Application | Comment | Organism |
---|---|---|
drug development | MAO-A is a target for a series of therapeutically valuable drugs. Thus, selective MAO-A inhibitors are used as antidepressants | Rattus norvegicus |
drug development | MAO-B is a target for a series of therapeutically valuable drugs. Thus, selective MAO-B inhibitors are used in the treatment of Parkinsons disease | Rattus norvegicus |
medicine | MAO-A is a target for a series of therapeutically valuable drugs. Thus, selective MAO-A inhibitors are used as antidepressants | Rattus norvegicus |
medicine | MAO-B is a target for a series of therapeutically valuable drugs. Thus, selective MAO-B inhibitorsare used in the treatment of Parkinsons disease | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6-benzyloxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
(6-butoxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
(6-ethoxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
(6-methoxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
(6-methylthio-2-naphthyl)isopropylamine | - |
Rattus norvegicus | |
(6-propoxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(1-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(4-benzyloxyphenyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(4-butoxyphenyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(4-ethoxyphenyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(4-methoxy-phenyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(4-methylthiophenyl)-2-aminopropane | - |
Rattus norvegicus | |
1-(4-propoxyphenyl)-2-aminopropane | - |
Rattus norvegicus | |
1-phenyl-2-aminopropane | - |
Rattus norvegicus | |
additional information | naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors of isozymes MAO-A and MAO-B, molecular docking, overview. Replacement of the phenyl ring of amphetamine derivatives by a naphthalene system resulted in more potent compounds results in increased electron-donating capacity and size of the aromatic moiety; naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors of isozymes MAO-B, molecular docking, overview. Replacement of the phenyl ring of amphetamine derivatives by a naphthalene system resulted in more potent compounds results in increased electron-donating capacity and size of the aromatic moiety. No inhibition of MAOB by N-4-methoxybenzyl-(4-methylthioamphetamine) hydrochloride, N-4-butoxybenzyl-(4-methylthioamphetamine) hydrochloride, and N-4-benzyloxybenzyl-(4-methylthioamphetamine) hydrochloride | Rattus norvegicus | |
N-(4-benzyloxybenzyl)-4-methylthioamphetamine | - |
Rattus norvegicus | |
N-(4-butoxybenzyl)-4-methylthioamphetamine | - |
Rattus norvegicus | |
N-(4-hydroxybenzyl)-4-methylthioamphetamine | weak inhibition of MAO-A; weak inhibition of MAO-B | Rattus norvegicus | |
N-(4-methoxybenzyl)-4-methylthioamphetamine | - |
Rattus norvegicus | |
N-benzyl-(4-methylthioamphetamine) | weak inhibition of MAO-A; weak inhibition of MAO-B | Rattus norvegicus | |
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus | |
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P19643 | MAOB | - |
Rattus norvegicus | P21396 | MAOA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-dimethylaminophenethylamine + H2O + O2 | substrate of MAO-B | Rattus norvegicus | ? | - |
? | |
serotonin + H2O + O2 | substrate of MAO-A | Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
1-(4-propoxyphenyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00018 | - |
(6-methoxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00022 | - |
1-(4-ethoxyphenyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00025 | - |
1-(4-methoxy-phenyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00025 | - |
1-(4-methylthiophenyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00032 | - |
1-(4-butoxyphenyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00042 | - |
1-(2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00045 | - |
(6-ethoxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.0005 | - |
(6-methylthio-2-naphthyl)isopropylamine | MAO-A | Rattus norvegicus | |
0.00068 | - |
(6-propoxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00071 | - |
1-(4-benzyloxyphenyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.00153 | - |
(6-butoxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00256 | - |
(6-benzyloxy-2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.00342 | - |
1-(4-benzyloxyphenyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00378 | - |
(6-benzyloxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.0056 | - |
1-(1-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.00693 | - |
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.009 | - |
N-(4-butoxybenzyl)-4-methylthioamphetamine | MAO-A | Rattus norvegicus | |
0.0122 | - |
1-phenyl-2-aminopropane | MAO-A | Rattus norvegicus | |
0.0136 | - |
(6-propoxy-2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.0145 | - |
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane | MAO-A | Rattus norvegicus | |
0.0163 | - |
(6-ethoxy-2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.0222 | - |
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.0247 | - |
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.1 | - |
N-benzyl-(4-methylthioamphetamine) | - |
Rattus norvegicus | |
0.1 | - |
N-(4-hydroxybenzyl)-4-methylthioamphetamine | - |
Rattus norvegicus | |
0.1 | - |
1-(4-ethoxyphenyl)-2-aminopropane | above, MAO-B | Rattus norvegicus | |
0.1 | - |
1-(4-propoxyphenyl)-2-aminopropane | above, MAO-B | Rattus norvegicus | |
0.1 | - |
1-(4-butoxyphenyl)-2-aminopropane | above, MAO-B | Rattus norvegicus | |
0.1 | - |
N-(4-methoxybenzyl)-4-methylthioamphetamine | MAO-A | Rattus norvegicus | |
0.1 | - |
N-(4-benzyloxybenzyl)-4-methylthioamphetamine | MAO-A | Rattus norvegicus | |
0.1 | - |
1-(1-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.1 | - |
1-(2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus | |
0.1 | - |
(6-methoxy-2-naphthyl)-2-aminopropane | MAO-B | Rattus norvegicus |