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Information on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.41

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IUBMB Comments

Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NADP+ but much more slowly .

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
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isocitrate
+
NAD+
=
2-oxoglutarate
+
CO2
+
NADH
+
H+
+
=
+
+
+

Synonyms
isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitric dehydrogenase, nad-dependent isocitrate dehydrogenase, idh3a, nad-idh, nad-isocitrate dehydrogenase, nad-icdh, nad+-dependent isocitrate dehydrogenase, nad-linked isocitrate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
nitrogen remobilization from senescing leaves, TCA cycle II (plants and fungi), TCA cycle III (animals)