Cloned (Comment) | Organism |
---|---|
His-tagged isozymes NMNAT1, NMNAT2, and NMNAT3, expression in Escherichia coli strain BL21(DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphosphate | product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN; product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN; product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN | Homo sapiens | |
gallotannin | polyphenolic plant metabolite that inhibits all three human NMNATs; polyphenolic plant metabolite that inhibits all three human NMNATs; polyphenolic plant metabolite that inhibits all three human NMNATs | Homo sapiens | |
NaAD+ | i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP | Homo sapiens | |
NAD+ | product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP | Homo sapiens | |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | - |
Homo sapiens | |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | - |
Homo sapiens | |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | - |
Homo sapiens | |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | i.e. Np3AD; i.e. Np3AD; i.e. Np3AD | Homo sapiens | |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | i.e. Np4AD; i.e. Np4AD; i.e. Np4AD | Homo sapiens | |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | i.e. Nap4AD; i.e. Nap4AD; i.e. Nap4AD | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview | Homo sapiens | |
0.0145 | - |
nicotinic acid mononucleotide | NMNAT2 | Homo sapiens | |
0.0145 | - |
nicotinic acid mononucleotide | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
0.0213 | - |
NMN | NMNAT2 | Homo sapiens | |
0.0213 | - |
NMN | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
0.0223 | - |
NMN | NMNAT1 | Homo sapiens | |
0.0223 | - |
NMN | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
0.0421 | - |
ATP | NMNAT3 | Homo sapiens | |
0.0421 | - |
ATP | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
0.0585 | - |
ATP | NMNAT1 | Homo sapiens | |
0.0585 | - |
ATP | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
0.0662 | - |
NMN | NMNAT3 | Homo sapiens | |
0.0662 | - |
NMN | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
0.0677 | - |
nicotinic acid mononucleotide | NMNAT1 | Homo sapiens | |
0.0677 | - |
nicotinic acid mononucleotide | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
0.0889 | - |
ATP | NMNAT2 | Homo sapiens | |
0.0889 | - |
ATP | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
0.111 | - |
nicotinic acid mononucleotide | NMNAT3 | Homo sapiens | |
0.111 | - |
nicotinic acid mononucleotide | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
0.13 | - |
NMNH | NMNAT3 | Homo sapiens | |
0.13 | - |
NMNH | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
0.276 | - |
GTP | NMNAT3 | Homo sapiens | |
0.294 | - |
NMNH | NMNAT1 | Homo sapiens | |
0.294 | - |
NMNH | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
0.304 | - |
NMNH | NMNAT2 | Homo sapiens | |
0.304 | - |
NMNH | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
0.35 | - |
ITP | NMNAT3 | Homo sapiens | |
0.37 | - |
tiazofurin monophosphate | NMNAT1 | Homo sapiens | |
0.37 | - |
tiazofurin riboside 5'-monophosphate | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
2.01 | - |
tiazofurin monophosphate | NMNAT3 | Homo sapiens | |
2.1 | - |
tiazofurin riboside 5'-monophosphate | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
100 | - |
tiazofurin monophosphate | NMNAT2 | Homo sapiens | |
100 | - |
tiazofurin riboside 5'-monophosphate | above, pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | NMNAT2 | Homo sapiens | 5794 | - |
Golgi apparatus | isozyme NMNAT2 | Homo sapiens | 5794 | - |
mitochondrion | NMNAT3 | Homo sapiens | 5739 | - |
mitochondrion | isozyme NMNAT3 | Homo sapiens | 5739 | - |
nucleus | Nmnat1 | Homo sapiens | 5634 | - |
nucleus | isozyme NMNAT1 | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | most effective ion with NMNAT2 and NMNAT3 | Homo sapiens | |
Mg2+ | most effective ion with isozymes NMNAT2 and NMNAT3 | Homo sapiens | |
additional information | NMNAT activity requires the presence of divalent cations. | Homo sapiens | |
Zn2+ | most effective ion with NMNAT1 | Homo sapiens | |
Zn2+ | most effective ion with isozyme NMNAT1 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32700 | - |
for NMNAT3, SDS-PAGE | Homo sapiens |
32700 | - |
x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE | Homo sapiens |
36000 | - |
for NMNAT1, SDS-PAGE | Homo sapiens |
36000 | - |
x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE | Homo sapiens |
37000 | - |
for NMNAT2, SDS-PAGE | Homo sapiens |
37000 | - |
x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NMN | Homo sapiens | - |
diphosphate + NAD+ | - |
? | |
GTP + nicotinamide ribonucleotide | Homo sapiens | only isoenzyme NMNAT3 | nicotineamide guanine dinucleotide + diphosphate | - |
? | |
ITP + nicotinamide ribonucleotide | Homo sapiens | only isoenzyme NMNAT3 | nicotinamide hypoxanthine dinucleotide + diphosphate | - |
? | |
NMN + ATP | Homo sapiens | - |
NAD+ + diphosphate | - |
? | |
tiazofurin monophosphate + ATP | Homo sapiens | - |
tiazofurin adenine dinucleotide + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96T66 | - |
- |
Homo sapiens | Q96T66 | isozyme NMNAT3; isozyme NMNAT3 | - |
Homo sapiens | Q9BZQ4 | - |
- |
Homo sapiens | Q9BZQ4 | isozyme NMNAT2; isozyme NMNAT2 | - |
Homo sapiens | Q9HAN9 | - |
- |
Homo sapiens | Q9HAN9 | isozyme NMNAT1; isozyme NMNAT1 | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged isozymes NMNAT1, NMNAT2, and NMNAT3 from Escherichia coli strain BL21(DE3) by nickel or TALON affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | predominance of isozyme NMNAT1 | Homo sapiens | - |
Hep-G2 cell | hepatocellular carcinoma cell line, predominance of isozyme NMNAT1, isozyme NMNAT3 is only present in liver and HepG2 cells | Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | predominance of isozyme NMNAT1, isozyme NMNAT3 is only present in liver and HepG2 cells | Homo sapiens | - |
SK-HEP-1 cell | hepatocellular carcinoma cell line, isozyme NMNAT2 is found exclusively in SK-HEP1 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + nicotinate D-ribonucleotide | - |
Homo sapiens | diphosphate + nicotinate adenine dinucleotide | i.e. nicotinic acid adenine dinucleotide | ? | |
ATP + NMN | - |
Homo sapiens | diphosphate + NAD+ | - |
? | |
ATP + NMN | ATP binds before NMN with nuclear isozyme NMNAT1 and Golgi apparatus NMNAT2, but the opposite order is observed with the mitochondrial isozyme NMNAT3 | Homo sapiens | diphosphate + NAD+ | - |
? | |
ATP + NMNH | - |
Homo sapiens | diphosphate + NADH | - |
? | |
ATP + tiazofurin 5'-monophosphate | i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2 | Homo sapiens | ? | - |
? | |
ATP + tiazofurin monophosphate | i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2 | Homo sapiens | ? | - |
? | |
GTP + nicotinamide ribonucleotide | only isoenzyme NMNAT3 | Homo sapiens | nicotineamide guanine dinucleotide + diphosphate | - |
? | |
GTP + NMN | substrates of isozyme NMNAT3 | Homo sapiens | diphosphate + NGD+ | i.e. nicotinamide guanosine dinucleotide | ? | |
ITP + nicotinamide ribonucleotide | only isoenzyme NMNAT3 | Homo sapiens | nicotinamide hypoxanthine dinucleotide + diphosphate | - |
? | |
ITP + NMN | substrates of isozyme NMNAT3 | Homo sapiens | diphosphate + inosine nicotinamide dinucleotide | i.e. nicotinamide hypoxanthine dinucleotide | ? | |
nicotinic acid mononucleotide + ATP | - |
Homo sapiens | nicotinic acid adenine dinucleotide + diphosphate | - |
? | |
NMN + ATP | - |
Homo sapiens | NAD+ + diphosphate | - |
? | |
tiazofurin monophosphate + ATP | - |
Homo sapiens | tiazofurin adenine dinucleotide + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE | Homo sapiens |
hexamer | NMNAT1 | Homo sapiens |
monomer | NMNAT2 | Homo sapiens |
tetramer | NMNAT3 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
human nicotinamide mononucleotide adenylyl-transferase | - |
Homo sapiens |
nicotinamide mononucleotide adenylyl-transferase | - |
Homo sapiens |
NMN-adenylyltransferase | - |
Homo sapiens |
NMNAT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.42 | - |
tiazofurin riboside 5'-monophosphate | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
0.55 | - |
tiazofurin riboside 5'-monophosphate | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
2.5 | - |
ATP | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
2.5 | - |
NMN | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
3.3 | - |
NMNH | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
3.8 | - |
nicotinic acid mononucleotide | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
6.9 | - |
nicotinic acid mononucleotide | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
7.2 | - |
NMNH | pH 7.5, 37°C, isozyme NMNAT3 | Homo sapiens | |
8.8 | - |
ATP | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
8.8 | - |
NMN | pH 7.5, 37°C, isozyme NMNAT2 | Homo sapiens | |
14.9 | - |
tiazofurin riboside 5'-monophosphate | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
18.6 | - |
NMNH | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
42.9 | - |
nicotinic acid mononucleotide | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
53.8 | - |
NMN | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens | |
53.9 | - |
ATP | pH 7.5, 37°C, isozyme NMNAT1 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0217 | - |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | substrate: NMN, isoenzyme: NMNAT3 | Homo sapiens | |
0.0217 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate NaMN | Homo sapiens | |
0.023 | - |
NaAD+ | product inhibition of NMNAT2, substrate ATP | Homo sapiens | |
0.0242 | - |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | substrate: ATP, isoenzyme: NMNAT2 | Homo sapiens | |
0.0242 | - |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP | Homo sapiens | |
0.0258 | - |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | substrate: NMN, isoenzyme: NMNAT2 | Homo sapiens | |
0.0258 | - |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN | Homo sapiens | |
0.0298 | - |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | substrate: ATP, isoenzyme: NMNAT3 | Homo sapiens | |
0.0298 | - |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP | Homo sapiens | |
0.0311 | - |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | substrate: NMN, isoenzyme: NMNAT1 | Homo sapiens | |
0.0311 | - |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN | Homo sapiens | |
0.0315 | - |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | substrate: NMN, isoenzyme: NMNAT2 | Homo sapiens | |
0.0315 | - |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN | Homo sapiens | |
0.0328 | - |
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate | substrate: ATP, isoenzyme: NMNAT3 | Homo sapiens | |
0.0328 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP | Homo sapiens | |
0.0359 | - |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | substrate: ATP, isoenzyme: NMNAT2 | Homo sapiens | |
0.0359 | - |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP | Homo sapiens | |
0.0369 | - |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | substrate: NMN, isoenzyme: NMNAT1 | Homo sapiens | |
0.0369 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate NaMN | Homo sapiens | |
0.0406 | - |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | substrate: ATP, isoenzyme: NMNAT3 | Homo sapiens | |
0.0406 | - |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP | Homo sapiens | |
0.041 | - |
NaAD+ | product inhibition of NMNAT2, substrate NMN | Homo sapiens | |
0.0431 | - |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | substrate: ATP, isoenzyme: NMNAT3 | Homo sapiens | |
0.0431 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP | Homo sapiens | |
0.0492 | - |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | substrate: ATP, isoenzyme: NMNAT1 | Homo sapiens | |
0.0492 | - |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP | Homo sapiens | |
0.0563 | - |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | substrate: ATP, isoenzyme: NMNAT1 | Homo sapiens | |
0.0563 | - |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP | Homo sapiens | |
0.0591 | - |
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate | substrate: ATP, isoenzyme: NMNAT1 | Homo sapiens | |
0.0591 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP | Homo sapiens | |
0.0668 | - |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | substrate: NMN, isoenzyme: NMNAT3 | Homo sapiens | |
0.0668 | - |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN | Homo sapiens | |
0.067 | - |
NAD+ | product inhibition of NMNAT2, substrate NMN | Homo sapiens | |
0.0679 | - |
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate | substrate: NMN, isoenzyme: NMNAT1 | Homo sapiens | |
0.0679 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN | Homo sapiens | |
0.0736 | - |
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate | substrate: NMN, isoenzyme: NMNAT3 | Homo sapiens | |
0.0736 | - |
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN | Homo sapiens | |
0.0845 | - |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | substrate: ATP, isoenzyme: NMNAT1 | Homo sapiens | |
0.0845 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP | Homo sapiens | |
0.0883 | - |
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate | substrate: NMN, isoenzyme: NMNAT3 | Homo sapiens | |
0.0883 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN | Homo sapiens | |
0.089 | - |
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate | substrate: NMN, isoenzyme: NMNAT1 | Homo sapiens | |
0.089 | - |
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate | pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN | Homo sapiens | |
0.095 | - |
NAD+ | product inhibition of NMNAT2, substrate ATP | Homo sapiens | |
0.1257 | - |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | substrate: NMN, isoenzyme: NMNAT2 | Homo sapiens | |
0.1257 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate NaMN | Homo sapiens | |
0.16 | - |
diphosphate | product inhibition of NMNAT2, substrate NMN | Homo sapiens | |
0.1745 | - |
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate | substrate: ATP, isoenzyme: NMNAT2 | Homo sapiens | |
0.1745 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP | Homo sapiens | |
0.175 | - |
diphosphate | product inhibition of NMNAT1, substrate ATP | Homo sapiens | |
0.205 | - |
NaAD+ | product inhibition of NMNAT3, substrate ATP | Homo sapiens | |
0.305 | - |
NaAD+ | product inhibition of NMNAT1, substrate ATP | Homo sapiens | |
0.3283 | - |
P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate | substrate: NMN, isoenzyme: NMNAT2 | Homo sapiens | |
0.3283 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN | Homo sapiens | |
0.334 | - |
diphosphate | product inhibition of NMNAT3, substrate ATP | Homo sapiens | |
0.361 | - |
diphosphate | product inhibition of NMNAT2, substrate ATP | Homo sapiens | |
0.364 | - |
NaAD+ | product inhibition of NMNAT3, substrate NMN | Homo sapiens | |
0.39 | - |
diphosphate | product inhibition of NMNAT1, substrate NMN | Homo sapiens | |
0.418 | - |
NAD+ | product inhibition of NMNAT1, substrate NMN | Homo sapiens | |
0.502 | - |
NaAD+ | product inhibition of NMNAT1, substrate NMN | Homo sapiens | |
0.6576 | - |
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate | substrate: ATP, isoenzyme: NMNAT2 | Homo sapiens | |
0.6576 | - |
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate | pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP | Homo sapiens | |
0.749 | - |
NAD+ | product inhibition of NMNAT1, substrate ATP | Homo sapiens | |
1 | - |
diphosphate | product inhibition of NMNAT3, substrate NMN | Homo sapiens | |
1.017 | - |
NAD+ | product inhibition of NMNAT3, substrate NMN | Homo sapiens | |
1.418 | - |
NAD+ | product inhibition of NMNAT3, substrate ATP | Homo sapiens |