Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-5-(4-acetylaminophenyl)-N-phenyl-4,5-dihydro-1H -pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-5-(4-acetylaminophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-5-(4-methylphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-N,5-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
4-[1-(cyclopropylcarbamothioyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | - |
Rattus norvegicus | |
4-[1-(ethylcarbamothioyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | - |
Rattus norvegicus | |
4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | - |
Rattus norvegicus | |
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
Clorgyline | - |
Rattus norvegicus | |
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | - |
Rattus norvegicus | |
Pargyline | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P19643 | - |
- |
Rattus norvegicus | P21396 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-tyramine + H2O + O2 | - |
Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
benzylamine + H2O + O2 | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
monoamine oxidase A | - |
Rattus norvegicus |
monoamine oxidase B | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00172 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | Clorgyline | |
0.00625 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.00834 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.01339 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.0199 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.0299 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.03044 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.03724 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.05522 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.06128 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.08991 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.09045 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.09053 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.09821 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.09856 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.0999 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.10077 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | |
0.1842 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.1859 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.19356 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.19723 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.19844 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.19886 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.20534 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.2459 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.25623 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.26476 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.39 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | Pargyline | |
0.43089 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.47004 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.47019 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.47021 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-N-methyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.47022 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.47045 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 4-[3-(4-fluorophenyl)-1-(methylcarbamothioyl)-4,5-dihydro-1H-pyrazol-5-yl]-N-methylbenzamide | |
0.47066 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | N-ethyl-3-(4-fluorophenyl)-5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.47067 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.48023 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-N-ethyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.48055 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | N-cyclopropyl-3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.4874 | - |
isoform MAO-A, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(2-naphthyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.48882 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.49622 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-bromophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.50011 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-N-cyclopropyl-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.50023 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 5-(4-chlorophenyl)-3-(4-fluorophenyl)-N-methyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | |
0.50045 | - |
isoform MAO-B, at pH 7.6 and 37°C | Rattus norvegicus | 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide |