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Literature summary for 1.14.11.65 extracted from

  • Tee, A.E.; Ling, D.; Nelson, C.; Atmadibrata, B.; Dinger, M.E.; Xu, N.; Mizukami, T.; Liu, P.Y.; Liu, B.; Cheung, B.; Pasquier, E.; Haber, M.; Norris, M.D.; Suzuki, T.; Marshall, G.M.; Liu, T.
    The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1 (2014), Oncotarget, 5, 1793-1804 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.65

Application

Application Comment Organism
drug development the enzyme is a target for development of more potent JMJD1A/MALAT1 inhibitors for the prevention of tumor metastasis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DMOG a small molecule JMJD1A inhibitor. N-oxalglycine dimethyl ester prodrug, DMOG, exerts histone lysine methylating activity in cells Homo sapiens
N-oxalylglycine NOG, selectively inhibits JMJD1A Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens JMJD1A binds to the MALAT1 gene promoter and demethylates histone H3K9 at the MALAT1 gene promoter histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens D6W5M4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BE(2)-C cell
-
 Homo sapiens
-
CHP134 cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 JMJD1A binds to the MALAT1 gene promoter and demethylates histone H3K9 at the MALAT1 gene promoter Homo sapiens histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone demethylase
-
 Homo sapiens
JMJD1A
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.067
-
 pH and temperature not specified in the publication Homo sapiens N-oxalylglycine

Expression

Organism Comment Expression
Homo sapiens JMJD1A gene expression is downregulated by the microRNA mir-155 down
Homo sapiens JMJD1A gene expression is upregulated by beta-adrenergic agonists, and by hypoxia-inducible factor 1alpha (HIF1alpha), hypoxia, starvation and iron scavengers in tumor tissues up

General Information

General Information Comment Organism
metabolism identification of a pathway through which N-Myc causes neuroblastoma cell migration and invasion, N-Myc modulates target gene expression partly through up-regulating JMJD1A gene expression Homo sapiens
physiological function histone demethylase JMJD1A activates gene transcription by demethylating the lysine 9 residue of histone H3 (H3K9) at target gene promoters. Enzyme JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1. JMJD1A and MALAT1 induce, while the small molecule JMJD1A inhibitor DMOG suppresses, neuroblastoma cell migration and invasion. The long noncoding RNA MALAT1 induces lung cancer cell migration and plays a pivotal role in lung cancer metastasis. JMJD1A induces neuroblastoma cell migration and invasion. Enzyme JMJD1A directly binds to promoter regions of beta-adrenergic agonist target genes such as Ucp1, demethylates histone H3K9 at the promoters, and activates gene transcription. Genome-wide analysis reveals that JMJD1A siRNA-1 reduces the expression of 0.15% (63 probes/41717 probes) of genes, but upregulated the expression of 0.67% (280 probes/41717 probes) of genes. 1.59% (1 probe/63 probes) of genes downregulated by JMJD1A siRNA-1 are up-regulated by N-Myc siRNA-1, 7.94% (5 probes/63 probes) of genes downregulated by JMJD1A siRNA-1 are also downregulated by N-Myc siRNA-1 Homo sapiens