Literature summary for 3.4.22.56 extracted from

Kim, K.W.; Moretti, L.; Lu, B.
M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models (2008), PLoS ONE, 3, e2275.

Search for more literature for 3.4.22.56

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a caspase-3/-7 double-knockout mouse embryonic fibroblasts cell model for studying of autophagy contributing to the mechanism of increased cell death, following inhibition of apoptosis	Mus musculus
additional information	construction of an in vivo mouse hind limb H460 lung cancer model	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-({2-[5-tert-butyl-3-{[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]amino}-2-oxopyrazin-1(2H)-yl]butanoyl}amino)-5-[methyl(pentyl)amino]-4-oxopentanoic acid	a chemical and reversible caspase-3 inhibitor, M867 reduces clonogenic survival in H460 lung cancer cells	Homo sapiens
3-({2-[5-tert-butyl-3-{[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]amino}-2-oxopyrazin-1(2H)-yl]butanoyl}amino)-5-[methyl(pentyl)amino]-4-oxopentanoic acid	a chemical and reversible caspase-3 inhibitor, M867 with ionizing radiation in an in vivo mouse hind limb lung cancer model is well tolerated, and produces a significant tumor growth delay compared to radiation alone	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	embryonic	Mus musculus	-
lung cancer cell	-	Homo sapiens	-
NCI-H460 cell	-	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)