EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
lung cancer cell |
- |
668172, 685958 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
lung cancer cell |
loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer |
685958 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
lung cancer cell |
- |
739864 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
lung cancer cell |
- |
761332 |
1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |
lung cancer cell |
- |
764434 |
1.13.11.34 | arachidonate 5-lipoxygenase |
lung cancer cell |
high enzyme expression level |
686278 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
lung cancer cell |
increased LH2 enzyme activity in lung carcinoma compared to healthy lung |
745445 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
lung cancer cell |
- |
745939 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
lung cancer cell |
- |
753157, 756531 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
lung cancer cell |
elevated activity of JMJD2B expression |
724694 |
1.14.11.69 | [histone H3]-trimethyl-L-lysine36 demethylase |
lung cancer cell |
- |
753157 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
lung cancer cell |
- |
674047 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
lung cancer cell |
- |
727426 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
lung cancer cell |
lung carcinoma, GI-117 |
675897 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
lung cancer cell |
lung carcinoma, LX-1 |
675897 |
1.2.1.36 | retinal dehydrogenase |
lung cancer cell |
- |
763529, 763530 |
1.2.1.4 | aldehyde dehydrogenase (NADP+) |
lung cancer cell |
cancerous pneumocytes develop significant higher levels of ALDH3A1 expression than normal pneumocytes |
688781 |
1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] |
lung cancer cell |
- |
763529 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
lung cancer cell |
- |
689367 |
1.3.1.91 | tRNA-dihydrouridine20 synthase [NAD(P)+] |
lung cancer cell |
isozyme Dus2 is upregulated |
745924 |
1.4.3.13 | protein-lysine 6-oxidase |
lung cancer cell |
LOX gene expression is reduced in lung cancer cells |
685949 |
1.5.3.13 | N1-acetylpolyamine oxidase |
lung cancer cell |
- |
703028 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
lung cancer cell |
- |
742556 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
lung cancer cell |
- |
692674 |
1.8.98.2 | sulfiredoxin |
lung cancer cell |
Srx is highly expressed in primary specimen of lung cancer patients |
765061 |
2.1.1.1 | nicotinamide N-methyltransferase |
lung cancer cell |
- |
733449 |
2.1.1.1 | nicotinamide N-methyltransferase |
lung cancer cell |
serum levels of NNMT are signficantly higher in lung cancer patients, overview |
704775 |
2.1.1.319 | type I protein arginine methyltransferase |
lung cancer cell |
- |
757337 |
2.1.1.320 | type II protein arginine methyltransferase |
lung cancer cell |
- |
757337 |
2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase |
lung cancer cell |
- |
753720 |
2.1.1.360 | [histone H3]-lysine79 N-trimethyltransferase |
lung cancer cell |
- |
753306 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
lung cancer cell |
- |
485501 |
2.1.2.1 | glycine hydroxymethyltransferase |
lung cancer cell |
- |
756705 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
lung cancer cell |
- |
740340 |
2.3.1.48 | histone acetyltransferase |
lung cancer cell |
- |
756850 |
2.3.1.57 | diamine N-acetyltransferase |
lung cancer cell |
- |
756851 |
2.3.2.34 | E2 NEDD8-conjugating enzyme |
lung cancer cell |
- |
756564, 757651 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
lung cancer cell |
- |
759839 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
lung cancer cell |
- |
759882 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
lung cancer cell |
- |
686257 |
2.4.1.65 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase |
lung cancer cell |
- |
637647 |
2.4.1.90 | N-acetyllactosamine synthase |
lung cancer cell |
A-549 cells |
658123 |
2.4.2.10 | orotate phosphoribosyltransferase |
lung cancer cell |
- |
672923 |
2.4.2.3 | uridine phosphorylase |
lung cancer cell |
- |
684470 |
2.4.2.4 | thymidine phosphorylase |
lung cancer cell |
- |
638468, 638469 |
2.5.1.60 | protein geranylgeranyltransferase type II |
lung cancer cell |
large cell lung carcinomas, significant overexpression of RabGGT-beta compared to normal tissue |
658377 |
2.7.1.105 | 6-phosphofructo-2-kinase |
lung cancer cell |
- |
737973, 761491 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
lung cancer cell |
- |
760540, 762015 |
2.7.1.171 | protein-fructosamine 3-kinase |
lung cancer cell |
- |
760823 |
2.7.1.183 | glycoprotein-mannosyl O6-kinase |
lung cancer cell |
- |
762066 |
2.7.1.32 | choline kinase |
lung cancer cell |
- |
760183 |
2.7.1.48 | uridine/cytidine kinase |
lung cancer cell |
A549 lung carcinoma cells, uridine kinases mRNA expression is higher than in normal tissue |
641654 |
2.7.1.74 | deoxycytidine kinase |
lung cancer cell |
adult non-small cell lung cancer |
662521 |
2.7.1.91 | sphingosine kinase |
lung cancer cell |
