Literature summary for 3.4.24.23 extracted from

Wang, X.Y.; Demelash, A.; Kim, H.; Jensen-Taubman, S.; Dakir, e.l..H.; Ozbun, L.; Birrer, M.J.; Linnoila, R.I.
Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer (2009), Am. J. Pathol., 175, 592-604.

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Protein Variants

Protein Variants	Comment	Organism
additional information	matrilysin-1 suppression by siRNA	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
lung adenocarcinoma cell	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-
additional information	matrilysin-1 is expressed in injured lung and in cancer but not in normal epithelia and cell line BEAS-2B	Homo sapiens	-
NCI-H23 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-casein + H2O	casein zymography	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
matrilysin-1	-	Homo sapiens
Matrix metalloproteinase-7	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	matrilysin-1 promotes migration and proliferation of airway epithelial cells in vitro, and matrilysin-1 may play an important role in the bronchiolization of alveoli by promoting proliferation, migration, and attenuation of apoptosis involving multiple genes in the MAP kinase pathway in vivo. Matrilysin-1 inhibits apoptosis in vitro, mechanism, overview	Homo sapiens

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Release 2023.1 (January 2023)