Literature summary for 1.4.3.4 extracted from

Ma, J.; Yoshimura, M.; Yamashita, E.; Nakagawa, A.; Ito, A.; Tsukihara, T.
Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors (2004), J. Mol. Biol., 338, 103-114.

Search for more literature for 1.4.3.4

Application

Application	Comment	Organism
medicine	the enzyme is a target for anti-depression drug design	Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method, crystal structure of the enzyme complexed with the specific inhibitor, clorgyline, at 3.2 A resolution	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Clorgyline	MAOA-specific irreversible inhibitor, used clinically as antidepressant. It foms a covalent bond with FAD	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	outer membrane, the enzyme has a transmembrane helix at the C-terminal region	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	the enzyme catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P21396	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
MAOA	-	Rattus norvegicus
monoamine oxidase A	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	cofactor burried in the inside of the molecule, cofactor acts covalently with Cys406	Rattus norvegicus

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Release 2023.1 (January 2023)