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Information on EC 1.1.1.300 - NADP-retinol dehydrogenase

for references in articles please use BRENDA:EC1.1.1.300

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IUBMB Comments

Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary β-carotene by EC 1.13.11.63 (β-carotene 15,15'-monooxygenase) . Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH. This enzyme is distinct from EC 1.1.1.71, alcohol dehydrogenase (NAD(P)+), which shows a broad specificity for aldehydes.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes

Synonyms
prrdh, retinol dehydrogenase 11, retinol dehydrogenase 8, ralr1, nrdrb1, mrdh11, nadp(h)-dependent retinol dehydrogenase/reductase, photoreceptor retinol dehydrogenase, rdh14, retinol dehydrogenase-10, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
retinol + NADP+ = retinal + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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