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Information on EC 3.4.21.B42 - hippostasin
for references in articles please use BRENDA:EC3.4.21.B42
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preliminary BRENDA-supplied EC number
EC Tree 3 Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.B42 hippostasin
The enzyme appears in viruses and cellular organisms
- 3.4.21.B42
- kallikreins
- klk8
-
prostate-specific
- medicine
- soman
- diagnostics
-
immunofluorometric
showSynonyms
klk11, hippostasin, kallikrein-like protease, gk-11, human kallikrein 11, kallikrein 11, prostate-type klk11, tissue kallikrein 11, kallikrein-related peptidase 11, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
hK11
human kallikrein 11
kallikrein 11
kallikrein-related peptidase 11
KLK11
S01.257
-
-
-
-
tissue kallikrein 11
TLSP
kallikrein 11
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
proteolytic cleavage of polypeptides, preferential cleavage site: Arg-
enzyme is trypsin-like a serine protease
proteolytic cleavage of polypeptides, preferential cleavage site: Arg-
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
hydrolysis of peptide bond
-
-
-
-
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CAS REGISTRY NUMBER
COMMENTARY
342900-22-5
-
9001-01-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
acetyl-Arg-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
Arg-4-methyl-coumaryl-7-amide + H2O
Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
benzyl-Arg-4-methyl-coumaryl-7-amide + H2O
benzyl-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
benzyl-Phe-Arg-4-methyl-coumaryl-7-amide + H2O
benzyl-Phe-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
benzyloxycarbonyl-Gln-Ala-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
benzyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
benzyloxycarbonyl-Val-Leu-Lys-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
benzyloxycarbonyl-Val-Pro-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
Gln-Ala-Arg + 7-amino-4-methylcoumarin
Substrates: -
Products: -
Products: -
?
Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
Gly-Pro-Arg + 7-amino-4-methylcoumarin
Substrates: -
Products: -
Products: -
?
insulin-like growth factor-binding protein 3 + H2O
?
Substrates: insulin-like growth factor-binding protein 3 is cleaved into 3 fragments of 25000, 20000 and 17000 Da length, respectively
Products: -
Products: -
?
Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
Phe-Ser-Arg + 7-amino-4-methylcoumarin
Substrates: -
Products: -
Products: -
?
Pro-Phe-Arg-4-methyl-coumaryl-7-amide + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
Pro-Phe-Arg + 7-amino-4-methylcoumarin
Substrates: -
Products: -
Products: -
?
Pyr-Gly-Arg-4-methyl-coumaryl-7-amide + H2O
Pyr-Gly-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
Val-Pro-Arg + 7-amino-4-methylcoumarin
Substrates: -
Products: -
Products: -
?
acetyl-Phe-Arg-4-methyl-coumaryl-7-amide + H2O
acetyl-Phe-Arg + 7-amino-4-methylcoumarin
Substrates: best substrate
Products: -
Products: -
?
acetyl-Phe-Arg-4-methyl-coumaryl-7-amide + H2O
acetyl-Phe-Arg + 7-amino-4-methylcoumarin
Substrates: recombinant enzyme
Products: -
Products: -
?
additional information
?
-
Substrates: kallikrein 11 is able to degrade itself
Products: -
Products: -
?
additional information
?
-
-
Substrates: kallikrein 11 is able to degrade itself
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients.
Adenoma
Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer.
beta-Thalassemia
Demonstration of kallikrein-like protease activity in nonactivated plasma of patients with Cooley's anemia.
Brain Neoplasms
Immunoreactivity, ultrastructural localization, and transcript expression of prostate-specific antigen in human neuroblastoma cell lines.
Breast Neoplasms
Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B? receptor in breast cancer cells.
Breast Neoplasms
Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.
Breast Neoplasms
Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3.
Breast Neoplasms
Novel Biomarkers Aim at Detecting Metastatic Sentinel Lymph Nodes in Breast Cancer
Carcinogenesis
KLK11 suppresses cellular proliferation via inhibition of Wnt/?-catenin signaling pathway in esophageal squamous cell carcinoma.
