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Literature summary for 1.14.11.66 extracted from

  • Toyokawa, G.; Cho, H.; Iwai, Y.; Yoshimatsu, M.; Takawa, M.; Hayami, S.; Maejima, K.; Shimizu, N.; Tanaka, H.; Tsunoda, T.; Field, H.; Kelly, J.; Neal, D.; Ponder, B.; Maehara, Y.; Nakamura, Y.; Hamamoto, R.
    The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6 (2011), Cancer Prev. Res. (Phila), 4, 2051-2061.
    View publication on PubMed
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Application

Application Comment Organism
medicine JMJD2B is a feasible molecular target for anticancer therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
JMJD2B quantitative real-time PCR expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
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 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O94953
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-

Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell elevated activity of JMJD2B expression Homo sapiens
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urinary bladder cancer cell elevated levels of JMJD2B expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
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 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone demethylase
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 Homo sapiens
JMJD2B
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction siRNA-mediated reduction of expression of JMJD2B in bladder and lung cancer cell lines significantly suppresses the proliferation of cancer cells, and suppressing JMJD2B expression leads to a decreased population of cancer cells in S phase, with a concomitant increase of cells in G1 phase Homo sapiens
metabolism expression levels of JMJD2B and CDK6 were significantly correlated in various types of cell lines Homo sapiens
physiological function histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6, transactivation of JMJD2B in lung cancer, elevated levels of JMJD2B expression in bladder cancer. The demethylase activity of JMJD2B possesses an oncogenic activity Homo sapiens