Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Abz-GMQWLKTQGN-(3-NO2-Tyr) + H2O
?
-
-
-
?
Abz-ISLMKYRPPGF-(3-NO2)-Tyr + H2O
?
very low activity
-
-
?
Abz-SPFRSSR-(3-NO2)-Tyr + H2O
?
low activity
-
-
?
alpha2-antiplasmin + H2O
?
-
-
-
-
?
Antithrombin III + H2O
?
-
-
-
-
?
Boc-VPR-7-amido-4-methylcoumarin + H2O
Boc-VPR + 7-amino-4-methylcoumarin
-
-
-
?
C1 inhibitor + H2O
?
-
-
-
-
?
CCN1 protein + H2O
?
i.e. (cyr61,ctgf, nov), the main cleavage site is localized in the hinge region between the first and second half of the recombinant protein at Lys88-Gly89, Lys208-Arg209, Arg218-Ile219, Lys291-Lys292, and Lys345-Asn346
-
-
?
CCN2 protein + H2O
?
-
-
-
?
CCN3 protein + H2O
?
-
-
-
?
CCN4 protein + H2O
?
-
-
-
?
CCN5 protein + H2O
?
cleavage site is at Arg215-Val216
-
-
?
CCN6 protein + H2O
?
-
-
-
?
D-Val-Leu-Lys-thiobenzyl ester + H2O
D-Val-Leu-Lys + thiobenzyl alcohol
-
100% activity
-
-
?
high molecular weight kininogen + H2O
?
proteolysis pattern, overview. Release of bradykinin, a fragment containing the C-terminal end of kinins. The kininogenase activity of the enzyme is poor due to the resistance of hydrolysis of the K-R bond on the N-terminal side of the bradykinin sequence in the kininogen
-
-
?
influenza hemagglutinin precursor + H2O
mature influenza hemagglutinin + ?
platelet-derived growth factor B precursor + H2O
mature platelet-derived growth factor B + ?
polypeptide + H2O
peptides
protein C inhibitor + H2O
?
-
-
-
-
?
tert-butyloxycarbonyl-DPR-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-DPR + 7-amino-4-methylcoumarin
-
55% activity compared to D-Val-Leu-Lys-thiobenzyl ester
-
-
?
tert-butyloxycarbonyl-FSR-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-FSR + 7-amino-4-methylcoumarin
-
13% activity compared to D-Val-Leu-Lys-thiobenzyl ester
-
-
?
tert-butyloxycarbonyl-QAR-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-QAR + 7-amino-4-methylcoumarin
-
98% activity compared to D-Val-Leu-Lys-thiobenzyl ester
-
-
?
tert-butyloxycarbonyl-VPR-7-amido-4-methylcoumarin + H2O
tert-butyloxycarbonyl-VPR + 7-amino-4-methylcoumarin
-
85% activity compared to D-Val-Leu-Lys-thiobenzyl ester
-
-
?
additional information
?
-
Fibronectin + H2O
?
-
-
-
?
Fibronectin + H2O
?
the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration. KLK12-mediated fibronectin proteolysis antagonizes fibronectin polymerization and fibronectin fibril formation by endothelial cells, leading to an increase in cell migration
-
-
?
influenza hemagglutinin precursor + H2O
mature influenza hemagglutinin + ?
the enzyme shows a preference for the H1 and H2 subtypes, the amino acids neighboring the arginine cleavage site affect cleavage efficiency
-
-
?
influenza hemagglutinin precursor + H2O
mature influenza hemagglutinin + ?
the enzyme shows a preference for the H1 and H2 subtypes, essentially no cleavage of the H3 subtype, the amino acids neighboring the arginine cleavage site affect cleavage efficiency
-
-
?
platelet-derived growth factor B precursor + H2O
mature platelet-derived growth factor B + ?
membrane bound zymogen
soluble mature paracrine factor, soluble mature protein
-
?
platelet-derived growth factor B precursor + H2O
mature platelet-derived growth factor B + ?
-
membrane bound zymogen
soluble mature protein
-
?
polypeptide + H2O
peptides
-
-
?
polypeptide + H2O
peptides
involved in posttranslational processing of polypeptide precursors
-
?
tenascin + H2O
?
-
-
-
?
tenascin + H2O
?
the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration
-
-
?
additional information
?
-
hormonal reglation of enzyme expression, overview
-
-
?
additional information
?
-
-
hormonal reglation of enzyme expression, overview
-
-
?
additional information
?
-
-
no cleavage is observed for tert-butyloxycarbonyl-QGR-7-amido-4-methylcoumarin, benzyloxycarbonyl-GGR-7-amido-4-methylcoumarin, L-Pro-Phe-Arg-7-amido-4-methylcoumarin, succinyl-AFK-7-amido-4-methylcoumarin, succinyl-AAPF-7-amido-4-methylcoumarin, succinyl-ALPF-7-amido-4-methylcoumarin, succinyl-LLVY-7-amido-4-methylcoumarin, L-Tyr-7-amido-4-methylcoumarin, and S2586
-
-
?
additional information
?
-
-
pro-KLK12 can undergo autoactivation
-
-
?
additional information
?
-
active KLK12 possesses trypsin-like activity, targeting peptide bonds featuring either arginine or lysine at their P1 position
-
-
?
additional information
?
-
Abz-GPFTDVRAAVY-(3-NO2-Tyr) is not efficiently hydrolyzed
-
-
?
additional information
?
-
-
Abz-GPFTDVRAAVY-(3-NO2-Tyr) is not efficiently hydrolyzed
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CCN1 protein + H2O
?
i.e. (cyr61,ctgf, nov), the main cleavage site is localized in the hinge region between the first and second half of the recombinant protein at Lys88-Gly89, Lys208-Arg209, Arg218-Ile219, Lys291-Lys292, and Lys345-Asn346
-
-
?
CCN2 protein + H2O
?
-
-
-
?
CCN3 protein + H2O
?
-
-
-
?
CCN4 protein + H2O
?
-
-
-
?
CCN5 protein + H2O
?
cleavage site is at Arg215-Val216
-
-
?
CCN6 protein + H2O
?
-
-
-
?
Fibronectin + H2O
?
the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration. KLK12-mediated fibronectin proteolysis antagonizes fibronectin polymerization and fibronectin fibril formation by endothelial cells, leading to an increase in cell migration
-
-
?
influenza hemagglutinin precursor + H2O
mature influenza hemagglutinin + ?
the enzyme shows a preference for the H1 and H2 subtypes, the amino acids neighboring the arginine cleavage site affect cleavage efficiency
-
-
?
platelet-derived growth factor B precursor + H2O
mature platelet-derived growth factor B + ?
membrane bound zymogen
soluble mature paracrine factor
-
?
polypeptide + H2O
peptides
involved in posttranslational processing of polypeptide precursors
-
?
tenascin + H2O
?
the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration
-
-
?
additional information
?
-
additional information
?
-
hormonal reglation of enzyme expression, overview
-
-
?
additional information
?
-
-
hormonal reglation of enzyme expression, overview
-
-
?
additional information
?
-
active KLK12 possesses trypsin-like activity, targeting peptide bonds featuring either arginine or lysine at their P1 position
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Breast Neoplasms
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12).
Breast Neoplasms
Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors.
Breast Neoplasms
Human kallikrein-related peptidase 12 (KLK12) splice variants expression in breast cancer and their clinical impact.
Breast Neoplasms
KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.
Carcinogenesis
Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues.
Colorectal Neoplasms
Knockdown of KLK12 inhibits viability and induces apoptosis in human colorectal cancer HT-29 cell line.
Colorectal Neoplasms
Silencing KLK12 expression via RGDfC-decorated selenium nanoparticles for the treatment of colorectal cancer in vitro and in vivo.
Dermatitis, Atopic
Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans.
Dermatitis, Atopic
Corrigendum: Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans.
Dry Eye Syndromes
Elevated Immunoglobulin to Tissue KLK11 in Patients With Sjögren Syndrome.
Hypertension
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.
Infections
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Influenza, Human
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
Lung Neoplasms
CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer.
Neoplasms
Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway.
Neoplasms
CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer.
Neoplasms
Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
Neoplasms
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12).
Neoplasms
Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors.
Neoplasms
Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology.
Neoplasms
Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients.
Neoplasms
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.
Neoplasms
Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor.
Obesity
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.
Polycythemia
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.
Prostatic Neoplasms
Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
Prostatic Neoplasms
Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues.
Prostatic Neoplasms
KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.
Stomach Neoplasms
Clinical significance of human kallikrein 12 gene expression in gastric cancer.
Stomach Neoplasms
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration.
Stomach Neoplasms
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.
Triple Negative Breast Neoplasms
Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.012
Abz-GMQWLKTQGN-(3-NO2-Tyr)
37°C, pH 7.5
0.0294
D-Val-Leu-Lys-thiobenzyl ester
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.35
tert-butyloxycarbonyl-DPR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.565
tert-butyloxycarbonyl-FSR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.0686
tert-butyloxycarbonyl-QAR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.2
tert-butyloxycarbonyl-VPR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
additional information
additional information
-
additional information
additional information
enzyme reaction kinetics, overview
-
additional information
additional information
-
enzyme reaction kinetics, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2.45
Abz-GMQWLKTQGN-(3-NO2-Tyr)
37°C, pH 7.5
12.42
D-Val-Leu-Lys-thiobenzyl ester
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.017 - 32.65
tert-butyloxycarbonyl-DPR-7-amido-4-methylcoumarin
0.052 - 10.06
tert-butyloxycarbonyl-FSR-7-amido-4-methylcoumarin
0.97 - 17.26
tert-butyloxycarbonyl-QAR-7-amido-4-methylcoumarin
8.1 - 25.81
tert-butyloxycarbonyl-VPR-7-amido-4-methylcoumarin
0.017
tert-butyloxycarbonyl-DPR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
32.65
tert-butyloxycarbonyl-DPR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.052 - 2.1
tert-butyloxycarbonyl-FSR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
10.06
tert-butyloxycarbonyl-FSR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
0.97
tert-butyloxycarbonyl-QAR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
17.26
tert-butyloxycarbonyl-QAR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
8.1
tert-butyloxycarbonyl-VPR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
25.81
tert-butyloxycarbonyl-VPR-7-amido-4-methylcoumarin
-
in 0.1 M Tris, 10 mM CaCl2, 0.15 M NaCl, pH 8.0, at 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
-
knockdown of KLK12 results in a significant downregulation of autophagy and apoptosis in Mycobacterium bovis infected bone marrow derived macrophages
metabolism
PDGF-B is probably one of the molecules linking the interaction between enzyme-induced endothelial cells and fibroblasts. Expression of both KLK12 and PDGFB genes is regulated by hypoxia in the lung tumor microenvironment
physiological function
fragmentation of CCN1 or CCN5 by KLK12 prevents vascular endothelial growth factor165 binding, whereas it also triggers the release of intact vascular endothelial growth factor and bone morphogenetic protein 2 from the CCN protein complexes. The KLK12-mediated release of transforming growth factor-beta1 and fibroblast growth factor-2 is concentration-dependent. KLK12 may indirectly regulate the bioavailability and activity of several growth factors through processing of their CCN binding partners
physiological function
cleavage of the influenza hemagglutinin precursor by host proteases, e.g. kallikrein-related peptidase 12, is a critical step in the virus life cycle. Cleavage activation of influenza hemagglutinin enables fusion with the host endosome, allowing for release of the viral genome into the host cel
physiological function
expression profile of the splice variants KLK12sv3 and KLK12sv1/KLK12sv2 of kallikrein-related peptidase 12 in breast cancer patients and their clinical significance, overview. Positive KLK12sv3 expression is associated with longer patient disease-free survival and higher progesterone receptor concentration. KLK12sv1/KLK12sv2 expression is statistically associated with KLK12sv3 expression
physiological function
proangiogenic activity of the enzyme in lung endothelial cells. The enzyme may interfere with kininostatin-related antiangiogenic activity by cleaving the D5 domain
physiological function
the enzyme induces the formation of pulmonary endothelial cell tubule-like structures. The enzyme converts the extracellular matrix- or membrane-bound precursor of platelet-derived growth factor B (PDGF-B) into a soluble active form. Both PDGF-B and vascular endothelial growth factor A (VEGF-A) take part in the induction of angiogenesis by enzyme KLK12 in a coculture model of angiogenesis that mimics endothelial tubule formation. Release of mature PDGF-B by enzyme KLK12 leads to the fibroblast-mediated secretion of VEGF-A, which stimulates endothelial cell differentiation and the formation of capillary tube-like structures. PDGF-B signaling ultimately results in cell growth, migration, and protection against apoptosis, overview
physiological function
implicated in the cancer progression
physiological function
-
the enzyme regulates innate resistance of murine macrophages against Mycobacterium bovis infection by modulating autophagy and apoptosis
physiological function
the enzyme stimulates endothelial cell migration by remodeling the fibronectin matrix
additional information
KLK12 is a trypsin-like kallikrein-related peptidase that is abundant in a variety of human tissues
additional information
-
KLK12 is a trypsin-like kallikrein-related peptidase that is abundant in a variety of human tissues
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9UKR0)
brenda
Yousef, G.M.; Magklara, A.; Diamandis, E.P.
KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer
Genomics
69
331-341
2000
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Shinmura, K.; Tao, H.; Yamada, H.; Kataoka, H.; Sanjar, R.; Wang, J.; Yoshimura, K.; Sugimura, H.
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity
Hum. Mutat.
24
273-274
2004
Homo sapiens
brenda
Luo, L.; Jiang, W.
Inhibition profiles of human tissue kallikreins by serine protease inhibitors
Biol. Chem.
387
813-816
2006
Homo sapiens
brenda
Memari, N.; Jiang, W.; Diamandis, E.P.; Luo, L.Y.
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)
Biol. Chem.
388
427-435
2007
Homo sapiens
brenda
Shaw, J.L.; Diamandis, E.P.
Distribution of 15 human kallikreins in tissues and biological fluids
Clin. Chem.
53
1423-1432
2007
Homo sapiens (Q9UKR0)
brenda
Memari, N.; Diamandis, E.P.; Earle, T.; Campbell, A.; Van Dekken, H.; Van der Kwast, T.H.
Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues
Prostate
67
1465-1474
2007
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Guillon-Munos, A.; Oikonomopoulou, K.; Michel, N.; Smith, C.R.; Petit-Courty, A.; Canepa, S.; Reverdiau, P.; Heuze-Vourch, N.; Diamandis, E.P.; Courty, Y.
Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors
J. Biol. Chem.
286
25505-25518
2011
Homo sapiens (Q9UKR0)
brenda
Kryza, T.; Lalmanach, G.; Lavergne, M.; Lecaille, F.; Reverdiau, P.; Courty, Y.; Heuze-Vourch, N.
Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor
Biol. Chem.
394
385-391
2013
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Kryza, T.; Achard, C.; Parent, C.; Marchand-Adam, S.; Guillon-Munos, A.; Iochmann, S.; Korkmaz, B.; Respaud, R.; Courty, Y.; Heuze-Vourch, N.
Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway
FASEB J.
28
740-751
2014
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Hamilton, B.S.; Whittaker, G.R.
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12
J. Biol. Chem.
288
17399-17407
2013
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Talieri, M.; Devetzi, M.; Scorilas, A.; Pappa, E.; Tsapralis, N.; Missitzis, I.; Ardavanis, A.
Human kallikrein-related peptidase 12 (KLK12) splice variants expression in breast cancer and their clinical impact
Tumour Biol.
33
1075-1084
2012
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Adamopoulos, P.G.; Kontos, C.K.; Scorilas, A.
Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology
Biol. Chem.
399
1065-1071
2018
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Sabir, N.; Hussain, T.; Liao, Y.; Wang, J.; Song, Y.; Shahid, M.; Cheng, G.; Mangi, M.H.; Yao, J.; Yang, L.; Zhao, D.; Zhou, X.
Kallikrein 12 regulates innate resistance of murine macrophages against Mycobacterium bovis infection by modulating autophagy and apoptosis
Cells
8
415
2019
Mus musculus
brenda
Papachristopoulou, G.; Tsapralis, N.; Michaelidou, K.; Ardavanis-Loukeris, G.; Griniatsos, I.; Scorilas, A.; Talieri, M.
Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors
Clin. Biochem.
58
78-85
2018
Homo sapiens (Q9UKR0), Homo sapiens
brenda
Kryza, T.; Parent, C.; Pardessus, J.; Petit, A.; Burlaud-Gaillard, J.; Reverdiau, P.; Iochmann, S.; Labas, V.; Courty, Y.; Heuze-Vourch, N.
Human kallikrein-related peptidase 12 stimulates endothelial cell migration by remodeling the fibronectin matrix
Sci. Rep.
8
6331
2018
Homo sapiens (Q9UKR0), Homo sapiens
brenda