Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H24A | protein expressed from the mutant construct is greatly reduced in activity compared with the wild-type protein | Homo sapiens |
W92G | protein expressed from the mutant construct is greatly reduced in activity compared with the wild-type protein | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
nicotinamide ribonucleotide | hNMNAT-2 | Homo sapiens | |
0.107 | - |
ATP | hNMNAT -2 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZQ4 | - |
- |
Purification (Comment) | Organism |
---|---|
hNMNAT-2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | hNMNAT-2, whole cerebrum, cerebellum, occipital, frontal and temporal lobe cortices, and the putamen. The medulla shows minimal expression, none is detectable in the spinal cord | Homo sapiens | - |
caudate putamen | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
frontal lobe | cortex | Homo sapiens | - |
occipital lobe | cortex | Homo sapiens | - |
pancreas | hNMNAT-2 is markedly expressed in the islets of Langerhans. However, the pancreatic exocrine cells exhibit weak expression of hNMNAT-2 protein. Sections of pancreas from insulinoma patients show strong expression of hNMNAT-2 protein in the insulin-producing tumour cells, acinar cells exhibit low expression of hNMNAT-2 protein | Homo sapiens | - |
temporal lobe | cortex | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
13 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + nicotinamide ribonucleotide | - |
Homo sapiens | diphosphate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hNMNAT-2 | - |
Homo sapiens |
nicotinamide 5'-mononucleotide adenylyltransferase | - |
Homo sapiens |
nicotinamide 5'-mononucleotide adenylyltransferase-2 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.6 | 8.5 | - |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | theoretical value | - |
6.59 |