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Information on EC 1.11.1.8 - iodide peroxidase

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.8 iodide peroxidase
IUBMB Comments
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
thyroid peroxidase, thyroperoxidase, bromoperoxidase, vanadium bromoperoxidase, iodide peroxidase, hrtpo, tyrosine iodinase, iodinase, hmw-tpo, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O
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(1)
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2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O
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(4)
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[thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O
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(3)
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[thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O
show the reaction diagram
(5)
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[thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O
show the reaction diagram
(2)
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PATHWAY SOURCE
PATHWAYS
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