Ligand water

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Basic Ligand Information

Molecular Structure
Picture of water (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2O
water
XLYOFNOQVPJJNP-UHFFFAOYSA-N
Synonyms:
3beta-hydroxyisopimara-8(14),15-diene, H2O, H2O ?, H2O[side 2], H3O+, HO-, hydroxyl radicals, OH-, [procollagen]-(5R)-5-hydroxy-L-lysine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8064 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TDP-D-glucose + 2 NADP+ + H2O = TDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+
show the reaction diagram
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(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O = (R)-sulfolactate + 2 NADH + 2 H+
show the reaction diagram
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4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ + H2O = 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H+
show the reaction diagram
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UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+
show the reaction diagram
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UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+
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mevaldyl-CoA + NADPH + H+ + H2O = (R)-mevalonate + CoA + NADP+
show the reaction diagram
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choline + 2 acceptor + H2O = glycine-betaine + 2 reduced acceptor + H+
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D-glucose + D-fructose + H2O = D-glucono-1,5-lactone + D-sorbitol
show the reaction diagram
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NAD+ + H2O = NADH + H2O2
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coelenterazine disulfate + ATP + O2 + H2O = coelenteramide disulfate + AMP + CO2 + diphosphate
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L-phenylalanine + O2 + H2O = 3-phenylpyruvic acid + ammonia + H2O2
show the reaction diagram
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anthranilic acid + NAD(P)H + O2 + H2O = catechol + CO2 + NAD(P)+ + NH3
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3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + O2 + H3O+ = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+ + H2O
show the reaction diagram
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11-deoxycortisol + adrenal ferredoxin + H2O = cortisol + reduced adrenal ferredoxin + O2
show the reaction diagram
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CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD+ + H2O = CDP-4-dehydro-6-deoxy-D-glucose + NADH + H+
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(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
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(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
show the reaction diagram
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lupanine + pyrroloquinoline quinone + H2O = 17-hydroxylupanine + pyrroloquinoline quinol
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2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
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phenylacetyl-CoA + H2O + ubiquinone = phenylglyoxylyl-CoA + ubiquinol
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caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced ferredoxin
show the reaction diagram
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
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isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
show the reaction diagram
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ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor
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queuosine34 in tRNA + acceptor + H2O = epoxyqueuosine34 in tRNA + reduced acceptor
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12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate
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5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+
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3-oxopropanoate + NAD+ + H2O = malonate + NADH
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2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
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benzaldehyde + NAD+ + H2O = benzoate + NADH + H+
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aromatic aldehydes + NAD+ + H2O = corresponding aromatic acids + NADH
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L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+
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D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+
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5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH
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4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH
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6-oxohexanoate + NADP+ + H2O = adipate + NADPH
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coniferyl aldehyde + H2O + NAD+ = ferulate + NADH
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fluroracetaldehyde + NAD+ + H2O = fluoroacetate + NADH
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2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + H+
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abietadienal + H2O + NAD+ = abietate + NADH + H+
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2-carboxybenzaldehyde + NAD+ + H2O = o-phthalic acid + NADH + H+
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beta-apo-4'-carotenal + NAD+ + H2O = beta-apo-4'-carotenoic acid + NADH + H+
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2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+
show the reaction diagram
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D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+
show the reaction diagram
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3,6-anhydro-alpha-L-galactopyranose + NAD(P)+ + H2O = 3,6-anhydro-alpha-L-galactonate + NAD(P)H + H+
show the reaction diagram
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2-hydroxy-2-methylpropanal + NAD+ + H2O = 2-hydroxy-2-methylpropanoate + NADH + H+
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CO + H2O + ferrocytochrome b-561 = CO2 + H+ + ferricytochrome b-561
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abscisic aldehyde + H2O + O2 = abscisate + H2O2
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glyoxylic acid + O2 + H2O = oxalate + H2O2
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indole-3-acetaldehyde + O2 + H2O = indole-3-acetate + H2O2
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pyridoxal + H2O + O2 = 4-pyridoxate + ?
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aromatic aldehyde + O2 + H2O = aromatic acid + H2O2
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acetaldehyde + a quinone + H2O = acetate + a quinol
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formaldehyde + H2O + oxidized ferredoxin = formate + H+ + reduced ferredoxin
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D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor
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magnesium-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H2O = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine
show the reaction diagram
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3,8-divinyl chlorophyllide a + reduced ferredoxin [iron-sulfur] cluster + ATP + H2O + H+ = bacteriochlorophyllide g + oxidized ferredoxin [iron-sulfur] cluster + ADP + phosphate
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benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin
show the reaction diagram
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Isoquinoline + acceptor + H2O = ?
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2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
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L-erythro-3,5-diaminohexanoate + H2O + NAD+ = 5-amino-3-oxohexanoate + NH3 + NADH + H+
show the reaction diagram
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L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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L-lysine + NAD+ + H2O = 1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
show the reaction diagram
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meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+
show the reaction diagram
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L-tryptophan + NAD+ + H2O = (indol-3-yl)pyruvate + NH3 + NADH + H+
show the reaction diagram
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L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
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L-Amino acid + H2O + NAD+ = ?
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L-valine + NAD(P)+ + H2O = 2-oxoisovalerate + NH3 + NAD(P)H
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putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2
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L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
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ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
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N-(4-aminobutyl)-L-glutamine + H2O + O2 = N-(4-oxobutyl)-L-glutamine + NH3 + H2O2
show the reaction diagram
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D-alanine + oxidized acceptor + H2O = pyruvate + NH3 + reduced acceptor
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L-glutamine + H2O = L-glutamate + NH3
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tauropine + NAD+ + H2O = taurine + pyruvate + NADH
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beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH + H+
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
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N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2
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N8-acetylspermidine + O2 + H2O = 1,3-diaminopropanal + H2O2 + ?
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L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
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epsilon-N-methyl groups in protein-bound methyllysine residues + O2 + H2O = demethylated lysine residues + formaldehyde + H2O2
show the reaction diagram
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(R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
show the reaction diagram
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L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor
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N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor
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L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor
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CO2 + H2O = HCO3- + H+
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nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor
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hydrazine + H2O + ferricytochrome c = nitric oxide + ammonium + ferrocytochrome c
show the reaction diagram
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hydroxylamine + 2 acceptor + H2O = nitrite + 2 reduced acceptor + H+
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hypotaurine + H2O + NAD+ = taurine + NADH
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dimethyl sulfide + ferricytochrome c2 + H2O = dimethyl sulfoxide + ferrocytochrome c2
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sulfite + O2 + H2O = sulfate + H2O2
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methanethiol + O2 + H2O = formaldehyde + H2S + H2O2
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S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
show the reaction diagram
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dimethylsulfide + menaquinone + H2O = dimethylsulfoxide + menaquinol
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hydrogen sulfide + oxidized ferredoxin + H2O = sulfite + reduced ferredoxin + H+
show the reaction diagram
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hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O = sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
show the reaction diagram
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S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
show the reaction diagram
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5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
show the reaction diagram
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10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O = tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
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5,10-methylenetetrahydrofolate + H2O + cytidylate = tetrahydrofolate + 5-hydroxymethylcytidylate
show the reaction diagram
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succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate
show the reaction diagram
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acetyl-CoA + H2O = acetate + CoA
show the reaction diagram
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4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2
show the reaction diagram
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acetyl-CoA + oxaloacetate + H2O = citrate + CoA
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lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA
show the reaction diagram
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an acyl-CoA + H2O = a (2R)-2-alkyl-3-oxoalkanoate + CoA
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dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA
show the reaction diagram
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butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA
show the reaction diagram
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2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate
show the reaction diagram
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S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + bicarbonate
show the reaction diagram
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phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate
show the reaction diagram
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N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O = N-acetyl-neuraminate 9-phosphate + phosphate
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phosphoenolpyruvate + 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O = phosphate + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid
show the reaction diagram
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S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+
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L-glutamate + tetrahydrodipicolinate + H2O = LL-diaminopimelate + 2-oxoglutarate
show the reaction diagram
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L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
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ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate
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ATP + 1,6-anhydro-beta-D-glucopyranose + H2O = ADP + 6-phospho-alpha-D-glucopyranose
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ATP + L-glutamine + H2O = AMP + phosphate + N5-phospho-L-glutamine
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NTP + H2O = NDP + phosphate
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adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = ?
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adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate + H2O = GMP + adenosylcobalamin + phosphate + H+
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ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate
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ATP + selenide + H2O = AMP + selenophosphate + phosphate
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ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate
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ATP + rifampicin + H2O = AMP + 21-phosphorifampicin + phosphate
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ATP + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + 5-methyuracil54 in tRNA + H2O = AMP + diphosphate + 5-methyl-2-thiouracil54 in tRNA + [TtuB sulfur-carrier protein]-Gly-Gly
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O-phospho-L-seryl-tRNASec + selenophosphate + H2O = L-selenocysteinyl-tRNASec + phosphate
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atropine + H2O = tropine + tropate
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chlorophyllide a + H2O = 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d + methanol + CO2
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[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
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D-glucono-1,5-lactone + H2O = D-gluconate
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