Carcinoma
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
Carcinoma
Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma.
Carcinoma
Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer.
Carcinoma
KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/?-catenin signaling.
Carcinoma
KLK11 suppresses cellular proliferation via inhibition of Wnt/?-catenin signaling pathway in esophageal squamous cell carcinoma.
Carcinoma
Over-expression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma.
Carcinoma
Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
Carcinoma
Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma.
Carcinoma, Hepatocellular
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
Carcinoma, Non-Small-Cell Lung
Is Human Kallikrein 11 in Non-small Cell Lung Cancer Treated Chemoradiotherapy Associated with Survival?
Carcinoma, Renal Cell
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
Cardiomegaly
KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
Colonic Neoplasms
The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer.
Colorectal Neoplasms
KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients.
Colorectal Neoplasms
Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer.
Colorectal Neoplasms
Knockdown of KLK11 reverses oxaliplatin resistance by inhibiting proliferation and activating apoptosis via suppressing the PI3K/AKT signal pathway in colorectal cancer cell.
Dermatitis, Atopic
Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients.
Dry Eye Syndromes
Elevated Immunoglobulin to Tissue KLK11 in Patients With Sjögren Syndrome.
Esophageal Squamous Cell Carcinoma
KLK11 suppresses cellular proliferation via inhibition of Wnt/?-catenin signaling pathway in esophageal squamous cell carcinoma.
hippostasin deficiency
KLK11 suppresses cellular proliferation via inhibition of Wnt/?-catenin signaling pathway in esophageal squamous cell carcinoma.
Laryngeal Neoplasms
Diagnostic and prognostic significance of human kallikrein 11 (KLK11) mRNA expression levels in patients with laryngeal cancer.
Lung Neoplasms
Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues.
Lung Neoplasms
Is Human Kallikrein 11 in Non-small Cell Lung Cancer Treated Chemoradiotherapy Associated with Survival?
Lymphatic Metastasis
Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
Lymphatic Metastasis
Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
Mesothelioma
Global Gene Expression Profiling of Pleural Mesotheliomas: Overexpression of Aurora Kinases and P16/CDKN2A Deletion as Prognostic Factors and Critical Evaluation of Microarray-Based Prognostic Prediction.
Nasopharyngeal Carcinoma
Diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma.
Neoplasm Metastasis
Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors.
Neoplasm Metastasis
Identification and validation of Kallikrein-ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry.
Neoplasm Metastasis
Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
Neoplasm Metastasis
Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
Neoplasm Metastasis
The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer.
Neoplasm, Residual
Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Neoplasms
Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.
Neoplasms
Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)-dependent manner.
Neoplasms
Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors.
Neoplasms
Diagnostic and prognostic significance of human kallikrein 11 (KLK11) mRNA expression levels in patients with laryngeal cancer.
Neoplasms
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients.
Neoplasms
Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer.
Neoplasms
Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer.
Neoplasms
Identification and validation of Kallikrein-ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry.
Neoplasms
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
Neoplasms
Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3.
Neoplasms
Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
Neoplasms
KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/?-catenin signaling.
Neoplasms
KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients.
Neoplasms
Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer.
Neoplasms
Novel Biomarkers Aim at Detecting Metastatic Sentinel Lymph Nodes in Breast Cancer
Neoplasms
Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology.
Neoplasms
Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
Neoplasms
Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues.
Neuroblastoma
Immunoreactivity, ultrastructural localization, and transcript expression of prostate-specific antigen in human neuroblastoma cell lines.
Ovarian Neoplasms
Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Ovarian Neoplasms
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients.
Ovarian Neoplasms
Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients.
Ovarian Neoplasms
Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer.
Ovarian Neoplasms
Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma.
Ovarian Neoplasms
Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma.
Pancreatic Neoplasms
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.
Prostatic Hyperplasia
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy.
Prostatic Hyperplasia
The usefulness of serum human kallikrein 11 for discriminating between prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines.
Prostatic Neoplasms
Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.
Prostatic Neoplasms
Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer.
Prostatic Neoplasms
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
Prostatic Neoplasms
Improved prostate cancer detection with a human kallikrein 11 and percentage free PSA-based artificial neural network.
Prostatic Neoplasms
Is there a role for serum human tissue kallikrein in detection of prostate cancer?
Prostatic Neoplasms
Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate.
Prostatic Neoplasms
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy.
Prostatic Neoplasms
Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues.
Prostatic Neoplasms
The usefulness of serum human kallikrein 11 for discriminating between prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11.
Psoriasis
Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy.
Seizures
Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11.
Squamous Cell Carcinoma of Head and Neck
KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/?-catenin signaling.
Stomach Neoplasms
Identification and validation of Kallikrein-ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.27
Gln-Ala-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20, pH 7.5, 37°C
1.18
Gly-Pro-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20, pH 7.5, 37°C
0.44
Phe-Ser-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20, pH 7.5, 37°C
0.53
Pro-Phe-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20, pH 7.5, 37°C
0.28
Val-Pro-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20, pH 7.5, 37°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.23
Gln-Ala-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20 (pH7.5), 37°C
0.21
Gly-Pro-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20 (pH7.5), 37°C
0.39
Phe-Ser-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20 (pH7.5), 37°C
1.86
Pro-Phe-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20 (pH7.5), 37°C
0.45
Val-Pro-Arg-7-amido-4-methylcoumarin
20 mM Tris, 150 mM NaCl, 0.01% Tween 20 (pH7.5), 37°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
KLK11 is upregulated by estrogens, dexamethasone, androgens and progestins in breast cancer cell lines
brenda
-
decreased mRNA level compared to nonmalignant lung tissue
brenda
KLK11 is upregulated by estrogens in cervical cancer cell lines but downregulated by dexamethasone
brenda
-
expression revealed by immunohistochemistry
brenda
-
decreased mRNA level compared to nonmalignant lung tissue
brenda
-
gene expression, no significant difference to non-cancerous tissue
brenda
patients with a high enzyme activity have a longer longer overall survival and progression free survival, expression analysis in 138 cancer samples and 40 healthy controls
brenda
overexpression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma
brenda
-
increased mRNA level compared to non-cancerous cells
brenda
-
higher levels of kallikrein 11 compared to non-cancerous cells
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
variants at residue Gly50 affecting the signal peptide cleavage of KLK11 cause a autosomal-dominant cornification disorder with abnormal desquamation
physiological function
up-regulation of KLK11 causes a significant inhibitory effect on the proliferation, colony formation and invasion of laryngeal squamous cell carcinoma (LSCC) cells. Knockdown of KLK11 markedly accelerates the proliferative and invasive abilities of LSCC cells. KLK11 overexpression decreases the phosphorylation of glycogen synthase kinase-3beta and down-regulates the expression of active beta-catenin. The up-regulation of KLK11 retards tumor formation and the growth of LSCC cells in vivo
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
G50E
heterozygous variant, mutation perturbes the signal peptide cleavage of KLK11, leading to subcellular mislocalization and impaired extracellular secretion. Both trypsin-like and chymotrypsin-like proteolytic activities are significantly decreased. The patient shows Mendelian disorders of cornification
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to homogeneity by immunoaffinity chromatography and high-performance liquid chromatography
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene KLK11, identical to gene TLSP or PRSS20, splicing variant 1, prostate-type isozyme, DNA sequence determination and analysis, transient expression of Myc-His-tagged enzyme in COS-7 cells, expression as fusion protein with trypsinogen signal peptide followed by a His-tag in insect cells via baculovirus infection
gene KLK11, splicing variant 2, brain-type isozyme, DNA sequence determination and analysis, transient expression of Myc-His-tagged enzyme in COS-7 cells, expression as fusion protein with trypsinogen signal peptide followed by a His-tag in insect cells via baculovirus infection
molecular cloning of four novel splice variants of the human KLK11 gene, discovered by combining 3' rapid amplification of cDNA ends (3' RACE), NGS technology, advanced bioinformatic analysis, and Sanger sequencing
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
both isoforms of KLK11 (prostate-type and brain-type) are significantly higher in cancer tissues compared with their normal counterparts
-
both the mRNA and protein expression of KLK11 are significantly lower in laryngeal squamous cell carcinoma tissues than in normal tissues. Low expression of KLK11 is also observed in laryngeal squamous cell carcinoma cell lines, and the up-regulation of KLK11 causes a significant inhibitory effect on the proliferation, colony formation and invasion of laryngeal squamous cell carcinoma cells
kallikrein 11 expression is significantly decreased in gastric cancer compared with that in normal gastric mucosa
-
kallikrein-related peptidase 11 expression is decreased in prostate cancer cells compared to normal/benign prostate cells
-
regarding prostate-type KLK11, there is a significant association between lower expression and higher tumor stage
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
diagnostics
medicine
diagnostics
the measurement of kallikrein-related peptidase 11, KLK11, might be a useful diagnostic and prognostic test for non-small cell lung cancer patients. Patients with a high enzyme activity have a longer longer overall survival and progression free survival
diagnostics
elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a favorable prognosis in advanced high-grade serous ovarian cancer patients
medicine
-
KLK11 mRNA may serve as a marker to discriminate between benign prostatic hyperplasia and prostate cancer
medicine
overexpression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma
medicine
-
the down-regulation of KLK11 gene in advanced and more aggressive tumors opens the feasibility of being used as biomarker distinguishing the tumor aggressiveness and prognostic indicators for human prostate cancer
medicine
-
negative kallikrein 11 expression is associated with nearly 5fold increased risk of distant metastasis after curative gastrectomy in gastric cancer patients. Kallikrein 11 expression is a significant independent prognostic factor for disease-free survival and overall survival in gastric cancer patients
medicine
up-regulation of KLK11 causes a significant inhibitory effect on the proliferation, colony formation and invasion of laryngeal squamous cell carcinoma cells
medicine
heterozygous variants affecting residue Gly50 significantly decrease trypsin-like and chymotrypsin-like proteolytic activities in the patients' stratum corneum samples. The patients show a thickened, dense stratum corneum, indicating abnormal skin desquamation
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P15946)
brenda
Mitsui, S.; Yamada, T.; Okui, A.; Kominami, K.; Uemura, H.; Yamaguchi, N.
A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate
Biochem. Biophys. Res. Commun.
272
205-211
2000
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Petraki, C.D.; Papanastasiou, P.A.; Karavana, V.N.; Diamandis, E.P.
Cellular distribution of human tissue kallikreins: immunohistochemical localization
Biol. Chem.
387
653-663
2006
Homo sapiens
brenda
Planque, C.; Ainciburu, M.; Heuze-Vourch, N.; Regina, S.; de Monte, M.; Courty, Y.
Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues
Biol. Chem.
387
783-788
2006
Homo sapiens
brenda
Scorilas, A.; Gregorakis, A.K.
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy
Biol. Chem.
387
789-793
2006
Homo sapiens
brenda
Diamandis, E.P.; Borgono, C.A.; Scorilas, A.; Harbeck, N.; Dorn, J.; Schmitt, M.
Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients
Clin. Biochem.
37
823-829
2004
Homo sapiens
brenda
Luo, L.Y.; Shan, S.J.; Elliott, M.B.; Soosaipillai, A.; Diamandis, E.P.
Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma
Clin. Cancer Res.
12
742-750
2006
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Stavropoulou, P.; Gregorakis, A.K.; Plebani, M.; Scorilas, A.
Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer
Clin. Chim. Acta
357
190-195
2005
Homo sapiens
brenda
Sasaki, H.; Kawano, O.; Endo, K.; Suzuki, E.; Haneda, H.; Yukiue, H.; Kobayashi, Y.; Yano, M.; Fujii, Y.
Decreased kallikrein 11 messenger RNA expression in lung cancer
Clin. Lung Cancer
8
45-48
2006
Homo sapiens
brenda
Stephan, C.; Meyer, H.A.; Cammann, H.; Nakamura, T.; Diamandis, E.P.; Jung, K.
Improved prostate cancer detection with a human kallikrein 11 and percentage free PSA-based artificial neural network
Biol. Chem.
387
801-805
2006
Homo sapiens (Q9UBX7), Homo sapiens
brenda
McIntosh, M.W.; Liu, Y.; Drescher, C.; Urban, N.; Diamandis, E.P.
Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma
Clin. Cancer Res.
13
4422-4428
2007
Homo sapiens
brenda
Mitsui, S.; Nakamura, T.; Okui, A.; Kominami, K.; Uemura, H.; Yamaguchi, N.
Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin
FEBS J.
273
3678-3686
2006
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Sano, A.; Sangai, T.; Maeda, H.; Nakamura, M.; Hasebe, T.; Ochiai, A.
Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3
Int. J. Oncol.
30
1493-1498
2007
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Fernando, S.C.; Buck, J.S.; Ashworth, M.D.; Ross, J.W.; Geisert, R.D.; DeSilva, U.
Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression
Reproduction
132
939-947
2006
Sus scrofa
brenda
Shaw, J.L.; Diamandis, E.P.
Regulation of human tissue kallikrein-related peptidase expression by steroid hormones in 32 cell lines
Biol. Chem.
389
1409-1419
2008
Homo sapiens (Q9UBX7)
brenda
Yu, X.; Tang, H.Y.; Li, X.R.; He, X.W.; Xiang, K.M.
Over-expression of human kallikrein 11 is associated with poor prognosis in patients with low rectal carcinoma
Med. Oncol.
27
40-44
2010
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Bi, X.; He, H.; Ye, Y.; Dai, Q.; Han, Z.; Liang, Y.; Zhong, W.
Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer
Med. Oncol.
27
145-151
2010
Homo sapiens
brenda
Wen, Y.G.; Wang, Q.; Zhou, C.Z.; Yan, D.W.; Qiu, G.Q.; Yang, C.; Tang, H.M.; Peng, Z.H.
Identification and validation of Kallikrein-ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry
J. Surg. Oncol.
104
516-524
2011
Homo sapiens
brenda
Jamaspishvili, T.; Scorilas, A.; Kral, M.; Khomeriki, I.; Kurfurstova, D.; Kolar, Z.; Bouchal, J.
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients
Neoplasma
58
298-303
2011
Homo sapiens
brenda
Xu, C.H.; Zhang, Y.; Yu, L.K.
The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer
Tumour Biol.
35
5199-5203
2014
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Geng, X.; Liu, Y.; Dreyer, T.; Bronger, H.; Drecoll, E.; Magdolen, V.; Dorn, J.
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients
Am. J. Cancer Res.
8
1856-1864
2018
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Adamopoulos, P.G.; Kontos, C.K.; Scorilas, A.
Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology
Biol. Chem.
399
1065-1071
2018
Homo sapiens (Q9UBX7), Homo sapiens
brenda
Gong, Z.; Dai, S.; Jiang, X.; Lee, M.; Zhu, X.; Wang, H.; Lin, Z.
Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder
Br. J. Dermatol.
188
100-111
2023
Homo sapiens (Q9UBX7)
brenda
Zhao, R.; Wang, S.; Liu, J.; Xu, C.; Zhang, S.; Shao, Y.; Duan, X.
KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/beta-catenin signaling
J. Bioenerg. Biomembr.
53
85-96
2021
Homo sapiens (Q9UBX7)
brenda
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