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Literature summary for 1.1.1.62 extracted from

  • Li, Y.; Qin, L.; Xiao, Z.J.; Wang, Y.L.; Herva, R.; Leng, J.H.; Lang, J.H.; Isomaa, V.; Piao, Y.S.
    Expression of P450 aromatase and 17beta-hydroxysteroid dehydrogenase type 1 at fetal-maternal interface during tubal pregnancy (2003), J. Steroid Biochem. Mol. Biol., 87, 241-246.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NAD(P)H Homo sapiens normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy estradiol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell of fallopian tube. Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy Homo sapiens
-
extravillous trophoblast association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion Homo sapiens
-
fallopian tube epithelial cells. Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy Homo sapiens
-
additional information no expression in villous cytotrophoblast cells Homo sapiens
-
placenta normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta Homo sapiens
-
syncytiotrophoblast normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NAD(P)H
-
Homo sapiens estradiol + NAD(P)+
-
?
estrone + NAD(P)H normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy Homo sapiens estradiol + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens
17HSD1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens