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Literature summary for 1.4.3.4 extracted from

  • Ogunrombi, M.O.; Malan, S.F.; TerreBlanche, G.; Castagnoli, K.; Castagnoli, N.; Bergh, J.J.; Petzer, J.P.
    Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline (2007), Life Sci., 81, 458-467.
    View publication on PubMed
Search for more literature for 1.4.3.4

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.021
-
 1-methyl-3-(4-chlorophenyl)-3-pyrroline pH 7.4, 37°C, enzyme from brain Mus musculus
0.0448
-
 1-methyl-3-(4-chlorophenyl)-3-pyrroline pH 7.4, 37°C Bos taurus
0.0461
-
 1-methyl-3-(4-chlorophenyl)-3-pyrroline pH 7.4, 37°C Papio sp.
0.0521
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pH 7.4, 37°C, enzyme from brain Mus musculus
0.0546
-
 1-methyl-3-phenyl-3-pyrroline pH 7.4, 37°C Papio sp.
0.0564
-
 1-methyl-3-phenyl-3-pyrroline pH 7.4, 37°C Bos taurus
0.0635
-
 1-methyl-3-(4-chlorophenyl)-3-pyrroline pH 7.4, 37°C, enzyme from liver Mus musculus
0.125
-
 1-methyl-3-phenyl-3-pyrroline pH 7.4, 37°C, enzyme from brain Mus musculus
0.138
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pH 7.4, 37°C Bos taurus
0.173
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pH 7.4, 37°C Papio sp.
0.461
-
 1-methyl-3-phenyl-3-pyrroline pH 7.4, 37°C, enzyme from liver Mus musculus
0.797
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pH 7.4, 37°C, enzyme from liver Mus musculus

Organism

Organism UniProt Comment Textmining
Bos taurus P56560
-
-
Mus musculus Q8BW75
-
-
Papio sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
liver
-
 Papio sp.
-
liver
-
 Mus musculus
-
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
-
 Papio sp. ?
-
 ?
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
-
 Mus musculus ?
-
 ?
1-methyl-3-(4-chlorophenyl)-3-pyrroline + H2O + O2
-
 Bos taurus ?
-
 ?
1-methyl-3-phenyl-3-pyrroline + H2O + O2 oxidation is a 2-electron process. Rapid clearance of 1-methyl-3-phenylpyrrole from the brain may contribute to their lack of neurotoxicity Papio sp. 1-methyl-3-phenylpyrrole + NH3 + H2O2
-
 ?
1-methyl-3-phenyl-3-pyrroline + H2O + O2 oxidation is a 2-electron process. Rapid clearance of 1-methyl-3-phenylpyrrole from the brain may contribute to their lack of neurotoxicity Mus musculus 1-methyl-3-phenylpyrrole + NH3 + H2O2
-
 ?
1-methyl-3-phenyl-3-pyrroline + H2O + O2 oxidation is a 2-electron process. Rapid clearance of 1-methyl-3-phenylpyrrole from the brain may contribute to their lack of neurotoxicity Bos taurus 1-methyl-3-phenylpyrrole + NH3 + H2O2
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2 the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is oxidized to 1-methyl-4-phenylpyridinium MPP+, a 4-electron oxidation product and a potent mitochondrial toxin Papio sp. 1-methyl-4-phenylpyridinium + 3 H2O2
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2 the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is oxidized to 1-methyl-4-phenylpyridinium MPP+, a 4-electron oxidation product and a potent mitochondrial toxin Mus musculus 1-methyl-4-phenylpyridinium + 3 H2O2
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 2 H2O + 2 O2 the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is oxidized to 1-methyl-4-phenylpyridinium MPP+, a 4-electron oxidation product and a potent mitochondrial toxin Bos taurus 1-methyl-4-phenylpyridinium + 3 H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-B
-
 Papio sp.
MAO-B
-
 Mus musculus
MAO-B
-
 Bos taurus
monoamine oxidase B
-
 Papio sp.
monoamine oxidase B
-
 Mus musculus
monoamine oxidase B
-
 Bos taurus