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Literature summary for 1.4.3.4 extracted from
- Purification and properties of mitochondrial monoamine oxidase type A from human placenta (1985), J. Biol. Chem., 260, 13199-13207.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-dipyridyl disulfide | - |
Homo sapiens |  |
| amphetamine | a competitive inhibitor of MAO-A | Homo sapiens | |
| Clorgyline | - |
Homo sapiens | |
| Deprenyl | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Km of membrane-bound and Triton X-100-solubilized enzyme | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RCH2NH2 + H2O + O2 | Homo sapiens | important functions in the metabolism of biogenic amines in the central nervous system and peripheral tissues | RCHO + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | - |
Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | important functions in the metabolism of biogenic amines in the central nervous system and peripheral tissues | Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 60000-64000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | isoforms differ in inhibitor sensitivity | Homo sapiens |
| More | MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.08 | - |
kynuramine | MAO-A | Homo sapiens | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | flavoprotein | Homo sapiens | |
| flavin | 1 flavin per subunit | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
amphetamine | - |
Homo sapiens | |
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