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Information on EC 2.7.12.2 - mitogen-activated protein kinase kinase

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IUBMB Comments
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
mek/erk, map kinase kinase, mapkk, mek-1, extracellular-signal-regulated kinase, mapk/erk kinase, erk 1, map2k4, mitogen-activated protein kinase kinase 1, erk 2, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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