Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme plays an important physiological role in the defense mechanism against a variety of infectious pathogens, in the regulation of T-cell function by macrophages and a subset of dendritic cells, and in the synthesis of UV filters in human lenses. Serious problems arise from the unregulated over-expression of the enzyme, which often results in a deleterious systemic Trp depletion and/or the accumulation of neurotoxin, quinolinic acidn the brain. Enzyme expression in malignant tumors helps them to avoid the immune surveillance through a local Trp depletion. The kynurenilation of the lens protein with UV filters thus appears to be the major cause of age-related cataract | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Oryctolagus cuniculus | - |
colon | - |
Oryctolagus cuniculus | - |
intestine | - |
Homo sapiens | - |
kidney | - |
Oryctolagus cuniculus | - |
large intestine | - |
Oryctolagus cuniculus | - |
lung | - |
Homo sapiens | - |
lung | - |
Oryctolagus cuniculus | - |
placenta | term placenta | Homo sapiens | - |
small intestine | - |
Oryctolagus cuniculus | - |
spleen | - |
Oryctolagus cuniculus | - |
stomach | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Trp + O2 | - |
Homo sapiens | D-formylkynurenine | - |
? | |
D-Trp + O2 | - |
Oryctolagus cuniculus | D-formylkynurenine | - |
? | |
L-Trp + O2 | - |
Homo sapiens | L-formylkynurenine | - |
? | |
L-Trp + O2 | - |
Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
additional information | the enzyme plays an important physiological role in the defense mechanism against a variety of infectious pathogens, in the regulation of T-cell function by macrophages and a subset of dendritic cells, and in the synthesis of UV filters in human lenses. Serious problems arise from the unregulated over-expression of the enzyme, which often results in a deleterious systemic Trp depletion and/or the accumulation of neurotoxin, quinolinic acidn the brain. Enzyme expression in malignant tumors helps them to avoid the immune surveillance through a local Trp depletion. The kynurenilation of the lens protein with UV filters thus appears to be the major cause of age-related cataract | Homo sapiens | ? | - |
? | |
serotonin + O2 | - |
Homo sapiens | ? | - |
? | |
serotonin + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
tryptamine + O2 | - |
Homo sapiens | ? | - |
? | |
tryptamine + O2 | - |
Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens | |
heme | - |
Oryctolagus cuniculus |