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Literature summary for 1.4.3.4 extracted from

  • Gooden, D.M.; Schmidt, D.M.; Pollock, J.A.; Kabadi, A.M.; McCafferty, D.G.
    Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B (2008), Bioorg. Med. Chem. Lett., 18, 3047-3051.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
2-(4-bromophenyl)cyclopropanamine
-
 Homo sapiens
2-(4-methoxyphenyl)cyclopropanamine
-
 Homo sapiens
2-(naphthalen-1-yl)cyclopropanamine
-
 Homo sapiens
2-(thiophen-3-yl)cyclopropanamine
-
 Homo sapiens
2-[4-(trifluoromethyl)phenyl]cyclopropanamine
-
 Homo sapiens
additional information synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7; synthesis of mechanism-based substituted trans-2-arylcyclopropylamine inhibitors, overview. No inhibition by 7 Homo sapiens
trans-2-phenylcyclopropylamine 2-PCPA; 2-PCPA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozyme active site structures, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More isozyme active site structures, overview Homo sapiens

Synonyms

Synonyms Comment Organism
monoamine oxidase A
-
 Homo sapiens
monoamine oxidase B
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
flavin dependent on Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0077
-
 2-[4-(trifluoromethyl)phenyl]cyclopropanamine inhibition of MAO-B Homo sapiens
0.0098
-
 2-(naphthalen-1-yl)cyclopropanamine inhibition of MAO-B Homo sapiens
0.0136
-
 trans-2-phenylcyclopropylamine inhibition of MAO-B Homo sapiens
0.0329
-
 2-(4-bromophenyl)cyclopropanamine inhibition of MAO-B Homo sapiens
0.0373
-
 trans-2-phenylcyclopropylamine inhibition of MAO-A Homo sapiens
0.0866
-
 2-(4-methoxyphenyl)cyclopropanamine inhibition of MAO-B Homo sapiens
1.548
-
 2-(thiophen-3-yl)cyclopropanamine inhibition of MAO-B Homo sapiens