- |
671356 |
2.7.10.1 | receptor protein-tyrosine kinase |
lung cancer cell |
- |
690303 |
2.7.10.1 | receptor protein-tyrosine kinase |
lung cancer cell |
overexpression of EGFR-TK |
662724 |
2.7.11.13 | protein kinase C |
lung cancer cell |
- |
760322 |
2.7.11.20 | elongation factor 2 kinase |
lung cancer cell |
- |
760810, 761285 |
2.7.11.21 | polo kinase |
lung cancer cell |
- |
760764 |
2.7.11.21 | polo kinase |
lung cancer cell |
expression appears to be down-regulated in lung carcinomas |
491304 |
2.7.11.21 | polo kinase |
lung cancer cell |
Plk1 |
662999 |
2.7.12.2 | mitogen-activated protein kinase kinase |
lung cancer cell |
- |
740944 |
2.7.12.2 | mitogen-activated protein kinase kinase |
lung cancer cell |
LX-1 cell, strong expression |
677913 |
2.7.2.3 | phosphoglycerate kinase |
lung cancer cell |
- |
761524 |
2.7.2.3 | phosphoglycerate kinase |
lung cancer cell |
there is no significant difference in cell proliferation between parental Lewis lung carcinoma (LLC-1) and LLC-1 transduced with PGK-1. Overexpression of PGK-1 in LLC-1 reduces the COX-2 expression, and, in turn, affects prostaglandin E2, cell invasion, angiogenesis, and the immune functions, and finally inhibit the tumor progression |
687149 |
2.7.7.1 | nicotinamide-nucleotide adenylyltransferase |
lung cancer cell |
NMNAT1 expression level is significantly reduced in a subset of lung tumor cell lines |
738586 |
2.7.7.6 | DNA-directed RNA polymerase |
lung cancer cell |
- |
704096 |
2.8.2.20 | protein-tyrosine sulfotransferase |
lung cancer cell |
- |
739085 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
lung cancer cell |
- |
662996 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
lung cancer cell |
- |
761220 |
2.8.2.B6 | [heparan sulfate]-iuronate 2-sulfotransferase |
lung cancer cell |
- |
761220 |
3.1.1.1 | carboxylesterase |
lung cancer cell |
- |
729652 |
3.1.1.1 | carboxylesterase |
lung cancer cell |
enzyme overexpression |
728935 |
3.1.1.34 | lipoprotein lipase |
lung cancer cell |
noncancer tissue. Lipoprotein lipase activity is higher in cancer tissue than in noncancer tissue. Lipoprotein lipase gene expression is higher in noncancer tissue compared to cancer tissue |
679692 |
3.1.3.1 | alkaline phosphatase |
lung cancer cell |
- |
679113 |
3.1.3.16 | protein-serine/threonine phosphatase |
lung cancer cell |
- |
752263 |
3.2.1.166 | heparanase |
lung cancer cell |
heparanase expression in lung cancer samples to understand lung tumor progression and malignancy, overview. Heparanase expression tends to correlate with tumor node metastasis staging in non-small cell lung carcinoma |
731350 |
3.2.2.23 | DNA-formamidopyrimidine glycosylase |
lung cancer cell |
- |
-, 708311 |
3.4.14.5 | dipeptidyl-peptidase IV |
lung cancer cell |
- |
703784 |
3.4.17.3 | lysine carboxypeptidase |
lung cancer cell |
metastatic |
36393 |
3.4.18.1 | cathepsin X |
lung cancer cell |
protein level of cathespin X does not differ significantly between matched pairs of lung tumor and adjacent lung tissue ontained from patients with lung cancer |
664854 |
3.4.21.107 | peptidase Do |
lung cancer cell |
primary cell |
717505 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
lung cancer cell |
KLK7 is strongly expressed in the tissue of patients with squamous cell carcinoma and differentiated tumors |
663866 |
3.4.21.118 | kallikrein 8 |
lung cancer cell |
- |
679020 |
3.4.21.119 | kallikrein 13 |
lung cancer cell |
expression of the KLK13 and KLK14 genes are examined at the mRNA and protein levels in a cohort of 57 patients with non-small-cell lung cancer. The mRNA levels, assessed by real-time RT-PCR, are significantly different in malignant tissues compared to adjacent non-malignant tissues. KLK13 and KLK14 mRNA overexpression in tumors is associated with a positive nodal status in multivariate analysis |
691155 |
3.4.21.26 | prolyl oligopeptidase |
lung cancer cell |
high enzyme content |
683926 |
3.4.21.35 | tissue kallikrein |
lung cancer cell |
KLK11 |
679016 |
3.4.21.37 | leukocyte elastase |
lung cancer cell |
primary lung cancer |
710206 |
3.4.21.B42 | hippostasin |
lung cancer cell |
gene expression, no significant difference to non-cancerous tissue |
667878 |
3.4.21.B43 | kallikrein 12 |
lung cancer cell |
- |
717833 |
3.4.22.56 | caspase-3 |
lung cancer cell |
- |
700881 |
3.4.22.63 | caspase-10 |
lung cancer cell |
- |
710209 |
3.4.22.B75 | SENP7 peptidase |
lung cancer cell |
- |
731599 |
3.4.23.36 | Signal peptidase II |
lung cancer cell |
- |
754940 |
3.4.23.5 | cathepsin D |
lung cancer cell |
- |
711855 |
3.4.23.B24 | signal peptide peptidase |
lung cancer cell |
high expression level |
754940 |
3.4.24.22 | stromelysin 2 |
lung cancer cell |
- |
718298, 734175 |
3.4.24.22 | stromelysin 2 |
lung cancer cell |
enzyme Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Mmp10 and Notch4 expression in primary and metastatic lung tumors |
-, 735049 |
3.4.24.23 | matrilysin |
lung cancer cell |
- |
707049 |
3.4.24.23 | matrilysin |
lung cancer cell |
expression levels of fibulin-5 and MMP-7 are inversely correlated in lung tumors |
707986 |