P)H + H+
-
-
-
?
pregnenolone + NAD+

progesterone + NADH + H+
-
-
-
?
pregnenolone + NAD+
progesterone + NADH + H+
-
the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview
-
?
pregnenolone + NAD+
progesterone + NADH + H+
-
-
-
?
pregnenolone + NADPH + H+

isoprogesterone + NADP+
-
-
?
pregnenolone + NADPH + H+
isoprogesterone + NADP+
-
-
-
?
testosterone + NAD(P)+

androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
r
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
r
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
r
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+

androstenedione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androstenedione + NAD(P)H + H+
-
-
r
testosterone + NADP+

androstenedione + NADPH + H+
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
r
additional information

?
-
the wild-type strain ATCC 119960 degrades steroids, such as testosterone, estradiol, or cholesterol, differences in the enzyme mutant strains, overview
-
?
additional information
?
-
the wild-type strain ATCC 119960 degrades steroids, such as testosterone, estradiol, or cholesterol, differences in the enzyme mutant strains, overview
-
?
additional information
?
-
evolutionary considerations
-
?
additional information
?
-
-
evolutionary considerations
-
?
additional information
?
-
no activity with androstanedione and androsterone
-
?
additional information
?
-
-
no activity with androstanedione and androsterone
-
?
additional information
?
-
-
activity of the enzyme is associated with the mechanism of prostatic regulation by androgens after castration, which is important in prostate cancer
-
?
additional information
?
-
-
evolutionary considerations
-
?
additional information
?
-
-
the enzyme is an important therapeutic target for androgen-sensitive diseases, overview
-
?
additional information
?
-
-
the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis
-
?
additional information
?
-
-
the isozyme might play an imporant role in modulation of active hormone levels in estrogen-sensitive cells or tissues
-
?
additional information
?
-
-
isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities
-
?
additional information
?
-
AKR1C3 physically interacts with the androgen receptor
-
?
additional information
?
-
-
AKR1C3 physically interacts with the androgen receptor
-
?
additional information
?
-
the enzyme AKR1C35 efficiently oxidizes various 3beta- and 17beta-hydroxysteroids, including biologically active 3beta-hydroxy-5alpha/beta-dihydro-C19/C21-steroids, dehydroepiandrosterone, and 17beta-estradiol, substrate specificity, detailed overview. Val54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS). No activity with 5beta-pregnan-3alpha-ol-20-one, 3alpha-hydroxyprogesterone, 5beta-androstan-3alpha-ol-17-one, 20alpha-hydroxyprogesterone, and 5alpha-pregnan-20alpha-ol-3-one
-
?
additional information
?
-
-
the enzyme AKR1C35 efficiently oxidizes various 3beta- and 17beta-hydroxysteroids, including biologically active 3beta-hydroxy-5alpha/beta-dihydro-C19/C21-steroids, dehydroepiandrosterone, and 17beta-estradiol, substrate specificity, detailed overview. Val54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS). No activity with 5beta-pregnan-3alpha-ol-20-one, 3alpha-hydroxyprogesterone, 5beta-androstan-3alpha-ol-17-one, 20alpha-hydroxyprogesterone, and 5alpha-pregnan-20alpha-ol-3-one
-
?
additional information
?
-
-
the enzyme plays a role in gonadal steroidogenesis
-
?
additional information
?
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-
poor activity with estrone
-
?
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(2,4-dihydroxyphenyl)-phenylmethanone
(3a,5a)-3-[[(2R,5S)-4-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-2,5-dimethylpiperazin-1-yl]methyl]-17-methylideneandrostan-3-ol
-
-
(3alpha,5alpha)-3-([(2R,5S)-2,5-dimethyl-4-[2-(trifluoromethyl)benzene-1-sulfonyl]piperazin-1-yl]methyl)-3-hydroxyandrostan-17-one
-
i.e. RM-532-105
(3alpha,5alpha)-3-[(2,5-dimethyl-4-{[2-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)methyl]-3-hydroxyandrostan-17-one
the inhibitor RM-532-105 seems to have difficulties in penetrating inside the testis and is concentrated in the testicular capsule. Therefore it is unable to inhibit the 17bets-HSD3 located inside the testis. At a higher concentration, RM-532-105 significantly decreases the level of testosterone and dihydrotestosterone in rat plasma, in vivo effects of the inhibitor in testis and plasma, detailed overview
(4-(2,4-dichlorophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(2-chlorophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(2-methoxyphenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(3-chlorophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-bromophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-chloro-2-(hydroxymethyl)phenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-chloro-2-methylphenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-chlorobenzoyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-chlorobenzyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-chlorophenyl)-1,4-diazepan-1-yl)(morpholino)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(1-oxido-4-thiomorpholino)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(4-methylpiperazin-1-yl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(cyclohexyl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(morpholino)methanethione
-
(4-(4-chlorophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(phenyl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(piperidin-1-yl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(pyridin-4-yl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone
-
(4-(4-chlorophenyl)piperazin-1-yl)(thiomorpholino)methanone
-
(4-(4-ethynylphenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-fluorophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-iodophenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(4-methoxyphenyl)piperazin-1-yl)(morpholino)methanone
-
(4-(6-bromopyridin-2-yl)piperazin-1-yl)(morpholino)methanone
-
(4-(6-chloropyridin-3-yl)piperazin-1-yl)(morpholino)methanone
-
(4-(biphenyl-4-yl)piperazin-1-yl)(morpholino)methanone
-
(5-(4-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)(morpholino)methanone
-
1-(11,12-dihydro-6H-dibenzo[b,f]oxocin-12-yl)ethanone
-
IC50: 0.00297 mM
1-(4-(4-(4-chlorophenyl)piperazine-1-carbonyl)piperazin-1-yl)-2-hydroxyethanone
-
1-(4-(4-chlorophenyl)piperazine-1-carbonyl)piperidine-4-carboxylic acid
-
1-(5,6,11,12-tetrahydrodibenzo[b,f]azocin-12-yl)ethanone
-
IC50: 0.00474 mM
1-[(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-2',17-dioxohexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-3,5'-[1,3]oxazolidin]-3'-yl]-3-(morpholin-4-yl)propan-2-yl cyclohexanecarboxylate
1-[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]ethanone
-
IC50: 0.02 nM
1-[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]methanamine
-
IC50: 0.00024 mM; IC50: 0.00029 mM
11-[3-hydroxy-17-beta-hydroxyestr-5(10)-en-17alpha-yl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl]-undecanoic acid butyl-methyl-amide
-
selective inhibition of type 2 17beta-HSD
12-acetyl-1-chloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.0115 mM
12-acetyl-11,12-dihydro-2-(trifluoromethyl)-6H-dibenzo(b,f)(1,4)thiazocine
-
12-acetyl-11,12-dihydro-6H-dibenzo(b,f)(1,4)thiazocine
-
12-acetyl-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocin-3-ol
-
IC50: 0.0049 mM
12-acetyl-2,3-dichloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00001 mM
12-acetyl-2-(trifluoromethyl)-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00281 mM
12-acetyl-2-chloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00003 mM
12-acetyl-3,4-dichloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00076 mM
12-acetyl-3-bromo-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00025 mM
12-acetyl-3-chloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00010 mM
12-acetyl-3-fluoro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.00009 mM
12-acetyl-3-methoxy-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.0021 mM
12-acetyl-3-methyl-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
-
IC50: 0.001 mM
17-hydroxy-7alpha-thioethyl-3-oxo-4-androstene-17alpha-propionic acid, gamma-lactone
-
IC50 for reduction of androst-4-en-3,17-dione: 0.0009 mM
17alpha-ethynyl-estradiol
-
0.01 mM, 54% inhibition, reaction with 0.002 mM estradiol; inhibits oxidation of testosterone
17beta-dihydroequilin
-
0.01 mM, 88% inhibition, reaction with 0.002 mM estradiol
2,2',4,4'-tetrahydroxybenzophenone
remaining 17beta HSD3 activity: 47%
2,5-dioxo-3-(2-propyn-1-yl)-3-pyrrolidinecarboxylic acid 2,3,3-triphenyl-2-propen-1-yl-ester
-
2-((3-chloro-4-hydroxybenzoyl)amino)-N-(2-(2-methoxyphenyl)ethyl)-5-phenoxy-benzamide
-
2-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo(b,f)azocin-8-yl)-benzoic acid methyl ester
-
2-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzonitrile
-
IC50: 3 nM
2-hydroxy-estradiol
-
0.01 mM, 67% inhibition, reaction with 0.002 mM estradiol
20alpha-dihydroprogesterone
-
0.01 mM, 71% inhibition, reaction with 0.002 mM estradiol, inhibits oxidation of testosterone
3,4-dihydrobenzoic acid
-
0.001 mM, 40% inhibition, reduction of androst-4-en-3,17-dione
3-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide
-
3-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzonitrile
-
IC50: 3 nM
3-benzylidene camphor
remaining 17beta HSD3 activity: 56%
3-hydroxy-1,3,5(10)-estratriene-17beta-O,17alpha-butanolactone
-
selective for type 2 17beta-HSD versus types 1, 3, and 7 but not versus type 5 17beta-HSD
3-oxo-17alpha-pregna-4-ene-7alpha-(benzylthia)-21,17-carbolactone
-
IC50 for reduction of androst-4-en-3,17-dione: 0.00042 mM,IC50 for oxidation of testosterone: 0.001 mM
3-oxo-17alpha-pregna-4-ene-7alpha-(phenylthia)-21,17-carbolactone
-
IC50 for reduction of androst-4-en-3,17-dione: 0.001 mM
3-oxo-17alpha-pregna-4-ene-7alpha-(propylthia)-21,17-carbolactone
-
IC50 for reduction of androst-4-en-3,17-dione: 0.0011 mM; IC50 for reduction of androst-4-en-3,17-dione: 0.0014 mM
3-oxo-17alpha-pregna-4-ene-7alpha-[4-[2-(1-piperidinyl)-ethoxy]benzylthia]-21,17-carbolactone
-
IC50 for oxidation of testosterone: 0.0007 mM, no inhibition of type 1, 3 and 5 17beta-HSD, nor against P450 aromatase
3alpha-alkylated androsterone derivatives
-
17-88% inhibition at 0.003 mM, overview
-
3alpha-butyl-3-hydroxy-5alpha-androstan-17-one
-
3alpha-ether-3beta-substituted androsterone derivatives
-
diverse derivatives, IC50: 70-760 nM, overview
-
3beta-alkylated androsterone derivatives
-
IC50: 57-147 nM
-
3beta-cyclohexylethyl-androsterone
-
-
3beta-hexyl-androsterone
-
-
3beta-phenyl-androsterone
-
mixed-type inhibition, shows some proliferative activity on AR+ and Er+ cell lines not mediated through androgen or estrogen receptors
3beta-phenylethyl-3alpha-methyl-O-androsterone
-
IC50: 73 nM
3beta-phenylethyl-androsterone
3beta-phenylmethyl-androsterone
3beta-substituted androsterone derivatives
-
IC50: 57-147 nM
-
4-((4-(4-chlorophenyl)piperazin-1-yl)sulfonyl)morpholine
-
4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide
-
4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzoic acid
-
4-(4-chlorophenyl)-N-cyclohexylpiperazine-1-carboxamide
-
4-(4-chlorophenyl)-N-phenylpiperazine-1-carboxamide
-
4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)-N-methylbenzamide
-
IC50: 25 nM
4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzonitrile
-
IC50: 5 nM
4-methylbenzylidene camphor
remaining 17beta HSD3 activity: 33%
4-[4-(4-chlorophenyl)piperazine-1-carbonyl]-thiomorpholine-1,1-dione
-
5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 0.00007 mM
5-acetyl-2-chloro-5,6-dihydro-dibenzo(b,f)azocine
-
5-acetyl-2-chloro-5,6-dihydrodibenzo[b,f]azocine
-
IC50: 0.00024 mM
5-acetyl-2-chloro-8-(2-methoxyphenyl)-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 3 nM
5-acetyl-2-chloro-8-(3-methoxyphenyl)-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 8 nM
5-acetyl-2-chloro-8-(4-methoxyphenyl)-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 2 nM
5-acetyl-2-chloro-8-phenyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 4 nM
5-acetyl-3-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 0.00005 mM
5-acetyl-5,6,11,12-tetrahydro-dibenzo(b,f)(1,4)diazocine
-
5-acetyl-5,6,11,12-tetrahydrodibenzo[b,f]azocin-9-amine
-
IC50: 0.00049 mM
5-acetyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine-9-carboxamide
-
IC50: 0.001 mM
5-acetyl-8-bromo-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 9 nM
5-acetyl-8-phenyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 0.02 nM
5-acetyl-9-bromo-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 7 nM
5-acetyl-N-cyclohexyl-5,6,11,12-tetrahydrodibenzo[b,f]azocin-9-amine
-
IC50: 8 nM
5alpha-androstane-3alpha,17beta-diol
-
0.01 mM, 87% inhibition, reaction with 0.002 mM estradiol
5alpha-dihydrotestosterone
-
inhibits oxidation of testosterone
5beta-androstane-3alpha,17beta-diol
-
0.01 mM, 83% inhibition, reaction with 0.002 mM estradiol
5beta-dihydrotestosterone
-
inhibits oxidation of testosterone
9-bromo-11,12-dihydrodibenzo[b,f]azocine-5(6H)-carboxamide
-
IC50: 0.00028 mM
9-bromo-5-butanoyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 0.00032 mM
9-bromo-5-ethyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
-
IC50: 0.001 mM
beta-octylglucoside
-
strong
chloromercuribenzene-p-sulfonic acid
-
-
danazol
-
inhibits oxidation of testosterone, 0.01 mM, 83% inhibition
dibenzothiazocine
-
IC50: 0.0004 mM
dodecyl-beta-D-maltoside
-
inhibition above 0.5%
EM-919
-
a 17beta-HSD type 2 inhibitor
estradiol
-
inhibits oxidation of testosterone
gallic acid
-
0.001 mM, 50% inhibition, reduction of androst-4-en-3,17-dione
GTx-560
competitively and selectively inhibits AKR1C3-dependent androgen receptor transactivation. GTx-560 completely blocks the formation of testosterone from androstenedione, indicating the ability of AKR1C3 inhibitors, unlike 5alpha-reductase inhibitors, to reduce testosterone levels
methyl 12-acetyl-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine-3-sulfinate
-
IC50: 0.01 mM
methyl 3-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzoate
-
IC50: 0.00004 mM
methyl 4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzoate
-
methyl 4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzoate
-
IC50: 0.00004 mM; IC50: 0.7 nM
methyl [3-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]amidosulfite
-
IC50: 0.00014 mM
methyl [4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]amidosulfite
-
IC50: 2 nM
morpholino(4-(2-(trifluoromethyl)phenyl)piperazin-1-yl)methanone
-
morpholino(4-(4-nitrophenyl)piperazin-1-yl)methanone
-
morpholino(4-(naphthalen-2-yl)piperazin-1-yl)methanone
-
morpholino(4-(o-tolyl)piperazin-1-yl)methanone
-
morpholino(4-(p-tolyl)piperazin-1-yl)methanone
-
morpholino(4-(quinolin-3-yl)piperazin-1-yl)methanone
-
morpholino(4-phenylpiperazin-1-yl)methanone
-
-
morpholino-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)methanone
-
N,N-dimethyl-4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide
-
N-(((3,5)-3-hydroxy-17-oxoandrostan-3-yl)methyl)-N-(tricyclo(3.3.1.13.7)dec-2-ylmethyl)butanamide
-
N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)acetamide
-
N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide
-
N-(5-acetyl-5,6,11,12-tetrahydrodibenzo[b,f]azocin-9-yl)benzamide
-
IC50: 0.00016 mM
N-methyl-4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide
-
oleuropein glycoside
-
0.001 mM, 40% inhibition, reduction of androst-4-en-3,17-dione
Perfluorooctanoic acid
-
-
spiro-gamma-lactone-estradiol
-
inhibits the reduction of androst-4-en-3,17-dione, reversible, IC50: 0.00025 mM
spironolactone
-
IC50 for oxidation of testosterone: 0.0011 mM
testosterone
-
0.01 mM, 70% inhibition, reaction with 0.002 mM estradiol
tetrahydrodibenzazocine
-
IC50: 0.00009 mM
[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]methanol
-
IC50: 0.9 nM
(2,4-dihydroxyphenyl)-phenylmethanone

remaining 17beta HSD3 activity: 1.1%
(2,4-dihydroxyphenyl)-phenylmethanone
-
(2,4-dihydroxyphenyl)-phenylmethanone leads to inhibition of testosterone synthesis in freshly isolated mouse and rat testis tissue
(2,4-dihydroxyphenyl)-phenylmethanone
-
(2,4-dihydroxyphenyl)-phenylmethanone leads to inhibition of testosterone synthesis in freshly isolated mouse and rat testis tissue
1-[(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-2',17-dioxohexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-3,5'-[1,3]oxazolidin]-3'-yl]-3-(morpholin-4-yl)propan-2-yl cyclohexanecarboxylate

-
1-[(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-2',17-dioxohexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-3,5'-[1,3]oxazolidin]-3'-yl]-3-(morpholin-4-yl)propan-2-yl cyclohexanecarboxylate
-
D-5-2
3beta-phenylethyl-androsterone

-
IC50: 99 nM
3beta-phenylethyl-androsterone
-
-
3beta-phenylmethyl-androsterone

-
IC50: 57 nM
3beta-phenylmethyl-androsterone
-
mixed-type inhibition, shows some proliferative activity on AR+ and Er+ cell lines not mediated through androgen or estrogen receptors
9-cis-retinoic acid

-
weak
p-chloromercuribenzoate

-
-
p-chloromercuribenzoate
-
-
RM-532-105

-
RM-532-105
-
3beta-(o-trifluoromethylphenyl-sulfonyl-dimethylpipera-zino)-androsterone, a 3 beta-dimethylpiperazino-ADT sulfonamide derivative. RM-532-105 is a better competitor of labeled enzyme substrate [14C]-4-dione than the unlabeled natural substrate 4-dione (IC50 = 341 and 337 nM) used itself as an inhibitor
Strogen forte

-
standardized extract of the plant Sabalis serrulata, 0.212 mg/ml result in 50% enzyme inhibition
-
Strogen forte
-
standardized extract of the plant Sabalis serrulata, 0.4 mg/ml result in 50% enzyme inhibition
-
Triton X-100

-
significant
additional information

-
synthesis, inhibitory potency, and in vivo effects of the diverse inhibitor derivatives, detailed overview
-
additional information
-
design, synthesis and in vitro evaluation of 4-androstene-3,17-dione/adenosine hybrid compounds as bisubstrate inhibitors of type 3 17beta-HSD, the bisubstrate inhibitors are less potent in intact cells than in homogenated cells, overview, the best inhibitors of that series are those bearing an alkyl side-chain spacer of 11 or 12 methylenes with inhibition of 69% and 78% at 1 mM
-
additional information
high-throughput screening, a series of non-carboxylate morpholino(phenylpiperazin-1-yl)methanones are prepared by palladium-catalysed coupling of substituted phenyl or pyridyl bromides with morpholino(piperazin-1-yl)methanone, and are shown to be potent and very isoform-selective inhibitors of AKR1C3, competitive fluorescence assay, structure-activity relationships, overview
-
additional information
small-molecule inhibitors inhibit both the enzymatic and coactivator functions of AKR1C3 resulting in androgen-dependent prostate cancer and CRPC regression. No inhibition by indomethacin
-
additional information
-
small-molecule inhibitors inhibit both the enzymatic and coactivator functions of AKR1C3 resulting in androgen-dependent prostate cancer and CRPC regression. No inhibition by indomethacin
-
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0.028
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
0.0015
(S)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
0.0012
(S)-1-indanol
pH 7.4, 25°C, recombinant enzyme
0.023
1-Acenaphthenol
pH 7.4, 25°C, recombinant enzyme
0.0004
17beta-estradiol
pH 7.4, 25°C, recombinant enzyme
0.026
2-Cyclohexen-1-ol
pH 7.4, 25°C, recombinant enzyme
0.00053
20alpha-dihydroprogesterone
-
pH 7.4, with NAD+ as cofactor
0.685
3-acetylpyridine adenine dinucleotide
-
testosterone as substrate
0.063
3-pyridinealdehyde adenine dinucleotide
-
testosterone as substrate
0.0009
3beta-hydroxyprogesterone
pH 7.4, 25°C, recombinant enzyme
0.0081
4-androstene-3alpha,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.642
5-androsten-3beta-ol-17-one
50°C, pH 7.8
0.0033
5-androstene-3beta,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.09
5-pregnen-3beta-ol-20-one
50°C, pH 7.8
0.068 - 0.176
5alpha-Androst-16-en-3-one
0.0025
5alpha-Androstan-3beta-ol-17-one
pH 7.4, 25°C, recombinant enzyme
0.0076 - 0.2
5alpha-dihydrotestosterone
0.106
5alpha-pregnan-3,20-dione
50°C, pH 7.8
0.0039 - 0.116
5alpha-pregnan-3beta-ol-20-one
0.046
5beta-androstan-3beta-ol-17-one
pH 7.4, 25°C, recombinant enzyme
0.0039
5beta-androstane-3alpha,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.015
5beta-androstane-3beta,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.013
5beta-dihydrotestosterone
pH 7.4, 25°C, recombinant enzyme
0.21 - 1.725
5beta-pregnan-3,20-dione
0.015
5beta-pregnan-3beta,21-diol-20-one
pH 7.4, 25°C, recombinant enzyme
0.0068 - 0.314
5beta-Pregnan-3beta-ol-20-one
0.014
alpha-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
0.04
beta-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
0.001
beta-ionol
pH 7.4, 25°C, recombinant enzyme
0.0097
cis-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
0.074
Cyclohexanol
pH 7.4, 25°C, recombinant enzyme
0.00001 - 0.0043
dehydroepiandrosterone
0.00025
dihydrotestosterone
-
pH 7.4, with NAD+ as cofactor
0.00035
estradiol
-
pH 7.4, with NAD+ as cofactor
0.0012
farnesol
pH 7.4, 25°C, recombinant enzyme
0.0041
geraniol
pH 7.4, 25°C, recombinant enzyme
0.001
geranylgeraniol
pH 7.4, 25°C, recombinant enzyme
0.011
nerol
pH 7.4, 25°C, recombinant enzyme
0.00067
pregnenolone
-
pH and temperature not specified in the publication
0.00061 - 0.31
testosterone
0.083
Thionicotinamide adenine dinucleotide
-
testosterone as substrate
0.011
trans-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
additional information
additional information
-
0.068
5alpha-Androst-16-en-3-one

-
microsomal enzyme
0.107
5alpha-Androst-16-en-3-one
-
mitochondrial enzyme
0.176
5alpha-Androst-16-en-3-one
-
cytosolic enzyme
0.0076
5alpha-dihydrotestosterone

pH 7.4, 25°C, recombinant enzyme
0.14
5alpha-dihydrotestosterone
-
-
0.2
5alpha-dihydrotestosterone
-
cofactor NAD+ or NADP+
0.0039
5alpha-pregnan-3beta-ol-20-one

pH 7.4, 25°C, recombinant enzyme
0.116
5alpha-pregnan-3beta-ol-20-one
50°C, pH 7.8
0.21
5beta-pregnan-3,20-dione

-
-
1.725
5beta-pregnan-3,20-dione
50°C, pH 7.8
0.0068
5beta-Pregnan-3beta-ol-20-one

pH 7.4, 25°C, recombinant enzyme
0.314
5beta-Pregnan-3beta-ol-20-one
50°C, pH 7.8
0.00001
dehydroepiandrosterone

-
37°C, pH not specified in the publication
0.0043
dehydroepiandrosterone
pH 7.4, 25°C, recombinant enzyme
0.023
NAD+

pH 7.4, 25°C, with substrate S-tetralol
0.083
NAD+
-
testosterone as substrate
0.11
NAD+
-
pH 7.4, reaction with estradiol
0.167
NAD+
-
pH 7.4, reaction with testosterone
0.0053
NADH

-
pH 7.4, reaction with 4-dionetestosterone
0.0056
NADH
-
pH 7.4, reaction with estronel
0.017
NADH
pH 7.4, 25°C, with substrate S-camphorquinone
0.0082
NADP+

-
testosterone as substrate, 17beta-hydroxysteroid dehydrogenase activity
0.009
NADP+
-
3beta-hydroxy-5alpha-androstan-17-one as substrate, 3beta-hydroxysteroid dehydrogenase activity
2.4
NADP+
pH 7.4, 25°C, with substrate S-camphorquinone
9.6
NADP+
-
pH 7.4, reaction with estradiol
0.0018
NADPH

-
5alpha-dihydrotestosterone as substrate, 3-beta-hydroxysteroid dehydrogenase activity
0.0021
NADPH
-
estrone as substrate, 17beta-hydroxysteroid dehydrogenase activity
0.00061
testosterone

-
pH 7.4, with NAD+ as cofactor
0.0081
testosterone
pH 7.4, 25°C, recombinant enzyme
0.2
testosterone
-
cofactor NAD+ or NADP+
0.24
testosterone
-
NADP+ as variable substrate
additional information
additional information

Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.022
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
0.025
(S)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
0.028
(S)-1-indanol
pH 7.4, 25°C, recombinant enzyme
0.022
1-Acenaphthenol
pH 7.4, 25°C, recombinant enzyme
0.022
17beta-estradiol
pH 7.4, 25°C, recombinant enzyme
0.04
2-Cyclohexen-1-ol
pH 7.4, 25°C, recombinant enzyme
0.78
20alpha-dihydroprogesterone
-
pH 7.4, with NAD+ as cofactor
0.056
3beta-hydroxyprogesterone
pH 7.4, 25°C, recombinant enzyme
0.043
4-androstene-3alpha,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.043
5-androstene-3beta,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.027
5alpha-Androstan-3beta-ol-17-one
pH 7.4, 25°C, recombinant enzyme
0.057
5alpha-dihydrotestosterone
pH 7.4, 25°C, recombinant enzyme
0.013
5alpha-pregnan-3beta-ol-20-one
pH 7.4, 25°C, recombinant enzyme
0.022
5beta-androstan-3beta-ol-17-one
pH 7.4, 25°C, recombinant enzyme
0.012
5beta-androstane-3alpha,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.036
5beta-androstane-3beta,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.032
5beta-dihydrotestosterone
pH 7.4, 25°C, recombinant enzyme
0.0043
5beta-pregnan-3beta,21-diol-20-one
pH 7.4, 25°C, recombinant enzyme
0.0028
5beta-Pregnan-3beta-ol-20-one
pH 7.4, 25°C, recombinant enzyme
0.018
alpha-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
0.025
beta-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
0.022
beta-ionol
pH 7.4, 25°C, recombinant enzyme
0.025
cis-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
0.009
Cyclohexanol
pH 7.4, 25°C, recombinant enzyme
0.01
dehydroepiandrosterone
pH 7.4, 25°C, recombinant enzyme
2.4
dihydrotestosterone
-
pH 7.4, with NAD+ as cofactor
3.9
estradiol
-
pH 7.4, with NAD+ as cofactor
0.018
farnesol
pH 7.4, 25°C, recombinant enzyme
0.023
geraniol
pH 7.4, 25°C, recombinant enzyme
0.008
geranylgeraniol
pH 7.4, 25°C, recombinant enzyme
0.023
nerol
pH 7.4, 25°C, recombinant enzyme
0.0078 - 3.4
testosterone
0.033
trans-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
0.11
NAD+

