Cloned (Comment) | Organism |
---|---|
expression of MAO-A in Pichia pastoris mitochondria | Homo sapiens |
expression of MAO-B in Pichia pastoris mitochondria, recombinant MAO-B is situated on the cytosolic face of the outer membrane in Pichia mitochondria | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate | - |
Homo sapiens | |
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide | i.e. ParSL-1, a TEMPO-conjugated pargyline analogue; i.e. ParSL-1, a TEMPO-conjugated pargyline analogue | Homo sapiens | |
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide | i.e. ParSL-3, a TEMPO-conjugated pargyline analogue, specifically inhibits MAO-A | Homo sapiens | |
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-4-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide | i.e. ParSL-2, a TEMPO-conjugated pargyline analogue, specifically inhibits MAO-B | Homo sapiens | |
Pargyline | construction of three TEMPO-conjugated pargyline analogues ParSL-1, ParSL-2, and ParSL-3, which differ in flexibility and substituent positions of the linkers connecting the TEMPO group to the pargyline phenyl ring. The variations in conformational flexibility and substituent position have profound effects in tuning the specificities of these analogues toward the MAO isoforms, inhibitor synthesis, overview; construction of three TEMPO-conjugated pargyline analogues ParSL-1, ParSL-2, and ParSL-3, which differ in flexibility and substituent positions of the linkers connecting the TEMPO group to the pargyline phenyl ring. The variations in conformational flexibility and substituent position have profound effects in tuning the specificities of these analogues toward the MAO isoforms, inhibitor synthesis, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21397 | - |
- |
Homo sapiens | P27338 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MAOA | - |
Homo sapiens |
MAOB | - |
Homo sapiens |
monoamine oxidase A | - |
Homo sapiens |
monoamine oxidase B | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, overview | Homo sapiens | |
0.0013 | - |
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate | inhibition of MAO-B | Homo sapiens | |
0.015 | - |
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-4-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide | inhibition of MAO-B | Homo sapiens | |
0.0235 | - |
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate | inhibition of MAO-A | Homo sapiens | |
0.268 | - |
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide | inhibition of MAO-A | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0016 | - |
inhibition of MAO-B | Homo sapiens | methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate | |
0.0271 | - |
inhibition of MAO-A | Homo sapiens | methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate |