Cloned (Comment) | Organism |
---|---|
isozyme 11beta-HSD1 is expressed in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2alpha,3beta,5xi,6beta,9xi,18xi)-2,3,6,23-tetrahydroxyurs-12-en-28-oate | - |
Homo sapiens | |
(2alpha,3beta,5xi,9xi,18xi)-2,3,23-trihydroxyurs-12-en-28-oate | - |
Homo sapiens | |
(2R,4aR,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14b-octadecahydropicen-13(2H)-one | - |
Homo sapiens | |
(2R,4aS,6aS,12bR,14aS)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate | - |
Homo sapiens | |
(3beta,5xi,18xi)-oleana-9(11),12-diene-3,30-diol | - |
Homo sapiens | |
(3beta,5xi,9xi)-oleana-11,13(18)-diene-3,30-diol | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3,30-dihydroxyolean-12-en-11-one | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3-(acetyloxy)-11-oxours-12-en-24-oate | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3-(acetyloxy)urs-12-en-24-oate | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-al | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3-hydroxy-11-oxours-12-en-28-oate | - |
Homo sapiens | |
(3beta,5xi,9xi,18xi)-3-hydroxyolean-12-en-28-oate | - |
Homo sapiens | |
(5xi,9xi,18xi)-3,11-dioxoolean-12-en-30-al | - |
Homo sapiens | |
carbenoxolone | - |
Homo sapiens | |
ethyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | - |
Homo sapiens | |
methyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Homo sapiens | - |
liver | isozyme 11beta-HSD1 | Homo sapiens | - |
muscle fibre | - |
Homo sapiens | - |
placenta | isozyme 11beta-HSD2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | isozyme | Homo sapiens |
11beta-HSD2 | isozyme | Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
11beta-HSD2, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000012 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000012 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000049 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3,30-dihydroxyolean-12-en-11-one | |
0.000056 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (2R,4aR,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14b-octadecahydropicen-13(2H)-one | |
0.000061 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | methyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000068 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | ethyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000074 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (5xi,9xi,18xi)-3,11-dioxoolean-12-en-30-al | |
0.000119 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | methyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000122 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-al | |
0.000124 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (5xi,9xi,18xi)-3,11-dioxoolean-12-en-30-al | |
0.000141 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | ethyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.000149 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,9xi,18xi)-3,30-dihydroxyolean-12-en-11-one | |
0.000177 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-al | |
0.000244 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (2R,4aR,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14b-octadecahydropicen-13(2H)-one | |
0.001 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxours-12-en-28-oate | |
0.002 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,18xi)-oleana-9(11),12-diene-3,30-diol | |
0.002 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi)-oleana-11,13(18)-diene-3,30-diol | |
0.003 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (2alpha,3beta,5xi,6beta,9xi,18xi)-2,3,6,23-tetrahydroxyurs-12-en-28-oate | |
0.005 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (2alpha,3beta,5xi,9xi,18xi)-2,3,23-trihydroxyurs-12-en-28-oate | |
0.009 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-(acetyloxy)urs-12-en-24-oate | |
0.011 | - |
11beta-HSD1, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-(acetyloxy)-11-oxours-12-en-24-oate | |
0.012 | - |
11beta-HSD2, cortisol oxidation | Homo sapiens | (2R,4aR,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14b-octadecahydropicen-13(2H)-one | |
0.016 | - |
11beta-HSD2, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3,30-dihydroxyolean-12-en-11-one | |
0.016 | - |
11beta-HSD2, cortisol oxidation | Homo sapiens | (5xi,9xi,18xi)-3,11-dioxoolean-12-en-30-al | |
0.025 | - |
11beta-HSD2, cortisol oxidation | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-al | |
0.037 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,9xi)-oleana-11,13(18)-diene-3,30-diol | |
0.039 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,18xi)-oleana-9(11),12-diene-3,30-diol | |
0.068 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxours-12-en-28-oate | |
0.074 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (3beta,5xi,9xi,18xi)-3-(acetyloxy)-11-oxours-12-en-24-oate | |
0.112 | - |
11beta-HSD1, cortisone reduction | Homo sapiens | (2alpha,3beta,5xi,6beta,9xi,18xi)-2,3,6,23-tetrahydroxyurs-12-en-28-oate | |
0.2 | - |
11beta-HSD1, cortisol oxidation , IC50 above 0.2 mM | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxyolean-12-en-28-oate | |
0.2 | - |
11beta-HSD1, cortisone reduction, IC50 above 0.2 mM | Homo sapiens | (3beta,5xi,9xi,18xi)-3-hydroxyolean-12-en-28-oate | |
0.2 | - |
11beta-HSD1, cortisone reduction, IC50 above 0.2 mM | Homo sapiens | (3beta,5xi,9xi,18xi)-3-(acetyloxy)urs-12-en-24-oate | |
0.2 | - |
11beta-HSD1, cortisone reduction, IC50 above 0.2 mM | Homo sapiens | (2alpha,3beta,5xi,9xi,18xi)-2,3,23-trihydroxyurs-12-en-28-oate | |
0.2 | - |
11beta-HSD2, cortisol oxidation, IC50 above 0.2 mM | Homo sapiens | methyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.2 | - |
11beta-HSD2, cortisol oxidation, IC50 above 0.2 mM | Homo sapiens | ethyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate | |
0.2 | - |
11beta-HSD2, cortisol oxidation, IC50 above 0.2 mM | Homo sapiens | (3beta,5xi,18xi)-oleana-9(11),12-diene-3,30-diol | |
0.2 | - |
11beta-HSD2, cortisol oxidation, IC50 above 0.2 mM | Homo sapiens | (3beta,5xi,9xi)-oleana-11,13(18)-diene-3,30-diol |