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Literature summary for 1.1.1.31 extracted from
- Characterization of 3-hydroxyisobutyrate dehydrogenase, HIBADH, as a sperm-motility marker (2013), J. Assist. Reprod. Genet., 30, 505-512.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| additional information | the enzyme is located at the mid-piece (a specialized development from the mitochondria) of elongating, elongated, and mature sperm | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-2-methylpropanoate + NAD+ | Homo sapiens | - |
2-methyl-3-oxopropanoate + NADH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellum | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| additional information | HIBADH is downregulated in low-motility sperm, and is enriched expressed during human spermiogenesis, quantitative RT-PCR expression analysis, overview | Homo sapiens | - |
| neuronal cell | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| sperm | elongating, elongated, and mature sperm | Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-2-methylpropanoate + NAD+ | - |
Homo sapiens | 2-methyl-3-oxopropanoate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIBADH | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 10 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | HIBADH is downregulated in low-motility sperm, and is enriched expressed during human spermiogenesis | down |
| Homo sapiens | HIBADH is downregulated in low-motility sperm, and is enriched expressed during human spermiogenesis | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | 3-hydroxyisobutyrate dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ acceptors | Homo sapiens |
| additional information | enzyme activity of HIBADH in spermatozoa from patients with asthenozoospermia is reduced compared to controls | Homo sapiens |
| physiological function | 3-hydroxyisobutyrate dehydrogenase is one of the critical enzymes generating glucose by metabolizing amino acids in the gluconeogenesis pathway. It participates in valine, leucine, and isoleucine degradation and is a central metabolic enzyme in the valine catabolic pathway. The enzyme plays an important role in regulating sperm motility and may serve as a novel sperm-motility marker | Homo sapiens |
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