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Information on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

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IUBMB Comments
Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
[procollagen]-L-proline
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[procollagen]-trans-3-hydroxy-L-proline
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Synonyms
LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[procollagen]-L-proline + 2-oxoglutarate + O2 = [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
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PATHWAY SOURCE
PATHWAYS
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