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Information on EC 1.1.1.300 - NADP-retinol dehydrogenase

for references in articles please use BRENDA:EC1.1.1.300
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IUBMB Comments
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) . Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
rdh11, prrdh, retinol dehydrogenase 11, retinol dehydrogenase 8, ralr1, nrdrb1, mrdh11, photoreceptor retinol dehydrogenase, nadp(h)-dependent retinol dehydrogenase/reductase, rdh14, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
retinol + NADP+ = retinal + NADPH + H+
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PATHWAY SOURCE
PATHWAYS
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