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Literature summary for 2.7.7.1 extracted from

  • Yalowitz, J.A.; Xiao, S.; Biju, M.P.; Antony, A.C.; Cummings, O.W.; Deeg, M.A.; Jayaram, H.N.
    Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas (2004), Biochem. J., 377, 317-326.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
H24A protein expressed from the mutant construct is greatly reduced in activity compared with the wild-type protein Homo sapiens
W92G protein expressed from the mutant construct is greatly reduced in activity compared with the wild-type protein Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
nicotinamide ribonucleotide hNMNAT-2 Homo sapiens
0.107
-
ATP hNMNAT -2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZQ4
-
-

Purification (Commentary)

Purification (Comment) Organism
hNMNAT-2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain hNMNAT-2, whole cerebrum, cerebellum, occipital, frontal and temporal lobe cortices, and the putamen. The medulla shows minimal expression, none is detectable in the spinal cord Homo sapiens
-
caudate putamen
-
Homo sapiens
-
cerebellum
-
Homo sapiens
-
frontal lobe cortex Homo sapiens
-
occipital lobe cortex Homo sapiens
-
pancreas hNMNAT-2 is markedly expressed in the islets of Langerhans. However, the pancreatic exocrine cells exhibit weak expression of hNMNAT-2 protein. Sections of pancreas from insulinoma patients show strong expression of hNMNAT-2 protein in the insulin-producing tumour cells, acinar cells exhibit low expression of hNMNAT-2 protein Homo sapiens
-
temporal lobe cortex Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
13
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinamide ribonucleotide
-
Homo sapiens diphosphate + NAD+
-
?

Synonyms

Synonyms Comment Organism
hNMNAT-2
-
Homo sapiens
nicotinamide 5'-mononucleotide adenylyltransferase
-
Homo sapiens
nicotinamide 5'-mononucleotide adenylyltransferase-2
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6 8.5
-
Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens theoretical value
-
6.59