Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a caspase-3/-7 double-knockout mouse embryonic fibroblasts cell model for studying of autophagy contributing to the mechanism of increased cell death, following inhibition of apoptosis | Mus musculus |
additional information | construction of an in vivo mouse hind limb H460 lung cancer model | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-({2-[5-tert-butyl-3-{[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]amino}-2-oxopyrazin-1(2H)-yl]butanoyl}amino)-5-[methyl(pentyl)amino]-4-oxopentanoic acid | a chemical and reversible caspase-3 inhibitor, M867 reduces clonogenic survival in H460 lung cancer cells | Homo sapiens | |
3-({2-[5-tert-butyl-3-{[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]amino}-2-oxopyrazin-1(2H)-yl]butanoyl}amino)-5-[methyl(pentyl)amino]-4-oxopentanoic acid | a chemical and reversible caspase-3 inhibitor, M867 with ionizing radiation in an in vivo mouse hind limb lung cancer model is well tolerated, and produces a significant tumor growth delay compared to radiation alone | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | embryonic | Mus musculus | - |
lung cancer cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |