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ADP + nicotinamide ribonucleotide
NAD+ + phosphate
AMP + nicotinamide ribonucleotide
NAD+
ATP + 3-acetylpyridine-NAD+
?
ATP + 3-pyridinealdehyde-NAD+
?
ATP + beta-NMNH
diphosphate + ?
-
-
-
-
r
ATP + nicotinamide mononucleotide
diphosphate + NAD+
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
ATP + nicotinate D-ribonucleotide
diphosphate + deamino-NAD+
-
-
-
-
?
ATP + nicotinate D-ribonucleotide
diphosphate + nicotinate adenine dinucleotide
-
i.e. nicotinic acid adenine dinucleotide
-
?
ATP + nicotinate mononucleotide
diphosphate + nicotinate adenine dinucleotide
-
-
-
-
?
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
ATP + nicotinic acid mononucleotide
diphosphate + deamido-NAD+
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
ATP + NMN
diphosphate + NAD+
ATP + NMNH
diphosphate + NADH
-
-
-
?
ATP + tiazofurin
diphosphate + thiazole-4-carboxamide adenine dinucleotide
tiazofurin is a pro-drug that is metabolized by cytosolic nicotinamide mononucleotide adenylyltransferase2
-
-
?
ATP + tiazofurin 5'-monophosphate
?
i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2
-
-
?
ATP + tiazofurin monophosphate
?
i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2
-
-
?
CTP + nicotinamide ribonucleotide
diphosphate + nicotinamide cytosine dinucleotide
-
isoform yNMNAT-2
-
-
?
dATP + nicotinamide ribonucleotide
diphosphate + ?
-
isoform yNMNAT-1
-
-
?
dATP + nicotinamide ribonucleotide
diphosphate + nicotinamide deoxyadenosine dinucleotide
-
isoform yNMNAT-2
-
-
?
deoxy-ATP + nicotinamide ribonucleotide
?
deoxy-ATP + nicotinate ribonucleotide
?
diphosphate + NAD+
ATP + nicotinamide ribonucleotide
GTP + nicotinamide ribonucleotide
?
-
-
-
?
GTP + nicotinamide ribonucleotide
diphosphate + NGD+
GTP + nicotinamide ribonucleotide
diphosphate + nicotinamide guanine dinucleotide
-
isoform yNMNAT-2
-
-
?
GTP + nicotinamide ribonucleotide
nicotineamide guanine dinucleotide + diphosphate
only isoenzyme NMNAT3
-
-
?
GTP + NMN
diphosphate + NGD+
substrates of isozyme NMNAT3
i.e. nicotinamide guanosine dinucleotide
-
?
ITP + nicotinamide ribonucleotide
?
-
-
-
?
ITP + nicotinamide ribonucleotide
diphosphate + nicotinamide hypoxanthine dinucleotide
ITP + nicotinamide ribonucleotide
nicotinamide hypoxanthine dinucleotide + diphosphate
only isoenzyme NMNAT3
-
-
?
ITP + NMN
diphosphate + inosine nicotinamide dinucleotide
substrates of isozyme NMNAT3
i.e. nicotinamide hypoxanthine dinucleotide
-
?
nicotinamide hypoxanthine dinucleotide + diphosphate
?
98% of the activity with NAD+, NMNAT3
-
-
?
nicotinamide hypoxanthine dinucleotide + diphosphate
ITP + nicotinamide ribonucleotide
nicotinate mononucleotide + ATP
nicotinate adenine dinucleotide + diphosphate
nicotinic acid adenine dinucleotide phosphate + diphosphate
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
NMN + ATP
NAD+ + diphosphate
-
-
-
?
tiazofurin + ATP
tiazofurin adenine dinucleotide + diphosphate
tiazofurin monophosphate + ATP
tiazofurin adenine dinucleotide + diphosphate
-
-
-
?
additional information
?
-
ADP + nicotinamide ribonucleotide

NAD+ + phosphate
-
at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 17.5% of the activity with ATP as substrate
-
-
?
ADP + nicotinamide ribonucleotide
NAD+ + phosphate
-
at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 17.5% of the activity with ATP as substrate
-
-
?
AMP + nicotinamide ribonucleotide

NAD+
-
at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 50.6% of the activity with ATP as substrate
-
-
?
AMP + nicotinamide ribonucleotide
NAD+
-
at 70°C, ATP is a prominent donor. At 90°C the activity with ADP is 50.6% of the activity with ATP as substrate
-
-
?
ATP + 3-acetylpyridine-NAD+

?
-
poor substrate
-
-
?
ATP + 3-acetylpyridine-NAD+
?
-
reaction at 76% the rate of nicotinamide ribonucleotide
-
-
?
ATP + 3-pyridinealdehyde-NAD+

?
-
poor substrate
-
-
?
ATP + 3-pyridinealdehyde-NAD+
?
-
reaction at 28% the rate of nicotinamide ribonucleotide
-
-
?
ATP + nicotinamide mononucleotide

diphosphate + NAD+
-
-
-
?
ATP + nicotinamide mononucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide

diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
PreissâHandler-independent pathway
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
best substrate
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
reverse reaction at 17% the rate of deamido-NAD+-synthesis
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
no substrates are deamino-NAD+, NADP+, adenosine diphosphoribose, 3-acetylpyridine-deamino-NAD+, 3-pyridinealdehyde-deamino-NAD+, alpha-isomer of NAD+, ITP, GTP, UTP, CTP, or TTP
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
very poor substrate for wild-type
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
best substrate
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
reverse reaction at 17% the rate of deamido-NAD+-synthesis
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
no substrates are deamino-NAD+, NADP+, adenosine diphosphoribose, 3-acetylpyridine-deamino-NAD+, 3-pyridinealdehyde-deamino-NAD+, alpha-isomer of NAD+, ITP, GTP, UTP, CTP, or TTP
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
very poor substrate for wild-type
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
Frog
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
Frog
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
best substrate
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
strongly stereospecific: beta-, not alpha-anomer of nicotinamide ribonucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
key reaction of pyridine nucleotide metabolism
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
central enzyme of NAD biosynthetic pathway
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
NMNAT1
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
NMNAT2
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
NMNAT3
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
the enzyme plays a key role in NAD+ biosynthesis
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
the enzyme plays a key role in NAD+ biosynthesis
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
pheasant
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
pheasant
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
at 70°C, ATP is a prominent donor. However, above 80°C, a relatively small, but significant, NMNAT activity is detected when ATP was replaced by ADP or AMP in the reaction mixture
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
at 70°C, ATP is a prominent donor. However, above 80°C, a relatively small, but significant, NMNAT activity is detected when ATP was replaced by ADP or AMP in the reaction mixture
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
best substrate
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
no substrates are deamino-NAD+, NADP+, adenosine diphosphoribose, 3-acetylpyridine-deamino-NAD+, 3-pyridinealdehyde-deamino-NAD+, alpha-isomer of NAD+, ITP, GTP, UTP, CTP, or TTP
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
isoform yNMNAT-1
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
isoform yNMNAT-2
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
i.e. NMN or nicotinamide mononucleotide
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
stereochemistry: catalyses nucleotidyl transfer from adenosine (R)-5'-triphosphate to nicotinamide mononucleotide with inversion of configuration at the alpha-phosphate giving (S)-NAD+
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinate ribonucleotide

diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
best substrate
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
Frog
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
less efficient
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
pheasant
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
i.e. nicotinate mononucleotide
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
less efficient
-
-
r
ATP + nicotinate ribonucleotide
diphosphate + nicotinic acid-adenine dinucleotide
-
reaction at 77% the rate of nicotinamide ribonucleotide
-
-
r
ATP + nicotinic acid mononucleotide

diphosphate + deamido-NAD+
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + deamido-NAD+
-
-
-
?
ATP + nicotinic acid mononucleotide
diphosphate + deamido-NAD+
-
-
-
?
ATP + nicotinic acid mononucleotide

diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + nicotinic acid mononucleotide
diphosphate + nicotinic acid adenine dinucleotide
-
-
-
-
r
ATP + NMN

diphosphate + NAD+
the enzyme likely plays a central role in the pathway of NAD de novo synthesis in Francisella tularensis
-
-
?
ATP + NMN
diphosphate + NAD+
the enzyme is a bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase, structural aspects of the catalytic mechanism, overview
-
-
?
ATP + NMN
diphosphate + NAD+
-
-
-
?
ATP + NMN
diphosphate + NAD+
ATP binds before NMN with nuclear isozyme NMNAT1 and Golgi apparatus NMNAT2, but the opposite order is observed with the mitochondrial isozyme NMNAT3
-
-
?
ATP + NMN
diphosphate + NAD+
the enzyme from Synechocystis sp. is primarily involved in NAD savage/recycling pathways
-
-
?
ATP + NMN
diphosphate + NAD+
the enzyme is a bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase, structural aspects of the catalytic mechanism, overview
-
-
?
deoxy-ATP + nicotinamide ribonucleotide

?
-
-
-
-
?
deoxy-ATP + nicotinamide ribonucleotide
?
-
-
-
?
deoxy-ATP + nicotinamide ribonucleotide
?
-
-
-
-
?
deoxy-ATP + nicotinate ribonucleotide

?
-
reaction at 18% the rate of ATP
-
-
?
deoxy-ATP + nicotinate ribonucleotide
?
-
reaction at 30% the rate of ATP
-
-
?
diphosphate + NAD+

ATP + nicotinamide ribonucleotide
-
-
-
r
diphosphate + NAD+
ATP + nicotinamide ribonucleotide
-
-
-
-
r
GTP + nicotinamide ribonucleotide

diphosphate + NGD+
19% of the activity with GTP, reverse reaction with 57% of the activity with NAD+, NMNA3
-
-
r
GTP + nicotinamide ribonucleotide
diphosphate + NGD+
3% of the activity with GTP, reverse reaction with 5% of the activity with NAD+, NMNAT2
-
-
r
GTP + nicotinamide ribonucleotide
diphosphate + NGD+
7% of the activity with GTP, reverse reaction with 26% of the activity with NAD+, NMNAT1
-
-
r
ITP + nicotinamide ribonucleotide

diphosphate + nicotinamide hypoxanthine dinucleotide
27% of the activity with ATP, NMNAT3
-
-
?
ITP + nicotinamide ribonucleotide
diphosphate + nicotinamide hypoxanthine dinucleotide
5% of the activity with ATP, NMNAT2
-
-
?
ITP + nicotinamide ribonucleotide
diphosphate + nicotinamide hypoxanthine dinucleotide
6% of the activity with ATP, NMNAT1
-
-
?
ITP + nicotinamide ribonucleotide
diphosphate + nicotinamide hypoxanthine dinucleotide
-
isoform yNMNAT-2
-
-
?
NADH + diphosphate

?
53% of the activity with NAD+, NMNAT1
-
-
?
NADH + diphosphate
?
98% of the activity with NAD+, NMNAT2
-
-
?
NADH + diphosphate
?
99% of the activity with NAD+, NMNAT3
-
-
?
nicotinamide hypoxanthine dinucleotide + diphosphate

ITP + nicotinamide ribonucleotide
37% of the activity with NAD+, NMNAT2
-
-
?
nicotinamide hypoxanthine dinucleotide + diphosphate
ITP + nicotinamide ribonucleotide
55% of the activity with NAD+, NMNAT1
-
-
?
nicotinate mononucleotide + ATP

nicotinate adenine dinucleotide + diphosphate
PreissâHandler-dependent pathway
-
-
?
nicotinate mononucleotide + ATP
nicotinate adenine dinucleotide + diphosphate
-
-
-
-
?
nicotinate mononucleotide + ATP
nicotinate adenine dinucleotide + diphosphate
-
-
-
-
?
nicotinic acid adenine dinucleotide phosphate + diphosphate

?
93% of the activity with NAD+, NMNAT1
-
-
?
nicotinic acid adenine dinucleotide phosphate + diphosphate
?
98% of the activity with NAD+, NMNAT2
-
-
?
nicotinic acid adenine dinucleotide phosphate + diphosphate
?
as active as with NAD+, NMNAT3
-
-
?
nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate
-
-
-
-
r
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
-
-
-
r
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
-
-
-
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
activity observed with GTP, ITP
-
-
r
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
-
-
-
-
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
-
-
-
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
activity observed with dATP, ITP
-
-
r
tiazofurin + ATP

tiazofurin adenine dinucleotide + diphosphate
-
-
-
-
?
tiazofurin + ATP
tiazofurin adenine dinucleotide + diphosphate
-
-
-
?
tiazofurin + ATP
tiazofurin adenine dinucleotide + diphosphate
-
YLR010W
-
-
?
additional information

?
-
-
NAD synthase nicotinamide mononucleotide adenylyltransferase is a stress-response protein that acts as a chaperone for neuronal maintenance and protection
-
-
?
additional information
?
-
-
NAD synthase nicotinamide mononucleotide adenylyltransferase displays chaperone function both in biochemical assays and cultured cells. It is upregulated in the brain upon overexpression of poly-glutamine expanded protein and recruited with the chaperone Hsp70 into protein aggregates.
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
isozyme NMNAT1 directly interacts with nucleolar protein nucleomethylin, NML
-
-
?
additional information
?
-
-
isozyme NMNAT1 directly interacts with nucleolar protein nucleomethylin, NML
-
-
?
additional information
?
-
NMNAT2 complexes with heat shock protein 90 (HSP90)
-
-
?
additional information
?
-
-
bifunctional enzyme, additionally catalyzes the reaction with nicotinate ribonucleotide, reaction of EC 2.7.7.18
-
-
-
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP
-
-
?
additional information
?
-
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP
-
-
?
additional information
?
-
the wild-type enzyme traps a molecule of NADP+ in the active site. This NADP+ molecule is bound in a conformation different from that displayed by NAD+ in the enzyme complex. Binding structure of wild-type and mutant enzymes with NAD+ and NADP+, detailed overview
-
-
?
additional information
?
-
-
the wild-type enzyme traps a molecule of NADP+ in the active site. This NADP+ molecule is bound in a conformation different from that displayed by NAD+ in the enzyme complex. Binding structure of wild-type and mutant enzymes with NAD+ and NADP+, detailed overview
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP
-
-
?
additional information
?
-
the wild-type enzyme traps a molecule of NADP+ in the active site. This NADP+ molecule is bound in a conformation different from that displayed by NAD+ in the enzyme complex. Binding structure of wild-type and mutant enzymes with NAD+ and NADP+, detailed overview
-
-
?
additional information
?
-
-
the following substrates are inert: GDP, CDP, UDP, IDP, GTP, CTP, ITP, IMP, CMP, TTP, and UTP
-
-
?
additional information
?
-
-
the following substrates are inert: GDP, CDP, UDP, IDP, GTP, CTP, ITP, IMP, CMP, TTP, and UTP
-
-
?
additional information
?
-
the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity
-
-
?
additional information
?
-
-
the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity
-
-
?
additional information
?
-
the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity
-
-
?
additional information
?
-
no donors: ADP, AMP, TMP, GMP, CMP, UMP and IMP
-
-
-
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
the enzyme shows activity for both NAMN and NMN, substrates used by NMNAT in the presence of ATP to form NAD+ and NAAD, respectively
-
-
?
additional information
?
-
-
the enzyme shows activity for both NAMN and NMN, substrates used by NMNAT in the presence of ATP to form NAD+ and NAAD, respectively
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
the enzyme shows activity for both NAMN and NMN, substrates used by NMNAT in the presence of ATP to form NAD+ and NAAD, respectively
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + nicotinamide mononucleotide
diphosphate + NAD+
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
ATP + nicotinic acid mononucleotide
diphosphate + deamido-NAD+
ATP + NMN
diphosphate + NAD+
ATP + tiazofurin
diphosphate + thiazole-4-carboxamide adenine dinucleotide
tiazofurin is a pro-drug that is metabolized by cytosolic nicotinamide mononucleotide adenylyltransferase2
-
-
?
GTP + nicotinamide ribonucleotide
nicotineamide guanine dinucleotide + diphosphate
only isoenzyme NMNAT3
-
-
?
ITP + nicotinamide ribonucleotide
nicotinamide hypoxanthine dinucleotide + diphosphate
only isoenzyme NMNAT3
-
-
?
nicotinate mononucleotide + ATP
nicotinate adenine dinucleotide + diphosphate
PreissâHandler-dependent pathway
-
-
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
NMN + ATP
NAD+ + diphosphate
-
-
-
?
tiazofurin monophosphate + ATP
tiazofurin adenine dinucleotide + diphosphate
-
-
-
?
additional information
?
-
ATP + nicotinamide mononucleotide

diphosphate + NAD+
-
-
-
?
ATP + nicotinamide mononucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide

diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
PreissâHandler-independent pathway
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
Frog
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
key reaction of pyridine nucleotide metabolism
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
central enzyme of NAD biosynthetic pathway
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
the enzyme plays a key role in NAD+ biosynthesis
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
the enzyme plays a key role in NAD+ biosynthesis
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
pheasant
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
final step in biosynthesis of NAD+
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
-
r
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
-
-
-
?
ATP + nicotinic acid mononucleotide

diphosphate + deamido-NAD+
-
-
-
?
ATP + nicotinic acid mononucleotide
diphosphate + deamido-NAD+
-
-
-
?
ATP + NMN

diphosphate + NAD+
the enzyme likely plays a central role in the pathway of NAD de novo synthesis in Francisella tularensis
-
-
?
ATP + NMN
diphosphate + NAD+
-
-
-
?
ATP + NMN
diphosphate + NAD+
the enzyme from Synechocystis sp. is primarily involved in NAD savage/recycling pathways
-
-
?
nicotinic acid mononucleotide + ATP

nicotinic acid adenine dinucleotide + diphosphate
-
-
-
-
?
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
-
-
-
?
additional information

?
-
-
NAD synthase nicotinamide mononucleotide adenylyltransferase is a stress-response protein that acts as a chaperone for neuronal maintenance and protection
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
isozyme NMNAT1 directly interacts with nucleolar protein nucleomethylin, NML
-
-
?
additional information
?
-
-
isozyme NMNAT1 directly interacts with nucleolar protein nucleomethylin, NML
-
-
?
additional information
?
-
NMNAT2 complexes with heat shock protein 90 (HSP90)
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP
-
-
?
additional information
?
-
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18. The enzyme reversibly catalyzes two closely related reactions: the biosyntheses of NAD+ and its nicotinic acid analogue (NaAD+) from their respective mononucleotide precursors and ATP
-
-
?
additional information
?
-
the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity
-
-
?
additional information
?
-
-
the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity
-
-
?
additional information
?
-
the amino acid sequence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT). Unlike other yeast NMNATs, Pof1 exhibits NMN-specific adenylyltransferase activity
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
additional information
?
-
bifunctional enzyme, that also shows nicotinate-nucleotide adenylyltransferase activity, EC 2.7.7.18
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.27
3-acetylpyridine-NAD+
-
37°C, pH 7.5
0.74
3-pyridinealdehyde-NAD+
-
37°C, pH 7.5
0.041
ADP-ribose
pH 8.2, 37°C
0.625
beta-NMNH
-
37°C, pH 7.4
0.0045 - 0.029
deamido-NAD+
0.083 - 166.6
diphosphate
0.021 - 0.7
nicotinamide mononucleotide
0.00295 - 178.5
nicotinamide ribonucleotide
0.08
nicotinate D-ribonucleotide
-
nicotinamide ribonucleotide
0.08 - 5
nicotinate ribonucleotide
0.0145 - 0.15
nicotinic acid mononucleotide
0.91
nicotinic acid-adenine dinucleotide
-
37°C, pH 7.4
0.0304
reduced nicotinamide mononucleotide
-
0.055
tiazofurin
-
YGR010W
0.37 - 100
tiazofurin monophosphate
0.37 - 100
tiazofurin riboside 5'-monophosphate
additional information
additional information
-
0.0008
ATP

-
70°C, pH 7.4
0.023
ATP
-
37°C, pH 7.4
0.023
ATP
-
37°C, pH 7.6
0.0335
ATP
isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.039
ATP
isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.0421
ATP
pH 7.5, 37°C, isozyme NMNAT3
0.056
ATP
-
pH 7.0, 70°C
0.0585
ATP
pH 7.5, 37°C, isozyme NMNAT1
0.06
ATP
-
37°C, pH 7.5, + nicotinate ribonucleotide
0.08
ATP
-
65°C, pH 7.5, H19A
0.082
ATP
isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.08425
ATP
-
wild type enzyme, in 50 mM HEPES-NaOH, pH 7.5, temperature not specified in the publication
0.0889
ATP
pH 7.5, 37°C, isozyme NMNAT2
0.113
ATP
-
mutant enzyme C164S/C165S, in 50 mM HEPES-NaOH, pH 7.5, temperature not specified in the publication
0.13
ATP
pH 7.4, 37°C, recombinant enzyme, kinetics following Hanes-Woolf method
0.15
ATP
pH 7.4, 37°C, recombinant enzyme, kinetics following Eadie-Hofstee method
0.1596
ATP
wild-type, pH 7.5, 42°C
0.16
ATP
-
65°C, pH 7.5, wild-type
0.189
ATP
pH 7.4, 37°C, recombinant enzyme, kinetics following Lineweaver-Burk method
0.19
ATP
-
isoform yNMNAT-1
0.21
ATP
-
65°C, pH 7.5, R11K
0.23
ATP
-
+ nicotinamide ribonucleotide, immobilized enzyme
0.33
ATP
-
65°C, pH 7.5, R11A
0.456
ATP
mutant C41A/C43A, pH not specified in the publication, temperature not specified in the publication
0.46
ATP
-
65°C, pH 7.5, R136K
0.5 - 0.52
ATP
-
37°C, pH 7.5
0.5 - 0.52
ATP
-
37°C, pH 7.6
0.525
ATP
wild-type, pH not specified in the publication, temperature not specified in the publication
0.624
ATP
mutant C43A, pH not specified in the publication, temperature not specified in the publication
1.1
ATP
-
65°C, pH 7.5, H16A
1.18
ATP
-
tiazofurin as second substrate, YGR010W
1.186
ATP
mutant C41A, pH not specified in the publication, temperature not specified in the publication
1.4
ATP
-
65°C, pH 7.5, R136A
1.4
ATP
-
isoform yNMNAT-2
1.48 - 1.52
ATP
pH 7.5, 26°C, recombinant isozyme GlNMNAT-A
1.8209
ATP
mutant R232Q, pH 7.5, 42°C
0.0045
deamido-NAD+

-
37°C, pH 7.5
0.029
deamido-NAD+
-
37°C, pH 7.5
0.083
diphosphate

-
0.083
diphosphate
-
isoform yNMNAT-1
0.125
diphosphate
-
37°C, pH 7.6
0.167
diphosphate
-
37°C, pH 7.4
0.65
diphosphate
-
37°C, pH 7.5
1.1
diphosphate
-
37°C, pH 7.5
5
diphosphate
-
isoform yNMNAT-2
166.6
diphosphate
-
pH 7.4, 20°C
0.023
NAD+

-
isoform yNMNAT-2
0.067 - 0.069
NAD+
-
37°C, pH 7.5
0.067 - 0.069
NAD+
-
37°C, pH 7.6
0.073
NAD+
-
isoform yNMNAT-1
0.37
NAD+
-
37°C, pH 7.5
0.37
NAD+
-
37°C, pH 7.4
412.2
NAD+
-
pH 7.4, 20°C
0.021
nicotinamide mononucleotide

range 0.021-0.032 mM
0.17
nicotinamide mononucleotide
-
0.7
nicotinamide mononucleotide
-
0.00295
nicotinamide ribonucleotide

-
mutant enzyme C164S/C165S, in 50 mM HEPES-NaOH, pH 7.5, temperature not specified in the publication
0.00691
nicotinamide ribonucleotide
-
wild type enzyme, in 50 mM HEPES-NaOH, pH 7.5, temperature not specified in the publication
0.016
nicotinamide ribonucleotide
pH 7.4, 23°C
0.0223
nicotinamide ribonucleotide
wild-type, pH 7.5, 42°C
0.025
nicotinamide ribonucleotide
mutant C43A, pH not specified in the publication, temperature not specified in the publication
0.0252
nicotinamide ribonucleotide
isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.03
nicotinamide ribonucleotide
hNMNAT-2
0.032
nicotinamide ribonucleotide
NMNAT2
0.034
nicotinamide ribonucleotide
NMNAT1
0.038
nicotinamide ribonucleotide
-
37°C, pH 7.6
0.0385
nicotinamide ribonucleotide
isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.04
nicotinamide ribonucleotide
wild-type, pH not specified in the publication, temperature not specified in the publication
0.061
nicotinamide ribonucleotide
-
pH 7.0, 70°C
0.11
nicotinamide ribonucleotide
-
isoform yNMNAT-1
0.1176
nicotinamide ribonucleotide
isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.12
nicotinamide ribonucleotide
-
-
0.13
nicotinamide ribonucleotide
-
isoform yNMNAT-2
0.147 - 0.2
nicotinamide ribonucleotide
-
-
0.147 - 0.2
nicotinamide ribonucleotide
-
37°C, pH 7.5
0.147 - 0.2
nicotinamide ribonucleotide
-
37°C, pH 7.6
0.147 - 0.2
nicotinamide ribonucleotide
-
37°C, pH 7.6
0.1789
nicotinamide ribonucleotide
-
pH 7.4, 20°C
0.209
nicotinamide ribonucleotide
NMNAT3
0.263
nicotinamide ribonucleotide
pH 8.0, 37°C
0.28
nicotinamide ribonucleotide
-
immobilized enzyme
0.346
nicotinamide ribonucleotide
mutant C41A/C43A, pH not specified in the publication, temperature not specified in the publication
0.4
nicotinamide ribonucleotide
-
37°C, pH 7.5
0.753
nicotinamide ribonucleotide
mutant C41A, pH not specified in the publication, temperature not specified in the publication
0.755
nicotinamide ribonucleotide
pH 7.4, 37°C, recombinant enzyme, kinetics following Hanes-Woolf method
0.76
nicotinamide ribonucleotide
mutant A86W/Y118N, pH 7.5, 30°C
0.8
nicotinamide ribonucleotide
mutant Y84V/Y118D, pH 7.5, 30°C
0.926
nicotinamide ribonucleotide
pH 7.4, 37°C, recombinant enzyme, kinetics following Eadie-Hofstee method
0.985
nicotinamide ribonucleotide
pH 7.4, 37°C, recombinant enzyme, kinetics following Lineweaver-Burk method
2.26
nicotinamide ribonucleotide
pH 10.0, 30°C, recombinant enzyme
2.53 - 2.72
nicotinamide ribonucleotide
pH 7.5, 26°C, recombinant isozyme GlNMNAT-A
9.4
nicotinamide ribonucleotide
wild-type, pH 7.5, 30°C
178.5
nicotinamide ribonucleotide
mutant R232Q, pH 7.5, 42°C
0.08
nicotinate ribonucleotide

-
37°C, pH 7.5
0.13
nicotinate ribonucleotide
-
37°C, pH 7.5
5
nicotinate ribonucleotide
-
-
5
nicotinate ribonucleotide
-
37°C, pH 7.6
0.0145
nicotinic acid mononucleotide

NMNAT2
0.0145
nicotinic acid mononucleotide
pH 7.5, 37°C, isozyme NMNAT2
0.015
nicotinic acid mononucleotide
-
0.017
nicotinic acid mononucleotide
-
70°C, pH 7.4
0.0677
nicotinic acid mononucleotide
NMNAT1
0.0677
nicotinic acid mononucleotide
pH 7.5, 37°C, isozyme NMNAT1
0.111
nicotinic acid mononucleotide
NMNAT3
0.111
nicotinic acid mononucleotide
pH 7.5, 37°C, isozyme NMNAT3
0.116
nicotinic acid mononucleotide
-
-
0.116
nicotinic acid mononucleotide
37°C
0.15
nicotinic acid mononucleotide
-
37°C, pH 7.4
0.000019
NMN

-
-
0.000019
NMN
-
37°C, pH 7.6
0.0014
NMN
-
70°C, pH 7.4
0.0213
NMN
pH 7.5, 37°C, isozyme NMNAT2
0.0223
NMN
pH 7.5, 37°C, isozyme NMNAT1
0.0662
NMN
pH 7.5, 37°C, isozyme NMNAT3
0.0719
NMN
-
25°C, pH 8.76
0.0752
NMN
-
25°C, pH 7.95
0.0791
NMN
-
25°C, pH 8.44
0.08
NMN
-
65°C, pH 7.5, wild-type
0.0877
NMN
-
25°C, pH 7.63
0.0879
NMN
-
25°C, pH 7.16
0.09
NMN
-
65°C, pH 7.5, H19A
0.105
NMN
-
25°C, pH 6.21
0.106
NMN
-
25°C, pH 9.55
0.108
NMN
-
25°C, pH 6.66
0.11
NMN
-
65°C, pH 7.5, R136A
0.1129
NMN
-
25°C, pH 9.4
0.13
NMN
-
65°C, pH 7.5, R11K
0.139
NMN
-
25°C, pH 5.85
0.14
NMN
-
65°C, pH 7.5, R136K and R11A
0.187
NMN
-
25°C, pH 5.53
0.2
NMN
-
65°C, pH 7.5, H16A
0.201
NMN
-
25°C, pH 9.77
0.298
NMN
-
25°C, pH 10.35
0.336
NMN
-
25°C, pH 10.55
0.45
NMN
-
25°C, pH 5.15
0.594
NMN
-
25°C, pH 4.95
0.13
NMNH

NMNAT3
0.13
NMNH
pH 7.5, 37°C, isozyme NMNAT3
0.294
NMNH
pH 7.5, 37°C, isozyme NMNAT1
0.304
NMNH
pH 7.5, 37°C, isozyme NMNAT2
0.37
tiazofurin monophosphate

NMNAT1
2.01
tiazofurin monophosphate
NMNAT3
100
tiazofurin monophosphate
NMNAT2
0.37
tiazofurin riboside 5'-monophosphate

pH 7.5, 37°C, isozyme NMNAT1
2.1
tiazofurin riboside 5'-monophosphate
pH 7.5, 37°C, isozyme NMNAT3
100
tiazofurin riboside 5'-monophosphate
above, pH 7.5, 37°C, isozyme NMNAT2
additional information
additional information

steady state kinetics
-
additional information
additional information
steady state kinetics
-
additional information
additional information
4.82 Vmax/KM NMN
-
additional information
additional information
-
4.82 Vmax/KM NMN
-
additional information
additional information
7.16 Vmax/KM NaMN
-
additional information
additional information
-
7.16 Vmax/KM NaMN
-
additional information
additional information
initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview
-
additional information
additional information
initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview
-
additional information
additional information
initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview
-
additional information
additional information
-
initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview
-
additional information
additional information
Michaelis-Menten kinetics are observed for NMN and ATP, but saturation is not accomplished with NAMN, implying low affinity yet detectable activity with this substrate. Double-reciprocal plots show no cooperativity for this enzyme
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3.6
ADP-ribose
pH 8.2, 37°C
11.2
diphosphate
-
pH 7.4, 20°C
16.6
NAD+
-
pH 7.4, 20°C
0.075 - 35.33
nicotinamide ribonucleotide
3.8 - 42.9
nicotinic acid mononucleotide
0.42 - 14.9
tiazofurin riboside 5'-monophosphate
0.0000333
ATP

-
65°C, pH 7.5, H19A
0.000117
ATP
-
65°C, pH 7.5, R136A
0.000133
ATP
-
65°C, pH 7.5, R11A
0.000167
ATP
-
65°C, pH 7.5, H16A
0.0008
ATP
-
65°C, pH 7.5, R11K
0.00222
ATP
-
65°C, pH 7.5, R136K
0.00278
ATP
-
65°C, pH 7.5, wild-type
0.037
ATP
mutant C41A, pH not specified in the publication, temperature not specified in the publication
0.082
ATP
wild-type, pH not specified in the publication, temperature not specified in the publication
0.31
ATP
mutant R232Q, pH 7.5, 42°C
0.7
ATP
mutant C43A, pH not specified in the publication, temperature not specified in the publication
0.74
ATP
isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.969
ATP
pH 7.4, 37°C, recombinant enzyme, kinetics following Hanes-Woolf method
0.984
ATP
pH 7.4, 37°C, recombinant enzyme, kinetics following Eadie-Hofstee method
1.174
ATP
pH 7.4, 37°C, recombinant enzyme, kinetics following Lineweaver-Burk method
1.92
ATP
mutant C41A/C43A, pH not specified in the publication, temperature not specified in the publication
2.33
ATP
isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C
2.41 - 2.44
ATP
pH 7.5, 26°C, recombinant isozyme GlNMNAT-A
2.5
ATP
pH 7.5, 37°C, isozyme NMNAT3
6.84
ATP
wild-type, pH 7.5, 42°C
8.8
ATP
pH 7.5, 37°C, isozyme NMNAT2
15
ATP
isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C
53.9
ATP
pH 7.5, 37°C, isozyme NMNAT1
0.075
nicotinamide ribonucleotide

mutant C41A, pH not specified in the publication, temperature not specified in the publication
0.087
nicotinamide ribonucleotide
wild-type, pH not specified in the publication, temperature not specified in the publication
0.2
nicotinamide ribonucleotide
-
pH 7.4, 20°C
0.654
nicotinamide ribonucleotide
-
wild type enzyme, in 50 mM HEPES-NaOH, pH 7.5, temperature not specified in the publication
0.718
nicotinamide ribonucleotide
pH 7.4, 37°C, recombinant enzyme, kinetics following Hanes-Woolf method
0.73
nicotinamide ribonucleotide
pH 7.4, 37°C, recombinant enzyme, kinetics following Eadie-Hofstee method
0.75
nicotinamide ribonucleotide
isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C
0.76
nicotinamide ribonucleotide
wild-type, pH 7.5, 30°C
0.76
nicotinamide ribonucleotide
pH 7.4, 37°C, recombinant enzyme, kinetics following Lineweaver-Burk method
1.3
nicotinamide ribonucleotide
mutant C43A, pH not specified in the publication, temperature not specified in the publication
2.87
nicotinamide ribonucleotide
isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C
2.93
nicotinamide ribonucleotide
mutant C41A/C43A, pH not specified in the publication, temperature not specified in the publication
2.97 - 3.04
nicotinamide ribonucleotide
pH 7.5, 26°C, recombinant isozyme GlNMNAT-A
3 - 6
nicotinamide ribonucleotide
mutant A86W/Y118N, pH 7.5, 30°C
6.6
nicotinamide ribonucleotide
mutant Y84V/Y118D, pH 7.5, 30°C
7.21
nicotinamide ribonucleotide
-
mutant enzyme C164S/C165S, in 50 mM HEPES-NaOH, pH 7.5, temperature not specified in the publication
15.5
nicotinamide ribonucleotide
isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C
35.33
nicotinamide ribonucleotide
pH 10.0, 30°C, recombinant enzyme
3.8
nicotinic acid mononucleotide