pH 7.4, 25°C, with substrate S-tetralol
2.9
NAD+
-
pH 7.4, reaction with testosterone
4.7
NAD+
-
pH 7.4, reaction with estradiol
0.1
NADH

pH 7.4, 25°C, with substrate S-camphorquinone
0.27
NADH
-
pH 7.4, reaction with 4-dionetestosterone
0.33
NADH
-
pH 7.4, reaction with estronel
0.15
NADP+

pH 7.4, 25°C, with substrate S-camphorquinone
1.3
NADP+
-
pH 7.4, reaction with estradiol
0.0078
testosterone

pH 7.4, 25°C, recombinant enzyme
3.4
testosterone
-
pH 7.4, with NAD+ as cofactor
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.78
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
16.67
(S)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
23.3
(S)-1-indanol
pH 7.4, 25°C, recombinant enzyme
0.95
1-Acenaphthenol
pH 7.4, 25°C, recombinant enzyme
116.7
17beta-estradiol
pH 7.4, 25°C, recombinant enzyme
1.55
2-Cyclohexen-1-ol
pH 7.4, 25°C, recombinant enzyme
63.33
3beta-hydroxyprogesterone
pH 7.4, 25°C, recombinant enzyme
5.5
4-androstene-3alpha,17beta-diol
pH 7.4, 25°C, recombinant enzyme
9.67
5-androstene-3beta,17beta-diol
pH 7.4, 25°C, recombinant enzyme
10.67
5alpha-Androstan-3beta-ol-17-one
pH 7.4, 25°C, recombinant enzyme
2.83
5alpha-dihydrotestosterone
pH 7.4, 25°C, recombinant enzyme
3.33
5alpha-pregnan-3beta-ol-20-one
pH 7.4, 25°C, recombinant enzyme
0.47
5beta-androstan-3beta-ol-17-one
pH 7.4, 25°C, recombinant enzyme
3
5beta-androstane-3alpha,17beta-diol
pH 7.4, 25°C, recombinant enzyme
2.5
5beta-androstane-3beta,17beta-diol
pH 7.4, 25°C, recombinant enzyme
0.6
5beta-dihydrotestosterone
pH 7.4, 25°C, recombinant enzyme
0.28
5beta-pregnan-3beta,21-diol-20-one
pH 7.4, 25°C, recombinant enzyme
0.42
5beta-Pregnan-3beta-ol-20-one
pH 7.4, 25°C, recombinant enzyme
1.3
alpha-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
0.63
beta-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
21.67
beta-ionol
pH 7.4, 25°C, recombinant enzyme
2.5
cis-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
0.117
Cyclohexanol
pH 7.4, 25°C, recombinant enzyme
2.33
dehydroepiandrosterone
pH 7.4, 25°C, recombinant enzyme
14.17
farnesol
pH 7.4, 25°C, recombinant enzyme
5.67
geraniol
pH 7.4, 25°C, recombinant enzyme
7.67
geranylgeraniol
pH 7.4, 25°C, recombinant enzyme
5
NAD+
pH 7.4, 25°C, with substrate S-tetralol
6
NADH
pH 7.4, 25°C, with substrate S-camphorquinone
0.063
NADP+
pH 7.4, 25°C, with substrate S-camphorquinone
2.17
nerol
pH 7.4, 25°C, recombinant enzyme
3.5
testosterone
pH 7.4, 25°C, recombinant enzyme
3
trans-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.001
(2,4-dihydroxyphenyl)-phenylmethanone
Homo sapiens
pH 7.4, 37°C
0.000262
(3a,5a)-3-[[(2R,5S)-4-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-2,5-dimethylpiperazin-1-yl]methyl]-17-methylideneandrostan-3-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000085
(3alpha,5alpha)-3-([(2R,5S)-2,5-dimethyl-4-[2-(trifluoromethyl)benzene-1-sulfonyl]piperazin-1-yl]methyl)-3-hydroxyandrostan-17-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00297
1-(11,12-dihydro-6H-dibenzo[b,f]oxocin-12-yl)ethanone
Homo sapiens
-
IC50: 0.00297 mM
0.00474
1-(5,6,11,12-tetrahydrodibenzo[b,f]azocin-12-yl)ethanone
Homo sapiens
-
IC50: 0.00474 mM
0.000037 - 0.000051
1-[(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-2',17-dioxohexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-3,5'-[1,3]oxazolidin]-3'-yl]-3-(morpholin-4-yl)propan-2-yl cyclohexanecarboxylate
Rattus norvegicus
-
pH 7.4, 37°C
0.00000002
1-[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]ethanone
Homo sapiens
-
IC50: 0.02 nM
0.00024 - 0.00029
1-[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]methanamine
0.0115
12-acetyl-1-chloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.0115 mM
0.00281
12-acetyl-11,12-dihydro-2-(trifluoromethyl)-6H-dibenzo(b,f)(1,4)thiazocine
Homo sapiens
pH and temperature not specified in the publication
0.0004
12-acetyl-11,12-dihydro-6H-dibenzo(b,f)(1,4)thiazocine
Homo sapiens
pH and temperature not specified in the publication
0.0049
12-acetyl-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocin-3-ol
Homo sapiens
-
IC50: 0.0049 mM
0.00001
12-acetyl-2,3-dichloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00001 mM
0.00281
12-acetyl-2-(trifluoromethyl)-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00281 mM
0.00003
12-acetyl-2-chloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00003 mM
0.00076
12-acetyl-3,4-dichloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00076 mM
0.00025
12-acetyl-3-bromo-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00025 mM
0.0001
12-acetyl-3-chloro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00010 mM
0.00009
12-acetyl-3-fluoro-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.00009 mM
0.0021
12-acetyl-3-methoxy-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.0021 mM
0.001
12-acetyl-3-methyl-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine
Homo sapiens
-
IC50: 0.001 mM
0.0009
17-hydroxy-7alpha-thioethyl-3-oxo-4-androstene-17alpha-propionic acid, gamma-lactone
Homo sapiens
-
IC50 for reduction of androst-4-en-3,17-dione: 0.0009 mM
0.0181
2,2',4,4'-tetrahydroxybenzophenone
Homo sapiens
pH 7.4, 37°C
0.00915
2,5-dioxo-3-(2-propyn-1-yl)-3-pyrrolidinecarboxylic acid 2,3,3-triphenyl-2-propen-1-yl-ester
Homo sapiens
pH and temperature not specified in the publication
0.00006
2-((3-chloro-4-hydroxybenzoyl)amino)-N-(2-(2-methoxyphenyl)ethyl)-5-phenoxy-benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00000002
2-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo(b,f)azocin-8-yl)-benzoic acid methyl ester
Homo sapiens
pH and temperature not specified in the publication
0.000003
2-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzonitrile
Homo sapiens
-
IC50: 3 nM
0.000003
3-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzonitrile
Homo sapiens
-
IC50: 3 nM
0.033
3-benzylidene camphor
Homo sapiens
pH 7.4, 37°C
0.001
3-oxo-17alpha-pregna-4-ene-7alpha-(benzylthia)-21,17-carbolactone
Homo sapiens
-
IC50 for reduction of androst-4-en-3,17-dione: 0.00042 mM,IC50 for oxidation of testosterone: 0.001 mM
0.001
3-oxo-17alpha-pregna-4-ene-7alpha-(phenylthia)-21,17-carbolactone
Homo sapiens
-
IC50 for reduction of androst-4-en-3,17-dione: 0.001 mM
0.0011 - 0.0014
3-oxo-17alpha-pregna-4-ene-7alpha-(propylthia)-21,17-carbolactone
0.0007
3-oxo-17alpha-pregna-4-ene-7alpha-[4-[2-(1-piperidinyl)-ethoxy]benzylthia]-21,17-carbolactone
Homo sapiens
-
IC50 for oxidation of testosterone: 0.0007 mM, no inhibition of type 1, 3 and 5 17beta-HSD, nor against P450 aromatase
0.000116
3alpha-butyl-3-hydroxy-5alpha-androstan-17-one
Homo sapiens
pH and temperature not specified in the publication
0.00007 - 0.00076
3alpha-ether-3beta-substituted androsterone derivatives
Homo sapiens
-
diverse derivatives, IC50: 70-760 nM, overview
-
0.000057 - 0.000147
3beta-alkylated androsterone derivatives
Homo sapiens
-
IC50: 57-147 nM
-
0.000073
3beta-phenylethyl-3alpha-methyl-O-androsterone
Homo sapiens
-
IC50: 73 nM
0.000099
3beta-phenylethyl-androsterone
Homo sapiens
-
IC50: 99 nM
0.000057
3beta-phenylmethyl-androsterone
Homo sapiens
-
IC50: 57 nM
0.000057 - 0.000147
3beta-substituted androsterone derivatives
Homo sapiens
-
IC50: 57-147 nM
-
0.000025
4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)-N-methylbenzamide
Homo sapiens
-
IC50: 25 nM
0.000005
4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzonitrile
Homo sapiens
-
IC50: 5 nM
0.00000145
4-MA
Homo sapiens
-
37°C, pH not specified in the publication
0.0107
4-methylbenzylidene camphor
Homo sapiens
pH 7.4, 37°C
0.00007
5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 0.00007 mM
0.00024
5-acetyl-2-chloro-5,6-dihydro-dibenzo(b,f)azocine
Homo sapiens
pH and temperature not specified in the publication
0.00024
5-acetyl-2-chloro-5,6-dihydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 0.00024 mM
0.000003
5-acetyl-2-chloro-8-(2-methoxyphenyl)-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 3 nM
0.000008
5-acetyl-2-chloro-8-(3-methoxyphenyl)-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 8 nM
0.000002
5-acetyl-2-chloro-8-(4-methoxyphenyl)-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 2 nM
0.000004
5-acetyl-2-chloro-8-phenyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 4 nM
0.00005
5-acetyl-3-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 0.00005 mM
0.00474
5-acetyl-5,6,11,12-tetrahydro-dibenzo(b,f)(1,4)diazocine
Homo sapiens
pH and temperature not specified in the publication
0.00049
5-acetyl-5,6,11,12-tetrahydrodibenzo[b,f]azocin-9-amine
Homo sapiens
-
IC50: 0.00049 mM
0.001
5-acetyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine-9-carboxamide
Homo sapiens
-
IC50: 0.001 mM
0.000009
5-acetyl-8-bromo-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 9 nM
0.00000002
5-acetyl-8-phenyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 0.02 nM
0.000007
5-acetyl-9-bromo-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 7 nM
0.000008
5-acetyl-N-cyclohexyl-5,6,11,12-tetrahydrodibenzo[b,f]azocin-9-amine
Homo sapiens
-
IC50: 8 nM
0.00092
7-hydroxyflavone
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.00028
9-bromo-11,12-dihydrodibenzo[b,f]azocine-5(6H)-carboxamide
Homo sapiens
-
IC50: 0.00028 mM
0.00032
9-bromo-5-butanoyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 0.00032 mM
0.001
9-bromo-5-ethyl-5,6,11,12-tetrahydrodibenzo[b,f]azocine
Homo sapiens
-
IC50: 0.001 mM
0.000337 - 0.000341
androstenedione
Rattus norvegicus
-
pH 7.4, 37°C
0.000182
androsterone
Homo sapiens
pH and temperature not specified in the publication
0.001
chrysin
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.00015
cyproterone acetate
Homo sapiens
-
37°C, pH not specified in the publication
0.0004
dibenzothiazocine
Homo sapiens
-
IC50: 0.0004 mM
0.0000062
epostane
Homo sapiens
-
37°C, pH not specified in the publication
0.005
galangin
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.0042
genistein
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.0065
Hexestrol
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.05
hinokitiol
Mesocricetus auratus
above, pH 7.4, 25°C, recombinant enzyme
0.0044
lithocholic acid
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.01
methyl 12-acetyl-11,12-dihydro-6H-dibenzo[b,f][1,4]thiazocine-3-sulfinate
Homo sapiens
-
IC50: 0.01 mM
0.00004
methyl 3-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzoate
Homo sapiens
-
IC50: 0.00004 mM
0.0000007 - 0.00004
methyl 4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzoate
0.00014
methyl [3-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]amidosulfite
Homo sapiens
-
IC50: 0.00014 mM
0.000002
methyl [4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]amidosulfite
Homo sapiens
-
IC50: 2 nM
0.000035
N-(((3,5)-3-hydroxy-17-oxoandrostan-3-yl)methyl)-N-(tricyclo(3.3.1.13.7)dec-2-ylmethyl)butanamide
Homo sapiens
pH and temperature not specified in the publication
0.00016
N-(5-acetyl-5,6,11,12-tetrahydrodibenzo[b,f]azocin-9-yl)benzamide
Homo sapiens
-
IC50: 0.00016 mM
0.0177 - 0.194
Perfluorooctanoic acid
0.05
Phenolphthalein
Mesocricetus auratus
above, pH 7.4, 25°C, recombinant enzyme
0.0026
quercetin
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.000026 - 0.0001
RM-532-105
0.00025
spiro-gamma-lactone-estradiol
Homo sapiens
-
inhibits the reduction of androst-4-en-3,17-dione, reversible, IC50: 0.00025 mM
0.0011
spironolactone
Homo sapiens
-
IC50 for oxidation of testosterone: 0.0011 mM
0.00009
tetrahydrodibenzazocine
Homo sapiens
-
IC50: 0.00009 mM
0.015
zearalenone
Mesocricetus auratus
pH 7.4, 25°C, recombinant enzyme
0.0000009
[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]methanol
Homo sapiens
-
IC50: 0.9 nM
0.00024
1-[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]methanamine

Homo sapiens
-
IC50: 0.00024 mM
0.00029
1-[4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)phenyl]methanamine
Homo sapiens
-
IC50: 0.00029 mM
0.0011
3-oxo-17alpha-pregna-4-ene-7alpha-(propylthia)-21,17-carbolactone

Homo sapiens
-
IC50 for reduction of androst-4-en-3,17-dione: 0.0011 mM
0.0014
3-oxo-17alpha-pregna-4-ene-7alpha-(propylthia)-21,17-carbolactone
Homo sapiens
-
IC50 for reduction of androst-4-en-3,17-dione: 0.0014 mM
0.0000007
methyl 4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzoate

Homo sapiens
-
IC50: 0.7 nM
0.00004
methyl 4-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo[b,f]azocin-8-yl)benzoate
Homo sapiens
-
IC50: 0.00004 mM
0.0177
Perfluorooctanoic acid

Rattus norvegicus
-
testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication
0.0532
Perfluorooctanoic acid
Rattus norvegicus
-
testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase
0.146
Perfluorooctanoic acid
Rattus norvegicus
-
intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase
0.194
Perfluorooctanoic acid
Rattus norvegicus
-
intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication
0.000026
RM-532-105

Rattus norvegicus
-
pH 7.4, 37°C, inhibition in recombinant HEK-293 cells overexpressing 17 beta-HSD3, overview
0.0001
RM-532-105
Rattus norvegicus
-
pH 7.4, 37°C, inhibition in wild-type rat testis, overview
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