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(1E)-1-phenylhexa-1,5-dien-3-amine + H2O + O2
-1-phenylhexa-1,5-dien-3-one + NH3 + H2O2
3% relative activity, enzyme variant D9
-
-
?
(1R,6S)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane + H2O + O2
?
MAO-B catalyzed ring alpha-carbon oxidation of 3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane is enantioselective with an almost 5fold preference for the (1R,6S) enantiomer based on Vmax/Km values
-
-
?
(1S,6R)-3-methyl-6-phenyl-3-azabicyclo[4.1.0]heptane + H2O + O2
?
MAO-B catalyzed ring alpha-carbon oxidation of 3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane is enantioselective with an almost 5fold preference for the (1R,6S) enantiomer based on Vmax/Km values
-
-
?
(S)-1,2,3,4-tetrahydro-1-methylisoquinoline + H2O + O2
? + H2O2
-
-
-
?
1,2,3,4-tetrahydro-1-phenylisoquinoline + H2O + O2
? + H2O2
-
-
-
?
1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
1,4-dibenzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine
?
-
-
-
-
?
1-(2 aminoethyl)pyrrolidine + H2O + O2
?
-
-
-
-
?
1-(2,4-difluorophenyl)ethan-1-amine + H2O + O2
1-(2,4-difluorophenyl)ethan-1-one + NH3 + H2O2
148% relative activity, enzyme variant D9
-
-
?
1-(2,6-difluorophenyl)ethan-1-amine + H2O + O2
1-(2,6-difluorophenyl)ethan-1-one + NH3 + H2O2
48% relative activity, enzyme variant D9
-
-
?
1-(2-aminoethyl)pyrrolidine + H2O + O2
2,5,6,7-tetrahydro-3H-pyrrolo[1,2-a]imidazole + NH3 + H2O2
-
-
-
-
?
1-(2-bromo-4-fluorophenyl)ethan-1-amine + H2O + O2
1-(2-bromo-4-fluorophenyl)ethan-1-one + NH3 + H2O2
28% relative activity, enzyme variant D9
-
-
?
1-(2-chloro-4-fluorophenyl)ethan-1-amine + H2O + O2
1-(2-chloro-4-fluorophenyl)ethan-1-one + NH3 + H2O2
96% relative activity, enzyme variant D9
-
-
?
1-(2-chlorophenyl)ethan-1-amine + H2O + O2
1-(2-chlorophenyl)ethan-1-one + NH3 + H2O2
19% relative activity, enzyme variant D9
-
-
?
1-(2-fluorophenyl)ethan-1-amine + H2O + O2
1-(2-fluorophenyl)ethan-1-one + NH3 + H2O2
175% relative activity, enzyme variant D9
-
-
?
1-(2-fluorophenyl)propan-2-amine + H2O + O2
1-(2-fluorophenyl)propan-2-one + NH3 + H2O2
16% relative activity, enzyme variant D9
-
-
?
1-(2-methoxyphenyl)ethan-1-amine + H2O + O2
1-(2-methoxyphenyl)ethan-1-one + NH3 + H2O2
59% relative activity, enzyme variant D9
-
-
?
1-(2-methylphenyl)ethan-1-amine + H2O + O2
1-(2-methylphenyl)ethan-1-one + NH3 + H2O2
23% relative activity, enzyme variant D9
-
-
?
1-(3,5-difluorophenyl)ethan-1-amine + H2O + O2
1-(3,5-difluorophenyl)ethan-1-one + NH3 + H2O2
8% relative activity, enzyme variant D9
-
-
?
1-(3-fluorophenyl)ethan-1-amine + H2O + O2
1-(3-fluorophenyl)ethan-1-one + NH3 + H2O2
30% relative activity, enzyme variant D9
-
-
?
1-(3-methylphenyl)but-3-en-1-amine + H2O + O2
1-(3-methylphenyl)but-3-en-1-one + NH3 + H2O2
9% relative activity, enzyme variant D9
-
-
?
1-(4-bromo-3-fluorophenyl)but-3-en-1-amine + H2O + O2
1-(4-bromo-3-fluorophenyl)but-3-en-1-one + NH3 + H2O2
16% relative activity, enzyme variant D9
-
-
?
1-(4-bromophenyl)ethan-1-amine + H2O + O2
1-(4-bromophenyl)ethan-1-one + NH3 + H2O2
147% relative activity, enzyme variant D9
-
-
?
1-(4-bromophenyl)methanamine + H2O + O2
4-bromobenzaldehyde + NH3 + H2O2
1-(4-chlorophenyl)but-3-en-1-amine + H2O + O2
1-(4-chlorophenyl)but-3-en-1-one + NH3 + H2O2
20% relative activity, enzyme variant D9
-
-
?
1-(4-chlorophenyl)ethan-1-amine + H2O + O2
1-(4-chlorophenyl)ethan-1-one + NH3 + H2O2
246% relative activity, enzyme variant D9
-
-
?
1-(4-chlorophenyl)methanamine + H2O + O2
4-chlorobenzaldehyde + NH3 + H2O2
1-(4-fluoro-2-methylphenyl)ethan-1-amine + H2O + O2
1-(4-fluoro-2-methylphenyl)ethan-1-one + NH3 + H2O2
19% relative activity, enzyme variant D9
-
-
?
1-(4-fluoro-3-methylphenyl)ethan-1-amine + H2O + O2
1-(4-fluoro-3-methylphenyl)ethan-1-one + NH3 + H2O2
74% relative activity, enzyme variant D9
-
-
?
1-(4-fluorophenyl)ethan-1-amine + H2O + O2
1-(4-fluorophenyl)ethan-1-one + NH3 + H2O2
123% relative activity, enzyme variant D9
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2
4-fluorobenzaldehyde + NH3 + H2O2
1-(4-iodophenyl)ethan-1-amine + H2O + O2
1-(4-iodophenyl)ethan-1-one + NH3 + H2O2
39% relative activity, enzyme variant D9
-
-
?
1-(4-methoxyphenyl)ethan-1-amine + H2O + O2
1-(4-methoxyphenyl)ethan-1-one + NH3 + H2O2
111% relative activity, enzyme variant D9
-
-
?
1-(4-methoxyphenyl)methanamine + H2O + O2
4-methoxybenzaldehyde + NH3 + H2O2
1-(4-methylphenyl)ethan-1-amine + H2O + O2
1-(4-methylphenyl)ethan-1-one + NH3 + H2O2
211% relative activity, enzyme variant D9
-
-
?
1-(4-methylphenyl)methanamine + H2O + O2
4-methylbenzaldehyde + NH3 + H2O2
1-(5,6,7,8-tetrahydronaphthalen-2-yl)propan-1-amine + H2O + O2
1-(5,6,7,8-tetrahydrynaphthalen-2-yl)ethan-1-one + NH3 + H2O2
18% relative activity, enzyme variant D9
-
-
?
1-(6-methoxynaphthalen-2-yl)ethan-1-amine + H2O + O2
1-(6-methoxynaphthalen-2-yl)ethan-1-one + NH3 + H2O2
4% relative activity, enzyme variant D9
-
-
?
1-(adamantan-1-yl)ethan-1-amine + H2O + O2
1-(adamantan-1-yl)ethan-1-one + NH3 + H2O2
50% relative activity, enzyme variant D9
-
-
?
1-(furan-2-yl)ethan-1-amine + H2O + O2
1-(furan-2-yl)ethan-1-one + NH3 + H2O2
9% relative activity, enzyme variant D9
-
-
?
1-(naphthalen-2-yl)but-3-en-1-amine + H2O + O2
1-(naphthalen-2-yl)but-3-en-1-one + NH3 + H2O2
22% relative activity, enzyme variant D9
-
-
?
1-(pyridin-4-yl)but-3-en-1-amine + H2O + O2
1-(pyridin-4-yl)but-3-en-1-one + NH3 + H2O2
28% relative activity, enzyme variant D9
-
-
?
1-(pyrimidin-4-yl)ethan-1-amine + H2O + O2
1-(pyrimidin-4-yl)ethan-1-one + NH3 + H2O2
11% relative activity, enzyme variant D9
-
-
?
1-(thiophen-2-yl)ethan-1-amine + H2O + O2
1-(thiophen-2-yl)ethan-1-one + NH3 + H2O2
10% relative activity, enzyme variant D9
-
-
?
1-cyclohexylethan-1-amine + H2O + O2
1-cyclohexylethan-1-one + NH3 + H2O2
202% relative activity, enzyme variant D9
-
-
?
1-cyclopropyl-1-(4-fluorophenyl)methanamine + H2O + O2
cyclopropyl(4-fluorophenyl)methanone + NH3 + H2O2
184% relative activity, enzyme variant D9
-
-
?
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
?
1-methyl-3-phenyl-3-pyrroline + H2O + O2
1-methyl-3-phenylpyrrole + NH3 + H2O2
1-methyl-4-(1-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
?
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2
?
1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2
1-methyl-4-phenylpyridinium + 3 H2O2
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + O2
1-methyl-4-phenyl-2,3-dihydropyridinium + H2O2
-
-
-
-
?
1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine + H2O + O2
?
-
-
-
?
1-methylhistamine + H2O + O2
1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate
-
-
?
1-methylhistamine + H2O + O2
?
reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate
-
-
?
1-methylhistamine + O2 + H2O
1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
?
1-phenylbut-3-en-1-amine + H2O + O2
1-phenylbut-3-en-1-one + NH3 + H2O2
5% relative activity, enzyme variant D9
-
-
?
1-phenylethan-1-amine + H2O + O2
1-phenylethan-1-one + NH3 + H2O2
100% relative activity, enzyme variant D9
-
-
?
1-phenylpropan-1-amine + H2O + O2
1-phenylpropan-1-one + NH3 + H2O2
34% relative activity, enzyme variant D9
-
-
?
1-phenylpropan-2-amine + H2O + O2
1-phenylpropan-2-one+ NH3 + H2O2
22% relative activity, enzyme variant D9
-
-
?
1-[4-(trifluoromethyl)phenyl]ethan-1-amine + H2O + O2
1-(4-trifluoromethylphenyl)ethan-1-one + NH3 + H2O2
125% relative activity, enzyme variant D9
-
-
?
1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
2 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 3 O2
1-methyl-4-phenyl-2,3-dihydropyridinium + 1-methyl-4-phenylpyridinium + 4 H2O2
2,3-dihydro-1H-benzo[b]cyclopenta[d]thiophen-1-amine + H2O + O2
2,3-dihydro-1H-benzo[b]cyclopenta[d]thiophen-1-one + NH3 + H2O2
12% relative activity, enzyme variant D9
-
-
?
2,3-dihydro-1H-inden-1-amine + H2O + O2
2,3-dihydro-1H-inden-1-one + NH3 + H2O2
199% relative activity, enzyme variant D9
-
-
?
2,3-dihydro-1H-inden-1-one + NH3 + H2O2
2,3-dihydro-1H-inden-1-amine + H2O + O2
165% relative activity, enzyme variant D11
-
-
?
2,3-dihydro-7-azaindole + H2O + O2
?
-
-
-
-
?
2-azabicyclo(2.2.1)hept-5-ene-3-one + H2O + O2
?
-
-
-
-
?
2-chlorobenzylamine + H2O + O2
2-chlorobenzaldehyde + NH3 + H2O2
-
-
-
-
r
2-methyl-1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
2-methyl-1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
4% relative activity, enzyme variant D9
-
-
?
2-phenyl-pyrroline + H2O + O2
? + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylacetaldehyde + NH3 + H2O2
-
the enzyme shows high substrate specificity for phenethylamine (100% activity)
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
2-phenylethylamine + H2O + O2
?
-
-
-
-
?
3,4-dihydro-2H-1-benzopyran-4-amine + H2O + O2
2,3-dihydro-4H-1-benzopyran-4-one + NH3 + H2O2
22% relative activity, enzyme variant D9
-
-
?
3-(2,3-dihydro-1H-indole-1-yl)propan-1-amine + H2O + O2
2,3,4,10-tetrahydropyrimido[1,2-a]indole + NH3 + H2O2
-
-
-
-
?
3-(2,3-dihydro-1H-indole-1-yl)propan-1-amine + H2O + O2
?
-
-
-
-
?
3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine + H2O + O2
3-(4-[3-[(thiophen-2-ylmethyl)amino]propoxy]butoxy)propanal + NH3 + H2O2
-
-
-
?
3-azabicyclo[3,3,0]octane + H2O + O2
3-azabicyclo-[3,3,0]oct-2-ene + NH3 + H2O2
-
-
-
-
?
3-chlorobenzylamine + H2O + O2
3-chlorobenzaldehyde + NH3 + H2O2
-
-
-
-
r
3-hydroxypiperidine + H2O + O2
?
-
-
-
-
?
3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane + H2O + O2
?
-
MAO-B selective substrate, no activity with MAO-A
-
-
?
3-methylbenzylamine + H2O + O2
3-methylbenzaldehyde + NH3 + H2O2
-
-
-
-
r
3-phenyl-3-pyrroline + H2O + O2
4-phenyl-2H-pyrrole + ?
-
4-phenyl-2H-pyrrole rapidly tautomerizes to 5-phenyl-2H-pyrrole
-
?
3-phenylpropylamine + H2O + O2
3-phenylpropanal + NH3 + H2O2
-
-
-
?
3-pyrroline + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
? + H2O2 + NH3
3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
-
r
4-bromo-2,3-dihydro-1H-inden-1-amine + H2O + O2
4-bromo-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
4% relative activity, enzyme variant D9
-
-
?
4-carboxybenzylamine + H2O + O2
?
-
-
-
-
?
4-chloro-2,3-dihydro-1H-inden-1-amine + H2O + O2
4-chloro-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
3% relative activity, enzyme variant D9
-
-
?
4-chlorobenzylamine + H2O + O2
4-chlorobenzaldehyde + NH3 + H2O2
-
-
-
-
r
4-dimethylaminophenethylamine + H2O + O2
?
substrate of MAO-B
-
-
?
4-dimethylaminophenylethylamine + H2O + O2
?
-
substrate of MAO-B
-
-
?
4-fluoro-2,3-dihydro-1H-inden-1-amine + H2O + O2
4-fluoro-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
101% relative activity, enzyme variant D9
-
-
?
4-hydroxy-3-methoxy-2-phenylethylamine + H2O + O2
?
-
-
-
-
r
4-methoxy-2-phenylethylamine + H2O + O2
?
-
-
-
-
r
4-methyl-1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
4-methyl-1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
5% relative activity, enzyme variant D9
-
-
?
4-methylpentan-2-amine + H2O + O2
4-methylpentan-2-one + NH3 + H2O2
69% relative activity, enzyme variant D9
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
proposed pathways for amine oxidation: the amine substrate may bind to oxidised enzyme (E/FADox), leading to the release of product imine via a binary (1) or ternary (2) pathway. The relative contributions of these pathways cannot be determined directly by steady-state approaches. In following pathway 1, the unoccupied reduced enzyme (E/FADred) is generated, to which substrate may also bind. Reoxidation of the E/FADredS species (pathway 3) bypasses direct regeneration of E/FADox, with the consequence that imine released subsequent to this step, whether through the binary or ternary pathways leading from E/FADredimine, is a product of substrate binding to a second enzyme species
-
-
?
4-phenylbutylamine + H2O + O2
?
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
4-tyramine + H2O + O2
2-(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
4-tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
5,6-dihydro-4H-cyclopenta[b]thiophen-4-amine + H2O + O2
6-dihydro-4H-cyclopenta[b]thiophen-4-one + NH3 + H2O2
33% relative activity, enzyme variant D9
-
-
?
5-amino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile + H2O + O2
5-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile + NH3 + H2O2
103% relative activity, enzyme variant D9
-
-
?
5-aminobenzimidazole + H2O + O2
?
-
-
-
-
?
5-fluoro-2,3-dihydro-1H-inden-1-amine + H2O + O2
5-fluoro-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
242% relative activity, enzyme variant D9
-
-
?
5-hydroxytryptamine + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
5-hydroxytryptamine + H2O + O2
?
-
-
-
?
5-methoxy-N,N-dimethyltryptamine + H2O + O2
?
5-methyl-2,3-dihydro-1H-inden-1-amine + H2O + O2
5-methyl-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
61% relative activity, enzyme variant D9
-
-
?
5-methyl-4,5,6,7-tetrahydro-1-benzofuran-4-amine + H2O + O2
5-methyl-4,5,6,7-tetrahydro-1-benzofuran-4-one + NH3 + H2O2
214% relative activity, enzyme variant D9
-
-
?
5-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulene + H2O + O2
6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one + methylamine + H2O2
6% relative activity, enzyme variant D9
-
-
?
5-methylindoline + H2O + O2
?
-
-
-
-
?
6-chloro-2,3-dihydro-1H-inden-1-amine + H2O + O2
6-chloro-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
103% relative activity, enzyme variant D9
-
-
?
6-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
6-fluoro-1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
155% relative activity, enzyme variant D9
-
-
?
6-fluoro-2,3-dihydro-1H-inden-1-amine + H2O + O2
6-fluoro-2,3-dihydro-1H-inden-1-one + NH3 + H2O2
143% relative activity, enzyme variant D9
-
-
?
6-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
6-methoxy-1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
49% relative activity, enzyme variant D9
-
-
?
6-methylhept-1-en-4-amine + H2O + O2
6-methylhept-1-en-4-one + NH3 + H2O2
27% relative activity, enzyme variant D9
-
-
?
7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
7-fluoro-1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
90% relative activity, enzyme variant D9
-
-
?
7-methyl-1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
7-methyl-1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
39% relative activity, enzyme variant D9
-
-
?
7-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-amine + H2O + O2
7-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one + NH3 + H2O2
14% relative activity, enzyme variant D9
-
-
?
alpha-methylbenzylamine + H2O + O2
alpha-methylbenzaldehyde + NH3 + H2O2
-
-
-
-
r
amylamine + H2O + O2
?
-
-
-
-
r
benzyl-2-azabicyclo[3.3.0]octane-3 carboxylate + H2O + O2
?
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
benzylamine + H2O + O2
benzylaldehyde + NH3 + H2O2
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
beta-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
-
-
-
?
bicyclo[4.2.0]octa-1,3,5-trien-7-amine + H2O + O2
bicyclo[4.2.0]octa-1,3,5-trien-7-one + NH3 + H2O2
12% relative activity, enzyme variant D9
-
-
?
butan-2-amine + H2O + O2
butan-2-one + NH3 + H2O2
67% relative activity, enzyme variant D9
-
-
?
cis-8-azabicyclo[4.3.0]nonane + H2O + O2
?
-
-
-
-
?
decahydroquinoline + H2O + O2
?
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
dopamine + H2O + O2
?
-
-
-
-
?
epinephrine + H2O + O2
?
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
-
50% activity compared to n-propylamine
-
-
?
ethylamine + H2O + O2
ethanal + NH3 + H2O2
heptamethyleneimine + H2O + O2
?
-
-
-
-
?
heptan-2-amine + H2O + O2
heptan-2-one + NH3 + H2O2
87% relative activity, enzyme variant D9
-
-
?
hexamethyleneimine + H2O + O2
?
-
-
-
-
?
hexylamine + H2O + O2
hexanal + NH3 + H2O2
-
7% activity compared to n-propylamine
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
histamine + O2 + H2O
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
kynuramine + H2O + O2
4-hydroxyquinoline + NH3 + H2O2
kynuramine + O2
4-hydroxyquinoline + NH3 + H2O2
methoxytryptamine + H2O + O2
?
methyl pyrrolidine + H2O + O2
?
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
34% activity compared to n-propylamine
-
-
?
n-butylamine + H2O + O2
butyraldehyde + NH3 + H2O2
N-methyl-1-phenylethan-1-amine + H2O + O2
1-phenylethan-1-one + methylamine + H2O2
14% relative activity, enzyme variant D9
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
n-pentylamine + H2O + O2
pentaldehyde + NH3 + H2O2
-
56% activity compared to n-propylamine
-
-
?
n-propylamine + H2O + O2
propionaldehyde + NH3 + H2O2
-
100% activity
-
-
?
N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine + H2O + O2
12-[(thiophen-2-ylmethyl)amino]dodecanal + NH3 + H2O2
-
-
-
?
N1-benzyl-N1-methyldodecane-1,12-diamine + H2O + O2
12-[benzyl(methyl)amino]dodecanal + NH3 + H2O2
-
-
-
?
N1-benzyldodecane-1,12-diamine + H2O + O2
12-(benzylamino)dodecanal + NH3 + H2O2
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
noradrenaline + H2O + O2
?
norepinephrine + H2O + O2
?
-
-
-
-
?
p-nitrobenzylamine + H2O + O2
4-nitrobenzaldehyde + NH3 + H2O2
p-nitrophenylethylamine + H2O + O2
4-nitrophenylacetaldehyde + NH3 + H2O2
good substrate for wild-type and mutant enzymes Y435H, Y435F, Y435L and Y435W
-
-
?
p-trifluoromethyl-benzylamine + H2O + O2
4-trifluoromethylbenzaldehyde + NH3 + H2O2
-
-
-
?
p-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
p-tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
phenylbutylamine + H2O + O2
2-phenylbutanal + NH3 + H2O2 + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2 + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylethanal + NH3 + H2O2
-
-
-
?
pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
? + H2O2 + NH3
-
-
-
?
pyrrolidine + H2O + O2
?
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
RCH2NHR' + H2O + O2
RCHO + R'NH2 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
serotonin + O2 + H2O
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
5-hydroxytryptamine, MAO-A
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
tryptamine + H2O + O2
1H-indol-3-yl-acetaldehyde + NH3 + H2O2
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
tyramine + O2 + H2O
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
additional information
?
-
1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
19% relative activity, enzyme variant D11
-
-
?
1,2,3,4-tetrahydronaphthalen-1-amine + H2O + O2
1,2,3,4-tetrahydronaphthalen-1-one + NH3 + H2O2
92% relative activity, enzyme variant D9
-
-
?
1-(4-bromophenyl)methanamine + H2O + O2
4-bromobenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-bromophenyl)methanamine + H2O + O2
4-bromobenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-chlorophenyl)methanamine + H2O + O2
4-chlorobenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-chlorophenyl)methanamine + H2O + O2
4-chlorobenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2
4-fluorobenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2
4-fluorobenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-methoxyphenyl)methanamine + H2O + O2
4-methoxybenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-methoxyphenyl)methanamine + H2O + O2
4-methoxybenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-methylphenyl)methanamine + H2O + O2
4-methylbenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-(4-methylphenyl)methanamine + H2O + O2
4-methylbenzaldehyde + NH3 + H2O2
-
-
-
-
?
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
?
-
-
-
?
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
?
-
-
-
?
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
?
-
-
-
-
?
1-methyl-3-phenyl-3-pyrroline + H2O + O2
1-methyl-3-phenylpyrrole + NH3 + H2O2
oxidation is a 2-electron process. Rapid clearance of 1-methyl-3-phenylpyrrole from the brain may contribute to their lack of neurotoxicity
-
-
?
1-methyl-3-phenyl-3-pyrroline + H2O + O2
1-methyl-3-phenylpyrrole + NH3 + H2O2
oxidation is a 2-electron process. Rapid clearance of 1-methyl-3-phenylpyrrole from the brain may contribute to their lack of neurotoxicity
-
-
?
1-methyl-3-phenyl-3-pyrroline + H2O + O2
1-methyl-3-phenylpyrrole + NH3 + H2O2
-
oxidation is a 2-electron process. Rapid clearance of 1-methyl-3-phenylpyrrole from the brain may contribute to their lack of neurotoxicity
-
-
?
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
i.e. MMTP, is oxidized to the corresponding dihydropyridinium metabolite, MMDP+
-
-
?
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
i.e. MMTP, is oxidized to the corresponding dihydropyridinium metabolite, MMDP+
-
-
?
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
-
?
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
i.e. MMTP
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2
1-methyl-4-phenylpyridinium + 3 H2O2
the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is oxidized to 1-methyl-4-phenylpyridinium MPP+, a 4-electron oxidation product and a potent mitochondrial toxin
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2
1-methyl-4-phenylpyridinium + 3 H2O2
the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is oxidized to 1-methyl-4-phenylpyridinium MPP+, a 4-electron oxidation product and a potent mitochondrial toxin
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2
1-methyl-4-phenylpyridinium + 3 H2O2
-
the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is oxidized to 1-methyl-4-phenylpyridinium MPP+, a 4-electron oxidation product and a potent mitochondrial toxin
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
1-methyl-4-phenylpyridinium is the ultimate product
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
-
-
-
?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
?
-
1-methyl-4-phenylpyridinium is the ultimate product
-
-
?
1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
-
-
-
-
?
1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
-
-
-
-
?
1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
-
-
-
-
?
2 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 3 O2
1-methyl-4-phenyl-2,3-dihydropyridinium + 1-methyl-4-phenylpyridinium + 4 H2O2
-
activation of the neurotoxin to neurotoxic pyridinium cations. MPTP easily crosses the blood-brain barrier and is preferentially metabolized by MAO-B present in glial cells to 1-methyl-4-phenyl-2,3-dihydropyridinium. This enzymatic metabolite is subsequently oxidized to 1-methyl-4-phenylpyridinium, which is selectively uptaken by dopaminergic cells, producing inhibition of complex I of mitochondria, energy depletion, oxidative stress and cell death
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is metabolically oxidized by alpha-carbon oxidation by MAO enzymes to give 1-methyl-4-phenyl-2,3-dihydropyridinium and hydrogen peroxide, which, in a further step, is readily oxidized to 1-methyl-4-phenylpyridinium, that is a directly-acting neurotoxic substance
-
?
2 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 3 O2
1-methyl-4-phenyl-2,3-dihydropyridinium + 1-methyl-4-phenylpyridinium + 4 H2O2
-
activation of the neurotoxin to neurotoxic pyridinium cations
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
MAO-B selective substrate
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
MAO-B selective substrate
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
MAO-B selective substrate
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
proposed pathways for amine oxidation: the amine substrate may bind to oxidised enzyme (E/FADox), leading to the release of product imine via a binary (1) or ternary (2) pathway. The relative contributions of these pathways cannot be determined directly by steady-state approaches. In following pathway 1, the unoccupied reduced enzyme (E/FADred) is generated, to which substrate may also bind. Reoxidation of the E/FADredS species (pathway 3) bypasses direct regeneration of E/FADox, with the consequence that imine released subsequent to this step, whether through the binary or ternary pathways leading from E/FADredimine, is a product of substrate binding to a second enzyme species
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
9% activity compared to n-propylamine
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
MAO-B selective substrate
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
reaction with MAO-A
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
reaction with MAO-B
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
3% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (serotonin, 1 mM) for various amine oxidases
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
4% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (1 mM) for various amine oxidases
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
substrate for isoform MAO A
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
4-tyramine + H2O + O2
2-(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
4-tyramine + H2O + O2
2-(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
4-tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
4-tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
in vivo activity, overview
-
-
?
4-tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
substrate for both hMAO-A and hMAO-B
-
-
?
4-tyramine + H2O + O2
?
-
-
-
-
?
4-tyramine + H2O + O2
?
-
substrate for both hMAO-A and hMAO-B
-
-
?
5-methoxy-N,N-dimethyltryptamine + H2O + O2
?
-
i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius. 5-MeO-DMT is known as a nonselective 5-HT receptor agonist. MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination
-
-
?
5-methoxy-N,N-dimethyltryptamine + H2O + O2
?
-
i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius
-
-
?
5-methoxy-N,N-dimethyltryptamine + H2O + O2
?
-
i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius. 5-MeO-DMT is known as a nonselective 5-HT receptor agonist. MAO-A eliminates the drug 5-MeO-DMT through oxidative deamination
-
-
?
5-methoxy-N,N-dimethyltryptamine + H2O + O2
?
-
i.e. 5-MeO-DMT, a psychoactive indolealkylamine drug found in a variety of plant preparations, e.g. Virola snuffs and Ayahuasca, and venom of psychoactive toads, e.g. Colorado River Bufo alvarius
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
60% activity compared to 2-phenylethylamine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
MAO-B selective substrate
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
analogs
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
MAO-A
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
MAO-A
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
insights into the interactions that take place on activation of the amine substrate by the aromatic cage residues in MAO-B Tyr398 and Try435
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
proposed pathways for amine oxidation: the amine substrate may bind to oxidised enzyme (E/FADox), leading to the release of product imine via a binary (1) or ternary (2) pathway. The relative contributions of these pathways cannot be determined directly by steady-state approaches. In following pathway 1, the unoccupied reduced enzyme (E/FADred) is generated, to which substrate may also bind. Reoxidation of the E/FADredS species (pathway 3) bypasses direct regeneration of E/FADox, with the consequence that imine released subsequent to this step, whether through the binary or ternary pathways leading from E/FADredimine, is a product of substrate binding to a second enzyme species
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
substrate for isoform MAO B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
74% activity compared to n-propylamine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
Neogale vison
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
11% activity compared to tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
32% activity compared to tyramine
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
MAO-B selective substrate
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
MAO-A
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
monoamine oxidase B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
reaction with MAO-A
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
reaction with MAO-B
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzylaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzylaldehyde + NH3 + H2O2
-
-
-
-
?
beta-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
Neogale vison
-
-
-
-
?
beta-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
nonselective substrate
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
ethylamine + H2O + O2
ethanal + NH3 + H2O2
-
-
-
?
ethylamine + H2O + O2
ethanal + NH3 + H2O2
-
84% activity compared to n-propylamine
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate
-
-
?
histamine + H2O + O2
?
reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate
-
-
?
histamine + H2O + O2
?
-
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
MAO-A
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
MAO-B
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
MAO-A
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
MAO-A
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
monoamine oxidase A
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
nonselective substrate
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
MAO-A
-
-
?
kynuramine + H2O + O2
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
4-hydroxyquinoline + NH3 + H2O2
-
-
-
?
kynuramine + H2O + O2
4-hydroxyquinoline + NH3 + H2O2
a method is decribed to measure MAO activity and inhibition based on the oxidation of kynuramine determined by HPLC-DAD, combined in the same assay with the oxidation of a peroxidase substrate
-
-
?
kynuramine + H2O + O2
?
-
-
-
-
?
kynuramine + H2O + O2
?
-
-
-
?
kynuramine + O2
4-hydroxyquinoline + NH3 + H2O2
-
-
-
-
?
kynuramine + O2
4-hydroxyquinoline + NH3 + H2O2
-
-
-
-
?
kynuramine + O2
4-hydroxyquinoline + NH3 + H2O2
-
-
-
?
kynuramine + O2
4-hydroxyquinoline + NH3 + H2O2
-
-
-
-
?
kynuramine + O2
4-hydroxyquinoline + NH3 + H2O2
-
-
-
?
methoxytryptamine + H2O + O2
?
-
-
-
-
?
methoxytryptamine + H2O + O2
?
-
-
-
-
?
n-butylamine + H2O + O2
butyraldehyde + NH3 + H2O2
-
-
-
-
r
n-butylamine + H2O + O2
butyraldehyde + NH3 + H2O2
-
98% activity compared to n-propylamine
-
-
?
n-butylamine + H2O + O2
butyraldehyde + NH3 + H2O2
-
-
-
-
r
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
N-methylhistamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + methylamine + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
(2R)-(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde + NH3 + H2O2
-
-
-
-
?
noradrenaline + H2O + O2
?
-
-
-
-
?
noradrenaline + H2O + O2
?
-
-
-
-
?
p-nitrobenzylamine + H2O + O2
4-nitrobenzaldehyde + NH3 + H2O2
poor substrate for wild-type enzyme and mutant enzymes Y435H and Y435F
-
-
?
p-nitrobenzylamine + H2O + O2
4-nitrobenzaldehyde + NH3 + H2O2
insights into the interactions that take place on activation of the amine substrate by the aromatic cage residues in MAO-B Tyr398 and Try435
-
-
?
p-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
p-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
p-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
MAO-B
-
-
?
p-tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
monoamine oxidase A
-
-
?
p-tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
monoamine oxidase B
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
MAO-A
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
MAO-A
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
MAO-A
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
norepinephrine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with octopamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
n-butylamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
specificity
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
specificity
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
benzylhydrazine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
oxidizes primary, secondary and tertiary amines
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
5-hydroxytryptamine, MAO-A selective substrate
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
5-hydroxytryptamine, MAO-A selective substrate
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
alpha-methylbenzylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
responsible for the catabolism of various biogenic amine neurotransmitters as well as for the metabolism of certain exogenous amines
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
important functions in the metabolism of biogenic amines in the central nervous system and peripheral tissues
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
5-hydroxytryptamine, MAO-A selective substrate
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
important functions in the metabolism of biogenic amines in the central nervous system and peripheral tissues
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
important functions in the metabolism of biogenic amines in the central nervous system and peripheral tissues
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
specificity
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
phenylethylhydrazine
-
-
r
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
norepinephrine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
5-hydroxytryptamine, MAO-A selective substrate
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
4-hydroxy-3-methoxy-2-phenylethylamine, nonselective substrate, 4-methoxy-2-phenylethylamine, 5-methoxytryptamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
octopamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
responsible for the catabolism of various biogenic amine neurotransmitters as well as for the metabolism of certain exogenous amines
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with spermidine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with spermidine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with histamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
no activity with spermine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
phenylethylhydrazine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
phenylethylhydrazine
-
r
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
isoamylamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
3-hydroxytyramine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
o-, m-, p-chlorobenzylamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
alpha-methylbenzylamine
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
amylamine
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
amylamine
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
r
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
monoamine oxidase A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin. MAO A is a putative target gene directly regulated by a transcription factor encoded by the sex-determining region Y, SRY, gene located on the Y chromosome, via the functional SRY-binding site in the MAO A core promoter
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
substrate of MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
Neogale vison
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
85% activity compared to tyramine
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
27% activity compared to tyramine
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
reaction with MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
substrate of MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
substrate of MAO-A
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
serotonin + H2O + O2
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
Neogale vison
-
-
-
-
?
tryptamine + H2O + O2
1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
80% activity compared to tyramine
-
-
?
tryptamine + H2O + O2
1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
73% activity compared to tyramine
-
-
?
tryptamine + H2O + O2
1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
?
-
-
-
-
?
tryptamine + H2O + O2
?
-
-
-
-
?
tryptamine + H2O + O2
?
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
nonselective substrate
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
nonselective substrate
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
Neogale vison
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
H2O2-generated during tyramine oxidation by MAO-A triggers a stress-induced mitogenic signaling via the MMP2/sphingolipid pathway, which could participate in excessive remodeling and alteration of the vascular wall
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
100% activity
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
100% activity
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
nonselective substrate
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
reaction with MAO-A
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
reaction with MAO-B
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
?
-
-
-
-
?
tyramine + H2O + O2
?
-
-
-
-
?
additional information
?
-
the enzyme is used to successfully identify the alkaloid (+/-)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% enantiomeric excess
-
-
?
additional information
?
-
-
the enzyme is used to successfully identify the alkaloid (+/-)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% enantiomeric excess
-
-
?
additional information
?
-
-
no activity with tyramine, tryptamine, serotonin, dopamine, ethanolamine, histamine, ethylamine, n-propylamine, n-butylamine, n-pentylamine, putrescine, and spermidine
-
-
?
additional information
?
-
-
3-aminomethylpyridine is not a substrate
-
-
?
additional information
?
-
-
enzyme is involved in the degradation of many biological amines in the nervous system and in peripheral organs
-
-
?
additional information
?
-
-
the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers
-
-
?
additional information
?
-
-
the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers
-
-
?
additional information
?
-
-
key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. Differential regulation of MAO A by glucocorticoid and androgen
-
-
?
additional information
?
-
the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines
-
-
?
additional information
?
-
the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines
-
-
?
additional information
?
-
-
the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines
-
-
?
additional information
?
-
MAO-A shows no activity with 3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane
-
-
?
additional information
?
-
MAO B is a stable trait marker for alcoholism. The associations obtained between platelet MAO B activity with executive neurocognitive task and hostility component may support the involvement of plateletMAOB activity in the further development of an impulsive cognitive style
-
-
?
additional information
?
-
-
MAO B is a stable trait marker for alcoholism. The associations obtained between platelet MAO B activity with executive neurocognitive task and hostility component may support the involvement of plateletMAOB activity in the further development of an impulsive cognitive style
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additional information
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active site structure, overview
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additional information
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active site structure, overview
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additional information
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active site structure, overview
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additional information
?
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in the catalytic cycle of MAO-B, one mol each of an iminiumyl intermediate that is hydrolyzed to the aldehyde product and H2O2 are produced for each mol of monoamine substrate oxidized. These catabolic products may be neurotoxic if not rapidly inactivated by centrally located aldehyde dehydrogenase and glutathione peroxidase, respectively
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additional information
?
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MAO-A degrades monoamines including neurotransmitters
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additional information
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isozyme active site structures, overview
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additional information
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isozyme active site structures, overview
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additional information
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isozyme active site structures, overview
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additional information
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structure-activity studies on wild-type and mutant enzymes, active site structure, overview
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additional information
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structure-activity studies on wild-type and mutant enzymes, active site structure, overview
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additional information
?
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ABTS assay is used to measure total antioxidant activity of nitroindazoles against the radical ABTS*+, overview
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additional information
?
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active site cavities in MAO-B and in MAO-A, in MAO-B the cavity is extended and substrate binding is likely to occur in proximity to the outer mitochondrial membrane surface region with the entrance loop, residues 99-110, involved in the access, overview
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additional information
?
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development of a facile capillary electrophoresis method for detection of MAO-B activity in plant extracts, evaluation, overview
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additional information
?
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the enzyme does not deaminate histamine
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additional information
?
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the enzyme does not deaminate histamine and putrescine
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additional information
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substrate activation of MAO can interact with adipocyte metabolism by mimicking diverse effects of insulin in addition to preventing tumor necrosis factor alpha-dependent responses
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additional information
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MAO A KO mice display attenuated endocrine responses to major stressors, such as restraint, cold temperature, prolonged water deprivation and chronic variable stress
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additional information
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MAO A deficiency in Tg8 mice is accompanied by increased expression of different kinds of aggression, as well as by disruption of normal pattern of social interaction
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additional information
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MAO A deficiency in Tg8 mice is accompanied by increased expression of different kinds of aggression, as well as by disruption of normal pattern of social interaction
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?
additional information
?
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in the catalytic cycle of MAO-B, one mol each of an iminiumyl intermediate that is hydrolyzed to the aldehyde product and H2O2 are produced for each mol of monoamine substrate oxidized. These catabolic products may be neurotoxic if not rapidly inactivated by centrally located aldehyde dehydrogenase and glutathione peroxidase, respectively
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additional information
?
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no activity with tryptamine, serotonin, dopamine, tyramine, histamine, putrescine, cadaverine, diaminodecane, spermidine, and spermine
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additional information
?
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Neogale vison
-
substrate specificity, overview, no activity with histamine
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additional information
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the enzyme does not deaminate histamine
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additional information
?
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molecular modelling of MAO-B ligand binding, overview
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additional information
?
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the enzyme does not deaminate histamine
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?
additional information
?
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the enzyme does not deaminate putrescine and cadaverine
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additional information
?
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the enzyme does not deaminate histamine
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additional information
?
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the enzyme catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design
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additional information
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no significant activity with serotonin
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additional information
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MAOB shows no activity with serotonin
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additional information
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MAOB shows no activity with serotonin
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additional information
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active site structure, overview
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additional information
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active site structure, overview
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additional information
?
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substrate specificity, overview, no activity with histamine
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(+)-amphetamine
reversible competitive inhibitor
(+/-)-6-hydroxytrypargine
-
an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata, synthesized by reaction of 5-hydroxytryptamine hydrochloride with N-(3-[1,3]dioxolan-2-yl-propyl)-guanidine sulfate, overview
(1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine
-
-
(1R,2R)-(-)-psi-ephedrine
-
IC50 for soluble enzyme: 5.03 mM, IC50 for immobilized enzyme: 88 mM, monoamine oxidase B; IC50 for soluble enzyme: 5.35 mM, IC50 for immobilized enzyme: 14.86 mM, monoamine oxidase A
(1S,2S)-(+)-psi-ephedrine
-
IC50 for soluble enzyme: 0.88 mM, IC50 for immobilized enzyme: 1.77 mM, monoamine oxidase A; IC50 for soluble enzyme: 10 mM, IC50 for immobilized enzyme: 234 mM, monoamine oxidase B
(1Z)-2-methylcyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.39
(2-methylprop-2-en-1-yl)hydrazine
-
(2-phenylprop-2-en-1-yl)hydrazine
-
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
-
-
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-(4-methylphenyl)prop-2-en-1-one
-
-
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-phenylprop-2-en-1-one
-
-
(2E)-1-(4-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]prop-2-en-1-one
competitive inhibition
(2E)-1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
competitive inhibition
(2E)-1-[4-(benzyloxy)phenyl]-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-(3-hydroxyphenyl)ethanamide
-
-
(2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-phenylethanamide
-
-
(2E)-2-[(1H-indol-3-yl)methylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 10% inhibition; 0.1 mM, pH 7.4, 43% inhibition
-
(2E)-2-[(2-chloro-3-methoxyphenyl)methylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 17% inhibition
-
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carbothioamide
0.1 mM, pH 7.4, 32% inhibition
-
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide
-
-
(2E)-2-[1-(2,4,5-trifluorophenyl)ethylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 23% inhibition
-
(2E)-2-[1-(2,4-dihydroxy-5-nitrophenyl)ethylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 30% inhibition; 0.1 mM, pH 7.4, 8% inhibition
-
(2E)-2-[1-(4-chloro-3-nitrophenyl)ethylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 13% inhibition; 0.3% inhibition
-
(2E)-2-[1-(4-iodophenyl)ethylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 25% inhibition
-
(2E)-2-[1-[3-(dihydroxyamino)-4-methoxyphenyl]ethylidene]hydrazine-1-carboxamide
0.1 mM, pH 7.4, 19% inhibition; 0.1 mM, pH 7.4, 37.2% inhibition
-
(2E)-2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3(2H)-ylidene]-N-methylacetamide
-
-
(2E)-3-(2-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
competitive inhibition
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
-
(2E)-3-(3-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
competitive inhibition
(2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
-
inhibits MAO-A and MAO-B
(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
-
-
(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one
-
-
(2E)-3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
-
-
(2E)-3-(4-chlorophenyl)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one
-
-
(2E)-3-(4-chlorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
-
-
(2E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
-
-
(2E)-3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
competitive inhibition
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal
-
-
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal
-
-
(2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal
-
-
(2E)-3-[4-(benzyloxy)phenyl]-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one
-
-
(2E)-3-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)prop-2-en-1-one
-
-
(2E)-3-[4-(benzyloxy)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one
-
-
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
-
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide
i.e. guineensine, isolated from dried fruits of Piper longum, competitive inhibition; i.e. guineensine, isolated from dried fruits of Piper longum, competitive inhibition
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
i.e. methylpiperate, isolated from dried fruits of Piper longum, competitive inhibition; i.e. methylpiperate, isolated from dried fruits of Piper longum, competitive inhibition
(2R)-1-(3-methoxyphenoxy)-3-(1-methylhydrazino)propan-2-ol
-
-
(2R)-1-cyclohexyl-N-methyl-N-(1H-pyrrol-2-ylmethyl)propan-2-amine
-
(2S)-1-(3-methoxyphenoxy)-3-(1-methylhydrazino)propan-2-ol
-
-
(2S)-2-[4-(3-fluorobenzyloxy)benzylamino]propionamide
-
i.e. safinamide, a potent selective and reversible MAO-B inhibitor, occurs in two polymorphic forms. Both forms are orthorhombic and regarded as conformational polymorphs due to the differences in the orientation of the 3-fluorobenzyloxy and propanamide groups. Both structures pack with layers in the ac plane, structure overview
(3E)-3-[2-(ethylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
1% inhibition of isoform MAO-B at 0.01 mM, 14% inhibition of isoform MAO-A at 0.01 mM
(3E)-3-[2-(isopropylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
4% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3,3,3-trifluoropropane-1-sulfonate
-
5% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
-
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-cyanobenzenesulfonate
-
-
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-fluorobenzenesulfonate
-
6% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-(methylsulfonyl)benzenesulfonate
-
6%inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-acetylbenzenesulfonate
-
13% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-chlorobenzenesulfonate
-
-
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-cyanobenzenesulfonate
-
6% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-methoxybenzenesulfonate
-
5% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-nitrobenzenesulfonate
-
10% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 5-chlorothiophene-2-sulfonate
-
2% inhibition of isoform MAO-B at 0.01 mM
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl benzenesulfonate
-
-
(3E)-7-hydroxy-3-[(4-methoxyphenyl)methylidene]-2,3-dihydro-4H-1-benzopyran-4-one
-
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3,3,3-trifluoropropane-1-sulfonate
-
-
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
-
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-cyanobenzenesulfonate
-
-
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-methoxybenzenesulfonate
-
17% inhibition of isoform MAO-B at 0.01 mM
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl benzenesulfonate
-
6% inhibition of isoform MAO-B at 0.01 mM
(4-[[bis(methylene)(4-methylphenyl)-lambda6-sulfanyl]oxy]phenoxy)hydrazine
0.1 mM, complete inhibition
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
-
(5E)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
-
(5E)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
-
(5E)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5E)-5-(3-bromobenzylidene)-1,3-thiazolidine-2,4-dione
-
-
(5E)-5-(4-chlorobenzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5E)-5-(4-hydroxy-2,5-dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5E)-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
-
-
(5E)-5-benzylidene-2-imino-1,3-thiazolidin-4-one
-
-
(5E)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5E)-5-[(3,5-dibromo-4-hydroxycyclohexa-1,4-dien-1-yl)methylidene]-1,3-thiazolidine-2,4-dione
-
-
(5R)-3-(3-fluoro-4-morpholin-4-ylphenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one
-
(5R)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
-
(5R)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
-
(5R,5'R)-3,3'-[1,4-diazepane-1,4-diylbis(3-fluorobenzene-4,1-diyl)]bis[5-(hydroxymethyl)-1,3-oxazolidin-2-one]
IC50: 0.001mM, at 0.15 mM kynuramine
(5S)-5-(aminomethyl)-3-(3-fluoro-4-morpholin-4-ylphenyl)-1,3-oxazolidin-2-one
-
(5S)-5-(aminomethyl)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-1,3-oxazolidin-2-one
-
(5S)-5-(aminomethyl)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-1,3-oxazolidin-2-one
-
(5Z)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
L136468, binding mode, overview
(5Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
A6355
(5Z)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
L136662
(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
AS605240, binding mode, overview
(6-benzyloxy-2-naphthyl)-2-aminopropane
-
(6-butoxy-2-naphthyl)-2-aminopropane
-
(6-ethoxy-2-naphthyl)-2-aminopropane
-
(6-methoxy-2-naphthyl)-2-aminopropane
-
(6-methylthio-2-naphthyl)isopropylamine
-
(6-propoxy-2-naphthyl)-2-aminopropane
-
(7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile
-
-
(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile
-
-
(aminomethyl)trimethylsilane
-
-
(E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
-
-
(E)-2-(4-fluorophenethyl)-3-fluoroallylamine
-
-
(E)-3-(2-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(3,4-dimethoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(3-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-(diethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-(dimethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-chlorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-fluorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-methoxybenzylidene)-7-(10-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-methoxybenzylidene)-7-(5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyloxy)chroman-4-one
-
(E)-3-(4-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-methoxybenzylidene)-7-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-methoxybenzylidene)-7-(9-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-(4-methylbenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
-
(E)-5-(3-chlorostyryl)isatin
-
(E)-5-(3-fluorostyryl)isatin
-
(E)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(3,4,5-trimethoxybenzylidene)chroman-4-one
-
(E)-7-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(4-methoxybenzylidene)chroman-4-one
-
(E)-7-(8-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)3-(4-methoxybenzylidene)chroman-4-one
-
(E)-8-(2-furylethenyl)caffeine
-
-
(E)-8-(2-thienylethenyl)caffeine
-
-
(E)-8-(3,4-dichlorostyryl)caffeine
-
-
(E)-8-(3,5-ditrifluoromethylstyryl)caffeine
-
-
(E)-8-(3-bromostyryl)caffeine
-
-
(E)-8-(3-chlorostyryl)caffeine
(E)-8-(3-methylstyryl)caffeine
-
-
(E)-8-(3-trifluoromethylstyryl)caffeine
-
-
(E)-8-(4-chlorostyryl)caffeine
-
-
(E)-8-(4-fluorostyryl)caffeine
-
-
(E)-8-(4-methylstyryl)caffeine
-
-
(E)-8-(4-trifluoromethylstyryl)caffeine
-
-
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
-
(E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
-
-
(E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
-
-
(N-cyclopropyl-alpha-methylbenzylamine)
the inhibitor forms an adduct that allows reoxidation of the flavin on denaturation
(R)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
-
-
(R)-4-(2,4-difluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
(R)-4-(4-fluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
(R)-4-[2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
-
-
(R)-amphetamine
-
IC50 for soluble enzyme: 0.0311 mM, IC50 for immobilized enzyme: 0.0991 mM, monoamine oxidase A; IC50 for soluble enzyme: 0.246 mM, IC50 for immobilized enzyme: 4.03 mM, monoamine oxidase B
(R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
-
(R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
-
(R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine
-
specific inhibitor of isoform MAO-B
(R,S)-amphetamine
-
IC50 for soluble enzyme: 0.0031 mM, IC50 for immobilized enzyme: 0.0244 mM, monoamine oxidase A; IC50 for soluble enzyme: 0.0625 mM, IC50 for immobilized enzyme: 3 mM, monoamine oxidase B
(S)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
-
-
(S)-4-(2,4-difluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
(S)-4-(4-fluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
(S)-4-[2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
-
-
(S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)-benzo[d]isoxazol-3-yl]-oxazolidin-2-one
-
SL25.1188, inhibits MAO-B in the brain with 50% unspecific binding, overview
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo; i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
1,10 phenanthroline
-
weak inhibition
1,2,3,4-tetrahydroacridin-9-amine
-
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
1,3,7-trimethyl-8-[(E)-2-(3-thienyl)vinyl]-3,7-dihydro-1H-purine-2,6-dione
-
-
1,3-dimethyl-5-nitro-1H-indazole
-
-
1,3-dimethyl-6-phenyl-1H-pteridine-2,4-dione
-
-
1,3-diphenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0098 mM, MAO-A; IC50: 0.2 mM, MAO-B
1,4-diphenyl-1,3-butadiene
1-(1-methylhydrazino)-3-(phenylthio)propan-2-ol
-
-
1-(1-methylhydrazino)-3-[methyl(phenyl)amino]propan-2-ol
-
-
1-(1-naphthyl)-2-aminopropane
-
1-(2-naphthyl)-2-aminopropane
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(naphthalen-2-yl)ethylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-2-yl)-ethylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(benzodioxol-5-ylmethylene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)-hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-ylmethylene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(octan-2-ylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine
-
-
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine
-
-
1-(4-benzyloxyphenyl)-2-aminopropane
-
1-(4-butoxyphenyl)-2-aminopropane
-
1-(4-chlorobutyl)-5-nitro-1H-indazol-3-ol
-
-
1-(4-ethoxyphenyl)-2-aminopropane
-
1-(4-guanidinobutoxy)-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline
-
an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata
1-(4-methoxy-phenyl)-2-aminopropane
-
1-(4-methylthiophenyl)-2-aminopropane
-
1-(4-propoxyphenyl)-2-aminopropane
-
1-(benzylideneamino)-3,4-dihydroquinolin-2(1H)-one
selective for MAO-B
1-(N-methylthiocarbamoyl)-3-(3-methoxyphenyl)-4,5-dihydropyrazole
-
-
1-(N-methylthiocarbamoyl)-3-(3-methylphenyl)-4,5-dihydropyrazole
-
-
1-(N-methylthiocarbamoyl)-3-(4-chlorophenyl)-4-methyl-4,5-dihydropyrazole
-
-
1-(N-methylthiocarbamoyl)-3-(4-fluorophenyl)-4,5-dihydropyrazole
-
-
1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazole
-
-
1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole
-
-
1-(N-methylthiocarbamoyl)-3-(4-methylphenyl)-4,5-dihydropyrazole
-
-
1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole
IC50: 0.000009 mM, MAO-A; IC50: 0.041 mM, MAO-B
1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.00023 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.0002 mM, MAO-A; IC50: 0.14 mM, MAO-B
1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.00029 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.0003 mM, MAO-A; IC50: 0.09 mM, MAO-B
1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.0001 mM, MAO-A; IC50: 0.088 mM, MAO-B
1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.00024 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.00001 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.00001mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.0002 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole
IC50: 0.0001 mM, MAO-A; IC50: 0.02 mM, MAO-B
1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0001 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.00001 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0001 mM, MAO-A; IC50: 0.038 mM, MAO-B
1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.00001 mM, MAO-A; IC50: 0.025 mM, MAO-B
1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.000009 mM, MAO-A; IC50: 0.083 mM, MAO-B
1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.000008 mM, MAO-A; IC50: 0.1 mM, MAO-B
1-amino-3,4-dihydroquinolin-2(1H)-one
selective for MAO-B
1-benzyl-5-nitro-1H-indazol-3-ol
-
-
1-guanidino-6-hydroxy-3,5-dihydro-beta-carboline
-
an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata
1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile
-
-
1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid
-
-
1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
-
1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
-
1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
-
1-methoxy-3-(3-methylphenyl)pyrrole
-
-
1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
-
1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
-
1-methyl-2-[(E)-2-(4-methylphenyl)vinyl]-1H-benzimidazole
-
-
1-methyl-2-[(E)-2-phenylvinyl]-1H-benzimidazole
-
-
1-methyl-2-[(E)-2-[4-(trifluoromethyl)phenyl]vinyl]-1H-benzimidazole
-
-
1-methyl-3-(3-bromophenyl)pyrrole
-
-
1-methyl-3-(3-chlorophenyl)pyrrole
-
-
1-methyl-3-(3-fluorophenyl)pyrrole
-
-
1-methyl-3-(3-methylphenyl)-1H-pyrrole
-
-
1-methyl-3-(3-methylphenyl)pyrrole
-
-
1-methyl-3-(3-trifluoromethylphenyl)pyrrole
-
-
1-methyl-3-(4-methylphenyl)-1H-pyrrole
-
-
1-methyl-3-phenyl-1H-pyrrole
-
-
1-methyl-3-phenylpyrrole
-
-
1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrrole
-
-
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
-
1-methyl-4-phenylpyridinium
-
1-methyl-5-nitro-1H-indazol-3-ol
-
inhibits MAO-B by 34% at 0.015 mM
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
-
1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-A
1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-B
1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
non-selective inhibitor; non-selective inhibitor
1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-A
1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-B
1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
non-selective inhibitor; non-selective inhibitor
1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-A
1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-B
1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
non-selective inhibitor; non-selective inhibitor
1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-A
1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
selective for MAO-B
1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
non-selective inhibitor; non-selective inhibitor
1-O-n-octyl-beta-D-glucopyranoside
-
at concentrations well below the critical micelle concentration
1-phenyl-2-aminopropane
-
1-phenyl-N-(1H-pyrrol-2-ylmethyl)methanamine
-
1-phenylcyclopropylamine
the inhibitor forms an irreversible flavin adduct
1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-methoxyphenyl)-4,5-dihydropyrazole
-
-
1-thiocarbamoyl-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole
-
-
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-methylphenyl)-4,5-dihydropyrazole
-
-
1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
monoamine oxidase A; monoamine oxidase B
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
1-[3-(4-chlorophenoxy)-2-methoxypropyl]-1-methylhydrazine
-
-
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
11H-indolo[3,2-c]cinnoline
29% inhibition at 0.05 mM
2,2'-bipyridyl
-
50% inhibition at 1 mM
2,2'-dipyridyl disulfide
-
-
2,2-dibutyl-3-acetyl-5-(3,5-dimethylphenyl)-1,3,4-oxadiazoline
-
0.8 mM, 42.8% inhibition
2,2-dibutyl-5-(2,4-dichlorophenyl)-N-(2,3,5-trifluoro-4-methoxybenzoyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 82% inhibition
2,2-dibutyl-5-(2,4-dichlorophenyl)-N-(2,6-difluorobenzoyl)-1,3,4-oxadiazole-3(2H)-carboxamid
-
1 mM, 72% inhibition
2,2-dibutyl-5-(4-chlorophenyl)-N-(2,6-difluorobenzoyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 59% inhibition
2,2-dibutyl-N-(2,6-difluorobenzoyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 69% inhibition
2,2-dibutyl-N-(2,6-difluorobenzoyl)-5-(3,5-dimethylphenyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 69% inhibition
2,2-dibutyl-N-(2,6-difluorobenzoyl)-5-(furan-2-yl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 75% inhibition
2,2-dibutyl-N-(2-chlorobenzoyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 78% inhibition
2,2-dibutyl-N-(2-chlorobenzoyl)-5-(3,5-dimethylphenyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 73% inhibition
2,4-dichloro-N'-(nonan-5-yl)benzohydrazide
-
-
2,4-dichlorobenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.92
2,4-dichlorobenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.03
2,4-dimethoxy-5-hydroxybenzaldehyde
IC50: 0.042 mM, monoamine oxidase A; IC50: 0.39 mM
2,6-dimethoxyphenol
IC50: 0.0624 mM, monoamine oxidase A; IC50: above 0.5 mM, monoamine oxidase B
2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
IC50: 0.0001 mM, MAO-A; IC50: 0.019 mM, MAO-B
2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
IC50: 0.001 mM, MAO-A; IC50: 0.07 mM, MAO-B
2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
IC50: 0.000072 mM, MAO-A; IC50: 0.04 mM, MAO-B
2-(2,4-dichlorophenyl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(3-hydroxyphenyl)acetamide
6164872
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-phenylacetamide
6163851
2-(2-benzofuranyl)-2-imidazoline
at micromolar concentrations, to a site distinct from the active site on at least two forms of the pure enzyme, probably corresponding to oxidised and reduced enzyme states
2-(2-chlorophenyl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
-
-
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
-
-
2-(2-cycloheptylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
-
-
2-(2-cycloheptylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-(2-cycloheptylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
-
-
2-(2-cycloheptylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
-
-
2-(2-cycloheptylidenehydrazinyl)-4-phenyl-1,3-thiazole
-
-
2-(2-cyclohexylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
-
-
2-(2-cyclohexylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
-
-
2-(2-cyclohexylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-(2-cyclohexylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
-
-
2-(2-cyclohexylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
-
-
2-(2-cyclohexylidenehydrazinyl)-4-phenyl-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
-
-
2-(2-cyclopentylidenehydrazinyl)-4-phenyl-1,3-thiazole
-
-
2-(2-ethoxylpyridin-3-yl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(3,4,5-trimethoxyphenyl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(3,5-dimethylphenyl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(3-methylphenyl)-4-(butoxycarbonylethyl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(3-nitrophenyl)-9H-indeno[2,1-d]pyrimidin-9-one
12% inhibition at 0.001 mM; 5% inhition at 0.001 mM
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
2-(4'-butoxyphenyl)thiomorpholin-5-one
2-(4'-butoxyphenyl)thiomorpholine oxalate
2-(4'-ethoxyphenyl)thiomorpholin-5-one
2-(4'-ethoxyphenyl)thiomorpholine oxalate
2-(4'-methoxyphenyl)thiomorpholin-5-one
2-(4'-methoxyphenyl)thiomorpholine oxalate
2-(4'-propoxyphenyl)thiomorpholin-5-one
2-(4'-propoxyphenyl)thiomorpholine oxalate
2-(4,5-dihydroimidazol-2-yl)-isoquinoline
reversible non-competitive/mixed inhibitor
2-(4,5-dihydroimidazol-2-yl)-quinoline
reversible non-competitive/mixed inhibitor
2-(4-bromophenyl)cyclopropanamine
-
2-(4-chlorophenyl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(4-chlorophenyl)-N-cyclohexyl-2-(3-ethynyl-2-oxo-4-phenylquinolin-1(2H)-yl)acetamide
selective for MAO-B
2-(4-ethylphenyl)-4-(cyanoethyl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(4-ethylphenyl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(4-fluorophenyl)-4-(cyanoethyl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(4-methoxyphenyl)cyclopropanamine
-
2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile
-
-
2-(5,7-dibromobenzofuran-2-yl)-imidazoline
reversible non-competitive/mixed inhibitor
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide
-
-
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
-
-
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
-
-
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
-
-
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide
-
-
2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
-
-
2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
-
2-(aminooxy)-1-phenylethanol
-
2-(benzo[d][1,3]dioxol-5-yl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
-
-
2-(naphthalen-1-yl)cyclopropanamine
-
2-(naphthalen-2-yl)-4-(nonan-5-yl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-(thiophen-3-yl)cyclopropanamine
-
2-bromo-N-(2-morpholinoethyl)nicotinamide
-
2-bromo-N-(3-morpholinopropyl)nicotinamide
-
2-Bromoethylamine
-
complete inhibition at 0.01 mM
2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
-
-
2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
-
2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
-
2-chloro-N'-(nonan-5-yl)benzohydrazide
-
-
2-chloro-N-(2-morpholinoethyl)nicotinamide
-
2-chloro-N-(3-morpholinopropyl)nicotinamide
-
2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
-
-
2-ethoxy-N'-(nonan-5-yl)nicotinohydrazide
-
-
2-ethylaminobenzylamine dihydrochloride
-
2-hydrazinyl-4-(3-nitrophenyl)-1,3-thiazole
0.1 mM, pH 7.4, 10% inhibition; 0.1 mM, pH 7.4, 6% inhibition
-
2-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
2-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
2-hydroxyquinoline
-
reversible by dialysis
2-methoxyphenol
IC50: 0.175 mM, monoamine oxidase A; IC50: above 0.5 mM, monoamine oxidase B
2-methyl-5-methylaniline
IC50: 0.15 mM, monoamine oxidase A; IC50: above 0.5 mM
2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
-
2-methylaminobenzylamine dihydrochloride
-
2-methylbenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.45
2-methylbenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.18
2-oxo-2H-chromen-7-yl benzenesulfonate
-
2-oxo-N-(2,3,5,6-tetrafluoropyridin-4-yl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-(pentafluorophenyl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-(propan-2-yl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-[3-(trifluoromethyl)phenyl]-2H-chromene-3-carboxamide
-
-
2-oxo-N-[4-(propan-2-yl)phenyl]-2H-chromene-3-carboxamide
-
-
2-phenyl-2H-indeno[1,2-c]pyridazine-3,5-dione
46% inhibition at 0.05 mM
2-phenyl-4-(cyanoethyl)-4H-1,3,4-oxadiazin-5(6H)-one
-
-
2-phenyl-5H-indeno[1,2-d]pyrimidine
37% inhibition at 0.02 mM
2-phenyl-9H-indeno[2,1-d]pyrimidine
-
2-phenyl-N-(1H-pyrrol-2-ylmethyl)ethanamine
-
2-Phenylethylamine
time-dependent, slowly reversible suicide inhibition. Addition of 2-phenylethylamine (10mM) to the enzyme results in immediate bleaching of the absorbance peak at 460 nm, a consequence of rapid reduction of the flavin cofactor by 2-phenylethylamine at steady state
2-phenylthiomorpholin-5-one
2-phenylthiomorpholine oxalate
2-[(1E,3E)-4-(3-chlorophenyl)buta-1,3-dien-1-yl]-3,5,7-trimethyl-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
-
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-(4-methylphenyl)-1,3-thiazole
-
-
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
-
-
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
-
-
2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
-
-
2-[(E)-2-(4-bromophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
2-[(E)-2-(4-chlorophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
2-[(E)-2-(4-fluorophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
2-[(E)-2-(4-methoxyphenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.008 mM, MAO-A; IC50: 0.3 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.009 mM, MAO-A; IC50: 0.3 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0094 mM, MAO-A; IC50: 0.48 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.025 mM, MAO-B; IC50: 0.097 mM, MAO-A
2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.098 mM, MAO-A; IC50: 2.0 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.013 mM, MAO-A; IC50: 3.8 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.09 mM, MAO-A; IC50: 1.0 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.094 mM, MAO-A; IC50: 1.8 mM, MAO-B
2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.088 mM, MAO-A; IC50: 0.2 mM, MAO-B
2-[1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0095 mM, MAO-A
2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0000086 mM, MAO-A; IC50: 0.1 mM, MAO-B
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.00001 mM, MAO-A; IC50: 0.0001 mM, MAO-B
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.000008 mM, MAO-A; IC50: 0.019 mM, MAO-B
2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0001 mM, MAO-A; IC50: 0.04 mM, MAO-B
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.000028 mM, MAO-A; IC50: 0.00006 mM, MAO-B
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.000009 mM, MAO-A; IC50: 0.0072 mM, MAO-B
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.002 mM, MAO-A; IC50: 0.1 mM, MAO-B
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0000088 mM, MAO-A; IC50: 0.1 mM, MAO-B
2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.0001 mM, MAO-A; IC50: 0.06 mM, MAO-B
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-methylphenyl)-1,3-thiazole
-
-
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
-
-
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
-
-
2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide
-
-
2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide
-
-
2-[4-(trifluoromethyl)phenyl]cyclopropanamine
-
2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.089 mM, MAO-A; IC50: 0.25 mM, MAO-B
2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.12 mM, MAO-A; IC50: 1 mM, MAO-B
2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3-yl]-N-methylacetamide
-
-
2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
-
-
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide
-
-
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide
-
-
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide
-
-
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
-
-
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide
-
-
2-{1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl}phenol
IC50: 0.4 mM, MAO-B
2-{[(3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]methyl}benzonitrile
-
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
3,4,5-trimethoxy-N'-(nonan-5-yl)benzohydrazide
-
-
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
-
3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
-
-
3,4-dimethoxyaniline
IC50: 0.131 mM, monoamine oxidase A
3,4-dimethoxybenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.88
3,4-dimethoxybenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.52
3,4-dimethyl-2-oxo-2H-chromen-7-yl 4-methoxybenzenesulfonate
-
3,4-dimethyl-2-oxo-2H-chromen-7-yl benzenesulfonate
-
3,4-dimethyl-7-(2-oxo-2-phenylethoxy)-2H-chromen-2-one
-
3,4-dimethyl-7-(2-phenoxyethoxy)-2H-chromen-2-one
pIC50 for MAO-A: 4.99; pIC50 for MAO-B: 7.57
3,4-dimethyl-7-(2-phenylethyl)-2H-chromen-2-one
pIC50 for MAO-A: 5.15; pIC50 for MAO-B: 6.34
3,4-dimethyl-7-phenoxy-2H-chromen-2-one
pIC50 for MAO-A: 4.5; pIC50 for MAO-B: 5.49
3,4-dimethyl-7-[(3-nitrobenzyl)oxy]-2H-chromen-2-one
-
3,4-dimethyl-7-[(pentafluorobenzyl)oxy]-2H-chromen-2-one
-
3,4-dimethyl-7-{[3-(trifluoromethoxy)benzyl]oxy}-2H-chromen-2-one
-
3,5,7-trimethyl-2-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
-
3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
-
-
3,5-dimethyl-N'-(nonan-5-yl)benzohydrazide
-
-
3,5-diphenyl-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0018 mM, MAO-A; IC50: 0.04 mM, MAO-B
3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.01 mM, MAO-A; IC50: 0.5 mM, MAO-B
3-(2-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
-
-
3-(2-naphthyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(2-nitrophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
-
-
3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.003 mM, MAO-A; IC50: 0.017 mM, MAO-B
3-(3-aminophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one
12% inhibition at 0.01 mM; 17% inhibition at 0.01 mM
3-(3-bromophenyl)-1-methyl-1H-pyrrole
-
-
3-(3-bromophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(3-chlorophenyl)-1-methyl-1H-pyrrole
-
-
3-(3-fluorophenyl)-1-methyl-1H-pyrrole
-
-
3-(3-fluorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(3-methoxyphenyl)-1-methyl-1H-pyrrole
-
-
3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.000014 mM, MAO-A; IC50: 0.001 mM, MAO-B
3-(3-methoxyphenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.09 mM, MAO-A; IC50: 0.98 mM, MAO-B
3-(3-nitrophenyl)-5H-indeno[2,1-e][1,2,4]triazin-5-one
3% inhibition at 0.01 mM
3-(3-nitrophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one
23% inhibition at 0.01 mM
3-(3-tert-butylphenyl)-1-methyl-1H-pyrrole
-
-
3-(4-bromophenyl)-1-methyl-1H-pyrrole
-
-
3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0074 mM, MAO-A; IC50: 0.087 mM, MAO-B
3-(4-bromophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(4-chlorophenyl)-1-methyl-1H-pyrrole
-
-
3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0099 mM, MAO-A; IC50: 0.1 mM, MAO-B
3-(4-chlorophenyl)-5-(4-fluorocyclohexa-1,5-dien-1-yl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-chlorophenyl)-5-(4-methoxycyclohexa-1,5-dien-1-yl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-chlorophenyl)-5-(4-methylcyclohexa-1,5-dien-1-yl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-chlorophenyl)-5-cyclohexa-1,5-dien-1-yl-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-fluorophenyl)-1-methyl-1H-pyrrole
-
-
3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(4-acetylaminophenyl)-N-phenyl-4,5-dihydro-1H -pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(4-acetylaminophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(4-methoxycyclohexa-1,5-dien-1-yl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(4-methylcyclohexa-1,5-dien-1-yl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-5-(4-methylphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-N,5-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
3-(4-hydroxyphenyl)-2-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid
-
-
3-(4-hydroxyphenyl)propionic acid
-
-
3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile
-
-
3-(4-methoxybenzyl)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
3-(4-methoxyphenyl)-1-methyl-1H-pyrrole
-
-
3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.00011 mM, MAO-A; IC50: 0.0125 mM, MAO-B
3-(4-methoxyphenyl)-5-(4-methylcyclohexa-1,5-dien-1-yl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
3-(4-methoxyphenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.0069 mM, MAO-A; IC50: 0.05 mM, MAO-B
3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
IC50: 0.000086 mM, MAO-A; IC50: 0.00145 mM, MAO-B
3-(4-nitrophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(5-oxo-5H-indeno[1,2-c]pyridazin-3-yl)benzonitrile
-
3-(benzyloxy)-5-nitro-1H-indazole
-
-
3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one
-
3-(benzyloxy)-6a,10a-dihydro-6H-benzo[c]chromen-6-one
-
3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one
-
3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
-
-
3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
-
3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile
-
-
3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
-
-
3-acetyl-1-hydroxy-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile
-
-
3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
-
3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile
-
-
3-amino-4-aminomethylpyridine dihydrochloride
-
3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid
-
-
3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
3-benzyl-5-nitro-1H-indazole
-
-
3-benzyl-5H-indeno[1,2-c]pyridazin-5-one
-
3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
-
3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile
-
-
3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
-
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
-
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
3-hydroxyphenylacetic acid
-
-
3-methoxy-1-methyl-5-nitro-1H-indazole
-
inhibits MAO-B by 52% at 0.015 mM
3-methoxy-5-nitro-1H-indazole
-
-
3-methoxyphenol
IC50: 0.024 mM, monoamine oxidase A
3-methyl-5-nitro-1H-indazole
-
-
3-methyl-8-(4,4,4-trifluoro-butoxy)indeno[1.2-c]pyridazin-5-one
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
3-methylamino-4-aminomethylpyridine dihydrochloride
-
3-oxo-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
-
3-phenyl-4-(phenylseleno)isoquinoline
reversibly inhibits isoform MAO-B activity
3-phenyl-4-(phenylthio)isoquinoline
-
3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one
21% inhibition at 0.01 mM
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
-
3-[(4-fluorophenoxy)methyl]-5H-indeno[1,2-c]pyridazin-5-one
12% inhibition at 0.01 mM
3-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]propanenitrile
-
-
3-[(5E)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid
R598127
3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
-
-
3-[(E)-2-phenylvinyl]-5H-indeno[1,2-c]pyridazin-5-one
-
3-[2-(ethylamino)-2-oxoethyl]-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
17% inhibition of isoform MAO-A at 0.01 mM
3-[2-(methylamino)-2-oxoethyl]-1-benzofuran-6-yl 3-chlorobenzenesulfonate
-
31% inhibition of isoform MAO-A at 0.01 mM
3-[4-(trifluoromethyl)phenyl]-5H-indeno[1,2-c]pyridazin-5-one
-
3-[[4-(trifluoromethyl)phenoxy]methyl]-5H-indeno[1,2-c]pyridazin-5-one
48% inhibition at 0.01 mM
3-{[(3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]methyl}benzonitrile
-
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol
IC50: 0.0001 mM, MAO-A; IC50: 0.39 mM, MAO-B
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
IC50: 0.0001 mM, MAO-A; IC50: 0.08 mM, MAO-B
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
IC50: 0.00005 mM, MAO-A; IC50: 0.062 mM, MAO-B
4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
IC50: 0.0001 mM, MAO-A; IC50: 0.03 mM, MAO-B
4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
IC50: 0.000073 mM, MAO-A; IC50: 0.003 mM, MAO-B
4-(2,4-dichlorophenyl)-2-hydrazinyl-1,3-thiazole
0.1 mM, pH 7.4, 25% inhibition; 0.1 mM, pH 7.4, 31% inhibition
-
4-(2,4-dichlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(2,4-dichlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(2,4-difluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(2,4-difluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
-
-
4-(2-bromophenyl)-2-hydrazinyl-1,3-thiazole
0.1 mM, pH 7.4, 24% inhibition
-
4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
-
-
4-(4-chlorophenyl)-2-(2-cycloheptylidenehydrazinyl)-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-(2-cyclohexylidenehydrazinyl)-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
4-(4-fluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(4-fluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(4-fluorophenylseleno)-3-phenylisoquinoline
-
4-(4-methoxyphenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(4-methoxyphenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
-
-
4-(aminomethyl)-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
-
-
4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one
-
-
4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
-
-
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
4-([6-[(4-cyanophenyl)methoxy]-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
-
4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one
-
-
4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine
-
-
4-chloro-N'-(nonan-5-yl)benzohydrazide
-
-
4-chloro-N-(2-morpholinoethyl)nicotinamide
-
4-chloro-N-(3-morpholinopropyl)nicotinamide
-
4-chlorobenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.42
4-chlorobenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.0
4-ethyl-N'-(nonan-5-yl)benzohydrazide
-
-
4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol
IC50: 0.0089 mM, monoamine oxidase B; IC50: 0.0134 mM, monoamine oxidase A
4-Hydroxy-3-methoxybenzylamine
IC50: 0.13 mM, monoamine oxidase A; IC50: 0.382 mM, monoamine oxidase B
4-hydroxy-3-methoxyphenethyl alcohol
IC50: 0.18 mM, monoamine oxidase A
4-hydroxy-3-methoxyphenyl acetone
IC50: 0.0302 mM, monoamine oxidase A
4-hydroxyphenylacetic acid
-
-
4-methoxybenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.72
4-methoxybenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.3
4-methylbenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 6.69
4-methylbenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.67
4-methylcyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.0
4-oxo-4H-chromene-3-carboxylic acid
-
specific for MAO-B
4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
-
4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl methanesulfinate
-
-
4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
-
-
4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one
-
-
4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid
-
-
4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate
-
-
4-[(methylamino)carbonyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
-
9% inhibition of isoform MAO-B at 0.01 mM, 8% inhibition of isoform MAO-A at 0.01 mM
4-[(methylamino)methyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
-
-
4-[1-(cyclopropylcarbamothioyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide
-
4-[1-(ethylcarbamothioyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide
-
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.0001 mM, MAO-A; IC50: 0.038 mM, MAO-B
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.00001 mM, MAO-A; IC50: 0.02 mM, MAO-B
4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0000086 mM, MAO-A; IC50: 0.087 mM, MAO-B
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.000008 mM, MAO-A; IC50: 0.13 mM, MAO-B
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0000088 mM, MAO-A; IC50: 0.1 mM, MAO-B
4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.00001 mM, MAO-A; IC50: 0.00002 mM, MAO-B
4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.00001 mM, MAO-A; IC50: 0.023 mM, MAO-B
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.000013 mM, MAO-A; IC50: 0.000038 mM, MAO-B
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.000008 mM, MAO-A; IC50: 0.019 mM, MAO-B
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.00001 mM, MAO-A; IC50: 0.12mM, MAO-B
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0001 mM, MAO-A; IC50: 0.04 mM, MAO-B
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.000009 mM, MAO-A; IC50: 0.083 mM, MAO-B
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.000009 mM, MAO-A; IC50: 0.0072 mM, MAO-B
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
IC50: 0.000009 mM, MAO-A; IC50: 0.042 mM, MAO-B
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
IC50: 0.0001mM, MAO-A; IC50: 0.03 mM, MAO-B
4-[2-(2-cycloheptylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
-
-
4-[2-(2-cyclohexylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
-
-
4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
-
-
4-[2-(methylamino)-2-oxoethyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
-
-
4-[2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
-
-
4-[2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
-
-
4-[2-[4-(benzyloxy)phenoxy]hydrazino]butanenitrile
0.1 mM, 39% inhibition
4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide
-
4-[[(4-oxo-3,4-dihydroquinazolin-6-yl)oxy]methyl]benzonitrile
-
-
4-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid
-
-
5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
-
5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
-
5,7-diethyl-3-methyl-2-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
-
5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
-
-
5-(4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl)-1,3-thiazolidine-2,4-dione
i.e. rosiglitazone
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorocyclohexa-1,5-dien-1-yl)-3-(4-chlorophenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-chlorocyclohexa-1,5-dien-1-yl)-3-(4-fluorophenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-chlorocyclohexa-1,5-dien-1-yl)-3-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-chlorocyclohexa-1,5-dien-1-yl)-3-(4-methylphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorophenyl)-3-phenyl-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-fluorocyclohexa-1,5-dien-1-yl)-3-(4-fluorophenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-fluorocyclohexa-1,5-dien-1-yl)-3-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-fluorocyclohexa-1,5-dien-1-yl)-3-(4-methylphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-fluorophenyl)-3-phenyl-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-hydroxy-3,5-dimethylbenzyl)-1,3-thiazolidine-2,4-dione
-
-
5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
-
-
5-(4-methoxycyclohexa-1,5-dien-1-yl)-3-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-methoxycyclohexa-1,5-dien-1-yl)-3-(4-methylphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-methoxycyclohexa-1,5-dien-1-yl)-3-phenyl-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-methylcyclohexa-1,5-dien-1-yl)-3-(4-methylphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-methylcyclohexa-1,5-dien-1-yl)-3-phenyl-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
5-(4-[(1-methylcyclohexyl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione
i.e. ciglitazone
5-(4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione
i.e. troglitazone
5-(4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl)-1,3-thiazolidine-2,4-dione
i.e. pioglitazone, docking of R-pioglitazone in the substrate cavity of MAO-B
5-(aminomethyl)-3-aryl-2-oxazolidinones
-
-
5-(benzo[d][1,3]dioxol-5-yl)-2,2-dibutyl-N-(2,6-difluorobenzoyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 78% inhibition
5-(benzo[d][1,3]dioxol-5-yl)-2,2-dibutyl-N-(2-chlorobenzoyl)-1,3,4-oxadiazole-3(2H)-carboxamide
-
1 mM, 75% inhibition
5-bromo-N-(2-morpholinoethyl)nicotinamide
-
5-bromo-N-(3-morpholinopropyl)nicotinamide
-
5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
-
-
5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
-
-
5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
5-cyclohexa-1,5-dien-1-yl-3-(4-fluorophenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-cyclohexa-1,5-dien-1-yl-3-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-cyclohexa-1,5-dien-1-yl-3-(4-methylphenyl)-1-propionyl-4,5-dihydro-1H-pyrazole
-
5-fluoro-alpha-methyltryptamine
-
a drug causing head-twitch response, IC50: 0.00018 mM
5-fluorotryptamine
-
a drug causing head-twitch response, IC50: 0.00018 mM
5-nitro-1-(pyridin-2-ylmethyl)-1H-indazol-3-ol
-
-
5-nitroindazole
-
inhibits MAO-B by 98.5% at 0.015 mM
5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-1,3-thiazolidine-2,4-dione ammoniate (1:1)
-
-
5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-2-imino-1,3-thiazolidin-4-one
-
-
6,11-dihydro-5H-benzo[a]carbazole
38% inhibition at 0.025 mM
6-(3-chlorophenyl)-1,3-dimethyl-1H-pteridine-2,4-dione
-
-
6-amino-1,3-dimethyl-5-([1-phenylmeth-(E)-ylidene]-amino)-1H-pyrimidine-2,4-dione
-
-
6-amino-1,3-dimethyl-5-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-1H-pyrimidine-2,4-dione
-
-
6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione
-
-
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione
-
-
6-chloro-N-(2-morpholinoethyl)nicotinamide
-
6-chloro-N-(3-morpholinopropyl)nicotinamide
-
6-fluoro-alpha-methyltryptamine
-
a drug causing head-twitch response, IC50: 0.00018 mM
6-fluoro-N-(2-morpholinoethyl)nicotinamide
-
6-fluoro-N-(3-morpholinopropyl)nicotinamide
-
6-fluorotryptamine
-
a drug causing head-twitch response, IC50: 0.00018 mM
6-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
6-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
6-hydroxy-N-propargyl-1(R)-aminoindan
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
6-methyl-N-(2-morpholinoethyl)nicotinamide
-
6-methyl-N-(3-morpholinopropyl)nicotinamide
-
6-nitroindazole
-
inhibits MAO-B by 89% at 0.015 mM, also inhibits MAO-A
6-[(3-iodophenyl)methoxy]-3-[(3-iodophenyl)methyl]quinazolin-4(3H)-one
-
-
6-[(3-iodophenyl)methoxy]quinazolin-4(3H)-one
-
-
6-[(4-fluorophenyl)methoxy]-3-[(4-fluorophenyl)methyl]quinazolin-4(3H)-one
-
-
6-[(E)-2-(3-chloro-phenyl)-vinyl]-1,3-dimethyl-1H-pteridine-2,4-dione
-
-
6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione
-
-
7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one
-
-
7-(2-hydroxy-2-phenylethyloxy)-3,4-dimethyl-2H-chromen-2-one
-
7-(3-chlorobenzyloxy)-3-methyl-2H-chromen-2-one
pIC50 for MAO-A: 4.9; pIC50 for MAO-B: 8.29
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin
binds noncovalently to MAO B, occupying both the entrance and the substrate cavities
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin
binds noncovalently to MAO B, occupying both the entrance and the substrate cavities
7-(3-chlorobenzyloxy)-4-formylcoumarin
-
-
7-(3-phenylprop-2-en-1-yloxy)-3,4-dimethyl-2H-chromen-2-one
pIC50 for MAO-A: 4.5; pIC50 for MAO-B: 6.95
7-(anilinomethyl)-2H-chromen-2-one
-
7-(benzenesulfonylmethoxy)-3,4-dimethyl-2H-chromen-2-one
pIC50 for MAO-A: 5.55; pIC50 for MAO-B: 6.06
7-(benzylamino)-3,4-dimethyl-2H-chromen-2-one
-
7-(benzyloxy)-2H-chromen-2-one
-
7-(benzyloxy)-3,4-dimethyl-2H-chromen-2-one
-
7-(benzyloxy)-4-methyl-2H-chromen-2-one
-
7-(benzyloxy)-4-phenyl-2H-chromen-2-one
-
7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one
-
-
7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one
-
-
7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one
-
-
7-benzenesulfonyloxy-2H-chromen-2-one
pIC50 for MAO-A: 6.35; pIC50 for MAO-B: 4.26
7-benzyloxy-3-methyl-2H-chromen-2-one
pIC50 for MAO-A: 5.26; pIC50 for MAO-B: 8.18
7-benzylsulfonyl-3,4-dimethyl-2H-chromen-2-one
pIC50 for MAO-A: 4.73; pIC50 for MAO-B: 5.56
7-benzylthio-3,4-dimethyl-2H-chromen-2-one
pIC50 for MAO-A: 5.0; pIC50 for MAO-B: 7.4
7-nitroindazole
-
inhibits MAO-B by 35% at 0.015 mM
7-[(3-chlorobenzyl)oxy]-4-(chloromethyl)-2H-chromen-2-one
-
-
7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one
-
-
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
-
-
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate
-
-
7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one
-
-
7-[(3-chlorophenyl)methoxy]-4-(methylaminomethyl)chromen-2-one
-
7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate
-
-
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
-
-
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate
-
-
8-(-3-chlorostyryl)-caffeine
by means of its dual action as A2A antagonist and MAO-B inhibitor 8-(-3-chlorostyryl)-caffeine reverses behavior and biochemical alterations, observed in the 6-OHDA-lesioned rats, pointing out to its potential benefit for the treatment of Parkinson's disease
8-(3-chloro)styrylcaffeine
-
-
8-(3-chlorostrylyl)caffeine
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
8-(3-chlorostyryl)-caffeine
-
-
8-(3-chlorostyryl)caffeine
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
8-hydroxyquinoline
-
reversible by the addition of Zn2+, Ni2+, Co2+
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
9,11-dimethylpurino[7,8-c]quinazoline-8,10(9H,11H)-dione
-
-
Acetylcholine
competitively inhibits monoamine oxidase A in the brain in a tissue-dependent manner, inhibition of MAO-A in cerebellum; competitively inhibits monoamine oxidase B in the brain in a tissue-dependent manner, inhibition of MAO-B in basal ganglia
Acriflavin
-
irreversible inhibitor
aminoguanidine
-
complete impairment of SSAO activity produced by aminoguanidine-treatment in obese rats is likely responsible for a weak limitation of fat deposition. Aminoguanidine may be useful for treating obesity via its SSAO blocking properties
amitriptyline
competive inhibition with 2-phenylethylamine as substrate
befloxatone
-
the inhibitor induces changes in the spectrum of MAO A, consistent with stacking of inhibitor with the flavin in the active site
benzaldehyde
-
strong competitive inhibitor
benzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone
pKi: 8.14
benzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 5.92
benzhydrylidene-prop-2-ynyl-amine
-
-
benzoic acid (2H-2-oxochromen-7-yl)methyl ester
pIC50 for MAO-A: 5.02; pIC50 for MAO-B: 5.62
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
-
benzyl cyanide
-
reversible inhibitor
benzylhydrazine
the mode of irreversible MAO inhibition involves covalent modification of the flavin coenzyme, overview; the three-dimensional structures of phenylethylhydrazine- and benzylhydrazine-inhibited MAO B show that alkylation occurs at the N5 position on the re-face of the covalent flavin with loss of the hydrazyl nitrogens, mechanism, the mode of irreversible MAO inhibition involves covalent modification of the flavin coenzyme, overview
beta-carbolines
-
competitive reversible and potent inhibitor
beta-phenylethylidenehydrazine
a neuroprotective drug, inhibits MAO-A by 26.7%; a neuroprotective drug, inhibits MAO-B by 14.9%
CdSO4
-
1 mM, 10% inhibition, monoamine oxidase B; 1 mM, 90% inhibition with serotonin as substrate, monoamine oxidase A
cinnamyl alcohol
compound from Rhodiola rosea extract, inhibits both MAO A and MAO B
cis-2,4,5-trimethoxypropenylbenzene
IC50: 0.142 mM, monoamine oxidase A; IC50: 0.362 mM, monoamine oxidase B
cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
cis-N-benzyl-2-methoxycyclopropylamine
high inhibitory action, exhibits a poor isozyme selectivity; high inhibitory action, exhibits a poor isozyme selectivity
-
CuSO4
-
1 mM, 95% inhibition with serotonin as substrate, monoamine oxidase A
cyanidin
-
competitive interaction of cyanidin with MAO A plus a mixed competitive and non-competitive mode of interaction of cyanidin with MAO B
cyanidin-3,5-diglucoside
-
-
cyanidin-3-O-beta-D-galactoside
-
-
cyanidin-3-O-beta-D-glucoside
-
mixed competitive and non-competitive mode of interaction with both enzyme isozymes
cyanidin-3-O-beta-D-rutinoside
-
-
cyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 7.69
cyclopentanone (4-phenyl-1,3-thiazol-2-yl)hydrazone
pKi: 6.85
dehydroepiandrosterone
at 0.1 mM, inhibition of MAO-A by 44.2%; at 0.1 mM, inhibition of MAO-B by 61.2%
delphinidin-3-O-beta-D-glucoside
-
-
di(2-hydroxyethyl)methyldodecylammonium
reversible competitive inhibitor
di(2-hydroxyethyl)methyldodecylammonium ion
-
a biocide, inhibits MAO-B
epigallocatechin gallate dimer
compound from Rhodiola rosea extract, inhibits both MAO A and MAO B
esuprone
-
inhibits MAO-A reversibly
ethyl 4-hydroxy-3-methoxycinnamate
IC50: 0.0057 mM, monoamine oxidase B; IC50: 0.0247 mM, monoamine oxidase A
ethyl 4-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoate
-
-
ethyl-4-hydroxy-3-methoxyphenylacetate
IC50: 0.081 mM, monoamine oxidase A
eugenol
IC50: 0.0344 mM, monoamine oxidase A; IC50: 0.288 mM, monoamine oxidase B
eugenol methyl ether
IC50: 0.11 mM, monoamine oxidase A; IC50: 0.269 mM, monoamine oxidase B
harmalol
-
identification by HPLC-ESI-mass spectrometry
harmol
-
identification by HPLC-ESI-mass spectrometry
indol -2,3-dione
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
isoproniazid
-
inhibits MAO-A and MAO-B irreversibly
lamotrigine
its in vivo MAO-B inhibiting effect might contribute in part to its antidepressant activity
LU-53439
-
inhibits MAO-B reversibly
malvidin 3-O,5-O-di-beta-D-glucoside
-
-
malvidin-3-O-beta-D-galactoside
-
-
malvidin-3-O-beta-D-glucoside
-
-
Mesobuthus gibbosus venom peptide
-
with specific MAO-A inhibitory activity, reversible, non-competitive, may be responsible for the anxiogenic effects of the scorpion venom on animals and humans
-
metamphetamine
i.e. N-methyl-1-phenyl-2-propanamine; i.e. N-methyl-1-phenyl-2-propanamine
-
metanephrine
IC50: 0.252 mM, monoamine oxidase A
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
-
methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
-
-
N'-(2-cyanoethyl)-4-ethylbenzohydrazide
-
-
N'-(nonan-5-yl)-2-naphthohydrazide
-
-
N'-(nonan-5-yl)benzo[d][1,3]dioxole-5-carbohydrazide
-
-
N'-phenyl-7-benzyloxy-2-oxo-2H-chromene-3-carbohydrazide
-
-
N,1-dimethyl-N-prop-2-yn-1-yl-1H-pyrrole-2-carboxamide
-
N,N'-(1R,2S)-cyclohexane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
N,N'-1,2-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
N,N'-1,4-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
N,N'-bis[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]butanediamide
IC50: 0.09 mM, at 0.15 mM kynuramine
N,N'-butane-1,4-diylbis(2-oxo-2H-chromene-3-carboxamide)
N,N'-butane-1,4-diylbis(7-methoxy-2-oxo-2H-chromene-3-carboxamide)
N,N'-ethane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
N,N'-hexane-1,6-diylbis(2-oxo-2H-chromene-3-carboxamide)
N,N'-[(1,5-dioxopentane-1,5-diyl)bis[piperazine-4,1-diyl(3-fluorobenzene-4,1-diyl)[(5R)-2-oxo-1,3-oxazolidine-3,5-diyl]methanediyl]]diacetamide
IC50: 0.0005 mM, at 0.15 mM kynuramine
N-((4-isopropylphenyl)-2-oxo-2H-chromene-3-carboxamide)-amide
-
-
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide
i.e. ParSL-3, a TEMPO-conjugated pargyline analogue, specifically inhibits MAO-A
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-4-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide
i.e. ParSL-2, a TEMPO-conjugated pargyline analogue, specifically inhibits MAO-B
N-(1-phenylethyl)-1H-pyrrole-2-carboxamide
-
N-(1H-pyrrol-2-ylmethyl)prop-2-yn-1-amine
-
N-(2,3-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2,4-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2,6-difluorophenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2,6-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
-
-
N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-aminoethyl)-4-chlorobenzamide
-
N-(2-aminoethyl)-aryl-carboxamide
-
N-(2-aminoethyl)-p-chlorobenzamide
N-(2-benzylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-benzylphenyl)-7-(4-fluorobenzyloxy)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-benzylphenyl)-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-chloro-6-methylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-cyclohexylethyl)-N-methyl-1H-pyrrole-2-carboxamide
-
N-(2-methyl-1H-indol-5-yl)benzamide
-
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
-
N-(2-methyl-6-chlorophenyl)-7-(4-fluorobenzyloxy)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-methyl-6-chlorophenyl)-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-(2-morpholinoethyl)nicotinamide
-
N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide
-
N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-carboxamide
tight-binding mechanism of inhibition
-
N-(3'-chlorophenyl)-4-oxo-4H-chromene-3-carboxamide
tight-binding mechanism of inhibition
-
N-(3'-fluorophenyl)-4-oxo-4H-chromene-3-carboxamide
tight-binding mechanism of inhibition
-
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
N-(3,4-dimethoxyphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,4-dimethoxyphenyl)-7-(4-fluorobenzyloxy)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,4-dimethoxyphenyl)-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,4-dimethoxyphenyl)-7-benzyloxy-8-methyl-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,4-dimethoxyphenyl)-8-methyl-2-oxo-7-(2-phenylethyl)-2H-chromene-3-carboxamide
-
-
N-(3,4-dimethyl-2-oxo-2H-chromen-7-yl)benzamide
-
N-(3,4-dimethyl-2H-2-oxochromen-7-yl)-N,4-dimethylbenzensulfonamide
pIC50 for MAO-A: 5.34; pIC50 for MAO-B: 4.5
N-(3,4-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,5-dimethoxyphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,5-dimethoxyphenyl)-7-(4-fluorobenzyloxy)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,5-dimethoxyphenyl)-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
N-(3-fluorophenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3-morpholinopropyl)nicotinamide
-
N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide
-
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide
-
N-(3-trifluoromethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(3-{[(3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]methyl}phenyl)acetamide
-
N-(4-benzyloxybenzyl)-4-methylthioamphetamine
-
N-(4-butoxybenzyl)-4-methylthioamphetamine
-
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-7-(4-fluorobenzyloxy)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-ethylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-fluorophenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-hydroxybenzyl)-4-methylthioamphetamine
weak inhibition of MAO-A; weak inhibition of MAO-B
N-(4-isopropylphenyl)-7-(4-fluorobenzyloxy)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-isopropylphenyl)-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-methanesulfonylphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-methoxybenzyl)-4-methylthioamphetamine
-
N-(4-methoxyphenyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide
-
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide
-
N-(biphenyl-2-yl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(butan-2-yl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-(cycloheptylidenemethyl)-4-(3-methoxyphenyl)-1,3-thiazol-2-amine
-
-
N-(prop-2-ynyl)-2-oxo-2H-chromene-3-carboxamide
-
-
N-([(5S)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
-
N-([(5S)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
-
N-2-phenylethyl-1H-pyrrole-2-carboxamide
-
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide
-
N-benzyl-(4-methylthioamphetamine)
weak inhibition of MAO-A; weak inhibition of MAO-B
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane
-
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane
-
N-benzyl-1-(1-methyl-1H-pyrrol-2-yl)methanamine
most selective MAO-A inhibitor
N-benzyl-12-isothiocyanato-N-methyldodecan-1-amine
irreversible inhibition with respect to isoform MAO-A, competitive inhibition with respect to isoform MAO-B; irreversible inhibition with respect to isoform MAO-A, competitive inhibition with respect to isoform MAO-B
N-benzyl-1H-pyrrole-2-carboxamide
-
N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
-
-
N-benzyl-2-oxo-2H-chromene-3-carboxamide
-
-
N-benzyl-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-benzyl-N-methyl-1-(1-methyl-1H-pyrrol-2-yl)methanamine
-
N-benzyl-N-methyl-2-oxo-2H-chromene-3-carboxamide
-
-
N-benzyl-N-methylprop-2-yn-1-amine
-
i.e. pargyline
N-benzylprop-2-yn-1-amine
-
-
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
-
-
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
-
-
N-cyclohexyl-2-oxo-2H-chromene-3-carboxamide
-
-
N-cyclohexyl-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
N-isobutyl-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-isopropyl-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-methoxy-2-(3-methylphenyl)maleimide
-
-
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°Cmost selective MAO-B inhibitor
N-methyl-1-phenyl-N-(1H-pyrrol-2-ylmethyl)ethanamine
-
N-methyl-2-(3-bromophenyl)maleimide
-
-
N-methyl-2-(3-chlorophenyl)maleimide
-
-
N-methyl-2-(3-fluorophenyl)maleimide
-
-
N-methyl-2-(3-methylphenyl)maleimide
-
-
N-methyl-2-(3-trifluoromethylphenyl)maleimide
-
-
N-methyl-2-phenyl-N-(1H-pyrrol-2-ylmethyl)ethanamine
-
N-methyl-2-phenylmaleimide
-
-
N-methyl-3-phenyl-N-(1H-pyrrol-2-ylmethyl)propan-1-amine
-
N-methyl-4-phenyl-N-(1H-pyrrol-2-ylmethyl)butan-1-amine
-
N-methyl-N-(1-phenylethyl)-1H-pyrrole-2-carboxamide
-
N-methyl-N-benzyl-2-oxo-2H-chromene-3-carboxamide
-
-
N-methyl-N-phenyl-2-oxo-2H-chromene-3-carboxamide
-
-
N-methyl-N-phenyl-7-benzyloxy-2-oxo-2H-chromene-3-carboxamide
-
-
N-methyl-N-propargyl-1(R)-aminoindan
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
N-methyl-N-[(1-methyl-1H-pyrrol-2-yl)methyl]prop-2-yn-1-amine
-
N-phenyl-1H-indazole-5-carboxamide
N-phenyl-1H-pyrrole-2-carboxamide
-
N-prop-2-yn-1-yl-1H-pyrrole-2-carboxamide
-
N-propargyl-1(R)-aminoindan
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
N-propargyl-l(R)-aminoindan
i.e. rasagiline. N-Propargyl-l(R)-aminoindan is well tolerated and effective in the treatment of early Parkinson's disease and as adjunctive treatment in levodopa-treated patients with Parkinson's disease experiencing motor fluctuations
N-[(1R)-1-cyclohexylethyl]-1H-pyrrole-2-carboxamide
-
N-[(1S)-1-cyclohexylethyl]-1H-pyrrole-2-carboxamide
-
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
-
i.e. clorgiline
N-[4-(methylsulfonyl)phenyl]-2-oxo-2H-chromene-3-carboxamide
-
-
N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
-
N1,N12-dibenzyldodecane-1,12-diamine
-
N1-(3-aminopropyl)-N4-(3-((naphthalen-2-ylmethyl)amino)propyl)butane-1,4-diamine
-
N1-(3-aminopropyl)-N4-(3-((pyridin-3-ylmethyl)amino)propyl)butane-1,4-diamine
-
N1-(3-aminopropyl)-N4-(3-((thiophen-2-ylmethyl)amino)propyl)butane-1,4-diamine
mixed-type reversible inhibition with respect to isoform MAO-A and MAO-B; mixed-type reversible inhibition with respect to isoform MAO-A and MAO-B
naringenin
the content of naringenin in Mentha aquatica might explain its use in traditional medicine for depression-like conditions; the content of naringenin in Mentha aquatica might explain its use in traditional medicine for depression-like conditions
NW 1772
-
specific inhibitor of isoform MAO-B
o-eugenol
IC50: 0.101 mM, monoamine oxidase A; IC50: above 0.5 mM, monoamine oxidase B
oleamide
-
inhibits MAO B
p-(propylthio)-phenylisopropylamine
-
p-nitrobenzylamine
substrate for wild-type enzyme, competitive inhibitor for mutant enzyme Y435L
pelargonidin 3-O,5-O-di-beta-D-glucoside
-
-
peonidin-3-O-beta-D-glucoside
-
-
phenelzine sulfate
mixed irreversible MAO inhibitors (MAOI-A/B) tranylcypromine hydrochloride and phenelzine sulfate. Treatment with monoamine oxidase inhibitors (contained in cigarette smoke) dramatically prolong the aversive state associated with nicotine withdrawal but have little effect on the somatic signs of nicotine withdrawal; mixed irreversible MAO inhibitors (MAOI-A/B) tranylcypromine hydrochloride and phenelzine sulfate. Treatment with monoamine oxidase inhibitors (contained in cigarette smoke) dramatically prolong the aversive state associated with nicotine withdrawal but have little effect on the somatic signs of nicotine withdrawal
pirlindole
an MAO A specific reversible inhibitor
Proflavin
-
irreversible inhibitor
rhodiocyanoside A
compound from Rhodiola rosea extract, inhibits MAO B, not MAO A
rhodioloside B
compound from Rhodiola rosea extract, inhibits MAO B, not MAO A
rosiridin
compound from Rhodiola rosea extract, inhibits both MAO A and MAO B
salidroside
compound from Rhodiola rosea extract, inhibits MAO B, not MAO A
selegilline
-
specific inhibitor of isoform MAO-B
Sodium diethyldithiocarbamate
-
weak inhibition
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate
non-selective; non-selective
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl][2-(phenylcarbonyl)phenyl]amino]-2-oxoethyl)carbamate
selective for MAO-B
tetrahydroharmine
-
identification by HPLC-ESI-mass spectrometry
trans,trans-farnesol
monoamine oxidase B
trans-2,4,5-trimethoxypropenylbenzene
IC50: 0.124 mM, monoamine oxidase A; IC50: 0.338 mM, monoamine oxidase B
trans-2-phenylcyclopropylamine
trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
-
trans-trans-1,4-diphenyl-1,3-butadiene
-
-
tranylcypromine hydrochloride
mixed irreversible MAO inhibitors (MAOI-A/B) tranylcypromine hydrochloride and phenelzine sulfate. Treatment with monoamine oxidase inhibitors (contained in cigarette smoke) dramatically prolong the aversive state associated with nicotine withdrawal but have little effect on the somatic signs of nicotine withdrawal; mixed irreversible MAO inhibitors (MAOI-A/B) tranylcypromine hydrochloride and phenelzine sulfate. Treatment with monoamine oxidase inhibitors (contained in cigarette smoke) dramatically prolong the aversive state associated with nicotine withdrawal but have little effect on the somatic signs of nicotine withdrawal
triandrin
compound from Rhodiola rosea extract, inhibits MAO B, not MAO A
tyrosol
compound from Rhodiola rosea extract, inhibits MAO B, not MAO A
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
-
[(5E)-2,4-dioxo-5-(phenylimino)-1,3-thiazolidin-3-yl]acetonitrile
R598119
[(E)-1,3-dipropyl-7-methyl-8-(2-(3-thienyl)ethenyl)]xanthine
[(E)-N-(2-propynyl)-2-(phenyl)ethylidene]-hydrazine
synthesis and inhibition of MAO isozymes, overview; synthesis and inhibition of MAO isozymes, overview
[(E)-N-bis-(2-propynyl)-2-(phenyl)ethyidene]hydrazine
synthesis and inhibition of MAO isozymes, overview; synthesis and inhibition of MAO isozymes, overview
[(Z)-N-(2-propynyl)-2-(phenyl)ethylidene]-hydrazine
synthesis and inhibition of MAO isozymes, overview; synthesis and inhibition of MAO isozymes, overview
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
-
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
-
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
[4-(benzyloxy)phenoxy]hydrazine
0.1 mM, 43% inhibition
[Cu(2-[4-[bis(4-fluorophenyl)methyl]pipera-zin-1-yl]acetic acid)2(H2O)]
-
(E)-8-(3-chlorostyryl)caffeine
a specific reversible inhibitor of MAO-B
(E)-8-(3-chlorostyryl)caffeine
reversible MAO-B inhibitor, a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
(E)-8-(3-chlorostyryl)caffeine
-
reversible MAO-B inhibitor, a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
(E)-8-(3-chlorostyryl)caffeine
-
-
(E)-8-styrylcaffeine
reversible MAO-B inhibitor, a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
(E)-8-styrylcaffeine
-
reversible MAO-B inhibitor, a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
(R)-deprenyl
-
(R)-deprenyl
i.e. selegiline, a MAO-B inhibitor
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
-
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
-
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
-
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
-
1,4-diphenyl-1,3-butadiene
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
1,4-diphenyl-1,3-butadiene
-
-
1,4-diphenyl-2-butene
-
monoamine oxidase B
1,4-diphenyl-2-butene
-
inhibits by covalent binding to the flavin ring, reversible inhibitor of MAO-B
1,4-diphenyl-2-butene
monoamine oxidase B
1,4-diphenyl-2-butene
-
a component of polystyrene plasticware
1,4-diphenyl-2-butene
-
-
1,4-diphenyl-2-butene
monoamine oxidase B
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
-
-
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
-
-
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
-
-
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
-
-
2-(4'-butoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-butoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-butoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-butoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-ethoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-ethoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-ethoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-ethoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-methoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-methoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-methoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-methoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-propoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-propoxyphenyl)thiomorpholin-5-one
-
-
2-(4'-propoxyphenyl)thiomorpholine oxalate
-
-
2-(4'-propoxyphenyl)thiomorpholine oxalate
-
-
2-phenylcyclopropylamine
the inhibitor forms an adduct that allows reoxidation of the flavin on denaturation
2-phenylcyclopropylamine
moderate isoenzyme selectivity; moderate isoenzyme selectivity
2-phenylthiomorpholin-5-one
-
-
2-phenylthiomorpholin-5-one
-
-
2-phenylthiomorpholine oxalate
-
-
2-phenylthiomorpholine oxalate
-
-
4-Cyanophenol
-
weak inhibition
8-(3-chlorostyryl)caffeine
-
monoamine oxidase B
8-(3-chlorostyryl)caffeine
monoamine oxidase B
8-(3-chlorostyryl)caffeine
monoamine oxidase B
8-(3-chlorostyryl)caffeine
monoamine oxidase B
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
-
acridine
Neogale vison
-
derivatives, irrevrsible inhibition, sensitivity of isozymes, overview
acridine
-
derivatives, irrevrsible inhibition, sensitivity of isozymes, overview
Acridine orange
-
irreversible inhibitor
alpha-Naphthol
-
reversible by dialysis
amphetamine
-
-
amphetamine
-
a competitive inhibitor of MAO-A
beta-naphthol
-
reversible by dialysis
brofaromine
-
-
brofaromine
-
inhibitor of MAO-A
brofaromine
-
inhibits MAO-A reversibly
Caffeine
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
Caffeine
-
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
chlorgilin
-
i.e. N-[2,4-dichlorophenoxy]-propyl-N-methyl-2-propylamine
chlorgilin
-
i.e. N-[2,4-dichlorophenoxy]-propyl-N-methyl-2-propylamine
chlorgilin
-
i.e. N-[2,4-dichlorophenoxy]-propyl-N-methyl-2-propylamine
chlorgilin
-
i.e. N-[2,4-dichlorophenoxy]propyl-N-methyl-2-propynylamine
chlorgilin
-
i.e. N-[2,4-dichlorophenoxy]-propyl-N-methyl-2-propylamine
chlorgyline
-
-
chlorgyline
-
specific inhibitor of isoform MAO-A
Clorgyline
-
-
Clorgyline
complete inhibition at 0.01 mM
Clorgyline
-
irreversible inhibitor
Clorgyline
-
IC50: 0.00042 mM; IC50: 1.2 nM
Clorgyline
-
IC50: 0.000014 mM
Clorgyline
-
the irreversible MAO-A inhibitor shows anti-oncogenic and pro-differentiation effects on high grade prostate cancer cells, inhibition of MAO-A might restore differentiation and reverse the aggressive behavior of high grade prostate cancer cells, overview. The inhibitor has significant gene regulatory effects on the beta-catenin and ERBB2 pathways in vivo, overview
Clorgyline
an acetylenic inhibitor, addition of it results in the conversion of the oxidized flavin cofactors to their respective N(5) flavocyanine adducts
Clorgyline
inhibition of MAO A and MAO B
Clorgyline
-
inhibits both MAO-A and MAO-B
Clorgyline
-
inhibitor of MAO-A
Clorgyline
-
inhibits MAO-A irreversibly
Clorgyline
isoform MAO-A, 4.1% inhibition at 0.1 mM
Clorgyline
irreversible inhibitor of isoform MAO-A
Clorgyline
irreversible inhibitor of isoform MAO A
Clorgyline
-
selective inhibition of MAO-A
Clorgyline
complete inhibition at 0.01 mM
Clorgyline
-
MAO-A highly sensitive and MAO-B less sensitive to inhibition
Clorgyline
-
MAO-A highly sensitive and MAO-B less sensitive to inhibition; poor inhibition
Clorgyline
MAOA-specific irreversible inhibitor, used clinically as antidepressant. It foms a covalent bond with FAD
Clorgyline
monoamine oxidase A
Clorgyline
addition of the MAO-A inhibitor caused an increase in the maximal levels of extracellular serotonin achieved when challenged with 3,4-methylenedioxymethamphetamine
Clorgyline
the reversible and selective MAO-A inhibitor produces increases in 5-hydroxytryptamine syndrome in the 5-hydroxytryptamine-treated rats
Clorgyline
addition of a 10fold molar excess of the acetylenic inhibitor clorgyline to rat MAO-A results in the formation of flavocyanine adduct
Clorgyline
MAO-A forms a N(5) flavocyanine adduct on inhibition by clorgyline, MAO A is blocked at an N-terminal threonyl residue
Clorgyline
irreversible inhibitor of isoform MAO-A
Clorgyline
-
MAO-A highly sensitive and MAO-B less sensitive to inhibition
D-amphetamine
-
-
D-amphetamine
-
the inhibitor induces changes in the spectrum of MAO A, consistent with stacking of inhibitor with the flavin in the active site. Inhibitor stabilizes the semiquinone form of FAD during reduction of MAO A by dithionite and no further reduction of the inhibitor-MAO A complex occurs
D-amphetamine
competitive inhibition
D-amphetamine
a nonselective reversible MAO inhibitor, inhibits the MAO A S209E mutant with much lower affinity, 160fold and 20fold, respectively, than the wild-type enzyme
D-amphetamine
i.e. 1-phenyl-2-propanamine
D-amphetamine
reversible inhibitor; reversible inhibitor
deprenil
-
i.e. N-1-phenylisopropyl-N-methyl-2-propinylamine
deprenil
-
i.e. N-1-phenylisopropyl-N-methyl-2-propinylamine
deprenil
-
i.e. N-1-phenylisopropyl-N-methyl-2-propinylamine
deprenil
-
i.e. N-1-phenylisopropyl-N-methyl-2-propinylamine
Deprenyl
-
-
Deprenyl
-
i.e. N-1-phenylisopropyl-N-methyl-2-propynylamine
Deprenyl
complete inhibition at 0.01 mM
Deprenyl
-
inhibits the enzyme in vivo by 34-70% depending on the age, reversible by 4-chlorophenylalanine. Deprenyl administration decreases locomotion, altered vertical positioning and increased heart rate in larvae in vivo, 4-chlorophenylalanine normalizes serotonin levels and rescues the behavioral alteration
Deprenyl
-
IC50: 0.0023 mM; IC50: 3.3 mM
Deprenyl
-
IC50: 0.020 mM
Deprenyl
-
an acetylenic compound that forms covalent adducts with the N5 of the covalent FAD of MAO-B, pharmacologically inert as MAO-A inhibitor
Deprenyl
-
selective inhibition of MAO-B
Deprenyl
complete inhibition at 0.01 mM
Deprenyl
-
MAO-B sensitive
Harmaline
-
-
Harmaline
-
MAOI harmaline significantly reduces 5-MeO-DMT depletion and increases bufotenine formation in human hepatocytes
Harmaline
-
identification by HPLC-ESI-mass spectrometry. Potent reversible and strong inhibition of MAO-A, poor inhibition of MAO-B, from seeds
Harmaline
the ability of harmaline to modify the behavioral effects of 5-methoxy-N,N-dimethyltryptamine is mediated by the inhibition of MAOA. Serotonin2A receptors are responsible for the late hyperactivity induced by 5-methoxy-N,N-dimethyltryptamine in the presence of MAOA inhibitors
harman
-
-
harman
inhibition of MAO A
Harmane
-
-
Harmane
an MAO A specific reversible inhibitor
Harmane
-
reversible enzyme-specific inhibitor
harmine
-
the inhibitor induces changes in the spectrum of MAO A, consistent with stacking of inhibitor with the flavin in the active site. Inhibitor stabilizes the semiquinone form of FAD during reduction of MAO A by dithionite and no further reduction of the inhibitor-MAO A complex occurs
harmine
-
identification by HPLC-ESI-mass spectrometry. Potent reversible and strong inhibition of MAO-A, poor inhibition of MAO-B, from seeds
Iproniazid
-
-
Iproniazid
-
nonselective inhibitor
iproniazid phosphate
-
-
Iproniazide
-
inhibits both MAO-A and MAO-B
Iproniazide
-
inhibitor of MAO-A and MAO-B
isatin
-
isatin
monoamine oxidase A; monoamine oxidase B
isatin
a nonselective reversible MAO inhibitor, inhibits the MAO A S209E mutant with much lower affinity, 160fold and 20fold, respectively, than the wild-type enzyme
isatin
-
inhibitor of MAO-B
isatin
-
non-specific reversible inhibitor
isatin
competitive inhibitor; competitive inhibitor
isatin
reversible inhibitor; reversible inhibitor
isocarboxazide
-
-
isocarboxazide
-
inhibitor of MAO-A and MAO-B
isocarboxazide
-
inhibits MAO-A and MAO-B irreversibly
KF-17837
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
KF-17837
-
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
KW-6002
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
KW-6002
-
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
L-deprenyl
-
L-deprenyl
inhibition of MAO A and MAO B
L-deprenyl
-
irreversible cerebral MAO-B inhibitor
ladostigil
-
ladostigil
-
nonselective inhibitor
lazabemide
-
-
lazabemide
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
lazabemide
-
inhibitor of MAO-B
lazabemide
-
inhibits MAO-B reversibly
lazabemide
-
selective inhibition of MAO-B
methylene blue
-
-
methylene blue
-
reversible enzyme-specific inhibitor
moclobemide
-
moclobemide
the MAO inhibitor is promising in the therapeutic management of post-traumatic stress disorder and panic disorder; the MAO inhibitor is promising in the therapeutic management of post-traumatic stress disorder and panic disorder
moclobemide
-
specific for MAO-A
moclobemide
-
inhibitor of MAO-A
moclobemide
-
inhibits MAO-A reversibly
moclobemide
-
specific for MAO-A
moclobemide
reversible inhibitor of isoform MAO-A
moclobemide
-
specific inhibitor of isoform MAO-A
moclobemide
reversible inhibitor of isoform MAO-A
mofegiline
mechanism-based irreversible, competitive inhibition versus substrate of MAO-B with a 1:1 molar stoichiometry, also competitively inhibits MAO-A. Effects on UV absorption spectra of flavin, and inhibitor-bound enzyme structure, overview
mofegiline
-
a vinyl fluoroamine
N,N'-(1R,2S)-cyclohexane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-(1R,2S)-cyclohexane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-1,2-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-1,2-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-1,4-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-1,4-phenylenebis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-butane-1,4-diylbis(2-oxo-2H-chromene-3-carboxamide)
potent inhibitor of MAO-A with high selectivity towards MAO-B; potent inhibitor of MAO-A with high selectivity towards MAO-B
N,N'-butane-1,4-diylbis(2-oxo-2H-chromene-3-carboxamide)
potent inhibitor of MAO-A with high selectivity towards MAO-B
N,N'-butane-1,4-diylbis(7-methoxy-2-oxo-2H-chromene-3-carboxamide)
-
N,N'-butane-1,4-diylbis(7-methoxy-2-oxo-2H-chromene-3-carboxamide)
-
N,N'-ethane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-ethane-1,2-diylbis(2-oxo-2H-chromene-3-carboxamide)
-
N,N'-hexane-1,6-diylbis(2-oxo-2H-chromene-3-carboxamide)
potent inhibitor of MAO-A with high selectivity towards MAO-B; potent inhibitor of MAO-A with high selectivity towards MAO-B
N,N'-hexane-1,6-diylbis(2-oxo-2H-chromene-3-carboxamide)
potent inhibitor of MAO-A with high selectivity towards MAO-B
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
-
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
i.e. ParSL-1, a TEMPO-conjugated pargyline analogue; i.e. ParSL-1, a TEMPO-conjugated pargyline analogue
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
-
N-(2-aminoethyl)-p-chlorobenzamide
-
inhibits by covalent binding to the flavin ring
N-(2-aminoethyl)-p-chlorobenzamide
-
-
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
-
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
-
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
-
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
-
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
-
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
-
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
-
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
-
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
NTZ-1441; NTZ-1441
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
NTZ-1441; NTZ-1441
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
-
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
-
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
NTZ-1442; NTZ-1442
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
NTZ-1442; NTZ-1442
N-phenyl-1H-indazole-5-carboxamide
-
N-phenyl-1H-indazole-5-carboxamide
-
norharman
-
competitive reversible and potent inhibitor
norharman
inhibition of MAO A; inhibition of MAO B
Pargyline
-
-
Pargyline
-
MAO-B sensitive
Pargyline
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
Pargyline
construction of three TEMPO-conjugated pargyline analogues ParSL-1, ParSL-2, and ParSL-3, which differ in flexibility and substituent positions of the linkers connecting the TEMPO group to the pargyline phenyl ring. The variations in conformational flexibility and substituent position have profound effects in tuning the specificities of these analogues toward the MAO isoforms, inhibitor synthesis, overview; construction of three TEMPO-conjugated pargyline analogues ParSL-1, ParSL-2, and ParSL-3, which differ in flexibility and substituent positions of the linkers connecting the TEMPO group to the pargyline phenyl ring. The variations in conformational flexibility and substituent position have profound effects in tuning the specificities of these analogues toward the MAO isoforms, inhibitor synthesis, overview
Pargyline
-
inhibitor of MAO-A and MAO-B
Pargyline
-
inhibits MAO-A and MAO-B irreversibly
Pargyline
-
MAO-B sensitive
Pargyline
-
irreversible inhibitor
Pargyline
monoamine oxidase B
Pargyline
the irreversible and non-selective MAO inhibitor produces increases in 5-hydroxytryptamine syndrome in the 5-hydroxytryptamine-treated rats
Pargyline
-
irreversible inhibitor. Pargyline + semicarbazide-induced reduction of fat deposition results from decreased food intake and from impaired MAO and SSAO-dependent lipogenic and antilipolytic actions of endogenous or alimentary amines
ParSL
a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview
ParSL
a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview
Phenelzine
-
-
Phenelzine
concentration-dependent inhibition
Phenelzine
-
the nonselective irreversible inhibitor of monoamine oxidase causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition
Phenelzine
weak inhibition of MAO-A
pheniprazine
i.e. (1-methyl-2-phenylethyl)hydrazine. Mechanism-based MAO inhibitor
pheniprazine
i.e. (1-methyl-2-phenylethyl)hydrazine. As a reversible inhibitor it is selective towards rat liver MAO-A but the rate of irreversible inhibition of that enzyme is considerably slower; i.e. (1-methyl-2-phenylethyl)hydrazine. Mechanism-based MAO inhibitor
phentermine
-
phentermine
binding to the S209E mutant is reduced by 13fold compatred to the wild-type MAO A
phentermine
i.e. 2-methyl-1-phenyl-2-propanamine; i.e. 2-methyl-1-phenyl-2-propanamine
phentermine
reversible inhibitor; reversible inhibitor
Phenylethylhydrazine
the mode of irreversible MAO inhibition involves covalent modification of the flavin coenzyme, overview; the three-dimensional structures of phenylethylhydrazine- and benzylhydrazine-inhibited MAO B show that alkylation occurs at the N5 position on the re-face of the covalent flavin with loss of the hydrazyl nitrogens, mechanism, the mode of irreversible MAO inhibition involves covalent modification of the flavin coenzyme, overview
phenylhydrazine
-
-
phenylhydrazine
weak binding; weak binding
pirlindole mesylate
-
-
pirlindole mesylate
-
reversible enzyme-specific inhibitor
pyronine G
-
irreversible inhibitor
R-(-)-deprenyl
-
inhibits both MAO-A and MAO-B
R-(-)-deprenyl
-
inhibitor of MAO-B
R-(-)-deprenyl
-
inhibits MAO-B irreversibly
R-(-)-deprenyl
-
highly active with MAO-B
rasagiline
-
rasagiline
i.e. N-propargyl-1-R-aminoindan. Irreversible MAO B inhibitor. Rasagiline is initiated at 1 mg once-daily dosage as monotherapy in early Parkinsons disease patients and at 0.5-1 mg once-daily as adjunctive to levodopa in advanced Parkinsons disease patients. Rasagiline treatment is not associated with cheese effect and up to 20 mg per day is well tolerated. In Parkinsons disease patients with hepatic impairment, rasagiline dosage should be carefully adjusted. Rasagiline should not be administered with other MAO inhibitors and coadministration with certain antidepressants and opioids should be avoided. This drug provides an additional tool for Parkinsons disease therapy improvement in motor performance
rasagiline
-
an acetylenic compound that forms covalent adducts with the N5 of the covalent FAD of MAO-B, pharmacologically inert as MAO-A inhibitor. A rasagiline analog methylated on the amino moiety of the propargyline chain connecting the inhibitor to the flavin loses this characteristic specificity for MAO-B
rasagiline
-
inhibitor of MAO-B
rasagiline
-
inhibits MAO-B irreversibly
rasagiline
irreversible inhibitor of isoform MAO-B
rasagiline
irreversible inhibitor of isoform MAO-B
rasagiline
specific MAO-B inhibitor
Ro 41-1049
-
-
safinamide
binds noncovalently to MAO B, occupying both the entrance and the substrate cavities
safinamide
-
a very specific MAO B non-covalent inhibitor, may function effectively as a neuroprotectant
safinamide
reversible inhibitor of isoform MAO-B
safinamide
reversible inhibitor of isoform MAO-B
selegiline
-
selegiline
the experimentally tested model compound is docked computationally to the active site of the MAO-B enzyme. The AutoDock 3.0.5 program is employed to perform automated molecular docking. The free energies of binding and inhibition constants (Ki) of the docked compounds are calculated by the Lamarckian Genetic Algorithm of AutoDock 3.0.5. Excellent to good correlations between the calculated and experimental Ki values are obtained
selegiline
the MAO B inhibitor is efficacious in the therapeutic management of Parkinson's disease
selegiline
-
an effective and well-tolerated monoamine oxidase inhibitor for the treatment of depression
selegiline
irreversible inhibitor of isoform MAO-B
selegiline
irreversible inhibitor of isoform MAO B
selegiline
-
irreversible cerebral MAO-B inhibitor
selegiline
administration of the irreversible and selective MAO-B inhibitor selegiline does not produce any increase in 5-hydroxytryptamine syndrome in the 5-hydroxytryptamine-treated rats, compared with the saline control
selegiline
irreversible inhibitor of isoform MAO-B
selegiline
specific MAO-B inhibitor
Semicarbazide
-
-
Semicarbazide
-
complete inhibition at 0.01 mM
takrin
-
irreversible inhibitor
tetrindole
-
the inhibitor induces changes in the spectrum of MAO A, consistent with stacking of inhibitor with the flavin in the active site. Inhibitor stabilizes the semiquinone form of FAD during reduction of MAO A by dithionite and no further reduction of the inhibitor-MAO A complex occurs
tetrindole
an MAO A specific reversible inhibitor
tetrindole mesylate
-
-
tetrindole mesylate
-
reversible enzyme-specific inhibitor
toloxatone
-
-
toloxatone
-
inhibitor of MAO-A
toloxatone
-
inhibits MAO-A reversibly
trans-2-phenylcyclopropylamine
-
inhibits by covalent binding to the flavin ring
trans-2-phenylcyclopropylamine
2-PCPA; 2-PCPA
tranylcypromine
-
-
tranylcypromine
inhibition of MAO-B
tranylcypromine
inactivation of recombinant human MAO-B with tranylcypromine results in the formation of a high affinity I2 site on the enzyme, measured as an increase in binding of 2-(2-benzofuranyl)-2-imidazoline. Inhibition by tranylcypromine results in displacement of Q206 and closure of the I199 gate
tranylcypromine
-
nonselective inhibitor
ZnSO4
-
1 mM, 10% inhibition, monoamine oxidase B; 1 mM, 85% inhibition with serotonin as substrate, competitive, reversible, monoamine oxidase A
ZnSO4
-
1 mM, about 20% inhibition, monoamine oxidase A
ZnSO4
-
1 mM, about 20% inhibition, monoamine oxidase A
[(E)-1,3-dipropyl-7-methyl-8-(2-(3-thienyl)ethenyl)]xanthine
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
[(E)-1,3-dipropyl-7-methyl-8-(2-(3-thienyl)ethenyl)]xanthine
-
a dual-target-directed drug inhibiting MAO-B and antagonizing A2A receptors
[Cu(2-[4-[bis(4-fluorophenyl)methyl]pipera-zin-1-yl]acetic acid)2(H2O)]
the complex 1 is a potent MAO-B inhibitor
-
[Cu(2-[4-[bis(4-fluorophenyl)methyl]pipera-zin-1-yl]acetic acid)2(H2O)]
the complex 1 is a potent MAO-B inhibitor
-
additional information
-
enzyme activity is not inhibited by pargyline, clorgyline, semicarbazide, or sodium diethyldithiocarbamate
-
additional information
no inhibition of monoamine oxidase B: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene
-
additional information
-
no inhibition of monoamine oxidase B: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene
-
additional information
-
comparison of two regions in the polypeptide sequence of C-MAO determining possible substrate/inhibitor preferences of mammalian MAO-A and MAO-B show both 79.5% homologies, overview
-
additional information
-
not inhibited by D-amphetamine, farnesol, safinamide, 1,4-diphenyl-1,3-butadiene, and 1,4-diphenyl-2-butene
-
additional information
-
cigarette smoke is a potent inhibitor of MAO-A. Inhibition is partly reversible, competitive. beta-Carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers; cigarette smoke is a potent inhibitor of MAO-B. Inhibition is partly reversible, competitive. Veta-carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers
-
additional information
-
no inhibition by Mesobuthus gibbosus venom peptide
-
additional information
no inhibition by 4-hydroxy-3-methoxyophenylethyl alcohol, ethyl-4-hydroxy-3-methoxyphenylacetate, metanephrine, 3,4-dimethoxy-5-hydroxybenzaldehyde and 3-methoxyphenol
-
additional information
no inhibition by 4-hydroxy-3-methoxyophenylethyl alcohol, ethyl-4-hydroxy-3-methoxyphenylacetate, metanephrine, 3,4-dimethoxy-5-hydroxybenzaldehyde and 3-methoxyphenol
-
additional information
recombinant enzyme obtained from a Baculovirus expression system is validated as convenient enzyme source for MAO B inhibitor screening
-
additional information
-
recombinant enzyme obtained from a Baculovirus expression system is validated as convenient enzyme source for MAO B inhibitor screening
-
additional information
both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes; both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes
-
additional information
both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes; both the MAO-A and MAO-B isoforms, deposited in the Protein Data bank as the 2BXR and 1GOS models, respectively, are considered in a computational sttudy performed with docking techniques to explain the selective inhibitory activity towards the MAO-A and MAO-B enzymes
-
additional information
no inhibition of monoamine oxidase A: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene
-
additional information
no inhibition of monoamine oxidase A: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene
-
additional information
-
no inhibition of monoamine oxidase A: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene
-
additional information
coffee contains compounds acting as reversible and competitive inhibitors for MAO A; coffee contains compounds acting as reversible and competitive inhibitors for MAO B
-
additional information
coffee contains compounds acting as reversible and competitive inhibitors for MAO A; coffee contains compounds acting as reversible and competitive inhibitors for MAO B
-
additional information
-
coffee contains compounds acting as reversible and competitive inhibitors for MAO A; coffee contains compounds acting as reversible and competitive inhibitors for MAO B
-
additional information
evaluation of the application of UCSF DOCK to screen for inhibitors of MAO-B
-
additional information
the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs; the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs
-
additional information
the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs; the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs
-
additional information
-
the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs; the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs
-
additional information
no inhibition: 1,4-diphenyl-2-butene and chlorostyrylcaffeine
-
additional information
-
no inhibition: 1,4-diphenyl-2-butene and chlorostyrylcaffeine
-
additional information
synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7; synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7
-
additional information
synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7; synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7
-
additional information
-
synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7; synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7
-
additional information
synthesis and inhibhitory potencies of (E)-styrylisatin analogues on the enzyme, overview. No inhibition of MAO-A by (E)-8-(3-chlorostyryl)caffeine; synthesis and inhibhitory potencies of (E)-styrylisatin analogues on the enzyme, overview. The (E)-5-styrylisatin analogue binds more tightly than the (E)-6 analogue although the latter exhibits the highest MAO-B selectivity
-
additional information
synthesis and inhibhitory potencies of (E)-styrylisatin analogues on the enzyme, overview. No inhibition of MAO-A by (E)-8-(3-chlorostyryl)caffeine; synthesis and inhibhitory potencies of (E)-styrylisatin analogues on the enzyme, overview. The (E)-5-styrylisatin analogue binds more tightly than the (E)-6 analogue although the latter exhibits the highest MAO-B selectivity
-
additional information
-
synthesis and inhibhitory potencies of (E)-styrylisatin analogues on the enzyme, overview. No inhibition of MAO-A by (E)-8-(3-chlorostyryl)caffeine; synthesis and inhibhitory potencies of (E)-styrylisatin analogues on the enzyme, overview. The (E)-5-styrylisatin analogue binds more tightly than the (E)-6 analogue although the latter exhibits the highest MAO-B selectivity
-
additional information
successful SRY knockdown inhibits MAO A catalytic activity by 45%
-
additional information
-
successful SRY knockdown inhibits MAO A catalytic activity by 45%
-
additional information
Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B, no inhibition of both isozymes by rosavin, rosarin, and rosin
-
additional information
inhibitors of MAO-B can be adjunctive drugs to levodopa. Neuroprotective and anti-Parkinsonian effects of A2A receptor antogonistic drugs, overview
-
additional information
-
inhibitor binding affects the active site structures of MAO-A and MAO-B, overview
-
additional information
-
development and synthesis of benzylidene-prop-2-ynyl-amines analogues as monoamine oxidase inhibitors, ligand docking and molecular modelling, overview. In the active center, Ile199 is the gate residue, and two hydrophobic areas of the enzyme are implicated in the most stable binding mode. Hydrophobic pocket is delimited by Ile198, Ile199, Gln206, Phe343, and aromatic cage contains FAD, Tyr398 and Tyr435
-
additional information
-
evaluation of chromone carboxylic acids as enzyme inhibitors, only chromone-3-carboxylic acid is a potent MAO-B inhibitor, with a high degree of selectivity for MAO-B compared to MAO-A, no inhibition by 4-oxo-4H-chromene-2-carboxylic acid at 0.1 mM, molecular docking, overview
-
additional information
-
inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues, quantitative structure-activity relationship studies, overview
-
additional information
-
2-arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, as monoamine oxidase inhibitors, molecular docking using crystal structures of human MAO-B, PDB ID 1S3E, and MAO-A, PDB ID 2BXS, overview
-
additional information
-
cycloalkylidenhydrazothiazole derivative inhibitors derived from N1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole, molecular modeling, overview. No inhibition by 13, 42, and 44
-
additional information
-
synthesis and molecular modeling of selective monoamine oxidase inhibitors from a 2-thiazolylhydrazyne scaffold, structure-activity relationships, overview. No or poor activity against MAO-A with 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-2-yl)-ethylidene)hydrazine, and 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(naphthalen-2-yl)ethylidene)hydrazine, and against MAO-B with 5, 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-2-yl)-ethylidene)hydrazine, 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-ylmethylene)hydrazine, 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(naphthalen-2-yl)ethylidene)hydrazine, and 1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(benzodioxol-5-ylmethylene)-hydrazine
-
additional information
-
4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains as enzyme inhibitors. Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis, and antitumor activities against human lung cancer A-549 and human prostate cancer PC-3 cell lines, overview
-
additional information
design and synthesis of a series of indole and benzofuran derivatives, and evaluation as reversible inhibitors of the two MAO isozymes MAO-A and MAO-B, most compounds are selective MAO-B inhibitors, ligand docking study, overview
-
additional information
-
synthesis of 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives and evaluation of their monoamine oxidase inhibitory activity, ligand docking and mechanism of inhibition, molecular modelling, overview. Comparison with 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole and 2-thiazolyl hydrazones, overview. No or poor inhibition of MAO-A by all compounds tested, no inhibition of MAO-B by compounds 1-thiocarbamoyl-3-(4-fluorophenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(3-methylphenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(2-methylphenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(3-methoxyphenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(2,4-dichlorophenyl)-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(thiophen-2-yl)-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(2-methylphenyl)-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(thiophen-2-yl)-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(4-fluorophenyl)-4-methyl-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(4-fluorophenyl)-4-methyl-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-(4-methylphenyl)-4-methyl-4,5-dihydropyrazole, 1-thiocarbamoyl-3-(4-methylphenyl)-4-methyl-4,5-dihydropyrazole, 1-(N-methylthiocarbamoyl)-3-phenyl-4-methyl-4,5-dihydropyrazole, 1-thiocarbamoyl-3-phenyl-4-methyl-4,5-dihydropyrazole, and 1-thiocarbamoyl-3-(4-chlorophenyl)-4-methyl-4,5-dihydropyrazole
-
additional information
-
enzyme inhibition by beta-carboline alkaloids from seeds and roots of Peganum harmala, low levels in stems and leaves, and absence in flowers, overview. Seed extracts are potent reversible and competitive inhibitors of human MAO-A with an IC50 of 0.027 mg/L whereas root extracts strongly inhibit MAO-A with an IC50 of 0.159 mg/L. In contrast, they are poor inhibitors of MAO-B. Inhibition of MAO-A by seed extracts is quantitatively attributed to harmaline and harmine whereas inhibition by root extracts came from harmine with no additional interferences
-
additional information
-
nitroindazole isomers are good hydroxyl radical scavengers and inhibhit MPTP neurotoxin oxidation by MAO. Compounds 4, 5, 6, 7, 8, 9, 10, and 11 are poor inhibitors
-
additional information
-
extracts from Fructus crataegi and Radix polygoni multiflori plants show MAO-B inhibition by 56% and 69%, respectively. The extracts of several other plants are not inhibitory for MAO-B, overview
-
additional information
-
MAO-B and MAO-A, clinical study, in vivo inhibitory activity, detailed overview
-
additional information
-
synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins, molecular modeling, overview
-
additional information
-
MAO-A is not inhibited by most of the chalcone compounds tested for MAO inhibitory activity, no inhibition of MAO-B by 5c, 5d, and 5f, overview
-
additional information
-
25 anthocyanidins, anthocyanidin-3-glycosides, anthocyanidin-3,5-diglucosides, proanthocyanidins, and phenolic metabolites are examined as MAO inhibitors, overview
-
additional information
-
isoform MAO B is not inhibited by pirlindole
-
additional information
no inhibition by catechin and cyanidin; no inhibitipon by catechin and cyanidin
-
additional information
no inhibition by catechin and cyanidin; no inhibitipon by catechin and cyanidin
-
additional information
-
no inhibition by catechin and cyanidin; no inhibitipon by catechin and cyanidin
-
additional information
-
the enzyme is not suppressed by 10 mM semicarbazide
-
additional information
-
insensitive to semicarbazide
-
additional information
-
the inhibitors show no neuroprotective effects in female scrapie-infected hamsters, overview
-
additional information
inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine; inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine
-
additional information
inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine; inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine
-
additional information
-
inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine; inhibitory potencies of methylpiperate derivatives from Piper longum, no inhibition by isolated piperlonguminine
-
additional information
-
inhibitors of MAO-B can be adjunctive drugs to levodopa. Neuroprotective and anti-Parkinsonian effects of A2A receptor antogonistic drugs, overview
-
additional information
-
hardly inhibited by 1 mM o-phenanthroline (4%), pargyline (2%) and clorgyline (1%)
-
additional information
Neogale vison
-
the enzyme is not inhibited by semicarbazide
-
additional information
-
no inhibition of monoamine oxidase B: isatin, trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene
-
additional information
-
inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues, quantitative structure-activity relationship studies, overview
-
additional information
-
potent reversible pteridine-2,4-dione analogue inhibitor development and synthesis, molecular modelling of MAO-B ligand binding, overview
-
additional information
-
not inhibited by 100 mM semicarbazide
-
additional information
-
insensitive to semicarbazide
-
additional information
-
not inhibited by 100 mM semicarbazide
-
additional information
-
inhibitors with a substitution at the 5-position in 2-[N-(2-propynyl) aminomethyl]-1-methyl indole
-
additional information
-
overview: selective inhibitors of form A and B
-
additional information
-
no inhibition by Mesobuthus gibbosus venom peptide
-
additional information
alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors
-
additional information
alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors
-
additional information
no inhibition: 1-thiocarbamoyl-3-phenyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole, thiocarbamoyl-3-phenyl-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
-
additional information
the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs; the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs
-
additional information
the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs; the active site cavities in rat MAOs are significantly different compared to those in the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs
-
additional information
monoamine oxidase-B inhibitors and antiinflammatory agents might be effective in treating Alzheimers disease
-
additional information
monoamine oxidase-B inhibitors and antiinflammatory agents might be effective in treating Alzheimers disease
-
additional information
no inhibition: 1,4-diphenyl-2-butene and chlorostyrylcaffeine
-
additional information
-
SSAO inhibition is not sufficient to impair fat deposition. Combined MAO and SSAO inhibition limits adiposity in non-obese as well as in obese rats
-
additional information
naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors of isozymes MAO-A and MAO-B, molecular docking, overview. Replacement of the phenyl ring of amphetamine derivatives by a naphthalene system resulted in more potent compounds results in increased electron-donating capacity and size of the aromatic moiety; naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors of isozymes MAO-B, molecular docking, overview. Replacement of the phenyl ring of amphetamine derivatives by a naphthalene system resulted in more potent compounds results in increased electron-donating capacity and size of the aromatic moiety. No inhibition of MAOB by N-4-methoxybenzyl-(4-methylthioamphetamine) hydrochloride, N-4-butoxybenzyl-(4-methylthioamphetamine) hydrochloride, and N-4-benzyloxybenzyl-(4-methylthioamphetamine) hydrochloride
-
additional information
naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors of isozymes MAO-A and MAO-B, molecular docking, overview. Replacement of the phenyl ring of amphetamine derivatives by a naphthalene system resulted in more potent compounds results in increased electron-donating capacity and size of the aromatic moiety; naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors of isozymes MAO-B, molecular docking, overview. Replacement of the phenyl ring of amphetamine derivatives by a naphthalene system resulted in more potent compounds results in increased electron-donating capacity and size of the aromatic moiety. No inhibition of MAOB by N-4-methoxybenzyl-(4-methylthioamphetamine) hydrochloride, N-4-butoxybenzyl-(4-methylthioamphetamine) hydrochloride, and N-4-benzyloxybenzyl-(4-methylthioamphetamine) hydrochloride
-
additional information
no inhibhition of MAO-A by selegiline; no inhibition of MAO-B by clorgyline
-
additional information
no inhibhition of MAO-A by selegiline; no inhibition of MAO-B by clorgyline
-
additional information
-
no inhibhition of MAO-A by selegiline; no inhibition of MAO-B by clorgyline
-
additional information
-
no inhibition of MAO-A by farnesol, chlorostyrylcaffeine, and 1,4-diphenyl-2-butene; not inhibited by farnesol, chlorostyrylcaffeine and 1,4-diphenyl-2-butene
-
additional information
no inhibition of MAO-A by farnesol, chlorostyrylcaffeine, and 1,4-diphenyl-2-butene; not inhibited by farnesol, chlorostyrylcaffeine and 1,4-diphenyl-2-butene
-
additional information
-
the enzyme is not inhibited by semicarbazide
-
additional information
-
inhibitor binding affects the active site structures of MAO A and MAO B, overview
-
additional information
-
synthesis and molecular modeling of some hexahydroindazole derivatives as potent monoamine oxidase inhibitors, overview
-
additional information
-
2-arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, as monoamine oxidase inhibitors, overview
-
additional information
molecular docking of MAO-A and MAO-B, overview
-
additional information
-
design, synthesis, and evaluation of selective MAO-B inhibitors with favorable physicochemical and pharmacokinetic profiles, 7-[(m-halogeno)benzyloxy]coumarins bearing properly selected polar substituents at position 4, overview
-
additional information
-
isoform MAO-B is not inhibited by (3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl benzenesulfonate, (3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate, (3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-cyanobenzenesulfonate, (3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-acetylbenzenesulfonate, (3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-(methylsulfonyl)benzenesulfonate, (3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-cyanobenzenesulfonate, (3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-methoxybenzenesulfonate, (3E)-3-[2-(ethylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate, moclobemide, 3-oxo-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate, and 7-[(3-chlorobenzyl)oxy]-4-(chloromethyl)-2H-chromen-2-one
-
additional information
3-phenyl-4-(phenyltelluro) isoquinoline does not inhibit 50% of the isoform MAO-B activity up to concentration of 0.1 mM
-
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0.506 - 2.56
(+)-amphetamine
0.00036
(2E)-1-(4-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]prop-2-en-1-one
at pH 7.4 and 37°C
0.00022
(2E)-1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
at pH 7.4 and 37°C
0.00028
(2E)-3-(2-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
at pH 7.4 and 37°C
0.002 - 0.00423
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
0.00035
(2E)-3-(3-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
at pH 7.4 and 37°C
0.00027
(2E)-3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
at pH 7.4 and 37°C
0.00801 - 0.175
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
0.0013 - 0.0235
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
0.0122 - 0.1
(2S)-amphetamine
0.00106
(3E)-7-hydroxy-3-[(4-methoxyphenyl)methylidene]-2,3-dihydro-4H-1-benzopyran-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.001063 - 0.026622
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.001606 - 0.011244
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00007142 - 0.000293
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000034 - 0.001356
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0005343 - 0.006267
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000062 - 0.00036
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000716 - 0.005886
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000131 - 0.000222
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.011429 - 0.030444
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000054 - 0.000066
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00006285 - 0.00008
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000138 - 0.0007371
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00014 - 0.000951
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000126 - 0.000613
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00038 - 0.000453
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000062 - 0.011429
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000306 - 0.033956
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000284 - 0.008543
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0018622 - 0.012657
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0114 - 0.025244
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000154 - 0.021822
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000058 - 0.004429
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0012
(5R)-3-(3-fluoro-4-morpholin-4-ylphenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.00016
(5R)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.00034
(5R)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.116
(5S)-5-(aminomethyl)-3-(3-fluoro-4-morpholin-4-ylphenyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.0057
(5S)-5-(aminomethyl)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.023
(5S)-5-(aminomethyl)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.00256 - 0.00378
(6-benzyloxy-2-naphthyl)-2-aminopropane
0.00153
(6-butoxy-2-naphthyl)-2-aminopropane
MAO-A
0.00045 - 0.0163
(6-ethoxy-2-naphthyl)-2-aminopropane
0.00018 - 0.1
(6-methoxy-2-naphthyl)-2-aminopropane
0.0005
(6-methylthio-2-naphthyl)isopropylamine
MAO-A
0.00068 - 0.0136
(6-propoxy-2-naphthyl)-2-aminopropane
0.00179
(E)-3-(2-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.01973
(E)-3-(3,4-dimethoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0022
(E)-3-(3-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00103
(E)-3-(4-(dimethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0154
(E)-3-(4-chlorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00109
(E)-3-(4-fluorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00343
(E)-3-(4-methoxybenzylidene)-7-(10-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00116
(E)-3-(4-methoxybenzylidene)-7-(5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.000401
(E)-3-(4-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.000518
(E)-3-(4-methoxybenzylidene)-7-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.000437
(E)-3-(4-methoxybenzylidene)-7-(9-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00124
(E)-3-(4-methylbenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00019 - 0.001
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.0014 - 0.0125
(E)-5-(3-chlorostyryl)isatin
0.00056 - 0.022
(E)-5-(3-fluorostyryl)isatin
0.00031 - 0.0011
(E)-5-styrylisatin
0.0006 - 0.0045
(E)-6-styrylisatin
0.00136
(E)-7-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(4-methoxybenzylidene)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00156
(E)-7-(8-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)3-(4-methoxybenzylidene)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0397
(E)-8-(2-furylethenyl)caffeine
-
-
0.00158
(E)-8-(2-thienylethenyl)caffeine
-
-
0.000036
(E)-8-(3,4-dichlorostyryl)caffeine
-
-
0.000239
(E)-8-(3,5-ditrifluoromethylstyryl)caffeine
-
-
0.000083
(E)-8-(3-bromostyryl)caffeine
-
-
0.00003 - 0.000148
(E)-8-(3-chlorostyryl)caffeine
0.001431
(E)-8-(3-methylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000133
(E)-8-(3-trifluoromethylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.00026
(E)-8-(4-chlorostyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.001559
(E)-8-(4-fluorostyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000367
(E)-8-(4-methylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000245
(E)-8-(4-trifluoromethylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000094 - 0.00286
(E)-8-styrylcaffeine
MAO-B
0.00052 - 0.0033
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
1.4 - 2.7
(N-cyclopropyl-alpha-methylbenzylamine)
0.0000017 - 0.00003
(R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
0.00026 - 0.0015
(R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
0.00002 - 0.007
(R)-N-(alpha-cyclohexylethyl)-N-methyl,N-(pyrrol-2-ylmethyl)-amine
0.00122 - 0.0025
(R,S)-N-(alpha-phenylethyl)-1H-pyrrole-2-carboxamide
0.0001 - 0.0045
(R,S)-N-methyl,N-(alpha-phenylethyl),N-(pyrrol-2-ylmethyl)-amine
0.00001 - 0.0618
(R,S)-N-methyl,N-(alpha-phenylethyl)-1H-pyrrole- 2-carboxamide
0.00002 - 0.0041
(S)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
0.00033 - 0.0036
(S)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
0.000051 - 0.0013
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
0.00014 - 0.0004
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
0.0113
1,3,7-trimethyl-8-[(E)-2-(3-thienyl)vinyl]-3,7-dihydro-1H-purine-2,6-dione
-
-
0.001 - 0.007
1,4-diphenyl-1,3-butadiene
0.0007 - 0.0345
1,4-diphenyl-2-butene
0.0056 - 0.1
1-(1-naphthyl)-2-aminopropane
0.00042 - 0.1
1-(2-naphthyl)-2-aminopropane
0.00071 - 0.00342
1-(4-benzyloxyphenyl)-2-aminopropane
0.00032 - 0.1
1-(4-butoxyphenyl)-2-aminopropane
0.00022 - 0.1
1-(4-ethoxyphenyl)-2-aminopropane
0.00025
1-(4-methoxy-phenyl)-2-aminopropane
MAO-A
0.00025
1-(4-methylthiophenyl)-2-aminopropane
MAO-A
0.00013 - 0.1
1-(4-propoxyphenyl)-2-aminopropane
0.0417
1-methoxy-3-(3-methylphenyl)pyrrole
-
pH 7.4, 37°C
0.00326
1-methyl-2-[(E)-2-(4-methylphenyl)vinyl]-1H-benzimidazole
-
-
0.0187
1-methyl-2-[(E)-2-phenylvinyl]-1H-benzimidazole
-
-
0.00043
1-methyl-2-[(E)-2-[4-(trifluoromethyl)phenyl]vinyl]-1H-benzimidazole
-
-
0.0143
1-methyl-3-(3-bromophenyl)pyrrole
-
pH 7.4, 37°C
0.0209
1-methyl-3-(3-chlorophenyl)pyrrole
-
pH 7.4, 37°C
0.0389
1-methyl-3-(3-fluorophenyl)pyrrole
-
pH 7.4, 37°C
0.056
1-methyl-3-(3-methylphenyl)-1H-pyrrole
-
pH 7.4, 37°C
0.056
1-methyl-3-(3-methylphenyl)pyrrole
-
pH 7.4, 37°C
0.0066
1-methyl-3-(3-trifluoromethylphenyl)pyrrole
-
pH 7.4, 37°C
0.0225
1-methyl-3-(4-methylphenyl)-1H-pyrrole
-
pH 7.4, 37°C
0.118
1-methyl-3-phenyl-1H-pyrrole
-
pH 7.4, 37°C
0.118
1-methyl-3-phenylpyrrole
-
pH 7.4, 37°C
0.0013
1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrrole
-
pH 7.4, 37°C
0.182
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
-
0.0035 - 0.0045
1-methyl-4-phenylpyridinium
0.0055 - 0.0399
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
0.0333
1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.0337
1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, MAO-B, selective for MAO-B
0.0269
1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.024
1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, MAO-B, selective for MAO-B
0.013
1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.0125
1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-B
0.0608
1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.0371
1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, MAO-B, selective for MAO-B
0.0122
1-phenyl-2-aminopropane
MAO-A
7.3 - 12.8
1-phenylcyclopropylamine
0.00789 - 0.326
2-(2-benzofuranyl)-2-imidazoline
0.000048 - 0.1
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
0.000038 - 0.1
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
0.00016 - 0.0509
2-(4'-butoxyphenyl)thiomorpholin-5-one
0.000068 - 0.0141
2-(4'-butoxyphenyl)thiomorpholine oxalate
0.0034 - 0.06
2-(4'-ethoxyphenyl)thiomorpholin-5-one
0.0021 - 0.0096
2-(4'-ethoxyphenyl)thiomorpholine oxalate
0.00928 - 0.1
2-(4'-methoxyphenyl)thiomorpholin-5-one
0.0039 - 0.1
2-(4'-methoxyphenyl)thiomorpholine oxalate
0.0015 - 0.04
2-(4'-propoxyphenyl)thiomorpholin-5-one
0.00013 - 0.0066
2-(4'-propoxyphenyl)thiomorpholine oxalate
0.0652 - 0.513
2-(4,5-dihydroimidazol-2-yl)-isoquinoline
0.0817 - 0.385
2-(4,5-dihydroimidazol-2-yl)-quinoline
0.0329
2-(4-bromophenyl)cyclopropanamine
inhibition of MAO-B
0.0866
2-(4-methoxyphenyl)cyclopropanamine
inhibition of MAO-B
0.008 - 0.114
2-(5,7-dibromobenzofuran-2-yl)-imidazoline
0.0098
2-(naphthalen-1-yl)cyclopropanamine
inhibition of MAO-B
1.548
2-(thiophen-3-yl)cyclopropanamine
inhibition of MAO-B
0.25
2-hydroxyquinoline
-
-
0.2 - 0.31
2-phenylcyclopropylamine
0.00919 - 0.1
2-phenylthiomorpholin-5-one
0.0022 - 0.1
2-phenylthiomorpholine oxalate
0.000104
2-[(1E,3E)-4-(3-chlorophenyl)buta-1,3-dien-1-yl]-3,5,7-trimethyl-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
MAO-B
0.00254
2-[(E)-2-(4-bromophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.00283
2-[(E)-2-(4-chlorophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.01495
2-[(E)-2-(4-fluorophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.00582
2-[(E)-2-(4-methoxyphenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.0077
2-[4-(trifluoromethyl)phenyl]cyclopropanamine
inhibition of MAO-B
0.00003 - 0.0026
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
0.000149 - 0.000153
3,5,7-trimethyl-2-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
MAO-B
0.000006 - 0.00001
3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000027 - 0.00005
3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0143
3-(3-bromophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0209
3-(3-chlorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0389
3-(3-fluorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0417
3-(3-methoxyphenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.00655
3-(3-tert-butylphenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.00665
3-(4-bromophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0184
3-(4-chlorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.031
3-(4-fluorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.000008 - 0.00037
3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000007 - 0.00005
3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.00111
3-(4-methoxybenzyl)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0365
3-(4-methoxyphenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.00033 - 0.0082
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
0.00043 - 0.002
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.0683 - 0.0757
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
0.00000274
5,7-diethyl-3-methyl-2-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
MAO-B
0.00002 - 0.00005
5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000004 - 0.00017
5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000006 - 0.000041
5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000006 - 0.001
5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0000015 - 0.000031
5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.00001 - 0.00005
5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000032
5-fluoro-alpha-methyltryptamine
-
-
0.000102
5-nitroindazole
-
pH 7.4, 37°C, MAO-B
2.823
6-(3-chlorophenyl)-1,3-dimethyl-1H-pteridine-2,4-dione
-
pH 7.4, 37°C
6.958
6-amino-1,3-dimethyl-5-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-1H-pyrimidine-2,4-dione
-
pH 7.4, 37°C
4.06
6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione
-
pH 7.4, 37°C
0.348
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione
-
pH 7.4, 37°C
0.0016
6-fluoro-alpha-methyltryptamine
-
-
0.00067
6-nitroindazole
-
pH 7.4, 37°C, MAO-B
0.181
6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione
-
pH 7.4, 37°C
0.0001 - 0.0157
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin
0.0004 - 0.011
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin
0.0074
7-nitroindazole
-
pH 7.4, 37°C, MAO-B
0.00027 - 0.0017
8-(3-chloro)styrylcaffeine
0.0024
8-(3-chlorostyryl)-caffeine
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.0002 - 0.0014
8-(3-chlorostyryl)caffeine
0.00043 - 0.00144
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.65
8-hydroxyquinoline
-
-
0.000023 - 0.00033
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000036 - 0.00023
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00018 - 0.00037
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00034 - 0.0011
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.0399
9,11-dimethylpurino[7,8-c]quinazoline-8,10(9H,11H)-dione
-
-
0.0177 - 0.55
amitriptyline
0.0000026
Azure Blue
pH and temperature not specified in the publication
-
0.003
benzaldehyde
-
at pH 7.0 and 37°C
0.00305 - 0.00383
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.026 - 2.096
benzylhydrazine
0.00000128 - 0.058
Clorgyline
0.027267
clorogyline
pH and temperature not specified in the publication
-
0.0474 - 0.0611
cyanidin-3-O-beta-D-glucoside
0.0000087 - 0.0019214
Deprenyl
0.00298 - 0.0799
di(2-hydroxyethyl)methyldodecylammonium
0.00005554 - 0.00013
harman
0.000005
harmine
pH and temperature not specified in the publication
0.0000022 - 0.0000045
KW-6002
MAO-B
0.017 - 0.297
metamphetamine
-
0.0013 - 0.0235
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
0.000004 - 0.00101
methylene blue
0.00145 - 0.2
moclobemide
0.000028 - 0.0011
mofegiline
0.022 - 0.212
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
0.268
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide
inhibition of MAO-A
0.015
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-4-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide
inhibition of MAO-B
0.00002 - 0.000024
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
0.00165 - 0.0395
N-(2-methyl-1H-indol-5-yl)benzamide
0.003 - 0.0183
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
0.00002 - 0.085
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
0.000007 - 0.00012
N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide
0.000055
N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-carboxamide
pH 7.5, 25°C
-
0.000017
N-(3'-chlorophenyl)-4-oxo-4H-chromene-3-carboxamide
pH 7.5, 25°C
-
0.000031
N-(3'-fluorophenyl)-4-oxo-4H-chromene-3-carboxamide
pH 7.5, 25°C
-
0.00004 - 0.0089
N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide
0.0007 - 0.025
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide
0.1
N-(4-benzyloxybenzyl)-4-methylthioamphetamine
MAO-A
0.009
N-(4-butoxybenzyl)-4-methylthioamphetamine
MAO-A
0.1
N-(4-hydroxybenzyl)-4-methylthioamphetamine
-
0.1
N-(4-methoxybenzyl)-4-methylthioamphetamine
MAO-A
0.00009 - 0.0025
N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide
0.000055 - 0.057
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide
0.00035 - 0.0072
N-(benzyl),N-(pyrrol-2-ylmethyl)amine
0.0003 - 0.00062
N-(propargyl),N-(pyrrol-2-ylmethyl)amine
0.0016
N-([(5S)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
pH 7.2, 30°C
0.005
N-([(5S)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
pH 7.2, 30°C
0.00042
N-2-phenylethyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0006 - 0.15
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide
0.1
N-benzyl-(4-methylthioamphetamine)
-
0.0145 - 0.0222
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane
0.00693 - 0.0247
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane
0.00025 - 0.15
N-benzyl-1H-pyrrole-2-carboxamide
0.00856
N-methoxy-2-(3-methylphenyl)maleimide
-
pH 7.4, 37°C
0.00005 - 0.0007
N-methyl,N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
0.0001 - 0.002
N-methyl,N-(3-phenylbutyl),N-(pyrrol-2-ylmethyl)amine
0.00005 - 0.0048
N-methyl,N-(3-phenylpropyl),N-(pyrrol-2-ylmethyl)amine
0.00015 - 0.3
N-methyl,N-(benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
0.00002 - 0.0035
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine
0.00044
N-methyl,N-(propargyl),N-(1-methylpyrrol-2-ylmethyl)-amine
pH 7.4, 38°C
0.00699
N-methyl-2-(3-bromophenyl)maleimide
-
pH 7.4, 37°C
0.00666
N-methyl-2-(3-chlorophenyl)maleimide
-
pH 7.4, 37°C
0.00573
N-methyl-2-(3-fluorophenyl)maleimide
-
pH 7.4, 37°C
0.086
N-methyl-2-(3-methylphenyl)maleimide
-
pH 7.4, 37°C
0.011
N-methyl-2-(3-trifluoromethylphenyl)maleimide
-
pH 7.4, 37°C
0.00349
N-methyl-2-phenylmaleimide
-
pH 7.4, 37°C
0.0004
N-phenyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00083
N-propargyl,N-methyl-1-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00023 - 0.07
N-propargyl-1H-pyrrole-2-carboxamide
0.02
N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
pH 7.2, 30°C
0.00112 - 0.0012
norharman
0.000011 - 0.00003
p-(propylthio)-phenylisopropylamine
0.00004 - 0.00245
pheniprazine
0.015 - 0.128
Phenylethylhydrazine
0.205 - 0.791
phenylhydrazine
0.00077 - 0.0024
pirlindole mesylate
0.0033 - 0.0256
rasagiline
0.000021 - 0.365
safinamide
0.000055 - 0.0038
selegiline
0.000009
tetrindole
pH and temperature not specified in the publication
0.0036 - 0.0341
tetrindole mesylate
0.0023
trans,trans-farnesol
monoamine oxidase B
0.0136 - 0.0373
trans-2-phenylcyclopropylamine
0.007
trans-trans-1,4-diphenyl-1,3-butadiene
-
-
0.0038 - 0.017
tranylcypromine
0.00049
ZnSO4
-
monoamine oxidase A
additional information
additional information
-
0.506
(+)-amphetamine
30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine or benzylamine
2.56
(+)-amphetamine
30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine or benzylamine
0.002
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
pH 7.4, 37°C, MAO-A
0.00423
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
pH 7.4, 37°C, MAO-B
0.00801
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
pH 7.4, 37°C, MAO-B
0.175
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
pH 7.4, 37°C, MAO-A
0.0013
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
inhibition of MAO-B
0.0235
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
inhibition of MAO-A
0.0122
(2S)-amphetamine
-
pH 7.5, 25°C, MAO-A
0.1
(2S)-amphetamine
-
above, pH 7.5, 25°C, MAO-B
0.001063
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.026622
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.001606
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.011244
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00007142
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000293
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000034
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.001356
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.0005343
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.006267
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000062
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00036
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000716
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.005886
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000131
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000222
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.011429
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.030444
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000054
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000066
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00006285
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00008
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000138
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.0007371
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00014
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000951
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000126
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000613
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00038
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000453
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000062
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.011429
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000306
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.033956
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000284
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.008543
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.0018622
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.012657
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.0114
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.025244
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000154
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.021822
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.000058
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.004429
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
pH and temperature not specified in the publication
-
0.00256
(6-benzyloxy-2-naphthyl)-2-aminopropane
MAO-B
0.00378
(6-benzyloxy-2-naphthyl)-2-aminopropane
MAO-A
0.00045
(6-ethoxy-2-naphthyl)-2-aminopropane
MAO-A
0.0163
(6-ethoxy-2-naphthyl)-2-aminopropane
MAO-B
0.00018
(6-methoxy-2-naphthyl)-2-aminopropane
MAO-A
0.1
(6-methoxy-2-naphthyl)-2-aminopropane
MAO-B
0.00068
(6-propoxy-2-naphthyl)-2-aminopropane
MAO-A
0.0136
(6-propoxy-2-naphthyl)-2-aminopropane
MAO-B
0.00019
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-B
0.001
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-A
0.0014
(E)-5-(3-chlorostyryl)isatin
inhibition of MAO-B
0.0056
(E)-5-(3-chlorostyryl)isatin
inhibition of MAO-A
0.0125
(E)-5-(3-chlorostyryl)isatin
inhibition of MAO-B mutant I199A
0.00056
(E)-5-(3-fluorostyryl)isatin
inhibition of MAO-B
0.0022
(E)-5-(3-fluorostyryl)isatin
inhibition of MAO-B mutant I199A
0.022
(E)-5-(3-fluorostyryl)isatin
inhibition of MAO-A
0.00031
(E)-5-styrylisatin
inhibition of MAO-B
0.00078
(E)-5-styrylisatin
inhibition of MAO-A
0.0011
(E)-5-styrylisatin
inhibition of MAO-B mutant I199A
0.0006
(E)-6-styrylisatin
inhibition of MAO-B
0.0022
(E)-6-styrylisatin
inhibition of MAO-A
0.0045
(E)-6-styrylisatin
inhibition of MAO-B mutant I199A
0.00003 - 0.000081
(E)-8-(3-chlorostyryl)caffeine
MAO-B
0.000128
(E)-8-(3-chlorostyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000148
(E)-8-(3-chlorostyryl)caffeine
-
with benzylamine as substrate
0.00052
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-B
0.0033
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-A
1.4
(N-cyclopropyl-alpha-methylbenzylamine)
pH 7.2, 30°C, wild-type enzyme
2.7
(N-cyclopropyl-alpha-methylbenzylamine)
pH 7.2, 30°C, mutant enzyme C374A
0.0000017
(R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00003
(R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00026
(R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0015
(R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00002
(R)-N-(alpha-cyclohexylethyl)-N-methyl,N-(pyrrol-2-ylmethyl)-amine
pH 7.4, 38°C
0.007
(R)-N-(alpha-cyclohexylethyl)-N-methyl,N-(pyrrol-2-ylmethyl)-amine
pH 7.4, 38°C
0.00122
(R,S)-N-(alpha-phenylethyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0025
(R,S)-N-(alpha-phenylethyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0001
(R,S)-N-methyl,N-(alpha-phenylethyl),N-(pyrrol-2-ylmethyl)-amine
pH 7.4, 38°C
0.0045
(R,S)-N-methyl,N-(alpha-phenylethyl),N-(pyrrol-2-ylmethyl)-amine
pH 7.4, 38°C
0.00001
(R,S)-N-methyl,N-(alpha-phenylethyl)-1H-pyrrole- 2-carboxamide
pH 7.4, 38°C
0.0618
(R,S)-N-methyl,N-(alpha-phenylethyl)-1H-pyrrole- 2-carboxamide
pH 7.4, 38°C
0.00002
(S)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0041
(S)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00033
(S)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0036
(S)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.000051
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.000065
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0013
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00014
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00018
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0004
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.001
1,4-diphenyl-1,3-butadiene
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.007
1,4-diphenyl-1,3-butadiene
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0007
1,4-diphenyl-2-butene
monoamine oxidase B
0.006
1,4-diphenyl-2-butene
monoamine oxidase B
0.0081
1,4-diphenyl-2-butene
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0083
1,4-diphenyl-2-butene
-
monoamine oxidase B
0.0345
1,4-diphenyl-2-butene
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0056
1-(1-naphthyl)-2-aminopropane
MAO-A
0.1
1-(1-naphthyl)-2-aminopropane
MAO-B
0.00042
1-(2-naphthyl)-2-aminopropane
MAO-A
0.1
1-(2-naphthyl)-2-aminopropane
MAO-B
0.00071
1-(4-benzyloxyphenyl)-2-aminopropane
MAO-B
0.00342
1-(4-benzyloxyphenyl)-2-aminopropane
MAO-A
0.00032
1-(4-butoxyphenyl)-2-aminopropane
MAO-A
0.1
1-(4-butoxyphenyl)-2-aminopropane
above, MAO-B
0.00022
1-(4-ethoxyphenyl)-2-aminopropane
MAO-A
0.1
1-(4-ethoxyphenyl)-2-aminopropane
above, MAO-B
0.00013
1-(4-propoxyphenyl)-2-aminopropane
MAO-A
0.1
1-(4-propoxyphenyl)-2-aminopropane
above, MAO-B
0.0035
1-methyl-4-phenylpyridinium
pH 7.2, 30°C, wild-type enzyme
0.0045
1-methyl-4-phenylpyridinium
pH 7.2, 30°C, mutant enzyme C374A
0.0055
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
pH 7.4, 37°C, MAO-A
0.0399
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
pH 7.4, 37°C, MAO-B
7.3
1-phenylcyclopropylamine
pH 7.2, 30°C, wild-type enzyme
12.8
1-phenylcyclopropylamine
pH 7.2, 30°C, mutant enzyme C374A
0.00789
2-(2-benzofuranyl)-2-imidazoline
pH 7.4, 30°C, reductive half-reaction
0.326
2-(2-benzofuranyl)-2-imidazoline
pH 7.4, 30°C, oxidative half-reaction
0.000048
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-B
0.000074
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-B
0.0275
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-A
0.1
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
-
above, pH 7.4, 37°C, MAO-A
0.000038
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-B
0.00013
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-B
0.019
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-A
0.1
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
-
above, pH 7.4, 37°C, MAO-A
0.00016
2-(4'-butoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-B
0.00046
2-(4'-butoxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-B
0.01
2-(4'-butoxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-A
0.0509
2-(4'-butoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-A
0.000068
2-(4'-butoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-B
0.00027
2-(4'-butoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-B
0.0025
2-(4'-butoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-A
0.0141
2-(4'-butoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-A
0.0034
2-(4'-ethoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-B
0.0123
2-(4'-ethoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-A
0.0169
2-(4'-ethoxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-B
0.06
2-(4'-ethoxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-A
0.0021
2-(4'-ethoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-B
0.0022
2-(4'-ethoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-A
0.0022
2-(4'-ethoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-B
0.0096
2-(4'-ethoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-A
0.00928
2-(4'-methoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-A
0.0136
2-(4'-methoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-B
0.1
2-(4'-methoxyphenyl)thiomorpholin-5-one
-
above, pH 7.4, 37°C, MAO-A
0.1
2-(4'-methoxyphenyl)thiomorpholin-5-one
-
above, pH 7.4, 37°C, MAO-B
0.0039
2-(4'-methoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-B
0.0064
2-(4'-methoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-A
0.0162
2-(4'-methoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-A
0.1
2-(4'-methoxyphenyl)thiomorpholine oxalate
-
above, pH 7.4, 37°C, MAO-B
0.0015
2-(4'-propoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-B
0.0024
2-(4'-propoxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-B
0.0087
2-(4'-propoxyphenyl)thiomorpholin-5-one
-
pH 7.5, 25°C, MAO-A
0.04
2-(4'-propoxyphenyl)thiomorpholin-5-one
-
pH 7.4, 37°C, MAO-A
0.00013
2-(4'-propoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-B
0.00098
2-(4'-propoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-B
0.0037
2-(4'-propoxyphenyl)thiomorpholine oxalate
-
pH 7.5, 25°C, MAO-A
0.0066
2-(4'-propoxyphenyl)thiomorpholine oxalate
-
pH 7.4, 37°C, MAO-A
0.0652
2-(4,5-dihydroimidazol-2-yl)-isoquinoline
30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine
0.513
2-(4,5-dihydroimidazol-2-yl)-isoquinoline
30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine
0.0817
2-(4,5-dihydroimidazol-2-yl)-quinoline
30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine
0.385
2-(4,5-dihydroimidazol-2-yl)-quinoline
30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine
0.008
2-(5,7-dibromobenzofuran-2-yl)-imidazoline
30°C, pH 7, oxidative half-reaction, substrate: benzylamine
0.114
2-(5,7-dibromobenzofuran-2-yl)-imidazoline
30°C, pH 7, reductive half-reaction, substrate: benzylamine
0.2
2-phenylcyclopropylamine
pH 7.2, 30°C, wild-type enzyme
0.31
2-phenylcyclopropylamine
pH 7.2, 30°C, mutant enzyme C374A
0.00919
2-phenylthiomorpholin-5-one
-
pH 7.5, 25°C, MAO-A
0.0096
2-phenylthiomorpholin-5-one
-
pH 7.5, 25°C, MAO-B
0.1
2-phenylthiomorpholin-5-one
-
above, pH 7.4, 37°C, MAO-A
0.1
2-phenylthiomorpholin-5-one
-
above, pH 7.4, 37°C, MAO-B
0.0022
2-phenylthiomorpholine oxalate
-
pH 7.5, 25°C, MAO-B
0.0106
2-phenylthiomorpholine oxalate
-
pH 7.5, 25°C, MAO-A
0.1
2-phenylthiomorpholine oxalate
-
above, pH 7.4, 37°C, MAO-A
0.1
2-phenylthiomorpholine oxalate
-
above, pH 7.4, 37°C, MAO-B
0.00003
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
pH 7.4, 37°C, MAO-B
0.0026
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
pH 7.4, 37°C, MAO-A
0.000006
3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.00001
3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.000027
3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.00005
3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.000008
3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.00037
3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.000007
3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.00005
3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.00033
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
pH 7.4, 37°C, MAO-B
0.0082
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
pH 7.4, 37°C, MAO-A
0.00043
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-B
0.002
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-A
0.0683
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
pH 7.4, 37°C, MAO-A
0.0757
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
pH 7.4, 37°C, MAO-B
0.00002
5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.00005
5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.000004
5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.00017
5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.000006
5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.000041
5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.000006
5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.001
5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.0000015
5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.000031
5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.00001
5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-B
0.00005
5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
pH 7.4, 38°C, MAO-A
0.0001
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin
25°C, pH 7.5
0.0157
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin
25°C, pH 7.5
0.0004
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin
25°C, pH 7.5
0.011
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin
25°C, pH 7.5
0.00027
8-(3-chloro)styrylcaffeine
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0017
8-(3-chloro)styrylcaffeine
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0002
8-(3-chlorostyryl)caffeine
monoamine oxidase B
0.0002
8-(3-chlorostyryl)caffeine
monoamine oxidase B
0.0011
8-(3-chlorostyryl)caffeine
monoamine oxidase B
0.0014
8-(3-chlorostyryl)caffeine
-
monoamine oxidase B
0.00043
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00059
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00144
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000023
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.000065
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00033
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000036
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.000069
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00023
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00018
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00031
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00037
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00034
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00092
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0011
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0177
amitriptyline
30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine
0.55
amitriptyline
30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine
0.00305
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-A
0.00383
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
pH 7.4, 37°C, MAO-B
0.026
benzylhydrazine
pH 7.5, MAO-B, determined from competitive inhibition data of substrate oxidation at 25°C
0.048
benzylhydrazine
pH 7.5, MAO-B, determined from Kitz-Wilson plots of the hydrazine concentration dependence on rates in enzyme inhibition at 15°C
