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Literature summary for 2.7.7.1 extracted from

  • Zhang, X.; Kurnasov, O.V.; Karthikeyan, S.; Grishin, N.V.; Osterman, A.L.; Zhang, H.
    Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis (2003), J. Biol. Chem., 278, 13503-13511.
    View publication on PubMed
Search for more literature for 2.7.7.1

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli of PNAT-3 with a His-tag Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, 20 mg/ml protein mixed with an equal volume of reservoir solution containing 100 mM sodium cacodylate, pH 6-7, 200 mM Li2SO4 and 20-25% polyethylene glycol 400 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm PNAT-3 Homo sapiens 5737
-
mitochondrion PNAT-3 Homo sapiens 5739
-
nucleus PNAT-1 and PNAT-2 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + nicotinamide ribonucleotide Homo sapiens
-
 diphosphate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney PNAT-3 weak Homo sapiens
-
lung PNAT-3 Homo sapiens
-
placenta PNAT-3 weak Homo sapiens
-
spleen PNAT-3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Homo sapiens diphosphate + NAD+
-
 r
ATP + nicotinate ribonucleotide i.e. nicotinate mononucleotide Homo sapiens diphosphate + nicotinic acid-adenine dinucleotide
-
 r