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Literature summary for 1.4.3.4 extracted from

  • Upadhyay, A.K.; Borbat, P.P.; Wang, J.; Freed, J.H.; Edmondson, D.E.
    Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy (2008), Biochemistry, 47, 1554-1566.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of MAOA in Pichia pastoris KM71 cell mitochondria Rattus norvegicus
expression of MAOB in Pichia pastoris KM71 cell mitochondria Rattus norvegicus
expression of wild-type and mutant MAOA in Pichia pastoris KM71 cell mitochondria Homo sapiens
expression of wild-type and mutant MAOB in Pichia pastoris KM71 cell mitochondria Homo sapiens

Protein Variants

Protein Variants Comment Organism
E142K a MAOB mutant Homo sapiens
K151E a MAOA mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Clorgyline
-
Homo sapiens
Clorgyline
-
Rattus norvegicus
Pargyline
-
Homo sapiens
Pargyline
-
Rattus norvegicus
ParSL a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview Homo sapiens
ParSL a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
Homo sapiens 5741
-
mitochondrial outer membrane
-
Rattus norvegicus 5741
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397 MAOA
-
Homo sapiens P27338 MAOB
-
Rattus norvegicus P19643 MAOB
-
Rattus norvegicus P21396 MAOA
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
Homo sapiens
flavoprotein
-
Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
recombinant wild-type and mutant MAOA from Pichia pastoris KM71 cell mitochondria partially as mitochondrial outer membrane-bound proteins Homo sapiens
recombinant wild-type and mutant MAOB from Pichia pastoris KM71 cell mitochondria partially as mitochondrial outer membrane-bound proteins Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information active site structure, overview Homo sapiens ?
-
?
additional information active site structure, overview Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
dimer MAOB exists entirely as dimer Homo sapiens
dimer MAOB exists entirely as dimer Rattus norvegicus
monomer or dimer MAOA is partly dimeric in the mitochondrial outer membrane and in octyl beta-D-glucopyranoside micelles Homo sapiens
monomer or dimer MAOA is partly dimeric in the mitochondrial outer membrane and in octyl beta-D-glucopyranoside micelles Rattus norvegicus
More no role of the Glu-X-Lys motif in stabilizing dimeric structures of MAOs, three-dimensional structure analysis of MAOA, overview Homo sapiens
More no role of the Glu-X-Lys motif in stabilizing dimeric structures of MAOs, three-dimensional structure analysis of MAOB, overview Homo sapiens
More three-dimensional structure analysis of MAOA, overview Rattus norvegicus
More three-dimensional structure analysis of MAOB, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
MAOA
-
Homo sapiens
MAOA
-
Rattus norvegicus
MAOB
-
Homo sapiens
MAOB
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
flavin covalent flavin cofactor present in the MAO active sites Homo sapiens
flavin covalent flavin cofactor present in the MAO active sites Rattus norvegicus