1.95
benzylhydrazine
pH 7.5, MAO-A, determined from Kitz-Wilson plots of the hydrazine concentration dependence on rates in enzyme inhibition at 15°C
2.096
benzylhydrazine
pH 7.5, MAO-A, determined from competitive inhibition data of substrate oxidation at 25°C
0.00000128
Clorgyline
pH and temperature not specified in the publication
0.000012
Clorgyline
isoform MAO A, at pH 7.4 and 37°C
0.000054
Clorgyline
pH 7.4, 38°C
0.058
Clorgyline
pH 7.4, 38°C
0.0204
cyanidin
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0317
cyanidin
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0586
cyanidin
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0474
cyanidin-3-O-beta-D-glucoside
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0611
cyanidin-3-O-beta-D-glucoside
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.006
D-amphetamine
pH 7.5, 25°C, MAO-A
0.0115
D-amphetamine
pH 7.2, 30°C, mutant enzyme C374A
0.0144
D-amphetamine
pH 7.2, 30°C, wild-type enzyme
0.0144
D-amphetamine
-
pH 7.4, 37°C, MAO-A
0.015
D-amphetamine
pH and temperature not specified in the publication
0.038
D-amphetamine
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.28
D-amphetamine
-
pH 7.4, 37°C, MAO-B
6
D-amphetamine
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
0.0000087
Deprenyl
pH and temperature not specified in the publication
0.0019214
Deprenyl
pH and temperature not specified in the publication
0.00298
di(2-hydroxyethyl)methyldodecylammonium
30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine or benzylamine
0.00374
di(2-hydroxyethyl)methyldodecylammonium
30°C, pH 7, oxidative half-reaction, substrate: 4-phenylbutylamine
0.0799
di(2-hydroxyethyl)methyldodecylammonium
30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine, benzylamine or 4-phenylbutylamine
0.026
eugenol
monoamine oxidase A
0.211
eugenol
monoamine oxidase B
0.0023
farnesol
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0027
farnesol
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.018
farnesol
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.00005554
harman
-
pH 7.4, 37°C, monoamine oxidase A
0.000128
harman
pH 7.2, 30°C, wild-type enzyme
0.00013
harman
pH 7.2, 30°C, mutant enzyme C374A
0.00075
Harmane
-
at pH 7.5 and 25°C
0.013
Harmane
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.14
Harmane
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.165
Harmane
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.55
Harmane
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.0015
isatin
inhibition of MAO-A
0.002
isatin
isoform MAO B, at pH 7.4 and 37°C
0.003
isatin
monoamine oxidase B
0.003
isatin
inhibition of MAO-B
0.003
isatin
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.006
isatin
monoamine oxidase B
0.0063
isatin
pH 7.5, MAO-A incorporated into phospholipid nanodisks
0.0105
isatin
pH 7.5, 25°C, MAO-A
0.012
isatin
inhibition of MAO-B mutant I199A
0.012
isatin
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.015
isatin
monoamine oxidase A
0.015
isatin
pH 7.5, detergent solubilized MAO-A
0.016
isatin
isoform MAO A, at pH 7.4 and 37°C
0.36
isatin
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
10
isatin
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
0.017
metamphetamine
pH and temperature not specified in the publication
-
0.297
metamphetamine
pH and temperature not specified in the publication
-
0.0013
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
inhibition of MAO-B
0.0235
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
inhibition of MAO-A
0.000004
methylene blue
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.000026
methylene blue
-
at pH 7.5 and 25°C
0.000027
methylene blue
pH and temperature not specified in the publication
0.000143
methylene blue
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.000214
methylene blue
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.00101
methylene blue
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.00145
moclobemide
at pH 7.4 and 37°C
0.011 - 0.2
moclobemide
pH and temperature not specified in the publication
0.0115
moclobemide
pH 7.4, 38°C
0.000028
mofegiline
MAO B
0.022
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
pH 7.5
0.107
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
pH 7.5
0.151
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
pH 7.5
0.212
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
pH 7.5
0.00002
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.000024
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.00165
N-(2-methyl-1H-indol-5-yl)benzamide
pH 7.4, 37°C, MAO-B
0.0395
N-(2-methyl-1H-indol-5-yl)benzamide
pH 7.4, 37°C, MAO-A
0.003
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
pH 7.4, 37°C, MAO-B
0.0183
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
pH 7.4, 37°C, MAO-A
0.00002
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.085
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.000007
N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00012
N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00004
N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0089
N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0007
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.025
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00009
N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0025
N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.000055
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.057
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00035
N-(benzyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0072
N-(benzyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0003
N-(propargyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.00062
N-(propargyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0006
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.15
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0145
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane
MAO-A
0.0222
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane
MAO-B
0.00693
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane
MAO-A
0.0247
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane
MAO-B
0.00025
N-benzyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.15
N-benzyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00005
N-methyl,N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0007
N-methyl,N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0001
N-methyl,N-(3-phenylbutyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.002
N-methyl,N-(3-phenylbutyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.00005
N-methyl,N-(3-phenylpropyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0048
N-methyl,N-(3-phenylpropyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.00015
N-methyl,N-(benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.3
N-methyl,N-(benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.00002
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.0035
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine
pH 7.4, 38°C
0.00023
N-propargyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.07
N-propargyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00112
norharman
-
pH 7.4, 37°C, monoamine oxidase B
0.0012
norharman
-
pH 7.4, 37°C, monoamine oxidase A
0.000011
p-(propylthio)-phenylisopropylamine
pH 7.5, MAO-A incorporated into phospholipid nanodisks
0.00003
p-(propylthio)-phenylisopropylamine
pH 7.5, detergent solubilized MAO-A
0.00004
pheniprazine
in presence of 3 mM KCN
0.00005
pheniprazine
in presence of 2 mM KCN
0.00008
pheniprazine
in presence of 0.0125 mM KCN
0.00009
pheniprazine
in presence of 0.01 mM KCN
0.00025
pheniprazine
in presence of 0.007 mM KCN
0.00029
pheniprazine
in presence of 1 mM KCN
0.00042
pheniprazine
without KCN
0.00045
pheniprazine
without KCN
0.00075
pheniprazine
in presence of 0.005 mM KCN
0.00095
pheniprazine
in presence of 0.0035 mM KCN
0.00141
pheniprazine
in presence of 0.0025 mM KCN
0.00245
pheniprazine
without KCN
0.127
phentermine
pH 7.5, MAO-A incorporated into phospholipid nanodisks
0.138
phentermine
pH and temperature not specified in the publication
0.196
phentermine
pH and temperature not specified in the publication
0.498
phentermine
pH 7.5, detergent solubilized MAO-A
0.626
phentermine
pH 7.5, 25°C, MAO-A
625
phentermine
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
0.015
Phenylethylhydrazine
pH 7.5, MAO-B, determined from competitive inhibition data of substrate oxidation at 25°C
0.023
Phenylethylhydrazine
-
-
0.042
Phenylethylhydrazine
-
-
0.047
Phenylethylhydrazine
pH 7.5, MAO-A, determined from competitive inhibition data of substrate oxidation at 25°C
0.05
Phenylethylhydrazine
pH 7.5, MAO-A, determined from Kitz-Wilson plots of the hydrazine concentration dependence on rates in enzyme inhibition at 15°C
0.128
Phenylethylhydrazine
pH 7.5, MAO-B, determined from Kitz-Wilson plots of the hydrazine concentration dependence on rates in enzyme inhibition at 15°C
0.205
phenylhydrazine
pH 7.5, MAO-A, determined from competitive inhibition data of substrate oxidation at 25°C
0.523
phenylhydrazine
pH 7.5, MAO-A, determined from Kitz-Wilson plots of the hydrazine concentration dependence on rates in enzyme inhibition at 15°C
0.791
phenylhydrazine
pH 7.5, MAO-B, determined from Kitz-Wilson plots of the hydrazine concentration dependence on rates in enzyme inhibition at 15°C
0.00077
pirlindole mesylate
-
at pH 7.5 and 25°C
0.0024
pirlindole mesylate
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.0033
rasagiline
pH 7.5, MAO-A incorporated into phospholipid nanodisks
0.0097
rasagiline
pH 7.5, detergent solubilized MAO-A
0.000021
safinamide
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.00045
safinamide
25°C, pH 7.5
0.0005
safinamide
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.004
safinamide
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.365
safinamide
25°C, pH 7.5
0.000055
selegiline
isoform MAO B, at pH 7.4 and 37°C
0.00035
selegiline
at pH 7.4 and 37°C
0.00097
selegiline
pH 7.4, 38°C
0.0038
selegiline
pH 7.4, 38°C
0.0036
tetrindole mesylate
-
at pH 7.5 and 25°C
0.0341
tetrindole mesylate
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.0136
trans-2-phenylcyclopropylamine
inhibition of MAO-B
0.0373
trans-2-phenylcyclopropylamine
inhibition of MAO-A
0.0038
tranylcypromine
pH and temperature not specified in the publication
0.0077
tranylcypromine
pH and temperature not specified in the publication
0.011
tranylcypromine
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.016
tranylcypromine
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.017
tranylcypromine
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
additional information
additional information
-
-
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
inhibition kinetics, overview
-
additional information
additional information
inhibition kinetics, overview
-
additional information
additional information
-
inhibition kinetics, overview
-
additional information
additional information
-
sigmoidal doseresponse curve of the initial rates of oxidation of MMTP versus the logarithm of concentration of inhibiton
-
additional information
additional information
values for inhibition of isozyme MAO-A by acetylcholine are higher than those for isozyme MAO-B
-
additional information
additional information
values for inhibition of isozyme MAO-A by acetylcholine are higher than those for isozyme MAO-B
-
additional information
additional information
-
inhibition kinetics and specificity, overview
-
additional information
additional information
kinetic constants for pure hMAO-B oxidising different substrates in the presence of reversible competitive inhibitors or reversible non-competitive/mixed inhibitors
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.015 - 0.039
(+)-6-hydroxytrypargine
0.008 - 0.034
(-)-6-hydroxytrypargine
0.01665 - 0.1374
(1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine
14.86 - 88
(1R,2R)-(-)-psi-ephedrine
1.77 - 234
(1S,2S)-(+)-psi-ephedrine
0.02 - 0.35
(2-methylprop-2-en-1-yl)hydrazine
0.0013 - 0.071
(2-phenylprop-2-en-1-yl)hydrazine
0.00141
(2E)-1,3-diphenylprop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.00103
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-(4-methylphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.01876
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-phenylprop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.011
(2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-(3-hydroxyphenyl)ethanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.02 - 2
(2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-phenylethanamide
Homo sapiens
-
pH and temperature not specified in the publication
9.95
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carbothioamide
Homo sapiens
pH 7.4, temperature not specified in the publication
-
0.0056 - 17.7
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide
-
0.000036 - 0.0031
(2E)-2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3(2H)-ylidene]-N-methylacetamide
0.0077 - 0.00983
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
0.0000051 - 0.00495
(2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
0.0000044
(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.00125
(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.00016
(2E)-3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.000071
(2E)-3-(4-chlorophenyl)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.000031
(2E)-3-(4-chlorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.000054
(2E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.00222 - 0.00547
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal
-
0.00142 - 0.00459
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal
-
0.000193 - 0.00405
(2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal
-
0.05
(2E)-3-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.00045
(2E)-3-[4-(benzyloxy)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.01882 - 0.663
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
0.139
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide
Mus musculus
inhibition of MAO-A
0.0016 - 0.139
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
0.0042
(3E)-3-[2-(ethylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0000091
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3,3,3-trifluoropropane-1-sulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000041
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000019
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-cyanobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000041
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-fluorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000019
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-(methylsulfonyl)benzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000029
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-acetylbenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000012
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000045
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-cyanobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000016
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-methoxybenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000037
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-nitrobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0000098
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 5-chlorothiophene-2-sulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000034
(3E)-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl benzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000011
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3,3,3-trifluoropropane-1-sulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000015
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000011
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-cyanobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000007
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl 4-methoxybenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.000024
(3E)-7-methyl-3-[2-(methylamino)-2-oxoethylidene]-2,3-dihydro-1-benzofuran-6-yl benzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.00372 - 0.0599
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00562 - 0.0253
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00025 - 0.00066
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00012 - 0.00305
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00187 - 0.0141
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00014 - 0.00126
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00161 - 0.0206
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00046 - 0.0005
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0522 - 0.0685
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00015 - 0.00019
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00018 - 0.00022
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00031 - 0.00258
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00049 - 0.00214
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00044 - 0.00138
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00102 - 0.00133
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00014 - 40
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00107 - 0.0764
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00064 - 0.0299
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0419 - 0.0443
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0399 - 0.0568
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00054 - 0.0491
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00013 - 0.0155
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.027
(5E)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000082
(5E)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000195
(5E)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00607
(5E)-5-(3-bromobenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.03648
(5E)-5-(4-chlorobenzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.03165
(5E)-5-(4-hydroxy-2,5-dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00249
(5E)-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.013
(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.02405
(5E)-5-benzylidene-2-imino-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.01051
(5E)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00102
(5E)-5-[(3,5-dibromo-4-hydroxycyclohexa-1,4-dien-1-yl)methylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.001
(5R,5'R)-3,3'-[1,4-diazepane-1,4-diylbis(3-fluorobenzene-4,1-diyl)]bis[5-(hydroxymethyl)-1,3-oxazolidin-2-one]
Homo sapiens
IC50: 0.001mM, at 0.15 mM kynuramine
0.027
(5Z)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.000082
(5Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.000195
(5Z)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.013
(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.0002 - 0.00023
(7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile
0.000016 - 0.00047
(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile
0.00348 - 0.00527
(E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00019 - 0.00065
(E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00137 - 0.00161
(E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
0.00298 - 0.00828
(E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
0.00019 - 0.00063
(E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
0.0001 - 0.00048
(E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00171 - 0.00219
(E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
0.00018 - 0.00717
(E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
0.00044 - 0.0039
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.0000207
(E)-5-(3-chlorostyryl)isatin
Homo sapiens
-
0.000444
(E)-5-(3-fluorostyryl)isatin
Homo sapiens
-
0.0000417
(E)-5-styrylisatin
Homo sapiens
-
0.0000301
(E)-6-styrylisatin
Homo sapiens
-
0.0012 - 0.0125
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.00055 - 0.00439
(E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
0.00016 - 0.00114
(E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
0.0991 - 4.03
(R)-amphetamine
0.0244 - 3
(R,S)-amphetamine
0.0022 - 0.098
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
0.000112 - 0.00372
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
0.0004 - 0.000698
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
0.443
1,3-dimethyl-6-phenyl-1H-pteridine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
0.0098 - 0.2
1,3-diphenyl-4,5-dihydro-1H-pyrazole
0.000414 - 0.0008
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine
0.00556 - 0.00697
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine
0.000333 - 0.00168
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine
0.000455 - 0.00381
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine
0.000116 - 0.0037
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine
0.00055 - 0.000636
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine
0.0000122 - 0.000737
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine
0.0000266 - 0.000836
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine
0.0000727 - 0.000679
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine
0.000231 - 0.00145
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine
0.0000355 - 0.000749
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine
0.000875
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(benzodioxol-5-ylmethylene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.000343
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)-hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00678
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(furan-2-ylmethylene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.00115 - 0.00672
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine
0.0036
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(naphthalen-1-ylmethylene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00138
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(octan-2-ylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.000872 - 0.00131
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine
0.000772 - 0.000824
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine
0.00443 - 0.00507
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
0.000538 - 0.00291
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine
0.000698 - 0.00114
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine
0.000458 - 0.00049
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine
0.0000295 - 0.00178
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine
0.0000318 - 0.00191
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine
0.000592 - 0.00106
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine
0.066
1-(benzylideneamino)-3,4-dihydroquinolin-2(1H)-one
Rattus norvegicus
37°C, no preincubation
0.0713
1-(N-methylthiocarbamoyl)-3-(3-methoxyphenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0534
1-(N-methylthiocarbamoyl)-3-(3-methylphenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0348
1-(N-methylthiocarbamoyl)-3-(4-chlorophenyl)-4-methyl-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.051
1-(N-methylthiocarbamoyl)-3-(4-fluorophenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0137
1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0494
1-(N-methylthiocarbamoyl)-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0168
1-(N-methylthiocarbamoyl)-3-(4-methylphenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.000009 - 0.041
1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole
0.00023 - 0.1
1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0002 - 0.14
1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.00029 - 0.1
1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0003 - 0.09
1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole
0.0001 - 0.088
1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.00024 - 0.1
1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.00001 - 0.1
1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole
0.00001 - 0.1
1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole
0.0002 - 0.1
1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0001 - 0.02
1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole
0.0001 - 0.1
1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole
0.00001 - 0.1
1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.0001 - 0.038
1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.00001 - 0.025
1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.000009 - 0.083
1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.000008 - 0.1
1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.06
1-amino-3,4-dihydroquinolin-2(1H)-one
Rattus norvegicus
37°C, no preincubation
0.000447 - 0.00307
1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.0139 - 0.0179
1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile
-
0.0125 - 0.0216
1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid
-
0.027 - 0.117
1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.0022 - 0.00732
1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.0135 - 0.0166
1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
0.000049 - 0.00087
1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
0.000184 - 0.00129
1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
0.000175 - 0.0157
1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
0.000529 - 0.00231
1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
-
0.0208 - 0.0926
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
0.0679
1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.059
1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-B, no preincubation
0.366 - 0.39
1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
0.0445
1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.051
1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-B, no preincubation
0.33 - 0.38
1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
0.03
1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.029
1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-B, no preincubation
0.302 - 0.349
1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
0.098
1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.066
1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, selective for MAO-B, no preincubation
0.326 - 0.345
1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
0.402 - 0.49
1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.2853 - 0.51
1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0342 - 0.51
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0382 - 0.5
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0155
1-thiocarbamoyl-3-(4-methoxyphenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0846
1-thiocarbamoyl-3-(4-methoxyphenyl)-4-methyl-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.00496 - 0.485
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0067 - 0.53
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0181
1-thiocarbamoyl-3-(4-methylphenyl)-4,5-dihydropyrazole
Homo sapiens
-
pH 7.4, 37°C, recombinant MAO-B
0.0638 - 0.513
1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0523 - 0.501
1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.63 - 1
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
0.0297
11H-indolo[3,2-c]cinnoline
Rattus norvegicus
pH 7.4, 37°C
1
2,2'-bipyridyl
Narcissus tazetta
-
at pH 7.0 and 37°C
0.042 - 0.39
2,4-dimethoxy-5-hydroxybenzaldehyde
0.0624 - 0.5
2,6-dimethoxyphenol
0.0001 - 0.019
2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.001 - 0.07
2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.000072 - 0.04
2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.011
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(3-hydroxyphenyl)acetamide
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.022
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-phenylacetamide
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.00094 - 0.05928
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
0.000016 - 0.007229
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
0.000004 - 0.01028
2-(2-cycloheptylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
0.003925 - 0.005025
2-(2-cycloheptylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
0.00092 - 0.009612
2-(2-cycloheptylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
0.000011 - 0.01785
2-(2-cycloheptylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
0.000027 - 0.01485
2-(2-cycloheptylidenehydrazinyl)-4-phenyl-1,3-thiazole
0.000652 - 0.04575
2-(2-cyclohexylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
0.000004 - 0.0001752
2-(2-cyclohexylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
0.007509 - 0.01196
2-(2-cyclohexylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
0.003689 - 0.02373
2-(2-cyclohexylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
0.000086 - 0.02415
2-(2-cyclohexylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
0.000116 - 0.04835
2-(2-cyclohexylidenehydrazinyl)-4-phenyl-1,3-thiazole
0.000284 - 0.05451
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
0.000003 - 0.002318
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
0.00004 - 0.004436
2-(2-cyclopentylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
0.000164 - 0.001055
2-(2-cyclopentylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
0.000134 - 0.002019
2-(2-cyclopentylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
0.000094 - 0.000344
2-(2-cyclopentylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
0.000296 - 0.007883
2-(2-cyclopentylidenehydrazinyl)-4-phenyl-1,3-thiazole
0.063
2-(4-chlorophenyl)-N-cyclohexyl-2-(3-ethynyl-2-oxo-4-phenylquinolin-1(2H)-yl)acetamide
Rattus norvegicus
37°C, no preincubation
0.00797 - 0.0222
2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile
-
0.00004 - 0.1
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide
0.000024 - 0.0005
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
0.00003 - 0.026
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
0.00005 - 0.07
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
0.002 - 0.1
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide
0.001 - 0.0043
2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
0.036 - 8.2
2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
0.25 - 0.45
2-(aminooxy)-1-phenylethanol
0.00388 - 0.00991
2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
0.00032 - 0.0085
2-bromo-N-(2-morpholinoethyl)nicotinamide
0.0019 - 0.035
2-bromo-N-(3-morpholinopropyl)nicotinamide
0.00104 - 0.01062
2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.028 - 0.1
2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
0.1
2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
0.0018 - 0.0026
2-chloro-N-(2-morpholinoethyl)nicotinamide
0.0065 - 0.0094
2-chloro-N-(3-morpholinopropyl)nicotinamide
0.00088 - 0.00137
2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.045 - 0.1
2-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.1
2-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.175 - 0.5
2-methoxyphenol
0.15 - 0.5
2-methyl-5-methylaniline
0.0094 - 0.0471
2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
0.038
2-phenyl-2H-indeno[1,2-c]pyridazine-3,5-dione
Rattus norvegicus
pH 7.4, 37°C
0.018
2-phenyl-5H-indeno[1,2-d]pyrimidine
Rattus norvegicus
pH 7.4, 37°C
0.013 - 0.0167
2-phenyl-9H-indeno[2,1-d]pyrimidine
0.000143
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000032
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000711 - 0.04124
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
0.00014 - 0.00243
2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
0.008 - 0.3
2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.009 - 0.3
2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0094 - 0.48
2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.025 - 0.097
2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.098 - 2
2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.013 - 3.8
2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.09 - 1
2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.094 - 1.8
2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.088 - 0.2
2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0095
2-[1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0095 mM, MAO-A
0.0000086 - 0.1
2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.00001 - 0.0001
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000008 - 0.019
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0001 - 0.04
2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000028 - 0.00006
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000009 - 0.0072
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.002 - 0.1
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0000088 - 0.1
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0001 - 0.06
2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.005477 - 0.008109
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-methylphenyl)-1,3-thiazole
0.000362 - 0.02088
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
0.000259 - 0.03422
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
0.0013 - 0.021
2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide
0.002 - 0.0265
2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide
0.089 - 0.25
2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.12 - 1
2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000284 - 0.001
2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3-yl]-N-methylacetamide
0.00009 - 0.0025
2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
0.0004 - 0.0231
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide
0.000015 - 0.0028
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide
0.0002 - 0.008
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide
0.00004 - 0.00144
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
0.0063 - 0.1
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide
0.4
2-{1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl}phenol
Bos taurus
IC50: 0.4 mM, MAO-B
0.00006 - 0.0098
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
0.000014 - 0.000051
3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
0.131
3,4-dimethoxyaniline
Homo sapiens
IC50: 0.131 mM, monoamine oxidase A
0.000048 - 0.00283
3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
0.0018 - 0.04
3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.01 - 0.5
3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.00053 - 0.00358
3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00273 - 0.0028
3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0029 - 0.00318
3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0088 - 0.0707
3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00127 - 0.00136
3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
0.00027 - 0.002
3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.00042 - 0.0025
3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0017 - 0.0026
3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.0011 - 0.0021
3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
0.003 - 0.017
3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.000014 - 0.001
3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.09 - 0.98
3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.000912
3-(3-nitrophenyl)-5H-indeno[2,1-e][1,2,4]triazin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.00008
3-(3-nitrophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one
Rattus norvegicus
pH 7.4, 37°C
0.0074 - 0.087
3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0099 - 0.1
3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.09856 - 0.4874
3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.19356 - 0.25623
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.05522 - 0.50045
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.19844 - 0.20534
3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.09045 - 0.47019
3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.06128 - 0.47021
3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.2729
3-(4-hydroxyphenyl)-2-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
11.52
3-(4-hydroxyphenyl)propionic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.000532 - 0.000813
3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile
-
0.00011 - 0.0125
3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0069 - 0.05
3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.000086 - 0.00145
3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.055
3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.00251
3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.00357 - 0.00982
3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
-
0.00119 - 0.00317
3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
0.0356 - 0.0419
3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile
-
0.0157 - 0.0251
3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
-
0.0471
3-acetyl-1-hydroxy-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.018 - 0.0214
3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
0.0676 - 0.115
3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile
-
0.0135 - 0.0456
3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid
-
0.00399 - 0.0138
3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.000092 - 0.00119
3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.000458 - 0.000734
3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.00105 - 0.00132
3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.00004 - 0.000605
3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.000023 - 0.000178
3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
-
0.0191 - 0.0222
3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile
-
0.00279 - 0.00963
3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
-
0.00076 - 0.031
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
0.00099 - 0.0077
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.15
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
Rattus norvegicus
-
0.07 - 0.095
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.09
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
Rattus norvegicus
-
0.43
3-ethylamino-4-aminomethylpyridine dihydrochloride
Rattus norvegicus
-
17.75
3-hydroxyphenylacetic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.024
3-methoxyphenol
Homo sapiens
IC50: 0.024 mM, monoamine oxidase A
0.42
3-methylamino-4-aminomethylpyridine dihydrochloride
Rattus norvegicus
-
0.03645
3-phenyl-4-(phenylseleno)isoquinoline
Rattus norvegicus
isoform MAO-B, at pH 7.4 and 37°C
0.07586
3-phenyl-4-(phenylthio)isoquinoline
Rattus norvegicus
isoform MAO-B, at pH 7.4 and 37°C
0.00631
3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one
Rattus norvegicus
pH 7.4, 37°C
2 - 2.2
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
0.1759 - 0.259
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
0.0019
3-[(4-fluorophenoxy)methyl]-5H-indeno[1,2-c]pyridazin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.00229
3-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]propanenitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.6043
3-[(5E)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.056
3-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.00026 - 0.00084
3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
0.000409
3-[2-(methylamino)-2-oxoethyl]-1-benzofuran-6-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0001 - 0.39
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol
0.0001 - 0.08
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.00005 - 0.062
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.0001 - 0.03
4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.000073 - 0.003
4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.02681 - 0.0447
4-(2,4-dichlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.009446 - 0.08149
4-(2,4-dichlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.000014 - 0.03796
4-(2,4-difluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.000091 - 0.0195
4-(2,4-difluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.00025 - 0.0318
4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
0.000578 - 0.0035
4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
-
0.000477 - 0.006182
4-(4-chlorophenyl)-2-(2-cycloheptylidenehydrazinyl)-1,3-thiazole
0.000211 - 0.002911
4-(4-chlorophenyl)-2-(2-cyclohexylidenehydrazinyl)-1,3-thiazole
0.000262 - 0.00716
4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)-1,3-thiazole
0.01313 - 0.03522
4-(4-chlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.002411 - 0.01522
4-(4-chlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.0308
4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.000204 - 0.04356
4-(4-fluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.000043 - 0.04546
4-(4-fluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.08241
4-(4-fluorophenylseleno)-3-phenylisoquinoline
Rattus norvegicus
isoform MAO-B, at pH 7.4 and 37°C
0.002373 - 0.002762
4-(4-methoxyphenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.005763 - 0.0312
4-(4-methoxyphenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
0.000997 - 0.0033
4-(aminomethyl)-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
0.000021 - 0.0044
4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one
0.000015 - 0.002
4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
0.01 - 0.02
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
0.063 - 0.3
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.044 - 0.25
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.17
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.000847
4-([6-[(4-cyanophenyl)methoxy]-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
Homo sapiens
pH and temperature not specified in the publication
-
0.008 - 0.1
4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one
0.00075 - 0.074
4-chloro-N-(2-morpholinoethyl)nicotinamide
0.0075 - 0.053
4-chloro-N-(3-morpholinopropyl)nicotinamide
0.0089 - 0.0134
4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol
0.13 - 0.382
4-Hydroxy-3-methoxybenzylamine
0.18
4-hydroxy-3-methoxyphenethyl alcohol
Homo sapiens
IC50: 0.18 mM, monoamine oxidase A
0.0302
4-hydroxy-3-methoxyphenyl acetone
Homo sapiens
IC50: 0.0302 mM, monoamine oxidase A
20.28
4-hydroxyphenylacetic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0216 - 0.034
4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
0.047
4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl methanesulfinate
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.0036 - 0.1
4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
0.00051 - 0.1
4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one
0.056
4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0001 - 0.0226
4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate
0.0017 - 0.0054
4-[(methylamino)methyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
0.0001 - 0.038
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00001 - 0.02
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0000086 - 0.087
4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000008 - 0.13
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0000088 - 0.1
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.00001 - 0.00002
4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00001 - 0.023
4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000013 - 0.000038
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000008 - 0.019
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.00001 - 0.12
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0001 - 0.04
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000009 - 0.083
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000009 - 0.0072
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000009 - 0.042
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0001 - 0.03
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000046 - 0.004327
4-[2-(2-cycloheptylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
0.000053 - 0.004837
4-[2-(2-cyclohexylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
0.000221 - 0.000644
4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
0.000111 - 0.0083
4-[2-(methylamino)-2-oxoethyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
0.000026 - 0.03103
4-[2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
0.000061 - 0.006994
4-[2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
0.10077 - 0.47045
4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide
0.0158
4-[[(4-oxo-3,4-dihydroquinazolin-6-yl)oxy]methyl]benzonitrile
Homo sapiens
pH and temperature not specified in the publication
-
0.000084 - 0.048
5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
0.0001 - 0.045
5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
0.00238
5-(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000225
5-(4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.01339 - 0.49622
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.03044 - 0.47067
5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0299 - 0.48023
5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.00625 - 0.50023
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.03724 - 0.48882
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0199 - 0.50011
5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.00834 - 0.47022
5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.01606
5-(4-hydroxy-3,5-dimethylbenzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00225
5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000298
5-(4-[(1-methylcyclohexyl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.000832
5-(4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.000048
5-(4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl)-1,3-thiazolidine-2,4-dione
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.026 - 0.055
5-bromo-N-(2-morpholinoethyl)nicotinamide
0.023 - 0.065
5-bromo-N-(3-morpholinopropyl)nicotinamide
0.0009 - 0.0365
5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
0.00089 - 0.00234
5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
0.000045 - 0.026
5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.012 - 0.082
5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.00018
5-fluoro-alpha-methyltryptamine
Mus musculus
-
a drug causing head-twitch response, IC50: 0.00018 mM
0.00018
5-fluorotryptamine
Mus musculus
-
a drug causing head-twitch response, IC50: 0.00018 mM
0.00099
5-nitroindazole
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.0008
5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-1,3-thiazolidine-2,4-dione ammoniate (1:1)
Homo sapiens
-
pH and temperature not specified in the publication
0.3089
5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-2-imino-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.012
6,11-dihydro-5H-benzo[a]carbazole
Rattus norvegicus
pH 7.4, 37°C
0.467
6-amino-1,3-dimethyl-5-([1-phenylmeth-(E)-ylidene]-amino)-1H-pyrimidine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
6.968
6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
0.000602 - 0.577
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione
0.00018 - 0.034
6-chloro-N-(2-morpholinoethyl)nicotinamide
0.00038 - 0.075
6-chloro-N-(3-morpholinopropyl)nicotinamide
0.00018
6-fluoro-alpha-methyltryptamine
Mus musculus
-
a drug causing head-twitch response, IC50: 0.00018 mM
0.015 - 0.1
6-fluoro-N-(2-morpholinoethyl)nicotinamide
0.08 - 0.1
6-fluoro-N-(3-morpholinopropyl)nicotinamide
0.00018
6-fluorotryptamine
Mus musculus
-
a drug causing head-twitch response, IC50: 0.00018 mM
0.00043 - 0.1
6-hydroxy-N-(2-morpholinoethyl)nicotinamide
0.056 - 0.1
6-hydroxy-N-(3-morpholinopropyl)nicotinamide
0.086 - 0.1
6-methyl-N-(2-morpholinoethyl)nicotinamide
0.1
6-methyl-N-(3-morpholinopropyl)nicotinamide
0.00252
6-nitroindazole
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.0414
6-[(3-iodophenyl)methoxy]-3-[(3-iodophenyl)methyl]quinazolin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
-
0.00635
6-[(3-iodophenyl)methoxy]quinazolin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
-
0.000685
6-[(4-fluorophenyl)methoxy]-3-[(4-fluorophenyl)methyl]quinazolin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
-
0.000314
6-[(E)-2-(3-chloro-phenyl)-vinyl]-1,3-dimethyl-1H-pteridine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
1.057
6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
0.00002 - 0.0054
7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one
0.0018 - 0.1
7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one
0.0000128 - 0.0154
7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one
0.00046 - 0.026
7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one
0.0278
7-nitroindazole
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.000427
7-[(3-chlorobenzyl)oxy]-4-(chloromethyl)-2H-chromen-2-one
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.00112 - 0.0508
7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one
0.000013 - 0.006
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
0.0003 - 0.074
7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one
0.00207
7-[(3-chlorophenyl)methoxy]-4-(methylaminomethyl)chromen-2-one
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.0038 - 0.091
7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate
0.000018 - 0.0135
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
0.00124 - 0.00249
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000068 - 0.00094
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000107 - 0.00067
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000534 - 0.00107
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00101 - 0.00315
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000032 - 0.00011
benzhydrylidene-prop-2-ynyl-amine
0.00889 - 0.0116
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.142 - 0.362
cis-2,4,5-trimethoxypropenylbenzene
0.0312 - 0.0931
cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
0.038
clorgiline
Homo sapiens
pH and temperature not specified in the publication
-
0.0000012 - 20.27
Clorgyline
0.06135
clorogyline
Homo sapiens
pH and temperature not specified in the publication
-
0.0295
cyanidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.113 - 0.152
cyanidin-3,5-diglucoside
0.0359 - 0.0464
cyanidin-3-O-beta-D-galactoside
0.0343
cyanidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0332 - 0.0351
cyanidin-3-O-beta-D-rutinoside
0.0348 - 0.038
delphinidin
0.0294 - 0.0314
delphinidin-3-O-beta-D-glucoside
0.0057 - 0.0247
ethyl 4-hydroxy-3-methoxycinnamate
0.081
ethyl-4-hydroxy-3-methoxyphenylacetate
Homo sapiens
IC50: 0.081 mM, monoamine oxidase A
0.11 - 0.269
eugenol methyl ether
0.00047
fumarate
Rattus norvegicus
-
-
0.00759
iproniazid phosphate
Rattus norvegicus
pH and temperature not specified in the publication
-
0.00656 - 0.00754
Iproniazide
0.0000014
L-deprenyl
Mesocricetus auratus
-
pH 7.4, 37°C, cerebral MAO-B
0.0371
ladostigil
Homo sapiens
isoform MAO-B, at pH 8.0 and 37°C
0.0007
malate
Rattus norvegicus
-
-
0.0616 - 0.0733
malvidin 3-O,5-O-di-beta-D-glucoside
0.0341 - 0.0393
malvidin-3-O-beta-D-galactoside
0.0368 - 0.0478
malvidin-3-O-beta-D-glucoside
0.252
metanephrine
Homo sapiens
IC50: 0.252 mM, monoamine oxidase A
0.0016 - 0.0271
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
0.00234 - 0.00536
methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
0.09
N,N'-bis[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]butanediamide
Homo sapiens
IC50: 0.09 mM, at 0.15 mM kynuramine
0.0005
N,N'-[(1,5-dioxopentane-1,5-diyl)bis[piperazine-4,1-diyl(3-fluorobenzene-4,1-diyl)[(5R)-2-oxo-1,3-oxazolidine-3,5-diyl]methanediyl]]diacetamide
Homo sapiens
IC50: 0.0005 mM, at 0.15 mM kynuramine
0.01 - 0.1
N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
0.00384 - 0.15
N-(2-methyl-1H-indol-5-yl)benzamide
0.00696 - 0.0694
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
0.068 - 0.1
N-(2-morpholinoethyl)nicotinamide
0.00000108 - 0.01
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
0.000000386 - 0.01
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
0.000000586 - 0.01
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
0.00000144 - 0.00174
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
0.00000152 - 0.01
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
0.00000159 - 0.01
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
0.0000384 - 0.00764
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
0.000662 - 10
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
0.000000679 - 0.01
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
0.00136 - 10
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
0.1
N-(3-morpholinopropyl)nicotinamide
0.000202
N-(cycloheptylidenemethyl)-4-(3-methoxyphenyl)-1,3-thiazol-2-amine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.005 - 0.1
N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
0.000038
N-benzyl-N-methylprop-2-yn-1-amine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00401 - 0.1088
N-benzylprop-2-yn-1-amine
0.01 - 0.1
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
0.01 - 0.1
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
0.2459 - 0.26476
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0999 - 0.43089
N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.08991 - 0.48055
N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.19723 - 0.19886
N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.1842 - 0.1859
N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.09821 - 0.47066
N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.09053 - 0.47004
N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000117 - 0.01
N-phenyl-1H-indazole-5-carboxamide
0.0000022
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.955
naringenin
Rattus norvegicus
-
0.00405
paragyline
Rattus norvegicus
-
0.000188 - 0.39
Pargyline
0.0268 - 0.0426
pelargonidin
0.1173 - 0.242
pelargonidin 3-O,5-O-di-beta-D-glucoside
0.0381 - 0.0407
peonidin-3-O-beta-D-glucoside
0.0315 - 0.0432
petunidin
0.0005
pioglitazone
Homo sapiens
pH and temperature not specified in the publication
0.000017 - 0.0687
R-(-)-deprenyl
0.000048 - 580
safinamide
0.000006
sembragiline
Homo sapiens
pH and temperature not specified in the publication
-
0.00062
succinate
Rattus norvegicus
-
-
4.16
syringic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.25 - 0.33
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate
0.079
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl][2-(phenylcarbonyl)phenyl]amino]-2-oxoethyl)carbamate
Rattus norvegicus
37°C, no preincubation
0.124 - 0.338
trans-2,4,5-trimethoxypropenylbenzene
0.0201 - 0.0695
trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
3.89
vanillic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00065 - 0.0028
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
0.00229
[(5E)-2,4-dioxo-5-(phenylimino)-1,3-thiazolidin-3-yl]acetonitrile
Homo sapiens
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.002 - 0.09
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
0.001 - 0.0245
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
0.006 - 0.081
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
0.00185
[Cu(2-[4-[bis(4-fluorophenyl)methyl]pipera-zin-1-yl]acetic acid)2(H2O)]
Rattus norvegicus
pH and temperature not specified in the publication
-
additional information
additional information
-
0.015
(+)-6-hydroxytrypargine
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.039
(+)-6-hydroxytrypargine
Homo sapiens
-
pH 7.4, 37°C, MAO-A
0.008
(-)-6-hydroxytrypargine
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.034
(-)-6-hydroxytrypargine
Homo sapiens
-
pH 7.4, 37°C, MAO-A
0.01665
(1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.1374
(1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
14.86
(1R,2R)-(-)-psi-ephedrine
Homo sapiens
-
IC50 for soluble enzyme: 5.35 mM, IC50 for immobilized enzyme: 14.86 mM, monoamine oxidase A
88
(1R,2R)-(-)-psi-ephedrine
Homo sapiens
-
IC50 for soluble enzyme: 5.03 mM, IC50 for immobilized enzyme: 88 mM, monoamine oxidase B
1.77
(1S,2S)-(+)-psi-ephedrine
Homo sapiens
-
IC50 for soluble enzyme: 0.88 mM, IC50 for immobilized enzyme: 1.77 mM, monoamine oxidase A
234
(1S,2S)-(+)-psi-ephedrine
Homo sapiens
-
IC50 for soluble enzyme: 10 mM, IC50 for immobilized enzyme: 234 mM, monoamine oxidase B
0.02
(2-methylprop-2-en-1-yl)hydrazine
Homo sapiens
-
0.35
(2-methylprop-2-en-1-yl)hydrazine
Homo sapiens
-
0.0013
(2-phenylprop-2-en-1-yl)hydrazine
Homo sapiens
-
0.071
(2-phenylprop-2-en-1-yl)hydrazine
Homo sapiens
-
0.0056
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide
Homo sapiens
pH 7.4, temperature not specified in the publication
-
17.7
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide
Homo sapiens
pH 7.4, temperature not specified in the publication
-
0.000036
(2E)-2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3(2H)-ylidene]-N-methylacetamide
Rattus norvegicus
-
isoform MAO-B, pH and temperature not specified in the publication
0.0031
(2E)-2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3(2H)-ylidene]-N-methylacetamide
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0077
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.00983
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0000051
(2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-B
0.00495
(2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Homo sapiens
-
pH 7.4, 37°C, MAO-A
0.00222
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal
Homo sapiens
pH 7.4, 37°C
-
0.00547
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal
Homo sapiens
pH 7.4, 37°C
-
0.00142
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal
Homo sapiens
pH 7.4, 37°C
-
0.00459
(2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal
Homo sapiens
pH 7.4, 37°C
-
0.000193
(2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal
Homo sapiens
pH 7.4, 37°C
-
0.00405
(2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal
Homo sapiens
pH 7.4, 37°C
-
0.01882
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.663
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.0016
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
Mus musculus
inhibition of MAO-B
0.0271
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
Mus musculus
inhibition of MAO-A
0.139
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
Mus musculus
inhibition MAO-B
0.00372
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0599
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00562
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0253
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00025
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00066
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00012
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00305
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00187
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0141
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00014
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00126
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00161
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0206
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00046
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0005
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0522
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0685
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00015
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00019
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00018
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00022
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00031
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00258
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00049
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00214
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00044
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00138
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00102
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00133
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00014
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
40
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00107
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0764
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00064
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0299
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0419
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0443
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0399
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0568
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00054
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0491
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.00013
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0155
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
Homo sapiens
pH and temperature not specified in the publication
-
0.0002
(7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00023
(7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.000016
(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.00047
(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00348
(E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00527
(E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00019
(E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00065
(E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00137
(E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00161
(E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00298
(E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00828
(E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00019
(E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00063
(E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0001
(E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00048
(E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00171
(E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00219
(E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00018
(E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00717
(E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00044
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0039
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-A
0.0012
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0125
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-A
0.00055
(E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00439
(E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00016
(E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00114
(E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0991
(R)-amphetamine
Homo sapiens
-
IC50 for soluble enzyme: 0.0311 mM, IC50 for immobilized enzyme: 0.0991 mM, monoamine oxidase A
4.03
(R)-amphetamine
Homo sapiens
-
IC50 for soluble enzyme: 0.246 mM, IC50 for immobilized enzyme: 4.03 mM, monoamine oxidase B
0.0244
(R,S)-amphetamine
Homo sapiens
-
IC50 for soluble enzyme: 0.0031 mM, IC50 for immobilized enzyme: 0.0244 mM, monoamine oxidase A
3
(R,S)-amphetamine
Homo sapiens
-
IC50 for soluble enzyme: 0.0625 mM, IC50 for immobilized enzyme: 3 mM, monoamine oxidase B
0.0022
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
Homo sapiens
-
0.098
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
Homo sapiens
-
0.000112
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000152
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00372
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0004
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000546
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.000698
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0098
1,3-diphenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0098 mM, MAO-A
0.2
1,3-diphenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.2 mM, MAO-B
0.000414
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.0008
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.00556
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00697
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(coumarin-3-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000333
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00168
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(furan-2-yl)ethylidene)-hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000455
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00381
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-3-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000116
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.0037
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(pyridin-4-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00055
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000636
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(1-(thiophen-2-yl)-ethylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.0000122
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000737
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclohexylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.0000266
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000836
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(2-methylcyclopentylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.0000727
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000679
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.000231
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.00145
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(3-methylcyclopentylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.0000355
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000749
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(4-methylcyclohexylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00115
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00672
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(heptan-2-ylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000872
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.00131
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.000772
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000824
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pentan-3-ylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00443
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00507
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000538
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00291
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-3-ylmethylene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000698
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00114
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(pyridin-4-ylmethylene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000458
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00049
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-(thiophen-2-ylmethylene)hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.0000295
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.00178
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cycloheptylidene-hydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.0000318
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.00191
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.000592
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine
Homo sapiens
-
MAO A, pH 7.4, 37°C
0.00106
1-(4-(3-methoxyphenyl)thiazol-2-yl)-2-cyclopentylidenehydrazine
Homo sapiens
-
MAO B, pH 7.4, 37°C
0.000009
1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.000009 mM, MAO-A
0.041
1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.041 mM, MAO-B
0.00023
1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00023 mM, MAO-A
0.1
1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.0002
1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0002 mM, MAO-A
0.14
1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.14 mM, MAO-B
0.00029
1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00029 mM, MAO-A
0.1
1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.0003
1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0003 mM, MAO-A
0.09
1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.09 mM, MAO-B
0.0001
1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0001 mM, MAO-A
0.088
1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.088 mM, MAO-B
0.00024
1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00024 mM, MAO-A
0.1
1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.00001
1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00001 mM, MAO-A
0.1
1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.00001
1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00001mM, MAO-A
0.1
1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.0002
1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0002 mM, MAO-A
0.1
1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.0001
1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0001 mM, MAO-A
0.02
1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.02 mM, MAO-B
0.0001
1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0001 mM, MAO-A
0.1
1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.00001
1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00001 mM, MAO-A
0.1
1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.0001
1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0001 mM, MAO-A
0.038
1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.038 mM, MAO-B
0.00001
1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00001 mM, MAO-A
0.025
1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.025 mM, MAO-B
0.000009
1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.000009 mM, MAO-A
0.083
1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.083 mM, MAO-B
0.000008
1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.000008 mM, MAO-A
0.1
1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.000447
1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.00307
1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.0139
1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0179
1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0125
1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid
Homo sapiens
pH 7.4, 37°C
-
0.0216
1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid
Homo sapiens
pH 7.4, 37°C
-
0.027
1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.117
1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.0022
1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.00732
1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.0135
1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0166
1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.000049
1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.00087
1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.000184
1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.00129
1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.000175
1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.0157
1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.000529
1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.00231
1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde
Homo sapiens
pH 7.4, 37°C
-
0.0208
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.0926
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.366
1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation
0.39
1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation
0.33
1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation
0.38
1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation
0.302
1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation
0.349
1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation
0.326
1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation
0.345
1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
Rattus norvegicus
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation
0.402
1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.49
1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.2853
1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.499
1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.51
1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.0342
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.5
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.51
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.0382
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.486
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.5
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.00496
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.47
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.485
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.0067
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.5
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.53
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.0638
1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.069
1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.513
1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.0523
1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
preincubation 60 min, monoamine oxidase B
0.065
1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase B
0.501
1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
Rattus norvegicus
no preincubation, monoamine oxidase A
0.63
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
Rattus norvegicus
-
1
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
Rattus norvegicus
-
0.042
2,4-dimethoxy-5-hydroxybenzaldehyde
Homo sapiens
IC50: 0.042 mM, monoamine oxidase A
0.39
2,4-dimethoxy-5-hydroxybenzaldehyde
Homo sapiens
IC50: 0.39 mM
0.0624
2,6-dimethoxyphenol
Homo sapiens
IC50: 0.0624 mM, monoamine oxidase A
0.5
2,6-dimethoxyphenol
Homo sapiens
IC50: above 0.5 mM, monoamine oxidase B
0.0001
2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.019
2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.019 mM, MAO-B
0.001
2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
Bos taurus
IC50: 0.001 mM, MAO-A
0.07
2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
Bos taurus
IC50: 0.07 mM, MAO-B
0.000072
2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.000072 mM, MAO-A
0.04
2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.04 mM, MAO-B
0.00094
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.05928
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000016
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.007229
2-(2-cycloheptylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000004
2-(2-cycloheptylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.01028
2-(2-cycloheptylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.003925
2-(2-cycloheptylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.005025
2-(2-cycloheptylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00092
2-(2-cycloheptylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.009612
2-(2-cycloheptylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000011
2-(2-cycloheptylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.01785
2-(2-cycloheptylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000027
2-(2-cycloheptylidenehydrazinyl)-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.01485
2-(2-cycloheptylidenehydrazinyl)-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000652
2-(2-cyclohexylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.04575
2-(2-cyclohexylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000004
2-(2-cyclohexylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0001752
2-(2-cyclohexylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.007509
2-(2-cyclohexylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.01196
2-(2-cyclohexylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.003689
2-(2-cyclohexylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.02373
2-(2-cyclohexylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000086
2-(2-cyclohexylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.02415
2-(2-cyclohexylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000116
2-(2-cyclohexylidenehydrazinyl)-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.04835
2-(2-cyclohexylidenehydrazinyl)-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000284
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.05451
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-dichlorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000003
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.002318
2-(2-cyclopentylidenehydrazinyl)-4-(2,4-difluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00004
2-(2-cyclopentylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.004436
2-(2-cyclopentylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000164
2-(2-cyclopentylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.001055
2-(2-cyclopentylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000134
2-(2-cyclopentylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.002019
2-(2-cyclopentylidenehydrazinyl)-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000094
2-(2-cyclopentylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000344
2-(2-cyclopentylidenehydrazinyl)-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000296
2-(2-cyclopentylidenehydrazinyl)-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.007883
2-(2-cyclopentylidenehydrazinyl)-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00797
2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0222
2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00004
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.000024
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0005
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00003
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.026
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00005
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.07
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.002
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.1
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.001
2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0043
2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.036
2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
Homo sapiens
-
8.2
2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
Homo sapiens
-
0.25
2-(aminooxy)-1-phenylethanol
Homo sapiens
-
0.45
2-(aminooxy)-1-phenylethanol
Homo sapiens
-
0.00388
2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00991
2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00032
2-bromo-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0085
2-bromo-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.0019
2-bromo-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.035
2-bromo-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.00104
2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.01062
2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.028
2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.1
2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-A
0.1
2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.0018
2-chloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0026
2-chloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.0065
2-chloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0094
2-chloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.00088
2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00137
2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.045
2-hydroxy-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
2-hydroxy-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.1
2-hydroxy-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-A
0.1
2-hydroxy-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.175
2-methoxyphenol
Homo sapiens
IC50: 0.175 mM, monoamine oxidase A
0.5
2-methoxyphenol
Homo sapiens
IC50: above 0.5 mM, monoamine oxidase B
0.15
2-methyl-5-methylaniline
Homo sapiens
IC50: 0.15 mM, monoamine oxidase A
0.5
2-methyl-5-methylaniline
Homo sapiens
IC50: above 0.5 mM
0.0094
2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
Rattus norvegicus
pH 7.4, 37°C
0.0471
2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
Rattus norvegicus
pH 7.4, 37°C
0.013
2-phenyl-9H-indeno[2,1-d]pyrimidine
Rattus norvegicus
pH 7.4, 37°C
0.0167
2-phenyl-9H-indeno[2,1-d]pyrimidine
Rattus norvegicus
pH 7.4, 37°C
0.000711
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.04124
2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00014
2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00243
2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.008
2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.008 mM, MAO-A
0.3
2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.3 mM, MAO-B
0.009
2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.009 mM, MAO-A
0.3
2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.3 mM, MAO-B
0.0094
2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0094 mM, MAO-A
0.48
2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.48 mM, MAO-B
0.025
2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.025 mM, MAO-B
0.097
2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.097 mM, MAO-A
0.098
2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.098 mM, MAO-A
2
2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 2.0 mM, MAO-B
0.013
2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.013 mM, MAO-A
3.8
2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 3.8 mM, MAO-B
0.09
2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.09 mM, MAO-A
1
2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 1.0 mM, MAO-B
0.094
2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.094 mM, MAO-A
1.8
2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 1.8 mM, MAO-B
0.088
2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.088 mM, MAO-A
0.2
2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.2 mM, MAO-B
0.0000086
2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0000086 mM, MAO-A
0.1
2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.1 mM, MAO-B
0.00001
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.00001 mM, MAO-A
0.0001
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.0001 mM, MAO-B
0.000008
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.000008 mM, MAO-A
0.019
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.019 mM, MAO-B
0.0001
2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.04
2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.04 mM, MAO-B
0.000028
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.000028 mM, MAO-A
0.00006
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.00006 mM, MAO-B
0.000009
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.000009 mM, MAO-A
0.0072
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0072 mM, MAO-B
0.002
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.002 mM, MAO-A
0.1
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.1 mM, MAO-B
0.0000088
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0000088 mM, MAO-A
0.1
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.1 mM, MAO-B
0.0001
2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.06
2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.06 mM, MAO-B
0.005477
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.008109
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-methylphenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000362
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.02088
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-(4-nitrophenyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000259
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.03422
2-[2-(4-methylcyclohexylidene)hydrazinyl]-4-phenyl-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.0013
2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.021
2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.002
2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0265
2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.089
2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.089 mM, MAO-A
0.25
2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.25 mM, MAO-B
0.12
2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.12 mM, MAO-A
1
2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 1 mM, MAO-B
0.000284
2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3-yl]-N-methylacetamide
Rattus norvegicus
-
isoform MAO-B, pH and temperature not specified in the publication
0.001
2-[6-[(3-chlorobenzyl)oxy]-1-benzofuran-3-yl]-N-methylacetamide
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.00009
2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0025
2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0004
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0231
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.000015
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0028
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0002
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.008
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00004
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.00144
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0063
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.1
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.00006
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0098
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.000014
3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000051
3,4-dimethoxy-(benzylidene)-prop-2-ynylamine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000048
3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00283
3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0018
3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0018 mM, MAO-A
0.04
3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.04 mM, MAO-B
0.01
3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.01 mM, MAO-A
0.5
3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.5 mM, MAO-B
0.00053
3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.00358
3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.00273
3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.0028
3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0029
3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.00318
3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0088
3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0707
3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.00127
3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.00136
3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.00027
3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.002
3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.00042
3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0025
3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.0017
3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.0026
3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0011
3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.0021
3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.003
3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.003 mM, MAO-A
0.017
3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.017 mM, MAO-B
0.000014
3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.000014 mM, MAO-A
0.001
3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.001 mM, MAO-B
0.09
3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.09 mM, MAO-A
0.98
3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.98 mM, MAO-B
0.0074
3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0074 mM, MAO-A
0.087
3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.087 mM, MAO-B
0.0099
3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0099 mM, MAO-A
0.1
3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.1 mM, MAO-B
0.09856
3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.4874
3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.19356
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.25623
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.05522
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.50045
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.19844
3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.20534
3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.09045
3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.47019
3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.06128
3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.47021
3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.000532
3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.000813
3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00011
3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00011 mM, MAO-A
0.0125
3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0125 mM, MAO-B
0.0069
3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.0069 mM, MAO-A
0.05
3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.05 mM, MAO-B
0.000086
3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.000086 mM, MAO-A
0.00145
3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
Bos taurus
IC50: 0.00145 mM, MAO-B
0.00357
3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00982
3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00119
3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00317
3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0356
3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0419
3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0157
3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0251
3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.018
3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0214
3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0676
3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.115
3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0135
3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid
Homo sapiens
pH 7.4, 37°C
-
0.0456
3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid
Homo sapiens
pH 7.4, 37°C
-
0.00399
3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.0138
3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.000092
3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.00119
3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.000458
3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.000734
3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.00105
3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.00132
3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.00004
3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.000605
3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.000023
3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.000178
3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione
Homo sapiens
pH 7.4, 37°C
-
0.0191
3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.0222
3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00279
3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00963
3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile
Homo sapiens
pH 7.4, 37°C
-
0.00076
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.031
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.00099
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0077
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-A
0.07
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
Rattus norvegicus
-
0.095
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
Rattus norvegicus
-
2
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
Rattus norvegicus
-
2.2
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
Rattus norvegicus
-
0.1759
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
Homo sapiens
pH 7.4, 37°C, MAO-B
0.259
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
Homo sapiens
pH 7.4, 37°C, MAO-A
0.00026
3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00084
3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0001
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.39
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol
Bos taurus
IC50: 0.39 mM, MAO-B
0.0001
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.08
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
Bos taurus
IC50: 0.08 mM, MAO-B
0.00005
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.00005 mM, MAO-A
0.062
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.062 mM, MAO-B
0.0001
4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.03
4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
Bos taurus
IC50: 0.03 mM, MAO-B
0.000073
4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.000073 mM, MAO-A
0.003
4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
Bos taurus
IC50: 0.003 mM, MAO-B
0.02681
4-(2,4-dichlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0447
4-(2,4-dichlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.009446
4-(2,4-dichlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.08149
4-(2,4-dichlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000014
4-(2,4-difluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.03796
4-(2,4-difluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000091
4-(2,4-difluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.0195
4-(2,4-difluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00025
4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0318
4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.000578
4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
Homo sapiens
pH 7.4, temperature not specified in the publication
-
0.0035
4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
Homo sapiens
pH 7.4, temperature not specified in the publication
-
0.000477
4-(4-chlorophenyl)-2-(2-cycloheptylidenehydrazinyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.006182
4-(4-chlorophenyl)-2-(2-cycloheptylidenehydrazinyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000211
4-(4-chlorophenyl)-2-(2-cyclohexylidenehydrazinyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.002911
4-(4-chlorophenyl)-2-(2-cyclohexylidenehydrazinyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000262
4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00716
4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.01313
4-(4-chlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.03522
4-(4-chlorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.002411
4-(4-chlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.01522
4-(4-chlorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000204
4-(4-fluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.04356
4-(4-fluorophenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000043
4-(4-fluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.04546
4-(4-fluorophenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.002373
4-(4-methoxyphenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.002762
4-(4-methoxyphenyl)-2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.005763
4-(4-methoxyphenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.0312
4-(4-methoxyphenyl)-2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazole
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000997
4-(aminomethyl)-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0033
4-(aminomethyl)-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-B, pH and temperature not specified in the publication
0.000021
4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0044
4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.000015
4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.002
4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.01
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.02
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.063
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.3
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.044
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.25
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
Rattus norvegicus
-
0.008
4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00075
4-chloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.074
4-chloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0075
4-chloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.053
4-chloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0089
4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol
Homo sapiens
IC50: 0.0089 mM, monoamine oxidase B
0.0134
4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol
Homo sapiens
IC50: 0.0134 mM, monoamine oxidase A
0.13
4-Hydroxy-3-methoxybenzylamine
Homo sapiens
IC50: 0.13 mM, monoamine oxidase A
0.382
4-Hydroxy-3-methoxybenzylamine
Homo sapiens
IC50: 0.382 mM, monoamine oxidase B
0.0216
4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.034
4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
Rattus norvegicus
pH 7.4, 37°C
0.0036
4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00051
4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0001
4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0226
4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0017
4-[(methylamino)methyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-B, pH and temperature not specified in the publication
0.0054
4-[(methylamino)methyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0001
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.038
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.038 mM, MAO-B
0.00001
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.00001 mM, MAO-A
0.02
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.02 mM, MAO-B
0.0000086
4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0000086 mM, MAO-A
0.087
4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.087 mM, MAO-B
0.000008
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.000008 mM, MAO-A
0.13
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.13 mM, MAO-B
0.0000088
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0000088 mM, MAO-A
0.1
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.1 mM, MAO-B
0.00001
4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.00001 mM, MAO-A
0.00002
4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.00002 mM, MAO-B
0.00001
4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.00001 mM, MAO-A
0.023
4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.023 mM, MAO-B
0.000013
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.000013 mM, MAO-A
0.000038
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.000038 mM, MAO-B
0.000008
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.000008 mM, MAO-A
0.019
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.019 mM, MAO-B
0.00001
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.00001 mM, MAO-A
0.12
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.12mM, MAO-B
0.0001
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0001 mM, MAO-A
0.04
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.04 mM, MAO-B
0.000009
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.000009 mM, MAO-A
0.083
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.083 mM, MAO-B
0.000009
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.000009 mM, MAO-A
0.0072
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0072 mM, MAO-B
0.000009
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.000009 mM, MAO-A
0.042
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
Bos taurus
IC50: 0.042 mM, MAO-B
0.0001
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.0001mM, MAO-A
0.03
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
Bos taurus
IC50: 0.03 mM, MAO-B
0.000046
4-[2-(2-cycloheptylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.004327
4-[2-(2-cycloheptylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000053
4-[2-(2-cyclohexylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.004837
4-[2-(2-cyclohexylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000221
4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000644
4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000111
4-[2-(methylamino)-2-oxoethyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.0083
4-[2-(methylamino)-2-oxoethyl]-2-oxo-2H-chromen-7-yl 3-chlorobenzenesulfonate
Rattus norvegicus
-
isoform MAO-B, pH and temperature not specified in the publication
0.000026
4-[2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.03103
4-[2-[(2E)-2-(2-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.000061
4-[2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.006994
4-[2-[2-(4-methylcyclohexylidene)hydrazinyl]-1,3-thiazol-4-yl]benzonitrile
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.10077
4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.47045
4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.000084
5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.048
5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0001
5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.045
5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.01339
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.49622
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.03044
5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.47067
5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.0299
5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.48023
5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.00625
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.50023
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.03724
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.48882
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.0199
5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.50011
5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.00834
5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.47022
5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.026
5-bromo-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.055
5-bromo-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.023
5-bromo-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.065
5-bromo-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.0009
5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.0365
5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00089
5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00234
5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.000045
5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.026
5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.012
5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.082
5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.000602
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
0.577
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione
Papio sp.
-
pH 7.4, 37°C
0.00018
6-chloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.034
6-chloro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.00038
6-chloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.075
6-chloro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-B
0.015
6-fluoro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
6-fluoro-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.08
6-fluoro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
6-fluoro-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.00043
6-hydroxy-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
6-hydroxy-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.056
6-hydroxy-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
6-hydroxy-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.086
6-methyl-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
6-methyl-N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.1
6-methyl-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-A
0.1
6-methyl-N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.00002
7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0054
7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0018
7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0000128
7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0154
7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00046
7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.026
7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00112
7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0508
7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.000013
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.006
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0003
7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.074
7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.0038
7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.091
7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.000018
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.0135
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00124
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00177
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00249
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000068
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.000113
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00094
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000107
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00012
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00067
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000534
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000542
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00107
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00101
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.00159
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Papio anubis
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.00315
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000032
benzhydrylidene-prop-2-ynyl-amine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00011
benzhydrylidene-prop-2-ynyl-amine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.00889
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0116
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
Homo sapiens
pH 7.4, 37°C, MAO-A
0.142
cis-2,4,5-trimethoxypropenylbenzene
Homo sapiens
IC50: 0.142 mM, monoamine oxidase A
0.362
cis-2,4,5-trimethoxypropenylbenzene
Homo sapiens
IC50: 0.362 mM, monoamine oxidase B
0.0312
cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0931
cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.0000012
Clorgyline
Homo sapiens
-
IC50: 1.2 nM
0.0000044
Clorgyline
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000045
Clorgyline
Homo sapiens
pH and temperature not specified in the publication
0.0000052
Clorgyline
Homo sapiens
-
MAO-A, pH not specified in the publication, temperature not specified in the publication
0.000014
Clorgyline
Homo sapiens
-
IC50: 0.000014 mM
0.0003
Clorgyline
Rattus norvegicus
-
0.00042
Clorgyline
Homo sapiens
-
IC50: 0.00042 mM
0.00172
Clorgyline
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.00416
Clorgyline
Rattus norvegicus
monoamine oxidase A
0.0634
Clorgyline
Homo sapiens
-
MAO-B, pH not specified in the publication, temperature not specified in the publication
20.27
Clorgyline
Homo sapiens
pH and temperature not specified in the publication
0.113
cyanidin-3,5-diglucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.152
cyanidin-3,5-diglucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0359
cyanidin-3-O-beta-D-galactoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0464
cyanidin-3-O-beta-D-galactoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0332
cyanidin-3-O-beta-D-rutinoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0351
cyanidin-3-O-beta-D-rutinoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0348
delphinidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.038
delphinidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0294
delphinidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0314
delphinidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000019
Deprenyl
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000196
Deprenyl
Homo sapiens
pH and temperature not specified in the publication
0.0023
Deprenyl
Homo sapiens
-
IC50: 0.0023 mM
0.02
Deprenyl
Homo sapiens
-
IC50: 0.020 mM
0.06725
Deprenyl
Homo sapiens
pH and temperature not specified in the publication
0.105
Deprenyl
Rattus norvegicus
-
3.3
Deprenyl
Homo sapiens
-
IC50: 3.3 mM
0.0057
ethyl 4-hydroxy-3-methoxycinnamate
Homo sapiens
IC50: 0.0057 mM, monoamine oxidase B
0.0247
ethyl 4-hydroxy-3-methoxycinnamate
Homo sapiens
IC50: 0.0247 mM, monoamine oxidase A
0.0344
eugenol
Homo sapiens
IC50: 0.0344 mM, monoamine oxidase A
0.288
eugenol
Homo sapiens
IC50: 0.288 mM, monoamine oxidase B
0.11
eugenol methyl ether
Homo sapiens
IC50: 0.11 mM, monoamine oxidase A
0.269
eugenol methyl ether
Homo sapiens
IC50: 0.269 mM, monoamine oxidase B
0.00656
Iproniazide
Homo sapiens
-
MAO-A, pH not specified in the publication, temperature not specified in the publication
0.00754
Iproniazide
Homo sapiens
-
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.008566
isatin
Homo sapiens
inhibition of MAO-B
368.4
isatin
Homo sapiens
pH and temperature not specified in the publication
0.000091
lazabemide
Homo sapiens
pH 7.4, 37°C
0.000091
lazabemide
Homo sapiens
pH and temperature not specified in the publication
0.0187
malvidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0221
malvidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0616
malvidin 3-O,5-O-di-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0733
malvidin 3-O,5-O-di-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0341
malvidin-3-O-beta-D-galactoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0393
malvidin-3-O-beta-D-galactoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0368
malvidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0478
malvidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0016
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
Homo sapiens
inhibition of MAO-B
0.0271
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
Homo sapiens
inhibition of MAO-A
0.00234
methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.00536
methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.01
moclobemide
Rattus norvegicus
-
isoform MAO-A, pH and temperature not specified in the publication
0.361
moclobemide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.3614
moclobemide
Homo sapiens
-
MAO-A, pH not specified in the publication, temperature not specified in the publication
10.7
moclobemide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00384
N-(2-methyl-1H-indol-5-yl)benzamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.15
N-(2-methyl-1H-indol-5-yl)benzamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.00696
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
Homo sapiens
pH 7.4, 37°C, MAO-B
0.0694
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
Homo sapiens
pH 7.4, 37°C, MAO-A
0.068
N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
pH 7.4, 37°C, MAO-A
0.1
N-(2-morpholinoethyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.00000108
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00000382
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00287
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.000000386
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00000132
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.000000586
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00000143
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.00000144
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.0000225
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00042
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.00174
N-(3,4-dichlorophenyl)-2-methyl-2H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.00000152
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00000565
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-difluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.00000159
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00000889
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(3,4-difluorophenyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.0000384
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.000221
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00188
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.00764
N-(3,4-difluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.000662
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.708
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
10
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
10
N-(3-chloro-4-fluorophenyl)-1-methyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.000000679
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00000236
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.01
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.00136
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.00808
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
1.69
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
10
N-(3-chloro-4-fluorophenyl)-2-methyl-2H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.1
N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-A
0.1
N-(3-morpholinopropyl)nicotinamide
Rattus norvegicus
above, pH 7.4, 37°C, MAO-B
0.005
N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.00401
N-benzylprop-2-yn-1-amine
Homo sapiens
-
MAO A, pH not specified in the publication, temperature not specified in the publication
0.1088
N-benzylprop-2-yn-1-amine
Homo sapiens
-
MAO B, pH not specified in the publication, temperature not specified in the publication
0.01
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.01
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-B
0.1
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication, MAO-A
0.2459
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.26476
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.0999
N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.43089
N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.08991
N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.48055
N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.19723
N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.19886
N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.1842
N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.1859
N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.09821
N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.47066
N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.09053
N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.47004
N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
isoform MAO-B, at pH 7.6 and 37°C
0.000117
N-phenyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.000708
N-phenyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.01
N-phenyl-1H-indazole-5-carboxamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.01
N-phenyl-1H-indazole-5-carboxamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.101
o-eugenol
Homo sapiens
IC50: 0.101 mM, monoamine oxidase A
0.5
o-eugenol
Homo sapiens
IC50: above 0.5 mM, monoamine oxidase B
0.000188
Pargyline
Homo sapiens
isoform MAO-B, at pH 8.0 and 37°C
0.00272
Pargyline
Rattus norvegicus
-
0.00285
Pargyline
Rattus norvegicus
no preincubation, monoamine oxidase B
0.00405
Pargyline
Rattus norvegicus
no preincubation, monoamine oxidase B
0.39
Pargyline
Rattus norvegicus
isoform MAO-A, at pH 7.6 and 37°C
0.0268
pelargonidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0426
pelargonidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.1173
pelargonidin 3-O,5-O-di-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.242
pelargonidin 3-O,5-O-di-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0221
peonidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0305
peonidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0381
peonidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0407
peonidin-3-O-beta-D-glucoside
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.0315
petunidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-A
0.0432
petunidin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication, MAO-B
0.000017
R-(-)-deprenyl
Homo sapiens
-
MAO-B, pH not specified in the publication, temperature not specified in the publication
0.0687
R-(-)-deprenyl
Homo sapiens
-
MAO-A, pH not specified in the publication, temperature not specified in the publication
0.000048
safinamide
Homo sapiens
pH 7.4, 37°C
0.00045
safinamide
Homo sapiens
pH and temperature not specified in the publication
0.00518
safinamide
Homo sapiens
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.018
safinamide
Rattus norvegicus
isoform MAO-B, at pH 7.4, temperature not specified in the publication
0.039
safinamide
Homo sapiens
pH and temperature not specified in the publication
45
safinamide
Homo sapiens
isoform MAO-A, at pH 7.4, temperature not specified in the publication
223.5
safinamide
Homo sapiens
pH and temperature not specified in the publication
580
safinamide
Rattus norvegicus
isoform MAO-A, at pH 7.4, temperature not specified in the publication
0.033
selegiline
Homo sapiens
pH and temperature not specified in the publication
54.35
selegiline
Homo sapiens
pH and temperature not specified in the publication
0.25
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate
Rattus norvegicus
37°C, no preincubation
0.33
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate
Rattus norvegicus
37°C, no preincubation
0.00392
toloxatone
Homo sapiens
pH 7.4, 37°C
0.00392
toloxatone
Homo sapiens
pH and temperature not specified in the publication
0.124
trans-2,4,5-trimethoxypropenylbenzene
Homo sapiens
IC50: 0.124 mM, monoamine oxidase A
0.338
trans-2,4,5-trimethoxypropenylbenzene
Homo sapiens
IC50: 0.338 mM, monoamine oxidase B
0.0201
trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-A
0.0695
trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
Rattus norvegicus
-
pH 7.6, 37°C, MAO-B
0.00065
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
Homo sapiens
-
0.0028
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
Homo sapiens
-
0.002
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
Homo sapiens
-
0.09
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
Homo sapiens
-
0.001
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
Homo sapiens
-
0.0245
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
Homo sapiens
-
0.006
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
Homo sapiens
-
0.081
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
Homo sapiens
-
additional information
additional information
Rattus norvegicus
above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride, 1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, 1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, and above 0.17 mM for 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride, 3-methylamino-4-aminomethylpyridine dihydrochloride, and 3-ethylamino-4-aminomethylpyridine dihydrochloride. Above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride and above 0.1 mM for 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate, 2-methylaminobenzylamine dihydrochloride, and 2-ethylaminobenzylamine dihydrochloride
-
additional information
additional information
Rattus norvegicus
above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride, 1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, 1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, and above 0.17 mM for 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride, 3-methylamino-4-aminomethylpyridine dihydrochloride, and 3-ethylamino-4-aminomethylpyridine dihydrochloride. Above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride and above 0.1 mM for 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate, 2-methylaminobenzylamine dihydrochloride, and 2-ethylaminobenzylamine dihydrochloride
-
additional information
additional information
Rattus norvegicus
above 1.6 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, and above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride. Above 0.1 mM for 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate, 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, and 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
additional information
additional information
Rattus norvegicus
above 1.6 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, and above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride. Above 0.1 mM for 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate, 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, and 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
additional information
additional information
Homo sapiens
-
inhibition kinetics
-
additional information
additional information
Homo sapiens
pIC50 value of rosiridin for MAO B inhibition is 5.38, the pIC50 value for L-deprenyl is 7.23 for MAO B inhibition
-
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