pH 7.5, 37°C, isozyme NMNAT3
6.9
nicotinic acid mononucleotide
pH 7.5, 37°C, isozyme NMNAT2
42.9
nicotinic acid mononucleotide
pH 7.5, 37°C, isozyme NMNAT1
2.5
NMN

pH 7.5, 37°C, isozyme NMNAT3
8.8
NMN
pH 7.5, 37°C, isozyme NMNAT2
53.8
NMN
pH 7.5, 37°C, isozyme NMNAT1
3.3
NMNH

pH 7.5, 37°C, isozyme NMNAT2
7.2
NMNH
pH 7.5, 37°C, isozyme NMNAT3
18.6
NMNH
pH 7.5, 37°C, isozyme NMNAT1
0.42
tiazofurin riboside 5'-monophosphate

pH 7.5, 37°C, isozyme NMNAT3
0.55
tiazofurin riboside 5'-monophosphate
pH 7.5, 37°C, isozyme NMNAT2
14.9
tiazofurin riboside 5'-monophosphate
pH 7.5, 37°C, isozyme NMNAT1
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0315 - 0.089
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
0.0328 - 0.3283
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate
0.0242 - 0.0736
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
0.0217 - 0.6576
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
0.0315 - 0.089
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate
0.0242 - 0.0736
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate
0.0217 - 0.6576
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate
0.16
diphosphate

product inhibition of NMNAT2, substrate NMN
0.175
diphosphate
product inhibition of NMNAT1, substrate ATP
0.334
diphosphate
product inhibition of NMNAT3, substrate ATP
0.361
diphosphate
product inhibition of NMNAT2, substrate ATP
0.39
diphosphate
product inhibition of NMNAT1, substrate NMN
1
diphosphate
product inhibition of NMNAT3, substrate NMN
0.023
NaAD+

product inhibition of NMNAT2, substrate ATP
0.041
NaAD+
product inhibition of NMNAT2, substrate NMN
0.205
NaAD+
product inhibition of NMNAT3, substrate ATP
0.305
NaAD+
product inhibition of NMNAT1, substrate ATP
0.364
NaAD+
product inhibition of NMNAT3, substrate NMN
0.502
NaAD+
product inhibition of NMNAT1, substrate NMN
0.067
NAD+

product inhibition of NMNAT2, substrate NMN
0.095
NAD+
product inhibition of NMNAT2, substrate ATP
0.418
NAD+
product inhibition of NMNAT1, substrate NMN
0.749
NAD+
product inhibition of NMNAT1, substrate ATP
1.017
NAD+
product inhibition of NMNAT3, substrate NMN
1.418
NAD+
product inhibition of NMNAT3, substrate ATP
0.0315
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate

substrate: NMN, isoenzyme: NMNAT2
0.0359
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
substrate: ATP, isoenzyme: NMNAT2
0.0406
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
substrate: ATP, isoenzyme: NMNAT3
0.0563
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
substrate: ATP, isoenzyme: NMNAT1
0.0668
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
substrate: NMN, isoenzyme: NMNAT3
0.089
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
substrate: NMN, isoenzyme: NMNAT1
0.0328
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate

substrate: ATP, isoenzyme: NMNAT3
0.0591
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate
substrate: ATP, isoenzyme: NMNAT1
0.0679
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate
substrate: NMN, isoenzyme: NMNAT1
0.0883
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate
substrate: NMN, isoenzyme: NMNAT3
0.1745
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate
substrate: ATP, isoenzyme: NMNAT2
0.3283
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate
substrate: NMN, isoenzyme: NMNAT2
0.0242
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate

substrate: ATP, isoenzyme: NMNAT2
0.0258
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
substrate: NMN, isoenzyme: NMNAT2
0.0298
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
substrate: ATP, isoenzyme: NMNAT3
0.0311
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
substrate: NMN, isoenzyme: NMNAT1
0.0492
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
substrate: ATP, isoenzyme: NMNAT1
0.0736
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
substrate: NMN, isoenzyme: NMNAT3
0.0217
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate

substrate: NMN, isoenzyme: NMNAT3
0.0369
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
substrate: NMN, isoenzyme: NMNAT1
0.0431
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
substrate: ATP, isoenzyme: NMNAT3
0.0845
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
substrate: ATP, isoenzyme: NMNAT1
0.1257
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
substrate: NMN, isoenzyme: NMNAT2
0.6576
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
substrate: ATP, isoenzyme: NMNAT2
0.0315
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate

pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN
0.0359
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate
pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP
0.0406
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate
pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP
0.0563
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate
pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP
0.0668
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate
pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN
0.089
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate
pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN
0.0242
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate

pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP
0.0258
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate
pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN
0.0298
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate
pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP
0.0311
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate
pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN
0.0492
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate
pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP
0.0736
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate