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Literature summary for 1.1.1.172 extracted from

  • Suda, T.; Robinson, J.C.; Fjellstedt, T.A.
    Purification and properties of alpha-ketoadipate reductase, a newly discovered enzyme from human placenta (1976), Arch. Biochem. Biophys., 176, 610-620.
    View publication on PubMed
Search for more literature for 1.1.1.172

Inhibitors

Inhibitors Comment Organism Structure
NADH uncompetitive inhibition at high concentrations Homo sapiens
oxalate 10% inhibition at 0.5 mM Homo sapiens
p-chloromercuribenzoate slight inhibition at 0.02 mM, combined with 0.26 mM SDS Homo sapiens
SDS slight inhibition at 0.26 mM, combined with 0.02 mM p-chloromercuribenzoate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 NADH
-
 Homo sapiens
2.6
-
 2-oxoadipate
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoadipate + NADH Homo sapiens highly specific 2-hydroxyadipate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
near homogeneity, chromatography techniques, electrofocusing Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
4°C, 25 mM potassium phosphate, pH 7.5, 20% glycerol, no decrease of activity for several months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoadipate + NADH highly specific Homo sapiens 2-hydroxyadipate + NAD+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens