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Literature summary for 3.1.1.1 extracted from

  • Amissah, F.; Duverna, R.; Aguilar, B.J.; Poku, R.A.; Kiros, G.E.; Lamango, N.S.
    Polyisoprenylated methylated protein methyl esterase overexpression and hyperactivity promotes lung cancer progression (2014), Am. J. Cancer Res., 4, 116-134.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics possible use of the enzyme as a protein biomarker and drug target for lung cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanesulfonyl fluoride
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polyisoprenylated methylated protein + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell enzyme overexpression Homo sapiens
-
fibroblast lung Homo sapiens
-
lung
-
Homo sapiens
-
lung cancer cell enzyme overexpression Homo sapiens
-
NCI-H460 cell enzyme overexpression Homo sapiens
-
WI-38 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Homo sapiens ?
-
?
polyisoprenylated methylated protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PMPMEase
-
Homo sapiens
polyisoprenylated methylated protein methyl esterase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
malfunction polyisoprenylated methylated protein methyl esterase inhibition modulates polyisoprenylated protein function. Enzyme inhibition disrupts actin filament assembly, significantly inhibits cell migration and alters the transcription of cancer-related genes. Enzyme inhibition disrupts actin cytoskeleton organization, effects on F-actin filaments and Ras proteins, overview Homo sapiens
physiological function polyisoprenylated proteins play important roles in carcinogenesis, elevated PMPMEase activity spurs cell growth and migration Homo sapiens