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BRENDA support

Literature summary for 1.14.14.18 extracted from

  • Hirai, K.; Sasahira, T.; Ohmori, H.; Fujii, K.; Kuniyasu, H.
    Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice (2007), Int. J. Cancer, 120, 500-505.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cobalt protoporphyrin IX 1 mg/kg, 5.9fold increase of activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
zinc protoporphyrin IX 0.005 mg/kg, 82% inhibition Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + electron donor + O2
-
Mus musculus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
HO-1
-
Mus musculus