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Literature summary for 1.4.3.4 extracted from

  • Chimenti, F.; Bolasco, A.; Manna, F.; Secci, D.; Chimenti, P.; Granese, A.; Befani, O.; Turini, P.; Cirilli, R.; La Torre, F.; Alcaro, S.; Ortuso, F.; Langer, T.
    Synthesis, biological evaluation and 3D-QSAR of 1,3,5-trisubstituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase A inhibitors (2006), Curr. Med. Chem., 13, 1411-1428.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
1,3-diphenyl-4,5-dihydro-1H-pyrazole IC50: 0.0098 mM, MAO-A; IC50: 0.2 mM, MAO-B Bos taurus
1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole IC50: 0.000009 mM, MAO-A; IC50: 0.041 mM, MAO-B Bos taurus
1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.00023 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.0002 mM, MAO-A; IC50: 0.14 mM, MAO-B Bos taurus
1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.00029 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole IC50: 0.0003 mM, MAO-A; IC50: 0.09 mM, MAO-B Bos taurus
1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.0001 mM, MAO-A; IC50: 0.088 mM, MAO-B Bos taurus
1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.00024 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole IC50: 0.00001 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole IC50: 0.00001mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.0002 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole IC50: 0.0001 mM, MAO-A; IC50: 0.02 mM, MAO-B Bos taurus
1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.0001 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.00001 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.0001 mM, MAO-A; IC50: 0.038 mM, MAO-B Bos taurus
1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.00001 mM, MAO-A; IC50: 0.025 mM, MAO-B Bos taurus
1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.000009 mM, MAO-A; IC50: 0.083 mM, MAO-B Bos taurus
1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.000008 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol IC50: 0.0001 mM, MAO-A; IC50: 0.019 mM, MAO-B Bos taurus
2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol IC50: 0.001 mM, MAO-A; IC50: 0.07 mM, MAO-B Bos taurus
2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol IC50: 0.000072 mM, MAO-A; IC50: 0.04 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.008 mM, MAO-A; IC50: 0.3 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.009 mM, MAO-A; IC50: 0.3 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0094 mM, MAO-A; IC50: 0.48 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.025 mM, MAO-B; IC50: 0.097 mM, MAO-A Bos taurus
2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.098 mM, MAO-A; IC50: 2.0 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.013 mM, MAO-A; IC50: 3.8 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.09 mM, MAO-A; IC50: 1.0 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.094 mM, MAO-A; IC50: 1.8 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.088 mM, MAO-A; IC50: 0.2 mM, MAO-B Bos taurus
2-[1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0095 mM, MAO-A Bos taurus
2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0000086 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.00001 mM, MAO-A; IC50: 0.0001 mM, MAO-B Bos taurus
2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.000008 mM, MAO-A; IC50: 0.019 mM, MAO-B Bos taurus
2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0001 mM, MAO-A; IC50: 0.04 mM, MAO-B Bos taurus
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.000028 mM, MAO-A; IC50: 0.00006 mM, MAO-B Bos taurus
2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.000009 mM, MAO-A; IC50: 0.0072 mM, MAO-B Bos taurus
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.002 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0000088 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.0001 mM, MAO-A; IC50: 0.06 mM, MAO-B Bos taurus
2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.089 mM, MAO-A; IC50: 0.25 mM, MAO-B Bos taurus
2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.12 mM, MAO-A; IC50: 1 mM, MAO-B Bos taurus
2-{1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl}phenol IC50: 0.4 mM, MAO-B Bos taurus
3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.0018 mM, MAO-A; IC50: 0.04 mM, MAO-B Bos taurus
3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.01 mM, MAO-A; IC50: 0.5 mM, MAO-B Bos taurus
3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.003 mM, MAO-A; IC50: 0.017 mM, MAO-B Bos taurus
3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.000014 mM, MAO-A; IC50: 0.001 mM, MAO-B Bos taurus
3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.09 mM, MAO-A; IC50: 0.98 mM, MAO-B Bos taurus
3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.0074 mM, MAO-A; IC50: 0.087 mM, MAO-B Bos taurus
3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.0099 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.00011 mM, MAO-A; IC50: 0.0125 mM, MAO-B Bos taurus
3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.0069 mM, MAO-A; IC50: 0.05 mM, MAO-B Bos taurus
3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole IC50: 0.000086 mM, MAO-A; IC50: 0.00145 mM, MAO-B Bos taurus
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol IC50: 0.0001 mM, MAO-A; IC50: 0.39 mM, MAO-B Bos taurus
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol IC50: 0.0001 mM, MAO-A; IC50: 0.08 mM, MAO-B Bos taurus
4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol IC50: 0.00005 mM, MAO-A; IC50: 0.062 mM, MAO-B Bos taurus
4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol IC50: 0.0001 mM, MAO-A; IC50: 0.03 mM, MAO-B Bos taurus
4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol IC50: 0.000073 mM, MAO-A; IC50: 0.003 mM, MAO-B Bos taurus
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.0001 mM, MAO-A; IC50: 0.038 mM, MAO-B Bos taurus
4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.00001 mM, MAO-A; IC50: 0.02 mM, MAO-B Bos taurus
4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0000086 mM, MAO-A; IC50: 0.087 mM, MAO-B Bos taurus
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.000008 mM, MAO-A; IC50: 0.13 mM, MAO-B Bos taurus
4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0000088 mM, MAO-A; IC50: 0.1 mM, MAO-B Bos taurus
4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.00001 mM, MAO-A; IC50: 0.00002 mM, MAO-B Bos taurus
4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.00001 mM, MAO-A; IC50: 0.023 mM, MAO-B Bos taurus
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.000013 mM, MAO-A; IC50: 0.000038 mM, MAO-B Bos taurus
4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.000008 mM, MAO-A; IC50: 0.019 mM, MAO-B Bos taurus
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.00001 mM, MAO-A; IC50: 0.12mM, MAO-B Bos taurus
4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0001 mM, MAO-A; IC50: 0.04 mM, MAO-B Bos taurus
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.000009 mM, MAO-A; IC50: 0.083 mM, MAO-B Bos taurus
4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.000009 mM, MAO-A; IC50: 0.0072 mM, MAO-B Bos taurus
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol IC50: 0.000009 mM, MAO-A; IC50: 0.042 mM, MAO-B Bos taurus
4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol IC50: 0.0001mM, MAO-A; IC50: 0.03 mM, MAO-B Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus P21398
-
-
Bos taurus P56560
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2 MAO-A Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
kynuramine + H2O + O2 MAO-B Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Bos taurus
MAO-B
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000008
-
 IC50: 0.000008 mM, MAO-A Bos taurus 2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000008
-
 IC50: 0.000008 mM, MAO-A Bos taurus 4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000008
-
 IC50: 0.000008 mM, MAO-A Bos taurus 1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.000008
-
 IC50: 0.000008 mM, MAO-A Bos taurus 4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0000086
-
 IC50: 0.0000086 mM, MAO-A Bos taurus 4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0000086
-
 IC50: 0.0000086 mM, MAO-A Bos taurus 2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0000088
-
 IC50: 0.0000088 mM, MAO-A Bos taurus 2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0000088
-
 IC50: 0.0000088 mM, MAO-A Bos taurus 4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000009
-
 IC50: 0.000009 mM, MAO-A Bos taurus 1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole
0.000009
-
 IC50: 0.000009 mM, MAO-A Bos taurus 1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.000009
-
 IC50: 0.000009 mM, MAO-A Bos taurus 2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000009
-
 IC50: 0.000009 mM, MAO-A Bos taurus 4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000009
-
 IC50: 0.000009 mM, MAO-A Bos taurus 4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.000009
-
 IC50: 0.000009 mM, MAO-A Bos taurus 4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.00001
-
 IC50: 0.00001 mM, MAO-A Bos taurus 1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole
0.00001
-
 IC50: 0.00001mM, MAO-A Bos taurus 1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole
0.000013
-
 IC50: 0.000013 mM, MAO-A Bos taurus 4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000014
-
 IC50: 0.000014 mM, MAO-A Bos taurus 3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.00002
-
 IC50: 0.00002 mM, MAO-B Bos taurus 4-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000028
-
 IC50: 0.000028 mM, MAO-A Bos taurus 2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000038
-
 IC50: 0.000038 mM, MAO-B Bos taurus 4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.00005
-
 IC50: 0.00005 mM, MAO-A Bos taurus 4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.00006
-
 IC50: 0.00006 mM, MAO-B Bos taurus 2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.000072
-
 IC50: 0.000072 mM, MAO-A Bos taurus 2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.000073
-
 IC50: 0.000073 mM, MAO-A Bos taurus 4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.000086
-
 IC50: 0.000086 mM, MAO-A Bos taurus 3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol
0.0001
-
 IC50: 0.0001 mM, MAO-A Bos taurus 2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.0001
-
 IC50: 0.0001 mM, MAO-B Bos taurus 2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.0001
-
 IC50: 0.0001mM, MAO-A Bos taurus 4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.00011
-
 IC50: 0.00011 mM, MAO-A Bos taurus 3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0002
-
 IC50: 0.0002 mM, MAO-A Bos taurus 1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0002
-
 IC50: 0.0002 mM, MAO-A Bos taurus 1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.00023
-
 IC50: 0.00023 mM, MAO-A Bos taurus 1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.00024
-
 IC50: 0.00024 mM, MAO-A Bos taurus 1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.00029
-
 IC50: 0.00029 mM, MAO-A Bos taurus 1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.0003
-
 IC50: 0.0003 mM, MAO-A Bos taurus 1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole
0.001
-
 IC50: 0.001 mM, MAO-A Bos taurus 2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.001
-
 IC50: 0.001 mM, MAO-B Bos taurus 3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.00145
-
 IC50: 0.00145 mM, MAO-B Bos taurus 3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0018
-
 IC50: 0.0018 mM, MAO-A Bos taurus 3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.002
-
 IC50: 0.002 mM, MAO-A Bos taurus 2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.003
-
 IC50: 0.003 mM, MAO-A Bos taurus 3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.003
-
 IC50: 0.003 mM, MAO-B Bos taurus 4-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.0069
-
 IC50: 0.0069 mM, MAO-A Bos taurus 3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0072
-
 IC50: 0.0072 mM, MAO-B Bos taurus 2-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0072
-
 IC50: 0.0072 mM, MAO-B Bos taurus 4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0074
-
 IC50: 0.0074 mM, MAO-A Bos taurus 3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.008
-
 IC50: 0.008 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.009
-
 IC50: 0.009 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0094
-
 IC50: 0.0094 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0095
-
 IC50: 0.0095 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.0098
-
 IC50: 0.0098 mM, MAO-A Bos taurus 1,3-diphenyl-4,5-dihydro-1H-pyrazole
0.0099
-
 IC50: 0.0099 mM, MAO-A Bos taurus 3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.01
-
 IC50: 0.01 mM, MAO-A Bos taurus 3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.0125
-
 IC50: 0.0125 mM, MAO-B Bos taurus 3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.013
-
 IC50: 0.013 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.017
-
 IC50: 0.017 mM, MAO-B Bos taurus 3-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.019
-
 IC50: 0.019 mM, MAO-B Bos taurus 2-[1-acetyl-5-(2-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.019
-
 IC50: 0.019 mM, MAO-B Bos taurus 4-[1-acetyl-5-(3-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.019
-
 IC50: 0.019 mM, MAO-B Bos taurus 2-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.02
-
 IC50: 0.02 mM, MAO-B Bos taurus 4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.02
-
 IC50: 0.02 mM, MAO-B Bos taurus 1-acetyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole
0.023
-
 IC50: 0.023 mM, MAO-B Bos taurus 4-[1-acetyl-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.025
-
 IC50: 0.025 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.025
-
 IC50: 0.025 mM, MAO-B Bos taurus 1-acetyl-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.03
-
 IC50: 0.03 mM, MAO-B Bos taurus 4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.03
-
 IC50: 0.03 mM, MAO-B Bos taurus 4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.038
-
 IC50: 0.038 mM, MAO-B Bos taurus 1-acetyl-5-(2-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.038
-
 IC50: 0.038 mM, MAO-B Bos taurus 4-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.04
-
 IC50: 0.04 mM, MAO-B Bos taurus 4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.04
-
 IC50: 0.04 mM, MAO-B Bos taurus 2-[1-acetyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.04
-
 IC50: 0.04 mM, MAO-B Bos taurus 2-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.04
-
 IC50: 0.04 mM, MAO-B Bos taurus 3-(2,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.041
-
 IC50: 0.041 mM, MAO-B Bos taurus 1-acetyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole
0.042
-
 IC50: 0.042 mM, MAO-B Bos taurus 4-[1-acetyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.05
-
 IC50: 0.05 mM, MAO-B Bos taurus 3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.06
-
 IC50: 0.06 mM, MAO-B Bos taurus 2-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.062
-
 IC50: 0.062 mM, MAO-B Bos taurus 4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
0.07
-
 IC50: 0.07 mM, MAO-B Bos taurus 2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.08
-
 IC50: 0.08 mM, MAO-B Bos taurus 4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,3-diol
0.083
-
 IC50: 0.083 mM, MAO-B Bos taurus 1-acetyl-5-(3-methylphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.083
-
 IC50: 0.083 mM, MAO-B Bos taurus 4-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.087
-
 IC50: 0.087 mM, MAO-B Bos taurus 4-[1-acetyl-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.087
-
 IC50: 0.087 mM, MAO-B Bos taurus 3-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.088
-
 IC50: 0.088 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.088
-
 IC50: 0.088 mM, MAO-B Bos taurus 1-acetyl-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.089
-
 IC50: 0.089 mM, MAO-A Bos taurus 2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.09
-
 IC50: 0.09 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.09
-
 IC50: 0.09 mM, MAO-A Bos taurus 3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.09
-
 IC50: 0.09 mM, MAO-B Bos taurus 1-acetyl-3-(2-nitrophenyl)-4,5-dihydro-1H-pyrazole
0.094
-
 IC50: 0.094 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.097
-
 IC50: 0.097 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(2-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.098
-
 IC50: 0.098 mM, MAO-A Bos taurus 2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 2-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-5-(2,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 2-[1-acetyl-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-phenyl-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole
0.1
-
 IC50: 0.1 mM, MAO-B Bos taurus 1-acetyl-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.12
-
 IC50: 0.12 mM, MAO-A Bos taurus 2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.12
-
 IC50: 0.12mM, MAO-B Bos taurus 4-[1-acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.13
-
 IC50: 0.13 mM, MAO-B Bos taurus 4-[1-acetyl-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzene-1,3-diol
0.14
-
 IC50: 0.14 mM, MAO-B Bos taurus 1-acetyl-3-(2,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole
0.2
-
 IC50: 0.2 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.2
-
 IC50: 0.2 mM, MAO-B Bos taurus 1,3-diphenyl-4,5-dihydro-1H-pyrazole
0.25
-
 IC50: 0.25 mM, MAO-B Bos taurus 2-[5-(3-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.3
-
 IC50: 0.3 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.3
-
 IC50: 0.3 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.39
-
 IC50: 0.39 mM, MAO-B Bos taurus 4-(1-acetyl-4,5-dihydro-1H-pyrazol-3-yl)benzene-1,2,3-triol
0.4
-
 IC50: 0.4 mM, MAO-B Bos taurus 2-{1-(4-chlorophenyl)-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-pyrazol-3-yl}phenol
0.48
-
 IC50: 0.48 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
0.5
-
 IC50: 0.5 mM, MAO-B Bos taurus 3-(2-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
0.98
-
 IC50: 0.98 mM, MAO-B Bos taurus 3-(3-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
1
-
 IC50: 1 mM, MAO-B Bos taurus 2-[5-(4-bromophenyl)-1-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
1
-
 IC50: 1.0 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
1.8
-
 IC50: 1.8 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
2
-
 IC50: 2.0 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
3.8
-
 IC50: 3.8 mM, MAO-B Bos taurus 2-[1-(4-chlorophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol