Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9EPA7 | isoform NMNAT1, cf. EC 2.7.7.18 | - |
Synonyms | Comment | Organism |
---|---|---|
NMNAT1 | cf. EC 2.7.7.18 | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | crossing of htau mice, which express non-mutant human tau isoforms and represent a model of tauopathy relevant to Alzheimer's disease, with Nmnat1 transgenic and knockout mice. In the resulting offspring until the age of 6 months, overexpression of NMNAT1 ameliorates the early deficit in food burrowing characteristic of htau mice. At 6 months of age, htau mice do not show neurodegenerative changes in both the cortex and hippocampus, and these are not induced by downregulating NMNAT1 levels. Modulating NMNAT1 levels produces a corresponding effect on NMNAT enzymatic activity but does not alter NAD levels in htau mice | Mus musculus |