Literature summary for 2.7.7.1 extracted from

Ali, Y.O.; McCormack, R.; Darr, A.; Zhai, R.G.
Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway (2011), J. Biol. Chem., 286, 19089-19099.

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Synonyms

Synonyms	Comment	Organism
nicotinamide mononucleotide adenylyltransferase	-	Drosophila melanogaster
NMNAT	-	Drosophila melanogaster

Expression

Organism	Comment	Expression
Drosophila melanogaster	under hypoxia, hypoxia-inducible factor 1alpha up-regulates the enzyme indirectly through the induction of heat shock factor. Acute exposure to hypoxia (5% O2) for 3 h results in a 3.1fold up-regulation in enzyme transcript level. Heat shock at 37°C induces a 3fold increase in protein level between 8 and 12 h post-heat shock and a 3fold increase in enzyme transcript level at 3 h post-heat shock. A 3.3fold increase of protein level is seen in flies fed with 20 mM paraquat for 72 h	up

General Information

General Information	Comment	Organism
physiological function	nicotinamide mononucleotide adenylyltransferase (NMAT)is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway. NMAT is a stress response protein required for thermotolerance and mitigation of oxidative stress-induced shortened lifespan	Drosophila melanogaster

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Release 2023.1 (January 2023)