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Literature summary for 1.4.3.4 extracted from

  • Tao, G.; Irie, Y.; Li, D.J.; Keung, W.M.
    Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity (2005), Bioorg. Med. Chem., 13, 4777-4788.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,4-dimethoxy-5-hydroxybenzaldehyde IC50: 0.042 mM, monoamine oxidase A; IC50: 0.39 mM Homo sapiens
2,6-dimethoxyphenol IC50: 0.0624 mM, monoamine oxidase A; IC50: above 0.5 mM, monoamine oxidase B Homo sapiens
2-methoxyphenol IC50: 0.175 mM, monoamine oxidase A; IC50: above 0.5 mM, monoamine oxidase B Homo sapiens
2-methyl-5-methylaniline IC50: 0.15 mM, monoamine oxidase A; IC50: above 0.5 mM Homo sapiens
3,4-dimethoxyaniline IC50: 0.131 mM, monoamine oxidase A Homo sapiens
3-methoxyphenol IC50: 0.024 mM, monoamine oxidase A Homo sapiens
4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol IC50: 0.0089 mM, monoamine oxidase B; IC50: 0.0134 mM, monoamine oxidase A Homo sapiens
4-Hydroxy-3-methoxybenzylamine IC50: 0.13 mM, monoamine oxidase A; IC50: 0.382 mM, monoamine oxidase B Homo sapiens
4-hydroxy-3-methoxyphenethyl alcohol IC50: 0.18 mM, monoamine oxidase A Homo sapiens
4-hydroxy-3-methoxyphenyl acetone IC50: 0.0302 mM, monoamine oxidase A Homo sapiens
cis-2,4,5-trimethoxypropenylbenzene IC50: 0.142 mM, monoamine oxidase A; IC50: 0.362 mM, monoamine oxidase B Homo sapiens
ethyl 4-hydroxy-3-methoxycinnamate IC50: 0.0057 mM, monoamine oxidase B; IC50: 0.0247 mM, monoamine oxidase A Homo sapiens
ethyl-4-hydroxy-3-methoxyphenylacetate IC50: 0.081 mM, monoamine oxidase A Homo sapiens
eugenol IC50: 0.0344 mM, monoamine oxidase A; IC50: 0.288 mM, monoamine oxidase B Homo sapiens
eugenol methyl ether IC50: 0.11 mM, monoamine oxidase A; IC50: 0.269 mM, monoamine oxidase B Homo sapiens
metanephrine IC50: 0.252 mM, monoamine oxidase A Homo sapiens
additional information no inhibition by 4-hydroxy-3-methoxyophenylethyl alcohol, ethyl-4-hydroxy-3-methoxyphenylacetate, metanephrine, 3,4-dimethoxy-5-hydroxybenzaldehyde and 3-methoxyphenol Homo sapiens
o-eugenol IC50: 0.101 mM, monoamine oxidase A; IC50: above 0.5 mM, monoamine oxidase B Homo sapiens
trans-2,4,5-trimethoxypropenylbenzene IC50: 0.124 mM, monoamine oxidase A; IC50: 0.338 mM, monoamine oxidase B Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.192
-
serotonin monoamine oxidase A Homo sapiens
0.192
-
serotonin monoamine oxidase B Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + H2O + O2
-
Homo sapiens (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
?
serotonin + H2O + O2
-
Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
r
serotonin + H2O + O2 monoamine oxidase A Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAOA
-
Homo sapiens
MAOB
-
Homo sapiens
monoamine oxidase A
-
Homo sapiens
monoamine oxidase B
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.026
-
eugenol monoamine oxidase A Homo sapiens
0.211
-
eugenol monoamine oxidase B Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0057
-
IC50: 0.0057 mM, monoamine oxidase B Homo sapiens ethyl 4-hydroxy-3-methoxycinnamate
0.0089
-
IC50: 0.0089 mM, monoamine oxidase B Homo sapiens 4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol
0.0134
-
IC50: 0.0134 mM, monoamine oxidase A Homo sapiens 4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol
0.024
-
IC50: 0.024 mM, monoamine oxidase A Homo sapiens 3-methoxyphenol
0.0247
-
IC50: 0.0247 mM, monoamine oxidase A Homo sapiens ethyl 4-hydroxy-3-methoxycinnamate
0.0302
-
IC50: 0.0302 mM, monoamine oxidase A Homo sapiens 4-hydroxy-3-methoxyphenyl acetone
0.0344
-
IC50: 0.0344 mM, monoamine oxidase A Homo sapiens eugenol
0.042
-
IC50: 0.042 mM, monoamine oxidase A Homo sapiens 2,4-dimethoxy-5-hydroxybenzaldehyde
0.0624
-
IC50: 0.0624 mM, monoamine oxidase A Homo sapiens 2,6-dimethoxyphenol
0.081
-
IC50: 0.081 mM, monoamine oxidase A Homo sapiens ethyl-4-hydroxy-3-methoxyphenylacetate
0.101
-
IC50: 0.101 mM, monoamine oxidase A Homo sapiens o-eugenol
0.11
-
IC50: 0.11 mM, monoamine oxidase A Homo sapiens eugenol methyl ether
0.124
-
IC50: 0.124 mM, monoamine oxidase A Homo sapiens trans-2,4,5-trimethoxypropenylbenzene
0.13
-
IC50: 0.13 mM, monoamine oxidase A Homo sapiens 4-Hydroxy-3-methoxybenzylamine
0.131
-
IC50: 0.131 mM, monoamine oxidase A Homo sapiens 3,4-dimethoxyaniline
0.142
-
IC50: 0.142 mM, monoamine oxidase A Homo sapiens cis-2,4,5-trimethoxypropenylbenzene
0.15
-
IC50: 0.15 mM, monoamine oxidase A Homo sapiens 2-methyl-5-methylaniline
0.175
-
IC50: 0.175 mM, monoamine oxidase A Homo sapiens 2-methoxyphenol
0.18
-
IC50: 0.18 mM, monoamine oxidase A Homo sapiens 4-hydroxy-3-methoxyphenethyl alcohol
0.252
-
IC50: 0.252 mM, monoamine oxidase A Homo sapiens metanephrine
0.269
-
IC50: 0.269 mM, monoamine oxidase B Homo sapiens eugenol methyl ether
0.288
-
IC50: 0.288 mM, monoamine oxidase B Homo sapiens eugenol
0.338
-
IC50: 0.338 mM, monoamine oxidase B Homo sapiens trans-2,4,5-trimethoxypropenylbenzene
0.362
-
IC50: 0.362 mM, monoamine oxidase B Homo sapiens cis-2,4,5-trimethoxypropenylbenzene
0.382
-
IC50: 0.382 mM, monoamine oxidase B Homo sapiens 4-Hydroxy-3-methoxybenzylamine
0.39
-
IC50: 0.39 mM Homo sapiens 2,4-dimethoxy-5-hydroxybenzaldehyde
0.5
-
IC50: above 0.5 mM Homo sapiens 2-methyl-5-methylaniline
0.5
-
IC50: above 0.5 mM, monoamine oxidase B Homo sapiens 2,6-dimethoxyphenol
0.5
-
IC50: above 0.5 mM, monoamine oxidase B Homo sapiens 2-methoxyphenol
0.5
-
IC50: above 0.5 mM, monoamine oxidase B Homo sapiens o-eugenol