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Literature summary for 1.1.1.146 extracted from

  • Lakshim, V.; Nath, N.; Muneyyirci-Delale, O.
    Characterization of 11beta-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11beta-hydroxysteroid dehydrogenases (1993), J. Steroid Biochem. Mol. Biol., 45, 391-397.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ Homo sapiens i.e. cortisol 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisol r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Homo sapiens i.e. cortisone 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta two forms present, one NAD-specific the other NADP+-dependent Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol Homo sapiens 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisol r
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ i.e. cortisone Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
r

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens