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Literature summary for 2.7.7.1 extracted from
- Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy (2006), J. Neurosci., 26, 8484-8491.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | The expression of Nmnat1 itself is sufficient to protect axons in an in vitro Wallerian degeneration assay, suggesting that increased NAD production is crucial for axonal protection. | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | Nmnat1 | Mus musculus | 5737 | - |
| mitochondrion | NMNAT3 | Mus musculus | 5739 | - |
| nucleus | Nmnat1 | Mus musculus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | Mus musculus | - |
diphosphate + NAD+ | - |
? |  |
| nicotinic acid mononucleotide + ATP | Mus musculus | - |
nicotinic acid adenine dinucleotide + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q99JR6 | - |
- |
| Mus musculus | Q9EPA7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | - |
Mus musculus | diphosphate + NAD+ | - |
? | |
| nicotinic acid mononucleotide + ATP | - |
Mus musculus | nicotinic acid adenine dinucleotide + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nicotinamide mononucleotide adenylyltransferase 1 | - |
Mus musculus |
| NMNAT1 | - |
Mus musculus |
| NMNAT3 | - |
Mus musculus |
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