Literature summary for 3.4.21.118 extracted from

Sher, Y.P.; Chou, C.C.; Chou, R.H.; Wu, H.M.; Wayne Chang, W.S.; Chen, C.H.; Yang, P.C.; Wu, C.W.; Yu, C.L.; Peck, K.
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness (2006), Cancer Res., 66, 11763-11770.

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Application

Application	Comment	Organism
medicine	KLK8 overexpression suppresses tumor growth and cancer cell invasion in a mouse model in vivo. Early-stage non-small cell lung cancer patients with high KLK8 expression have a lower recurrence rate than patients with low KLK8 expression. KLK8 can be used as a prognostic marker in early-stage non-small cell lung cancer patients	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
KLK8 splice variants K8-2 and K8-R amplified and inserted into the pLNCX retroviral vector, CL1-5 cells transfected with each KLK8 splice variant. Expression of hK8 in s.c. tumors in SCID mice by injection of SCID mice s.c. with CL1-5/K8-2 or CL1-5/K8-R cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
shRNA	inhibition of endogenous KLK8 expression, reduces cancer cell invasiveness	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Fibronectin + H2O	proteins produced from KLK8 splice variants modify the extracellular microenvironment by cleaving fibronectin. Degradation of fibronectin by hK8 suppresses integrin signaling and retards cancer cell motility by inhibiting actin polymerization	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
hK8	-	Homo sapiens
kallikrein 8 protease	-	Homo sapiens
neuropsin	-	Homo sapiens
ovasin	-	Homo sapiens

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Release 2023.1 (January 2023)