show all | hide all No of entries

Information on EC 1.11.1.8 - iodide peroxidase

for references in articles please use BRENDA:EC1.11.1.8
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.8 iodide peroxidase
IUBMB Comments
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(3 overall reactions are displayed. Show all (5)>>)
2
+
+
2
=
+
2
[thyroglobulin]-L-tyrosine
+
+
=
[thyroglobulin]-3-iodo-L-tyrosine
+
2
[thyroglobulin]-3-iodo-L-tyrosine
+
+
=
[thyroglobulin]-3,5-diiodo-L-tyrosine
+
2
Synonyms
bromoperoxidase, DEHAL1, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), iodotyrosine deiodase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O
show the reaction diagram
(1)
-
-
-
2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O
show the reaction diagram
(4)
-
-
-
[thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O
show the reaction diagram
(3)
-
-
-
[thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O
show the reaction diagram
(5)
-
-
-
[thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O
show the reaction diagram
(2)
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.