Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-dimethyl-6-phenyl-1H-pteridine-2,4-dione | - |
Papio sp. | |
6-(3-chlorophenyl)-1,3-dimethyl-1H-pteridine-2,4-dione | - |
Papio sp. | |
6-amino-1,3-dimethyl-5-([1-phenylmeth-(E)-ylidene]-amino)-1H-pyrimidine-2,4-dione | - |
Papio sp. | |
6-amino-1,3-dimethyl-5-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-1H-pyrimidine-2,4-dione | - |
Papio sp. | |
6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione | - |
Papio sp. | |
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione | - |
Papio sp. | |
6-[(E)-2-(3-chloro-phenyl)-vinyl]-1,3-dimethyl-1H-pteridine-2,4-dione | - |
Papio sp. | |
6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione | - |
Papio sp. | |
additional information | potent reversible pteridine-2,4-dione analogue inhibitor development and synthesis, molecular modelling of MAO-B ligand binding, overview | Papio sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0683 | - |
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine | pH 7.4, 37°C | Papio sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Papio sp. | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papio sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2 | i.e. MMTP | Papio sp. | ? | - |
? | |
additional information | molecular modelling of MAO-B ligand binding, overview | Papio sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-B | - |
Papio sp. |
monoamine oxidase B | - |
Papio sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Papio sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Papio sp. |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | sigmoidal doseresponse curve of the initial rates of oxidation of MMTP versus the logarithm of concentration of inhibiton | Papio sp. | |
0.181 | - |
6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione | pH 7.4, 37°C | Papio sp. | |
0.348 | - |
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione | pH 7.4, 37°C | Papio sp. | |
2.823 | - |
6-(3-chlorophenyl)-1,3-dimethyl-1H-pteridine-2,4-dione | pH 7.4, 37°C | Papio sp. | |
4.06 | - |
6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione | pH 7.4, 37°C | Papio sp. | |
6.958 | - |
6-amino-1,3-dimethyl-5-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-1H-pyrimidine-2,4-dione | pH 7.4, 37°C | Papio sp. |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000314 | - |
pH 7.4, 37°C | Papio sp. | 6-[(E)-2-(3-chloro-phenyl)-vinyl]-1,3-dimethyl-1H-pteridine-2,4-dione | |
0.000602 | - |
pH 7.4, 37°C | Papio sp. | 6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione | |
0.443 | - |
pH 7.4, 37°C | Papio sp. | 1,3-dimethyl-6-phenyl-1H-pteridine-2,4-dione | |
0.467 | - |
pH 7.4, 37°C | Papio sp. | 6-amino-1,3-dimethyl-5-([1-phenylmeth-(E)-ylidene]-amino)-1H-pyrimidine-2,4-dione | |
0.577 | - |
pH 7.4, 37°C | Papio sp. | 6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione | |
1.057 | - |
pH 7.4, 37°C | Papio sp. | 6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione | |
6.968 | - |
pH 7.4, 37°C | Papio sp. | 6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione |
General Information | Comment | Organism |
---|---|---|
physiological function | MAO-Bis implicated in the pathology of neurodegenerative diseases | Papio sp. |