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Literature summary for 1.4.3.4 extracted from

  • Chimenti, F.; Fioravanti, R.; Bolasco, A.; Chimenti, P.; Secci, D.; Rossi, F.; Yanez, M.; Orallo, F.; Ortuso, F.; Alcaro, S.
    Chalcones: a valid scaffold for monoamine oxidases inhibitors (2009), J. Med. Chem., 52, 2818-2824.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-1,3-diphenylprop-2-en-1-one
-
Homo sapiens
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-(4-methylphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-phenylprop-2-en-1-one
-
Homo sapiens
(2E)-1-[4-(benzyloxy)phenyl]-3-(4-chlorophenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one inhibits MAO-A and MAO-B Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-[4-(benzyloxy)phenyl]-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-[4-(benzyloxy)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one
-
Homo sapiens
4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl methanesulfinate
-
Homo sapiens
Clorgyline
-
Homo sapiens
Iproniazid
-
Homo sapiens
moclobemide specific for MAO-A Homo sapiens
additional information MAO-A is not inhibited by most of the chalcone compounds tested for MAO inhibitory activity, no inhibition of MAO-B by 5c, 5d, and 5f, overview Homo sapiens
R-(-)-deprenyl highly active with MAO-B Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-tyramine + H2O + O2
-
Homo sapiens 4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-A
-
Homo sapiens
MAO-B
-
Homo sapiens
monoamine oxidases A
-
Homo sapiens
monoamine oxidases B
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000044
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
0.0000051
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
0.000031
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
0.000054
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
0.000071
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one
0.00016
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
0.00045
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-[4-(benzyloxy)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one
0.00103
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-(4-methylphenyl)prop-2-en-1-one
0.00125
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)prop-2-en-1-one
0.00141
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-1,3-diphenylprop-2-en-1-one
0.00495
-
pH 7.4, 37°C, MAO-A Homo sapiens (2E)-3-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
0.01876
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-1-(2-hydroxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-3-phenylprop-2-en-1-one
0.047
-
pH 7.4, 37°C, MAO-B Homo sapiens 4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl methanesulfinate
0.05
-
pH 7.4, 37°C, MAO-B Homo sapiens (2E)-3-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)prop-2-en-1-one