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L-methionine + nicotinamide
L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
nicotinamide + S-adenosyl-L-methionine
1-methylnicotinamide + S-adenosyl-L-homocysteine
S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + 2-methoxypyridine
S-adenosyl-L-homocysteine + 1-methyl-2-methoxypyridinium
-
-
-
?
S-adenosyl-L-methionine + 2-methylpyridine
S-adenosyl-L-homocysteine + 1,2-dimethylpyridinium
-
-
-
?
S-adenosyl-L-methionine + 3-acetylpyridine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + 3-acetylpyridine
S-adenosyl-L-homocysteine + N-methyl-3-acetylpyridinium
-
-
-
?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
S-adenosyl-L-methionine + 4-phenylpyridine
S-adenosyl-L-homocysteine + 1-methyl-4-phenylpyridine
poor substrate
-
-
?
S-adenosyl-L-methionine + isoquinoline
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + isoquinoline
S-adenosyl-L-homocysteine + N-methylisoquinoline
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
S-adenosyl-L-methionine + nicotinimidamide
S-adenosyl-L-homocysteine + N-methylnicotinimidamide
-
-
-
?
S-adenosyl-L-methionine + norharman + H+
S-adenosyl-L-homocysteine + 2-N-methylnorharman
-
-
-
?
S-adenosyl-L-methionine + quinoline
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + quinoline
S-adenosyl-L-homocysteine + N-methylquinoline
S-adenosyl-L-methionine + quinoline 3-carboxamide
S-adenosyl-L-homocysteine + N-methylquinoline 3-carboxamide
-
-
-
?
S-adenosyl-L-methionine + tetrahydroisoquinoline
S-adenosyl-L-homocysteine + N-methyltetrahydroisoquinoline
-
-
-
?
S-adenosyl-L-methionine + thionicotinamide
S-adenosyl-L-homocysteine + 1-methylthionicotinamide
additional information
?
-
nicotinamide + S-adenosyl-L-methionine
1-methylnicotinamide + S-adenosyl-L-homocysteine
-
-
-
-
?
nicotinamide + S-adenosyl-L-methionine
1-methylnicotinamide + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
assay for fluorometric determination of enzyme activity
-
-
?
S-adenosyl-L-methionine + 4-methylnicotinamide
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
assay for fluorometric determination of enzyme activity
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
441253, 441255, 701990, 733214, 733279, 733614, 733618, 733625, 733636, 734104, 734368 -
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
NNMT as potential candidate for a tumor marker
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
NNMT gene polymorphism as potential marker for cardiovascular risk factors
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
NNMT potential as tumor marker
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
polymorphism in the nicotinamide N-methyltransferase (NNMT) gene as risk factor for complex congenital heart defects (CHDs)
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
L-methionine + nicotinamide
-
-
?
S-adenosyl-L-methionine + nicotinamide
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
?
S-adenosyl-L-methionine + quinoline
S-adenosyl-L-homocysteine + N-methylquinoline
-
-
-
?
S-adenosyl-L-methionine + quinoline
S-adenosyl-L-homocysteine + N-methylquinoline
-
-
-
-
?
S-adenosyl-L-methionine + thionicotinamide
S-adenosyl-L-homocysteine + 1-methylthionicotinamide
-
-
-
?
S-adenosyl-L-methionine + thionicotinamide
S-adenosyl-L-homocysteine + 1-methylthionicotinamide
-
-
-
-
?
additional information
?
-
-
NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds
-
-
?
additional information
?
-
-
development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview
-
-
?
additional information
?
-
NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively
-
-
-
additional information
?
-
-
NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively
-
-
-
additional information
?
-
-
development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview
-
-
?
additional information
?
-
-
development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview
-
-
?
additional information
?
-
-
enzyme may function in detoxificating of numerous alkaloids
-
-
?
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malfunction
-
depletion of NNMT affects chemotaxis and chemokinesis
malfunction
-
alterations in in vivo enzyme NNMT activity are believed to be negatively associated with gene polymorphism and environmental influences are also considered to be significant
malfunction
-
enzyme NNMT plays an important role in PANC-1 cell proliferation, metastatic potential and survival under metabolic stress. Enzyme silencing markedly reduces cell proliferation, whereas enzyme overexpression promotes cell growth moderately. Knockdown of NNMT also significantly suppresses the migration and invasion capacities of pancreatic cancer PANC-1 cells. Enzyme NNMT upregulation enhances cell migration and invasion capacities. In addition, NNMT knockdown cells are much less resistant to glucose deprivation and rapamycin as well as glycolytic inhibitor 2-deoxyglucose whereas NNMT-overexpressing cells show opposite effects although the effects are not so striking
malfunction
-
nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma
malfunction
-
shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells
malfunction
-
suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have significantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes
malfunction
-
the enzyme effects on neurons are reduced in cells lacking epinephrin EFNB2 or Akt
malfunction
-
suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have significantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes
-
metabolism
-
enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability
metabolism
-
NNMTexpression is significantly positively associated with pAkt/protein kinase B expression
metabolism
-
the effects of enzyme NNMT expression in SH-SY5Y cells, e.g. protection against the toxicity of the Complex I (CxI) inhibitors 1-methyl-4-phenylpyridinium ion and rotenone, are mediated via increased CxI activity and ATP production and the sequential activation of the epinephrin EFNB2 and Akt signalling pathways
metabolism
-
enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability
-
physiological function
-
enzyme expression is associated with cell migration
physiological function
-
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
physiological function
-
the enzyme is involved in tumour differentiation in oral squamous cell carcinoma, overview
physiological function
-
effect of enzyme NNMT expression on cell survival under metabolic stress, the enzyme promotes cell survival and growth and increases cell migration and invasion capacities , NNMT-expressing cells demonstrate enhanced resistance to rapamycin, phenotype, overview
physiological function
-
expression of enzyme NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells significantly increases the expression of all three sirtuins, class III DNA deacetylase enzymes known to regulate mitochondrial energy production and cell cycle. Sirtuin 3 is a key mediator of NNMT-induced complex I activity and ATP synthesis. Central role for enzyme NNMT in the regulation of energy homeostasis
physiological function
-
nicotinamide N-methyltransferase is a metabolic regulator in adipocytes and also regulates hepatic nutrient metabolism through Sirt1 protein stabilization, the metabolic effects of the enzyme in the liver are mediated by its product 1-methylnicotinamide. Nnmt is a positive regulator of gluconeogenesis in primary hepatocytes. Methylation of nicotinamide by Nnmt is a major pathway for the clearance of excess vitamin B3 from the body
physiological function
-
nicotinamide N-methyltransferase is involved in the biotransformation and detoxification of many drugs and xenobiotic compounds, it enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells. The enzyme significantly accelerates cell proliferation, enhances colony formation in vitro and tumorigenicity in mice, and inhibits apoptosis, it promotes cell cycle progression, increases ATP and 1-methylnicotinamide level and decreases ROS levels. 1-Methylnicotinamide also accelerates cell growth, inhibits apoptosis, promotes cell cycle progression, attenuates ROS production and increases ATP levels. The enzyme may play a vital role in energy balance and ROS induction, 1-Methylnicotinamide is beneficial in conditions such as inflammation and antioxidation
physiological function
-
role of nicotinamide N-methyltransferase in non-small cell lung cancer
physiological function
-
the enzyme is overexpressed in many human cancers and is associated with poor prognosis. Enzyme NNMT might play a significant role in tumor progression and shorter survival time in patients with nasopharyngeal carcinoma, and it might promote the activation of MMP-2 via a pathway that sequentially involves pAkt signaling pathway
physiological function
-
the enzyme NNMT expression protects against neurotoxin-mediated cell death by increasing Complex I (CxI) activity, resulting in increased ATP synthesis, mediated via protection of the NDUFS3 subunit of CxI from degradation by increased 1-methylnicotinamide production. The enzyme expression increases neurite branching and the presynaptic marker synaptophysin, synaptophysin expression is induced by the enzyme. 1-Methylnicotinamide replicates the effects of enzyme NNMT expression upon SH-SY5Y neurite branching, effects of NNMT expression on neuron morphology and differentiation, overview. Recombinant NNMT-V5 expression in SH-SY5Y cells changes cellular morphology and increases dopamine uptake and release. The effects of enzyme NNMT expression in SH-SY5Y cells, e.g. protection against the toxicity of the Complex I (CxI) inhibitors 1-methyl-4-phenylpyridinium ion and rotenone, are mediated via increased CxI activity and ATP production and the sequential activation of the epinephrin EFNB2 and Akt signalling pathways. The enzyme NNMT reduces cholinergic phenotype but does not induce terminal differentiation
physiological function
cells expressing NMMT are less sensitive to beta-carbolines such as norharman
physiological function
down-regulation of NNMT in colorectal cancer HT-29 cells diminishes 5-fluorouracil resistance, while overexpression of NNMT in SW-480 cells enhances it. NNMT reduces reactive oxygen species production induced by 5-fluorouracil by increasing 1-methylnicotinamide in colorectal cancer cells. The reduction in ROS leads to inactivation of the ASK1-p38 mitogen-activated protein kinase pathway, which reduces 5-fluorouracil-induced apoptosis. In nude mice implanted with colorectal cancer xenografts, NNMT attenuates 5-fluorouracil-induced inhibition of colorectal cancer tumor growth
physiological function
exposure of BEAS-2B cells to nickel increases histone H3K9 dimethylation (H3K9me2), suppresses the expressions of H3K9me2-associated genes MAP2K3 and DKK1, and induces NNMT repression at both the protein and mRNA levels. Over-expression of NNMT inhibits nickel-induced H3K9me2 and alters the cellular SAM/SAH ratio
physiological function
exposure of BEAS-2B cells to nickel increases histone H3K9 dimethylation, suppresses the expressions of H3K9me2-associated genes MAP2K3 and DKK1, and induces NNMT repression at both the protein and mRNA levels. Overexpression of NNMT inhibits nickel-induced H3K9me2 and alters the cellular SAM/SAH ratio
physiological function
Nnmt overexpression decreases S-adenosyl-L-methionine (SAM) levels and the SAM/S-adenosylhomocysteine (SAH) ratio both in vivo and in vitro. Nnmt knockdown does not change methyl donor balance in mouse primary hepatocytes but increases SAM levels and the SAM/SAH ratio when Gnmt, the dominantly expressed methyltransferase in liver, is simultaneously knocked down. Expression of enzymatically deficient Nnmt increases the SAM/SAH ratio. Proteins Bhmt, Mat1a, and Ahcy, components of the methionine cycle, interact with NNMT in liver. Mutant Nnmt increases the level of remethylation of homocysteine to SAM
physiological function
ortholog ANMT-1 competes with the methyltransferase LCMT-1 for methyl groups from S-adenosyl methionine. Thereby, it regulates the catalytic capacities of LCMT-1, targeting NPRL-2, a regulator of autophagy. During aging, high neuronal ANMT-1 activity induce autophagy via NPRL-2. In younger animals, ANMT-1 activity disturbs neuronal homeostasis and dopamine signaling, causing abnormal behavior
physiological function
shRNA-mediated downregulation of NNMT expression levels inhibits the proliferation and density?-ependent growth of SCC-12 cells. The migration and invasion ofSCC cells are markedly decreased in NNMT-nockdown cells. High NNMT expression levels are accompanied by high expression levels of EMT-ssociated genes, and NNMT knockdown effectively suppresses the expression of matrix metalloproteinase 9, osteopontin, versican core protein and zinc finger protein SNAI2 in SCC-12 cells
physiological function
the expression level of NNMT is elevated in the peripheral blood and tissues of patients with prostate cancer. The overexpression of NNMT enhances PC-3 cell viability, invasion and migration capacity. The overexpression of NNMT significantly increases the mRNA level of sirtuin 1 in PC-3 cells. Nicotinamide treatment significantly suppresses the expression of SIRT1 even in PC-3 cells transfected with adeno-associated virus-NNMT
physiological function
the expression of NNMT in the SH-SY5Y cell-line has no effect on cell death, viability, ATP content or mitochondrial membrane potential
physiological function
-
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
-
physiological function
-
nicotinamide N-methyltransferase is a metabolic regulator in adipocytes and also regulates hepatic nutrient metabolism through Sirt1 protein stabilization, the metabolic effects of the enzyme in the liver are mediated by its product 1-methylnicotinamide. Nnmt is a positive regulator of gluconeogenesis in primary hepatocytes. Methylation of nicotinamide by Nnmt is a major pathway for the clearance of excess vitamin B3 from the body
-
additional information
-
in vitro overexpression of the enzyme has revealed many cytoprotective effects of NNMT, in particular increased complex I activity and ATP synthesis. siRNA-mediated silencing of sirtuin 3 expression decreases complex I activity in NNMT-expressing SH-SY5Y cells to that observed in wild-type SH-SY5Y, and significantly reduces cellular ATP content also
additional information
-
nicotinamide and 1-methylnicotinamide are neurotoxic, chronic exposure to Mn2+ plays a role in idiopathic Parkinson's disease associated to 1-methylnicotinamide. But no metal-increased NNMT activity can be measured
additional information
-
recombinant ectopic expression of NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells increased adenosine triphosphate synthesis and complex I activity, effects of which are replicated by the addition of 1-methylnicotinamide. The enzyme expression protects against the toxicity of mitochondrial toxins and abolishes the toxic effects of KCN, 2,4-dinitrophenol, and 6-hydroxydopamine, and reduced that of rotenone, while 1-methylnicotinamide significantly reduces the toxicity of rotenone, but has no effect on the toxicity of KCN, 2,4-dinitrophenol, and 6-hydroxydopamine. The enzyme is cytoprotective against toxins that inhibit various aspects of mitochondrial function, which are not mediated solely via increased 1-methylnicotinamide production, but in combination with other unidentified mechanisms
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Cantoni, G.L.
Methylation of nicotinamide with a soluble enzyme system from rat liver
J. Biol. Chem.
189
203-217
1951
Rattus norvegicus
brenda
Alston, T.A.; Abeles, R.H.
Substrate specificity of nicotinamide methyltransferase isolated from porcine liver
Arch. Biochem. Biophys.
260
601-608
1988
Sus scrofa
brenda
Rini, J.; Szumlanski, C.; Guerciolini, R.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation
Clin. Chim. Acta
186
359-374
1990
Homo sapiens
brenda
Smith, M.L.; Burnett, D.; Bennett, P.; Waring, R.H.; Brown, H.M.; Williams, A.C.; Ramsden, D.B.
A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol
Biochim. Biophys. Acta
1442
238-244
1998
Homo sapiens
brenda
Aksoy, S.; Szumlanski, C.L.; Weinshilboum, R.M.
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization
J. Biol. Chem.
269
14835-14840
1994
Homo sapiens
brenda
Yan, L.; Otterness, D.M.; Kozak, C.A.; Weinshilboum, R.M.
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization
DNA Cell Biol.
17
659-667
1998
Mus musculus
brenda
Fujimura, S.; Okamura, A.; Ohmura, Y.; Moriyama, Y.; Ohwada, H.; Horitsu, K.; Ohkubo, M.
Nicotinamide methyltransferase activity and cell-death in the liver of the mouse bearing Ehrlich ascites tumor
Adv. Exp. Med. Biol.
398
507-511
1996
Mus musculus, Rattus norvegicus
brenda
Scheller, T.; Orgacka, H.; Szumlanski, C.L.; Weinshilboum, R.M.
Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains
Pharmacogenetics
6
43-53
1996
Mus musculus, Mus musculus C57/BL6J
brenda
Aoyama, K.; Matsubara, K.; Kondo, M.; Murakawa, Y.; Suno, M.; Yamashita, K.; Yamaguchi, S.; Kobayashi, S.
Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease
Neurosci. Lett.
298
78-80
2001
Homo sapiens
brenda
Kassem, H.S.; Sangar, V.; Cowan, R.; Clarke, N.; Margison, G.P.
A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer
Int. J. Cancer
101
454-460
2002
Homo sapiens
brenda
Okamura, A.; Ohmura, Y.; Islam, M.M.; Tagawa, M.; Horitsu, K.; Moriyama, Y.; Fujimura, S.
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma
Jpn. J. Cancer Res.
89
649-656
1998
Mus musculus
brenda
Parsons, R.B.; Smith, M.L.; Williams, A.C.; Waring, R.H.; Ramsden, D.B.
Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain
J. Neuropathol. Exp. Neurol.
61
111-124
2002
Homo sapiens
brenda
Xu, J.; Moatamed, F.; Caldwell, J.S.; Walker, J.R.; Kraiem, Z.; Taki, K.; Brent, G.A.; Hershman, J.M.
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells
J. Clin. Endocrinol. Metab.
88
4990-4996
2003
Homo sapiens
brenda
Parsons, R.B.; Smith, S.W.; Waring, R.H.; Williams, A.C.; Ramsden, D.B.
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease
Neurosci. Lett.
342
13-16
2003
Homo sapiens
brenda
van Driel, L.M.; Smedts, H.P.; Helbing, W.A.; Isaacs, A.; Lindemans, J.; Uitterlinden, A.G.; van Duijn, C.M.; de Vries, J.H.; Steegers, E.A.; Steegers-Theunissen, R.P.
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide
Eur. Heart J.
29
1424-1431
2008
Homo sapiens (P40261), Homo sapiens
brenda
Tomida, M.; Ohtake, H.; Yokota, T.; Kobayashi, Y.; Kurosumi, M.
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells
J. Cancer Res. Clin. Oncol.
134
551-559
2008
Homo sapiens (P40261), Homo sapiens
brenda
Sartini, D.; Santarelli, A.; Rossi, V.; Goteri, G.; Rubini, C.; Ciavarella, D.; Lo Muzio, L.; Emanuelli, M.
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma
Mol. Med.
13
415-421
2007
Homo sapiens (P40261)
brenda
Zhang, L.; Miyaki, K.; Araki, J.; Nakayama, T.; Muramatsu, M.
The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men
Thromb. Res.
121
55-58
2007
Homo sapiens (P40261), Homo sapiens
brenda
Riederer, M.; Erwa, W.; Zimmermann, R.; Frank, S.; Zechner, R.
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine
Atherosclerosis
204
412-417
2009
Homo sapiens, Mus musculus
brenda
Lu, W.; Zhu, H.; Wen, S.; Yang, W.; Shaw, G.M.; Lammer, E.J.; Finnell, R.H.
Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida
Birth Defects Res. Part A Clin. Mol. Teratol.
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2008
Homo sapiens
brenda
Emanuelli, M.; Santarelli, A.; Sartini, D.; Ciavarella, D.; Rossi, V.; Pozzi, V.; Rubini, C.; Lo Muzio, L.
Nicotinamide N-methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma
Histol. Histopathol.
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2010
Homo sapiens
brenda
Dostalek, M.; Hardy, K.D.; Milne, G.L.; Morrow, J.D.; Chen, C.; Gonzalez, F.J.; Gu, J.; Ding, X.; Johnson, D.A.; Johnson, J.A.; Martin, M.V.; Guengerich, F.P.
Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems
J. Biol. Chem.
283
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Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
brenda
Tomida, M.; Mikami, I.; Takeuchi, S.; Nishimura, H.; Akiyama, H.
Serum levels of nicotinamide N-methyltransferase in patients with lung cancer
J. Cancer Res. Clin. Oncol.
135
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2009
Homo sapiens
brenda
Wu, Y.; Siadaty, M.S.; Berens, M.E.; Hampton, G.M.; Theodorescu, D.
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
Oncogene
27
6679-6689
2008
Homo sapiens
brenda
Mateuszuk, L.; Khomich, T.I.; Slominska, E.; Gajda, M.; Wojcik, L.; Lomnicka, M.; Gwozdz, P.; Chlopicki, S.
Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis
Pharmacol. Rep.
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2009
Mus musculus, Mus musculus C57/BL6J
brenda
Kim, H.C.; Mofarrahi, M.; Vassilakopoulos, T.; Maltais, F.; Sigala, I.; Debigare, R.; Bellenis, I.; Hussain, S.N.
Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
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2010
Homo sapiens
brenda
Parsons, R.B.; Aravindan, S.; Kadampeswaran, A.; Evans, E.A.; Sandhu, K.K.; Levy, E.R.; Thomas, M.G.; Austen, B.M.; Ramsden, D.B.
The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
Biochem. J.
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2011
Homo sapiens
brenda
Peng, Y.; Sartini, D.; Pozzi, V.; Wilk, D.; Emanuelli, M.; Yee, V.C.
Structural basis of substrate recognition in human nicotinamide N-methyltransferase
Biochemistry
50
7800-7808
2011
Homo sapiens (P40261), Homo sapiens
brenda
Sartini, D.; Pozzi, V.; Renzi, E.; Morganti, S.; Rocchetti, R.; Rubini, C.; Santarelli, A.; Lo Muzio, L.; Emanuelli, M.
Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease
Biol. Chem.
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2012
Homo sapiens
brenda
Tang, S.W.; Yang, T.C.; Lin, W.C.; Chang, W.H.; Wang, C.C.; Lai, M.K.; Lin, J.Y.
Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells
Carcinogenesis
32
138-145
2011
Homo sapiens
brenda
Xie, X.; Yu, H.; Wang, Y.; Zhou, Y.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Liu, H.; Zhang, J.
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells
Arch. Biochem. Biophys.
564
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2014
Homo sapiens
brenda
Liu, K.Y.; Mistry, R.J.; Aguirre, C.A.; Fasouli, E.S.; Thomas, M.G.; Klamt, F.; Ramsden, D.B.; Parsons, R.B.
Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
Biochem. Biophys. Res. Commun.
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2015
Homo sapiens
brenda
Sartini, D.; Seta, R.; Pozzi, V.; Morganti, S.; Rubini, C.; Zizzi, A.; Tomasetti, M.; Santarelli, L.; Emanuelli, M.
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity
Biol. Chem.
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2015
Homo sapiens
brenda
Bi, H.C.; Pan, Y.Z.; Qiu, J.X.; Krausz, K.W.; Li, F.; Johnson, C.H.; Jiang, C.T.; Gonzalez, F.J.; Yu, A.M.
N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis
Carcinogenesis
35
2264-2272
2014
Homo sapiens
brenda
Sartini, D.; Morganti, S.; Guidi, E.; Rubini, C.; Zizzi, A.; Giuliante, R.; Pozzi, V.; Emanuelli, M.
Nicotinamide N-methyltransferase in non-small cell lung cancer: promising results for targeted anti-cancer therapy
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67
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2013
Homo sapiens
brenda
Thomas, M.G.; Saldanha, M.; Mistry, R.J.; Dexter, D.T.; Ramsden, D.B.; Parsons, R.B.
Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling
Cell Death Dis.
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Homo sapiens
brenda
Yu, T.; Wang, Y.T.; Chen, P.; Li, Y.H.; Chen, Y.X.; Zeng, H.; Yu, A.M.; Huang, M.; Bi, H.C.
Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress
Cell. Physiol. Biochem.
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2015
Homo sapiens
brenda
Mori, Y.; Sugawara, A.; Tsuji, M.; Kakamu, T.; Tsuboi, S.; Kanda, H.; Hayakawa, T.; Fukushima, T.
Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese
Environ. Health Prev. Med.
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2012
Mus musculus
brenda
Milani, Z.H.; Ramsden, D.B.; Parsons, R.B.
Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide
J. Biochem. Mol. Toxicol.
27
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Homo sapiens
brenda
Patel, M.; Vasaya, M.M.; Asker, D.; Parsons, R.B.
HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples: evidence for substrate inhibition kinetics
J. Chromatogr. B
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Oryctolagus cuniculus, Homo sapiens, Mus musculus
brenda
Hong, S.; Moreno-Navarrete, J.M.; Wei, X.; Kikukawa, Y.; Tzameli, I.; Prasad, D.; Lee, Y.; Asara, J.M.; Fernandez-Real, J.M.; Maratos-Flier, E.; Pissios, P.
Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
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Mus musculus, Mus musculus C57Bl6/J
brenda
Win, K.T.; Lee, S.W.; Huang, H.Y.; Lin, L.C.; Lin, C.Y.; Hsing, C.H.; Chen, L.T.; Li, C.F.
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma
Tumour Biol.
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Homo sapiens
brenda
Swaminathan, S.; Birudukota, S.; Thakur, M.K.; Parveen, R.; Kandan, S.; Juluri, S.; Shaik, S.; Anand, N.N.; Burri, R.R.; Kristam, R.; Hallur, M.S.; Rajagopal, S.; Schreuder, H.; Langer, T.; Rudolph, C.; Ruf, S.; Dhakshinamoorthy, S.; Gosu, R.; Kannt, A.
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Biochem. Biophys. Res. Commun.
491
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2017
Macaca mulatta (F7ERX8), Mus musculus (O55239), Mus musculus
brenda
Thomas, M.G.; Sartini, D.; Emanuelli, M.; van Haren, M.J.; Martin, N.I.; Mountford, D.M.; Barlow, D.J.; Klamt, F.; Ramsden, D.B.; Reza, M.; Parsons, R.B.
Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous beta-carboline norharman evidence for a novel detoxification pathway
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Homo sapiens (P40261)
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Loring, H.S.; Thompson, P.R.
Kinetic mechanism of nicotinamide N-methyltransferase
Biochemistry
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5524-5532
2018
Homo sapiens (P40261), Homo sapiens
brenda
Hong, S.; Zhai, B.; Pissios, P.
Nicotinamide N-methyltransferase interacts with enzymes of the methionine cycle and regulates methyl donor metabolism
Biochemistry
57
5775-5779
2018
Mus musculus (O55239), Mus musculus
brenda
Ruf, S.; Hallur, M.S.; Anchan, N.K.; Swamy, I.N.; Murugesan, K.R.; Sarkar, S.; Narasimhulu, L.K.; Putta, V.P.R.K.; Shaik, S.; Chandrasekar, D.V.; Mane, V.S.; Kadnur, S.V.; Suresh, J.; Bhamidipati, R.K.; Singh, M.; Burri, R.R.; Kristam, R.; Schreuder, H.; Czech, J.; Rudolph, C.; Marker, A.; Langer, T.; Mullangi,
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Bioorg. Med. Chem. Lett.
28
922-925
2018
Homo sapiens (P40261)
brenda
Li, Q.; He, M.D.; Mao, L.; Wang, X.; Jiang, Y.L.; Li, M.; Lu, Y.H.; Yu, Z.P.; Zhou, Z.
Nicotinamide N-methyltransferase suppression participates in nickel-induced histone H3 lysine9 dimethylation in BEAS-2B cells
Cell. Physiol. Biochem.
41
2016-2026
2017
Homo sapiens (P40261), Homo sapiens
brenda
Kannt, A.; Pfenninger, A.; Teichert, L.; Toenjes, A.; Dietrich, A.; Schoen, M.R.; Kloeting, N.; Blueher, M.
Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance
Diabetologia
58
799-808
2015
Homo sapiens (P40261)
brenda
van Haren, M.J.; Thomas, M.G.; Sartini, D.; Barlow, D.J.; Ramsden, D.B.; Emanuelli, M.; Klamt, F.; Martin, N.I.; Parsons, R.B.
The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase Evidence for a novel mechanism of substrate inhibition
Int. J. Biochem. Cell Biol.
98
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2018
Homo sapiens (P40261), Homo sapiens
brenda
Neelakantan, H.; Wang, H.Y.; Vance, V.; Hommel, J.D.; McHardy, S.F.; Watowich, S.J.
Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase
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Homo sapiens (P40261)
brenda
Babault, N.; Allali-Hassani, A.; Li, F.; Fan, J.; Yue, A.; Ju, K.; Liu, F.; Vedadi, M.; Liu, J.; Jin, J.
Discovery of bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)
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Homo sapiens (P40261), Homo sapiens
brenda
Chen, D.; Li, L.; Diaz, K.; Iyamu, I.D.; Yadav, R.; Noinaj, N.; Huang, R.
Novel propargyl-linked bisubstrate analogues as tight-binding inhibitors for nicotinamide N-methyltransferase
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Homo sapiens (P40261)
brenda
Gao, Y.; van Haren, M.J.; Moret, E.E.; Rood, J.J.M.; Sartini, D.; Salvucci, A.; Emanuelli, M.; Craveur, P.; Babault, N.; Jin, J.; Martin, N.I.
Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity
J. Med. Chem.
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Homo sapiens (P40261), Homo sapiens
brenda
Policarpo, R.L.; Decultot, L.; May, E.; Kuzmic, P.; Carlson, S.; Huang, D.; Chu, V.; Wright, B.A.; Dhakshinamoorthy, S.; Kannt, A.; Rani, S.; Dittakavi, S.; Panarese, J.D.; Gaudet, R.; Shair, M.D.
High-affinity alkynyl bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)
J. Med. Chem.
62
9837-9873
2019
Homo sapiens (P40261)
brenda
You, Z.; Liu, Y.; Liu, X.
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
Oncol. Lett.
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9195-9201
2018
Homo sapiens (P40261), Homo sapiens
brenda
Hah, Y.; Cho, H.; Jo, S.; Park, Y.; Yoon, T.; Heo, E.
Nicotinamide N-methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells
Oncol. Rep.
42
1805-1814
2019
Homo sapiens (P40261)
brenda
Xie, X.; Liu, H.; Wang, Y.; Zhou, Y.; Yu, H.; Li, G.; Ruan, Z.; Li, F.; Wang, X.; Zhang, J.
Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway
Oncotarget
7
45837-45848
2016
Homo sapiens (P40261), Homo sapiens
brenda
van Haren, M.J.; Taig, R.; Kuppens, J.; Sastre Torano, J.; Moret, E.E.; Parsons, R.B.; Sartini, D.; Emanuelli, M.; Martin, N.I.
Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state
Org. Biomol. Chem.
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6656-6667
2017
Homo sapiens (P40261)
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Schmeisser, K.; Parker, J.
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy
PLoS Genet.
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2018
Caenorhabditis elegans (P34254)
brenda
van Haren, M.J.; Sastre Torano, J.; Sartini, D.; Emanuelli, M.; Parsons, R.B.; Martin, N.I.
A rapid and efficient assay for the characterization of substrates and inhibitors of nicotinamide N-methyltransferase
Biochemistry
55
5307-5315
2016
Homo sapiens (P40261), Homo sapiens
brenda