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Literature summary for 1.4.3.4 extracted from

  • Sunal, S.G.; Yabanoglu, S.; Yesilada, A.; Ucar, G.
    Monoamine oxidase inhibitory activities of novel 3,4-dihydroquinolin-(1H)-2-one derivatives (2007), J. Neural Transm., 114, 717-719.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
1-(benzylideneamino)-3,4-dihydroquinolin-2(1H)-one selective for MAO-B Rattus norvegicus
1-amino-3,4-dihydroquinolin-2(1H)-one selective for MAO-B Rattus norvegicus
2-(4-chlorophenyl)-N-cyclohexyl-2-(3-ethynyl-2-oxo-4-phenylquinolin-1(2H)-yl)acetamide selective for MAO-B Rattus norvegicus
paragyline
-
 Rattus norvegicus
Pargyline
-
 Rattus norvegicus
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate non-selective; non-selective Rattus norvegicus
tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl][2-(phenylcarbonyl)phenyl]amino]-2-oxoethyl)carbamate selective for MAO-B Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P19643
-
-
Rattus norvegicus P21396
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Rattus norvegicus
MAO-B
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00272
-
-
 Rattus norvegicus Pargyline
0.00405
-
-
 Rattus norvegicus paragyline
0.06
-
 37°C, no preincubation Rattus norvegicus 1-amino-3,4-dihydroquinolin-2(1H)-one
0.063
-
 37°C, no preincubation Rattus norvegicus 2-(4-chlorophenyl)-N-cyclohexyl-2-(3-ethynyl-2-oxo-4-phenylquinolin-1(2H)-yl)acetamide
0.066
-
 37°C, no preincubation Rattus norvegicus 1-(benzylideneamino)-3,4-dihydroquinolin-2(1H)-one
0.079
-
 37°C, no preincubation Rattus norvegicus tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl][2-(phenylcarbonyl)phenyl]amino]-2-oxoethyl)carbamate
0.25
-
 37°C, no preincubation Rattus norvegicus tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate
0.33
-
 37°C, no preincubation Rattus norvegicus tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate